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Klinik für Psychiatrie und Psychotherapie

Former Research group Biber

"Role of purine receptors in the regulation by glia cells of the inflammatory response in the brain"

Summary

Neurons under stress rapidly release purines like ATP or adenosine, which activate purine receptors in surrounding cells. Purines can therefore be seen as so-called danger molecules and they most likely are among the early signals in brain diseases. There are two families of purine receptors, P1 receptors are activated by adenosine and P2 receptors that respond to ATP. Both receptor families are expressed in glia cells, which makes purines important elements in neuron-glia communication. We showed already more than 10 years ago that the activation of purine receptors in glia cells is important for the expression and release of cytokines, which in turn are important for the survival of neurons under pathological circumstances. Since cytokines may have neuroprotective but also neurotoxic properties it is of interest to understand the purine-based communication between neurons and glia cells.

Key References

  • Biber K, Tsuda M, Tozaki-Saitoh H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K. (2011) Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development. EMBO J. 30:1864-73.
  • Biber K, Pinto-Duarte A, Wittendorp MC, Dolga AM, Fernandes CC, Von Frijtag Drabbe Künzel J, Keijser JN, de Vries R, Ijzerman AP, Ribeiro JA, Eisel U, Sebastião AM, Boddeke HWGM. (2008) Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection. Neuropsychopharmacology, Aug;33(9):2237-50.
  • Wittendorp MC, Künzel J, Ijzerman AP, Boddeke HWGM, Biber K. (2004) The mouse brain adenosine A1 receptor: functional expression and pharmacology. Eur. J. Pharmacol. 487: 73-79.

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