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Klinik für Psychiatrie und Psychotherapie

PI Serchov

Molecular Psychiatry

Research focus

Our research interests are to study the brain circuits and synaptic mechanisms involved in the regulation of mood and cognition and particularly to understand the molecular and cellular mechanisms of antidepressant therapy. We are investigating how the scaffolding interactions modulate glutamatergic neurotransmission and regulate mouse emotional behavior.

Research projects

Project 1: “The role of Homer1a-mediated regulation of glutamatergic signaling in the antidepressant therapy” funded by German Research Foundation (DFG) Grant SE 2666/2-1 for Temporary Position for Principal Investigator.

Project 2: “Investigation of the diagnostic potential of Homer1 as peripheral biomarker for depression and predictor of antidepressant treatment response” funded by the Forschungscomission (Research Committee) of the Medical Faculty of University Freiburg Grant SER1149/17 (in close collaboration with RG Domschke: Psychiatric Genetics and Epigenetics).

Selected publications

  • Serchov T, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M, Jacobson KA, de Bartolomeis A, Normann C, Biber K, van Calker D. (2015) Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. Neuron 87(3):549-62. doi: 10.1016/j.neuron.2015.07.010
  • Serchov T, van Calker D, Biber K. (2016) Light/Dark Transition Test to Assess Anxiety-like Behavior in Mice. Bio-protocol. 6 (19). doi: 10.21769/BioProtoc.1957
  • Serchov T, van Calker D, Biber K. (2016) Sucrose Preference Test to Measure Anhedonic Behavior in Mice. Bio-protocol. 6 (19). doi: 10.21769/BioProtoc.1958
  • Serchov T, Heumann R, van Calker D, Biber K. (2016) Signaling pathways regulating Homer1a expression: implications for antidepressant therapy. Biol Chem. 397(3):207-14. doi: 10.1515/hsz-2015-0267
  • Normann C, Frase S, Haug V, Wolf G, Clark K, Münzer P, Dorner A, Scholliers J, Horn M, Vo Van T, Seifert G, Serchov T, Biber K, Nissen C, Klugbauer N, Bischofsberger J. (2017) Antidepressants rescue stress-induced disruption of synaptic plasticity via serotonin transporter-independent inhibition of L-type Ca2+-channels. Biol Psychiatry doi: 10.1016/j.biopsych.2017.10.008
  • van Calker D, Serchov T, Normann C, Biber K. (2018) Recent insights into antidepressant therapy: Distinct pathways and potential common mechanisms in the treatment of depressive syndromes. Neurosci Biobehav Rev. 88:63-72. doi: 10.1016/j.neubiorev.2018.03.014

Klinik für Psychiatrie und Psychotherapie

Hauptstraße 5
79104 Freiburg

Information: 0761 270-65010


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