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Klinik für Psychiatrie und Psychotherapie

Research group Hölzel / Frank

Psychotherapy and Health Services Research
Research group leader:Dr. phil. Lars P. Hölzel   
Phone: +49 (0)761 270 - 69840   
Email: lars.hoelzel@uniklinik-freiburg.de
Research group co-leader:Prof. Dr. phil. Fabian Frank
Phone: +49 (0)761 270-69840
Email: fabian.frank@uniklinik-freiburg.de
Group members:Phone
[+49 (0)761]
Frederike Bjerregaard, M.Sc. Psychology290 - 9533frederike.bjerregaard@uniklinik-freiburg.de
Sabine Bott, M.A. Health Education270 - 69870sabine.bott@uniklinik-freiburg.de
Julia Albicker, M.Sc. Psychology270 - 69860julia.albicker@uniklinik-freiburg.de
Julia Zech, M.A. Social Work270 - 69840julia.zech@uniklinik-freiburg.de
Lyn Anne von Zepelin, B.Sc. Nursing Science290 - 9528 lyn.anne.zepelin@uniklinik-freiburg.de
Dora Meyer, M.Sc. Psychology270 - 69870dora.meyer@uniklinik-freiburg.de
Research assistants:
Pauline Grünewald270 - 69890pauline.gruenewald@uniklinik-freiburg.de
Svenja Anna-Lena Will, B.A. Educational Science270 - 69890svenja.anna-lena.will@uniklinik-freiburg.de

Research focus

The focus of our research group is on the development, implementation and evaluation of psychotherapeutic interventions and other measures to improve health care of patients with mental disorders – particularly with depression.

Fields of interest

Problem-Solving Therapy: We take large interest in the application of Problem-Solving Therapy in different settings. Problem-Solving Terapy is brief, easy to learn, highly flexible and has a strong evidence base.

Psychoeducation: Psychoeducation in patients and  their relatives is an important intervention to enhance illness related self-efficacy and stabilize treatment outcomes.

Cultural Adaptation: The cultural adaptation of information material and interventions for patients with a migration background are important measures to improve health care.

Telepsychotherapy: Telepsychotherapy, especially Videoconferencing Psychotherapy has a large potential to reach patients in rural and underserved regions. Web-based applications may therefore play a central role to improve health care in regions that are so fare underserved.

Webinar: The implementation of new psychotherapeutic methods is a major challenge to mental health care. Web-based seminars (webinars) have the potential to deliver trainings over large distances. This technology can also be used to conduct large multicenter randomized controlled psychotherapy trials in which the provision of highly standardized trainings is essential. Webinars may also be an efficient and economic instrument to simultaneously provide standardized trainings to multiple study sites.

Populations of central interest

  • migrants
  • elderly
  • patients with diabetes and comorbid depression
  • chronic depression
  • patients in rural regions
  • relatives
  • adults with autism spectrum disorder

Settings of central interest

  • inpatient depression treatment
  • transition between inpatient and outpatient treatment
  • collaborative care
  • primary care

Research projects

Since 2017:
LoChro – Local, collaborative, stepped and personalised care management for older people with chronic diseases: a randomised comparative effectiveness trial
(LoChro – Lokales Versorgungsmanagement für chonisch erkrankte ältere Menschen)
study description
Sponsor: Federal Ministry of Education and Research
Members of Research Group: Prof. Dr. Fabian Frank, Sabine Bott MA, Julia Zech MA, Frederike Bjerregaard MSc, Lyn Anne von Zepelin BSc

Since 2014:
SCHILD – protective intervention for longtime course in depression

(SCHILD – Schützende Intervention für den Langzeitverlauf bei Depression)
study description (deutsch)
Sponsor: Else Kröner-Fresenius-Stiftung
Members of Research Group: Dr. Lars P. Hölzel, Prof. Dr. Fabian Frank, Sabine Bott, M.A., Dora Meyer
In cooperation with:

  • Prof. Dr. Eva-Maria Bitzer, Department of Public Health and Health Education, University of Education Freiburg
  • Dr. Levente Kriston, Department of Medical Psychology, University Medical Center Hamburg-Eppendorf


  • Dr. Lars P. Hölzel: DGPPN-award for health services research in psychiatry and psychotherapy 2015
  • Fabian Frank: 2nd poster-award on the 9th congress of the Society for Research in Autism Spectrum Conditions (WGAS) 2015

Selected peer-reviewed publications

  • Frank F, Jablotschkin M, Arthen T, Riedel A, Fangmeier T, Hölzel LP, Tebartz van Elst L. (2018). Education and employment status of adults with autism spectrum disorders in Germany – a cross-sectional-survey. BMC Psychiatry; 18:75
  • Frank F, Gräder N, Dahlmann H, Berger M, Hölzel LP. (2018). Bereitschaft zur Inanspruchnahme internetbasierter Unterstützung nach stationärer Behandlung – eine Querschnittstudie. Psychiatrische Praxis; DOI: 10.1055/s-0043-119243
  • Ries Z, Frank F, Bermejo I, Kalaitsidou C, Zill J, Dirmaier J, Härter M, Bengel J, Hölzel LP. (2017). Auf dem Weg zu kultursensitiven Patienteninformationsmaterialien: Ergebnisse einer Fokusgruppenuntersuchung. Psychotherapie Psychosomatik Medizinische Psychologie; DOI: 10.1055/s-0043-117773;
  • Hölzel LP, Frank F, Bjerregaard F, Aréan PA, Niebling W, Berger M, Bermejo I. (2017). Problemlösetraining in der Primärversorgung – eine evidenzbasierte Methode für den Versorgungsalltag. Zeitschrift für Allgemeinmedizin; 93: 260-265
  • Frank F., Wilk J., Kriston L., Meister R., Shimodera S., Hesse K., Bitzer EM., Berger M., Hölzel LP. (2015). Effectiveness of a brief psychoeducational group intervention for relatives on the course of disease in patients after inpatient depression treatment compared with treatment as usual – study protocol of a multisite randomised controlled trial. BMC Psychiatry; 15: 259
  • Frank F., Hasenmüller M., Kaiser M., Ries Z., Bitzer EM., Hölzel LP. (2015). Psychoedukative Gruppen für Angehörige von depressiv Erkrankten: Analyse des Informationsbedarfs durch eine Fokusgruppenuntersuchung. Psychotherapie Psychosomatik Medizinische Psychologie; 65: 426-433
  • Bermejo I., Frank F,. Komarahadi F., Albicker J., Ries Z., Kriston L., Härter M. (2015). Transkulturelle Prävention von Alkoholerkrankungen – Effekte eines kultur- und migrationssensitiven Ansatzes auf Einstellungen und Verhalten älterer Personen mit Migrationshintergrund – Eine cluster-randomisierte kontrollierte Studie. Bundesgesundheitsblatt – Gesundheitsforschung - Gesundheitsschutz; 58: 738-748
  • Frank F., Rummel-Kluge C., Berger M., Bitzer EM., Hölzel L.P. (2014). Provision of group psychoeducation for relatives of persons in inpatient depression treatment - a cross-sectional survey of acute care hospitals in Germany. BMC Psychiatry, 14, 143.
  • Kriston L., von Wolff A., Westphal A., Hölzel L.P., Härter M. (2014). Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis. 01/2013; DOI 10.1002/da.22236 Depression and Anxiety.
  • Hölzel L.P., Bermejo I., Kriston L., von Wolff A., Kornacher J., Harter C. et al. (2014). Length of hospitalization for inpatient treatment of depression. Results of a multicentre study on the effects of a new treatment model. Der Nervenarzt, 85,344-349.


  • Bundesministerium für Bildung und Forschung (BMBF)
  • Wissenschaftliche Gesellschaft in Freiburg im Breisgau
  • Else Kröner-Fresenius-Stiftung


The following link guides you to material developed by our research group. In particular you can find psychometric tested questionnaires as well as practical material that can be used in treatment and prevention of mental illnesses.
[ Material ]

Klinik für Psychiatrie und Psychotherapie

Hauptstraße 5
79104 Freiburg

Information: 0761 270-65010

Aktuelle Weiterbildung

PPA-Symposium 19.09.2020 "Psychiatrie und Psychotherapie – aktuell" (Save the Date)