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Klinik für Psychiatrie und Psychotherapie

Research group Hölzel

Psychotherapy and Health Services Research
(former: Clinical Epidemiology and Health Services Research)
Research group leader:Dr. phil. Lars P. Hölzel   
Phone: +49 (0)761 270 - 69840   
Email: lars.hoelzel@uniklinik-freiburg.de
Research group
Dr. phil. Fabian Frank, M.A. Social Work
Phone: +49 (0)761 270-69840
Email: fabian.frank@uniklinik-freiburg.de
Group members:Phone [+49 (0)761]E-Mail
Zivile Ries,
270 - 69510zivile.ries@uniklinik-freiburg.de
Frederike Bjerregaard,
M.Sc. Psychology
290 - 9533frederike.bjerregaard@uniklinik-freiburg.de
Juliette Dockweiler,
270 - 69870juliette.dockweiler@uniklinik-freiburg.de
Sabine Bott, M.A.
Health Education
270 - 69870


Julia Albicker,
M.Sc. Psychology
270 - 69860


Research Assistants:
Julia Zech,
B.A. Social Work
270 - 69890julia.zech@uniklinik-freiburg.de
Dora Meyer,
B.Sc. Psychology
270 - 69890


Tobias Arthen,
B.Sc. Psychology
270 - 69890


Dennis Schwaiger270 - 69890dennis.marcus.schwaiger@uniklinik-freiburg.de
Joke Lembeck270 - 69890joke.lembeck@uniklinik-freiburg.de
Alexander Dihlmann 270 - 69890alexander.dihlmann@uniklinik-freiburg.de

Research focus

The focus of our research group is on the development, implementation and evaluation of psychotherapeutic interventions and other measures to improve health care of patients with mental disorders – particularly with depression.

Fields of interest

Problem-Solving Therapy: We take large interest in the application of Problem-Solving Therapy in different settings. Problem-Solving Terapy is brief, easy to learn, highly flexible and has a strong evidence base.

Psychoeducation: Psychoeducation in patients and  their relatives is an important intervention to enhance illness related self-efficacy and stabilize treatment outcomes.

Cultural Adaptation: The cultural adaptation of information material and interventions for patients with a migration background are important measures to improve health care.

Telepsychotherapy: Telepsychotherapy, especially Videoconferencing Psychotherapy has a large potential to reach patients in rural and underserved regions. Web-based applications may therefore play a central role to improve health care in regions that are so fare underserved.

Webinar: The implementation of new psychotherapeutic methods is a major challenge to mental health care. Web-based seminars (webinars) have the potential to deliver trainings over large distances. This technology can also be used to conduct large multicenter randomized controlled psychotherapy trials in which the provision of highly standardized trainings is essential. Webinars may also be an efficient and economic instrument to simultaneously provide standardized trainings to multiple study sites.

Populations of central interest

  • migrants
  • elderly
  • patients with diabetes and comorbid depression
  • chronic depression
  • patients in rural regions
  • relatives
  • adults with autism spectrum disorder

Settings of central interest

  • inpatient depression treatment
  • transition between inpatient and outpatient treatment
  • collaborative care
  • primary care

Research projects

Since 2014:
SCHILD – protective intervention for longtime course in depression
(SCHILD – Schützende Intervention für den Langzeitverlauf bei Depression)
study description (deutsch)
Sponsor: Else Kröner-Fresenius-Stiftung
Members of Research Group: Dr. Lars P. Hölzel, Fabian Frank MA, Sabine Bott, M.A., Julia Albicker M.Sc. und Juliette Wilk, Dipl.-Psych.
In cooperation with:

  • Prof. Dr. Eva-Maria Bitzer, Department of Public Health and Health Education, University of Education Freiburg
  • Dr. Levente Kriston, Department of Medical Psychology, University Medical Center Hamburg-Eppendorf

Since 2013:
Competency Center for Psychotherapy of the medical faculties Baden-Württemberg
(Kompetenzzentrum Psychotherapie an den medizinischen Fakultäten Baden-Württemberg)
project website
Sponsor: Ministry of Science, Research and the Arts Baden-Württemberg
Members of Research Group: Dr. Lars P. Hölzel, Dr. Nicole Ower, Philomena Storz, M.Sc.
In cooperation with:

  • Prof. Dr. Martin Bohus, Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim
  • Prof. Dr. Sabine Herpertz, Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg
  • Prof. Dr. Andreas J. Fallgatter, University Clinic Tuebingen, Department of Psychiatry and Psychotherapy

Since 2012:
Collaborative treatment of late-life depression in primary care: Implementation of the IMPACT program in Germany
study flyer
Sponsor: Federal Ministry of Education and Research (BMBF)
Members of Research Group: Dr. Lars P. Hölzel, Frederike Bjerregaard MSc., Antje Firus, Lyn Anne von Zepelin
In cooperation with:

  • Prof. Dr. Michael Hüll, Klinik für Geronto- und Neuropsychiatrie, Zentrum für Psychiatrie Emmendingen
  • Prof. Dr. Dr. Martin Härter, Department of Medical Psychology, University Medical Center Hamburg-Eppendorf
  • Prof. Dr. Martin Scherer, Department of Primary Medical Care, University Medical Center Hamburg- Eppendorf
  • Prof. Dr. Hans-Helmut König, Department for Medical Sociology and Health Economics, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf
  • Prof. Dr. Wilhelm Niebling, Department of Medicine, Division of General Practice, University Medical Centre Freiburg

Since 2011:
Culture-sensitive patient information for patients with migration background and a chronic disease
Sponsor: Federal Ministry of Education and Research (BMBF) Members of Research Group: Dr. Lars P. Hölzel, Zivile Ries MSc.
BMBF Förderkennzeichen: 01 GX 1031
Registrierungsnummer: Deutsches Register Klinischer Studien  DRKS-ID:DRKS00004241 Universal Trail Number: U1111-1135 8043 
In cooperation with:

  • Prof. Dr. Dr. Martin Härter, Dr. Levente Kriston, Dr. Jörg Dirmaier, Jördis Zill, M.Sc. Department of Medical Psychology, University Medical Center Hamburg-Eppendorf;
  • PD Dr. Isaac Bermejo, Celenus Kliniken GmbH;
  • PD Dr. Christine Rummel-Kluge, University of Leipzig, Department of Psychiatry; German Foundation Against Depression [Stiftung Deutsche Depressionshilfe];
  • Prof. Dr. Wilhelm Niebling, Teaching Unit for General Practice, University of Freiburg
  • Dr. Peter Ramme, physicians network Mülheim;
  • Hans Kokorsch, physicians network Duisburg-Süd;
  • Angela Brunöhler physicians network Oberhausen;
  • Dr. Friedrich Hugenschmidt, Ärztenetz Dreiländereck e.V.;

Since 2010:
Evaluation of the “Freiburg Alliance against Depression”
Sponsor: Scientific Society in Freiburg im Breisgau (“Wissenschaftliche Gesellschaft in Freiburg im Breisgau”)
Members of Research Group: Dr. Lars P. Hölzel, Fabian Frank M.A., Prof. Dr. Mathias Berger
In Cooperation with:

  • Dr. Levente Kriston, Department of Medical Psychology, University Medical Center Hamburg-Eppendorf;
  • PD Dr. Nicolas Rüsch, University of Zurich, Clinic for General and Social Psychiatry


  • Dr. Lars P. Hölzel: DGPPN-award for health services research in psychiatry and psychotherapy 2015
  • Fabian Frank: 2nd poster-award on the 9th congress of the Society for Research in Autism Spectrum Conditions (WGAS) 2015

Selected peer-reviewed publications

  • Frank F., Wilk J., Kriston L., Meister R., Shimodera S., Hesse K., Bitzer EM., Berger M., Hölzel LP. (2015). Effectiveness of a brief psychoeducational group intervention for relatives on the course of disease in patients after inpatient depression treatment compared with treatment as usual – study protocol of a multisite randomised controlled trial. BMC Psychiatry; 15: 259
  • Frank F., Hasenmüller M., Kaiser M., Ries Z., Bitzer EM., Hölzel LP. (2015). Psychoedukative Gruppen für Angehörige von depressiv Erkrankten: Analyse des Informationsbedarfs durch eine Fokusgruppenuntersuchung. Psychotherapie Psychosomatik Medizinische Psychologie; 65: 426-433
  • Bermejo I., Frank F,. Komarahadi F., Albicker J., Ries Z., Kriston L., Härter M. (2015). Transkulturelle Prävention von Alkoholerkrankungen – Effekte eines kultur- und migrationssensitiven Ansatzes auf Einstellungen und Verhalten älterer Personen mit Migrationshintergrund – Eine cluster-randomisierte kontrollierte Studie. Bundesgesundheitsblatt – Gesundheitsforschung - Gesundheitsschutz; 58: 738-748
  • Frank F., Rummel-Kluge C., Berger M., Bitzer EM., Hölzel L.P. (2014). Provision of group psychoeducation for relatives of persons in inpatient depression treatment - a cross-sectional survey of acute care hospitals in Germany. BMC Psychiatry, 14, 143.
  • Kriston L., von Wolff A., Westphal A., Hölzel L.P., Härter M. (2014). Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis. 01/2013; DOI 10.1002/da.22236 Depression and Anxiety.
  • Hölzel L.P., Bermejo I., Kriston L., von Wolff A., Kornacher J., Harter C. et al. (2014). Length of hospitalization for inpatient treatment of depression. Results of a multicentre study on the effects of a new treatment model. Der Nervenarzt, 85,344-349.
  • Hölzel L.P., Vollmer M., Kriston L., Siegel A. & Härter M. (2012). Integrierte Versorgung Gesundes Kinzigtal: Evaluationsergebnisse aus Patientensicht. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz, 55, 1524-1533.
  • Hölzel L.P., Kriston L., Weiser A.-K. & Härter M. (2011). Cross-national differences in inpatient depression treatment. European Psychiatric Review, 4, 32–34.
  • Hölzel L., Härter M., Reese C. & Kriston L. (2011). Risk factors for chronic depression – A systematic review. Journal of Affective Disorders, 129, 1–13.
  • Kriston L., von Wolff A. & Hölzel L. (2010). Effectiveness of psychotherapeutic, pharmacological, and combined treatments for chronic depression: a systematic review (METACHRON). BMC Psychiatry, 10, 95.
  • Hölzel L., von Wolff A., Kriston L. & Härter M. (2010). Unter welchen Bedingungen bleibt eine stationäre Depressionsbehandlung erfolglos? Eine Analyse an routinemäßig erhobenen Daten von 511 Patienten. Psychiatrische Praxis, 37, 27-33.


  • Bundesministerium für Bildung und Forschung (BMBF)
  • Wissenschaftliche Gesellschaft in Freiburg im Breisgau
  • Else Kröner-Fresenius-Stiftung


The following link guides you to material developed by our research group. In particular you can find psychometric tested questionnaires as well as practical material that can be used in treatment and prevention of mental illnesses.
[ Material ]

Klinik für Psychiatrie und Psychotherapie

Hauptstraße 5
79104 Freiburg

Information: 0761 270-65010