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Klinik für Psychiatrie und Psychotherapie

Prof. Dr. rer. nat. Knut Biber


Since May 2009 Head Molecular Psychiatry, Psychiatric Hospital, University of Freiburg
Since 2008 Adjunct Professor for Physiology, University Medical Center Groningen
Feb.-Jun. 2007 Guest Professor, Molecular Pharmacology, Kyushu University, Fukuoka, Japan
2005-2007 Associate professor, Medical Physiology, University Medical Center Groningen
1999-2004 Assistant professor, Medical Physiology Department, University of Groningen
1998-99 Postdoc, Medical Physiology Department, University of Groningen
1997-98 Postdoc, Department of Psychiatry, (Freiburg)
1994-97 PhD student, Department of Psychiatry (Freiburg). Thesis title: “Regulation of expression and signal transduction of adenosine receptors in cultured glial cells”
1992-93 Final thesis (Diplomarbeit) in the Department of Zoology (Freiburg). Thesis title: “Intercellular transport of proteins and organelles in ovarian follicles of meroistic insects”
1991-92 Employed in the PC-Service of BSC Computer (Freiburg)
1989-91 Study of Biology at the Albert-Ludwigs University (Freiburg), Master
1986-88 Study of Biology at the Free University (Berlin), Bachelor


1997Dissertation at the Department of Biology Freiburg with the topic: Regulation of expression and signal transduction of adenosine receptors in cultured glial cells.
OTHERS (Editorial work, Member of scientific councils, advisory boards)
Reviewer (Journals, ad hoc): Brain, EMBO J, J. Neurosc., J. Neuroinflam., PLOS one.
Reviewer (grants): EU FP7 program, ANR, NWO
Since 2006    Editorial board: GLIA

Selected publications

a) Manuscripts that are published in peer-reviewed journals

  • Rolyan H, Scheffold A, Heinrich A, Begus-Nahrmann Y, Langkopf BH, Hölter SM, Vogt-Weisenhorn DM, Liss B, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. (2011) Telomere shortening reduces Alzheimer's disease amyloid pathology in mice. Brain. 134:2044-56.
  • Biber K, Tsuda M, Tozaki-Saitoh H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K. (2011) Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development. EMBO J. 2011 May 4;30(9):1864-73.
  • de Jong EK, Vinet J, Stanulovic V, Wesseling EM, Meijer M, Schollema K, Boddeke HWGM, Biber K. (2008) Expression, transport and axonal sorting of neuronal CCL21 in large dense core vesicles. FASEB Journal, Dec;22(12):4136-45.
  • De Haas AH, Boddeke HWMG, Biber K. (2008) Region-specific expression of immunregulatory proteins on microglia in the healthy CNS. Glia, 56:888-94.
  • de Jong EK, Dijkstra IM, Hensens M, Brouwer N, Amerongen M, Liem RSB, Boddeke HWMG, Biber K (2005). Vesicle-mediated transport and release of CCL21 in endangered neurons: a possible explanation for microglia activation remote from a primary lesion. J. Neurosci. 25:7548-57.

b) Other publications

  • Miller RJ, Rostene W, Apartis E, Banisadr G, Biber K, Milligan ED, White FA, Zhang J. (2008) Chemokine action in the nervous system. J. Neurosci. Nov 12;28(46):11792-5.
  • Biber K, Neumann H, Inoue K, Boddeke HWGM. (2007) Neuronal On and Off signals control microglia. Trends in Neurosciences, 30: 598-602
  • Biber K, de Jong EK, de Haas A, van Weering H, Boddeke HWGM. (2007) Neuronal chemokines: Versatile messengers for cell-cell communication in the CNS? Mol. Neurobiol. 36:137-151.

c) patents sorted as submitted and granted

  • Nr. 02710550.1-2404-NL0200039 Cloning and expression of a new MCP-1 receptor in glial cells. K. Biber and H.W.G.M. Boddeke (2002)

Klinik für Psychiatrie und Psychotherapie

Hauptstraße 5
79104 Freiburg

Information: 0761 270-65010