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Division of Stereotactic and Functional Neurosurgery

MD Döbrössy Publications

PubMed Listing

PubMed list of Dr. M. Döbrössy (external link to PubMed data base)

Published peer reviewed manuscripts

71. Ashouri Vajari D, Ramanathan C, Tong Y, Stieglitz T, Coenen VA, Döbrössy MD: Medial forebrain bundle DBS differentially modulates dopamine release in the nucleus accumbens in a rodent model of depression. Exp Neurol, 2020; 327 (online): 113224. Epub

70. Coenen VA, Schlaepfer TE, Sajonz B, Döbrössy M, Kaller CP, Urbach H, Reisert M: Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders. Neuroimage-clin, 2020; 25:102165. Epub

69. Thiele S, Sörensen A, Weis J, Braun F, Meyer PT, Coenen VA, Döbrössy MD: Deep Brain Stimulation of the Medial Forebrain Bundle in a rodent model of Depression: Exploring Dopaminergic mechanisms with Raclopride and micro PET. Stereot Funct Neuros, 2020 (in print). Epub

68. Serchov T, Schwarz I, Theiss A, Sun L, Holz A, Döbrössy MD, Schwarz MK, Normann C, Biber K, van Calker D: Enhanced adenosine A1 receptor and Homer1a expression in hippocampus modulates the resilience to stress-induced depression-like behavior. Neuropharmacology, 2020; 162 (online):107834. Epub

67. Holz A, Mülsch F, Schwarz MK, Hollmann M, Döbrössy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, Serchov T: Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. Neuron, 2019; 104(2):338-352. Epub

66. Kaindlstorfer C, Stefanova N, Garcia J, Krismer F, Döbrössy M, Göbel G, Jellinger K, Granata R, Wenning GK: L-dopa response pattern in a rat model of mild striatonigral degeneration. Plos One, 2019; 14 (6) (online): e0218130. Epub

65. Tomov N, Surchev L, Wiedenmann C, Döbrössy M, Nikkhah G: Roscovitine, an experimental CDK5 inhibitor, causes delayed suppression of microglial, but not astroglial recruitment around intracerebral dopaminergic grafts. Exp Neurol 2019; 318:135-144. Epub

64. Thiele S, Furlanetti L, Pfeiffer LM, Coenen VA, Döbrössy MD: The effects of bilateral, continuous, and chronic Deep Brain Stimulation of the medial forebrain bundle in a rodent model of depression. Exp Neurol, 2018, 303:153-161.

63. Tomov N, Surchev L, Wiedenmann C, Döbrössy MD, Nikkhah G: Astrogliosis has Different Dynamics after Cell Transplantation and Mechanical Impact in the Rodent Model of Parkinson's Disease. Balkan Med J. 2018 Mar 15;35(2):141-147.

62. Winkler C, Reis J, Hoffmann N, Gellner AK, Münkel C, Curado M, Furlanetti L, Garcia J, Dobrossy MD, Fritsch B: Anodal transcranial Direct Current Stimulation enhances survival and integration of dopaminergic cell transplants in a rat Parkinson model. eNeuro, 2017; 4(5) (online): 0063.

61. Cook A, Pfeiffer LM, Thiele S, Coenen VA, Döbrössy MD: Olfactory discrimination and memory deficits in the Flinders Sensitive Line rodent model of depression. Behavioural Processes, 2017; 143:25-29.

60. Clinch S, Busse M, Döbrössy MD, Dunnett SB: Rehabilitation training in neural restitution. Prog Brain Res, 2017; 230: 305-329.

59. Capetian P, Azmitia L, Pauly MG, Krajka V, Stengel F, Bernhardi EM, Klett M, Meier B, Seibler P, Stanslowsky N, Moser A, Knopp A, Gillessen-Kaesbach G, Nikkhah G, Wegner F, Döbrössy M, Klein C. Plasmid-Based Generation of Induced Neural Stem Cells from Adult Human Fibroblasts. Front Cell Neurosci, 2016 (online). doi: 10.3389/fncel.2016.00245

58. Egger K, Janz P, Döbrössy MD, Bienert T, Reisert M, Obmann M, Glauche V, Haas C, Harsan LA, Urbach H, von Elverfeldt D: Microstructural effects of a neuro-modulating drug evaluated by Diffusion Tensor Imaging Neuroimage, 2016; 127: 1-10. doi: 10.1016/j.neuroimage.2015.10.091

57. Thiele S, Spehl TS, Frings L, Braun F, Ferch M, Meyer PT, Rezvani A, Furlanetti LL, Coenen VA, Döbrössy MD (2016). Long-term characterization of the Flinders Sensitive Line rodent model of depression: Behavioral and PET evidence of a dysfunctional entorhinal cortex. Behav Brain Res, 2016; 300: 11-24.

56. Furlanetti LL, Coenen VA, Döbrössy MD (2016). Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle. Behav. Bra. Res. 299: 132-134. doi: 10.1016/j.bbr.2015.11.036

55. Döbrössy MD, Furlanetti L, Coenen V (2015). Electrical stimulation of the Medial Forebrain Bundle in pre-clinical studies of psychiatric disorders. Neuroscience & Biobehavioral Reviews, 49: 32-42. doi: 10.1016/j.neubiorev. 2014.11.018.

54. Furlanetti LL, Döbrössy MD, Aranda IA, Coenen VA (2015). Feasibility and safety of continuous and chronic bilateral deep brain stimulation of the medial forebrain bundle in the naïve sprague-dawley rat. Behav Neurol. 2015;2015:256196. doi: 10.1155/2015/256196. Epub 2015 Apr 15.

53. Furlanetti LL, Cordeiro JG, Cordeiro KK, Garcia JAS, Winkler C, Lepski G, Coenen VA, Nikkhah G, and Döbrössy MD (2015). Continuous high frequency stimulation of the Subthalamic nucleus improves cell survival and functional recovery following dopaminergic cell transplantation in rodents. Neurorehab Neural Repair, doi: 10.1177/1545968315581419.

52. Döbrössy MD, Furlanetti LL, Aranda IA, and Coenen VA (2015). Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in Rats. Behav Neurology, doi: 10.1155/2015/256196.

51. Furlanetti LL, Coenen VA, Aranda IA, Döbrössy MD (2015). Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a hemiparkinsonian rodent model. Exp Brain Res. 2015 Jul 21. [Epub ahead of print]

50. Egger K, Janz P, Döbrössy MD, Bienert T, Reisert M, Obmann M, Glauche V, Haas C, Harsan LA, Urbach H, von Elverfeldt D (2015). Microstructural effects of a neuro-modulating drug evaluated by Diffusion Tensor Imaging. S1053-8119(15)01079-4. doi: 10.1016/j.neuroimage.2015.10.091.

49. Piroth T, Pauly M-C, Schneider C, Wittmer A, Möllers S, Döbrössy MD, Winkler C, and Nikkhah G (2014). Transplantation of Human Fetal Tissue for Neurodegenerative Diseases: Validation of a New Protocol for Microbiological Analysis and Bacterial Decontamination. Cell Transplantation 23, 995–1007.

48. Panksepp J, Wright JS, Döbrössy MD, Schlaepfer TE, Coenen VA (2014). Affective Neuroscience Strategies for Understanding and Treating Depression: From Preclinical Models to Three Novel Therapeutics. Clinical Psychological Science, Vol. 2(4): 472–494.

47. Büchele F, Döbrössy MD, Hackl C, Jiang W, Papazoglou A, Nikkhah G (2014). Two-step grafting significantly enhances the survival of foetal dopaminergic transplants and induces graft-derived vascularisation in a 6-OHDA model of Parkinson’s disease. Neurobiol Dis, 68:112-25.

46. Cordeiro KK, Cordeiro JG, Furlanetti L, Garcia J, Tenório SB, Winkler C, Döbrössy MD, and Nikkhah G (2014). Subthalamic nucleus lesion improves cell survival and functional recovery following dopaminergic cell transplantation in parkinsonian rats. Eur J Neurosci. 2014 Mar 14. doi: 10.1111/ejn.12541.

45. Pauly MC, Döbrössy MD, Nikkhah G, Winkler C, and Piroth T (2014). Organization of the human fetal subpallium. Front Neuroanat. 2014 Jan 16;7:54.

44. Lopez WO, Nikkhah G, Kahlert UD, Maciaczyk D, Bogiel T, Moellers S, Schültke E, Döbrössy MD, Maciaczyk J (2013). Clinical neurotransplantation protocol for Huntington's and Parkinson's disease. Restor Neurol Neurosci, 31(5):579-95.

43. Döbrössy MD and Pruszak J (2013). Neural repair with pluripotent stem cells. Methods Mol Biol, 1037: 117-44.

42. Schackel S, Pauly MC, Piroth T, Nikkhah G, and Döbrössy MD (2013). Donor age dependent graft development and recovery in a rat model of Huntington’s disease: Histological and behavioral analysis. Behav Brain Res,  256: 56-63.

41. Schültke E, Trippel M, Bräuer-Krisch E, Renier M, Prezado Y, Requardt H, Döbrössy MD, and Nikkhah G (2013). Pencilbeam irradiation technique for whole brain radiotherapy: Technical and biological challenges in a small animal model. PLoS ONE 8(1): e54960. doi:10.1371/journal.pone.0054960.

40. Pauly MC, Piroth T, Döbrössy MD, Nikkhah G (2012). Restoration of the striatal circuitry: from developmental aspects toward clinical applications. Front Cell Neurosci. 6:16, 1-14.

39. Kirch RD, Meyer PT, Geisler S, Braun F, Gehrig S, Langen K-J, Von Hörsten S, Nikkhah G, Cassel J-C,  Döbrössy MD (2012). Early deficits in declarative and procedural memory dependent behavioral function in a transgenic rat model of Huntington’s disease. Behav. Brain Res. 239C, 15–26.

38. Kahlert UD, Maciaczyk D, Dai F, Claus R, Firat E, Doostkam S, Bogiel T, Carro MS, Döbrössy MD, Herold-Mende C, Niedermann G, Prinz M, Nikkhah G, Maciaczyk J. (2012). Resistance to Hypoxia-Induced, BNIP3-Mediated Cell Death Contributes to an Increase in a CD133-Positive Cell Population in Human Glioblastomas In Vitro. J. Neuropathol. Exp. Neurol. 71, 1086–1099

37. Döbrössy MD and Nikkhah G (2012). Role of experience, training, and plasticity in the functional efficacy of striatal transplants. Prog. Brain Res. 200, 303–328.

36. García J, Carlsson T, Döbrössy MD, Nikkhah G, Winkler C (2012). Impact of dopamine versus serotonin cell transplantation for the development of graft-induced dyskinesia in a rat Parkinson model. Brain Res. 1470: 119-29.

35. Döbrössy MD, Braun F, Klein S, Garcia J, Langen KJ, Weber WA, Nikkhah G, Meyer PT (2012). [(18)F]desmethoxyfallypride as a novel PET radiotracer for quantitative in vivo dopamine D2/D3 receptor imaging in rat models of neurodegenerative diseases. Nucl Med Biol. 2012 May 14.

34. Kaindlstorfer C, García J, Winkler C, Wenning GK, Nikkhah G, Döbrössy MD (2012). Behavioral and histological analysis of a partial double-lesion model of parkinson-variant multiple system atrophy. J Neurosci Res. 90(6):1284-95.

33. García J, Carlsson T, Döbrössy MD, Nikkhah G, Winkler C (2011). Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. Exp Neurol. 232(2):270-9.

32. García J, Carlsson T, Döbrössy MD, Nikkhah G, Winkler C (2011). Impact of dopamine to serotonin cell ratio in transplants on behavioral recovery and L-DOPA-induced dyskinesia. Neurobiol Dis. 43(3):576-87.

31. Döbrössy MD, Klein A, Janghra N, Nikkhah G, and Dunnett SB (2011). Validating the use of M4-BAC-GFP mice as tissue donors in cell replacement therapies in a rodent model of Huntington’s disease. Journal of Neuroscience Methods 197(1):6-13.

30. Mazzocchi-Jones D, Döbrössy MD and Dunnett SB (2011). Environmental Enrichment Facilitates Long-Term Potentiation in Embryonic Striatal Grafts. Neurorehabil Neural Repair 25(6):548-57.

29. Capetian P, Döbrössy MD, Winkler C, Prinz M, Nikkhah G (2011). To be or not to be accepted: the role of immunogenicity of neural stem cells following transplantation into the brain in animal and human studies. Semin Immunopathol. 33(6):619-26.

28. Jiang W, Büchele F, Papazoglou A, Döbrössy MD, Nikkhah G (2010). Multi-tract microtransplantation increases the yield of DARPP-32 positive embryonic striatal cells in a rodent model of Huntington’s disease. Cell Transplant. 2010 Dec 22.

27. Cordeiro KK, Jiang W, Papazoglou A, Tenório SB, Döbrössy MD, and Nikkhah G (2010). Graft-mediated functional recovery on a skilled forelimb use paradigm in a rodent model of Parkinson's disease is dependent on reward contingency. Behav. Brain Res. 212(2):187-195.

26. Mazzocchi-Jones D, Döbrössy MD, Dunnett S (2010). Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington's disease. European Journal of Neuroscience, 30:2134-2142.

25. Döbrössy MD, Busse M, PirothT, Rosser A, Dunnett SB, and Nikkhah G (2010). Neurorehabilitation and Neural Transplantation. Neurorehabilitation and Neural Repair, 24(8):692-701.

24. Jiang W, Büchele F, Papazoglou A, Döbrössy MD and Nikkhah G (2009). Ketamine anaesthesia interferes with the quinolinic acid induced lesion in a rat model of Huntington’s disease. J Neurosci Meth 179: 219-223.

23. Brooks S, Fielding S, Döbrössy MD, Hörsten von S, and Dunnett S (2009). Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. Brain Res Bull 79(5):310-5.

22. Cunha C, Angelucci A, D’Antoni A, Döbrössy MD, Dunnett SB, Berardi N and Brambilla R (2009). Brain-Derived Neurotrophic Factor (BDNF) over-expression in the forebrain results in learning and memory impairments. Neurobiology of Disease 33:358-68.

21. Falkenstein G, Rosenthal C, Reum T, Morgenstern R, Döbrössy MD and Nikkhah G (2009). Pattern of long-term sensorimotor recovery following intrastriatal and –accumbens DA micrografts in a rat model of Parkinson's disease.  J Comp Neurol. 515 (1):41-55.

20. Döbrössy MD and Dunnett SB (2008). Environmental housing and duration of exposure affect striatal graft morphology in a rodent model of Huntington’s disease. Cell Transplantation., 17 (10-11): 1125-34.

19. Dupret D, Rodriguez JJ, Döbrössy MD, Aurousseau C, Stewart MG, Piazza PV and Abrous DN (2007). Spatial learning depends on both the addition and removal of new hippocampal neurons. PLoS Biol 5(8): 1683-1694. e214: doi:10.1371/journal.pbio.0050214.

18. Döbrössy MD and Dunnett SB (2007). The Corridor task: Striatal lesion effects and graft-mediated recovery in a model of Huntington’s disease. Behav Brain Res, 179(2):326-30.

17. Döbrössy MD and Dunnett SB (2006). Morphological and cellular changes within embryonic striatal grafts associated with enriched environment and involuntary exercise. Eur.J Neurosci. 24: 3223-3233.

16. Sloan HL, Döbrössy MD, Dunnett SB (2006). Hippocampal lesions impair performance on a conditional delayed matching and non-matching to position task in the rat. Behav Brain Res, 171(2): 240-250.

15. Döbrössy MD and Dunnett SB (2006). The effects of lateralised training on spontaneous forelimb preference, lesion deficits and graft mediated functional recovery after unilateral striatal lesions in rats. Exp Neurol, 199(2): 373-383.

14. Döbrössy MD and Dunnett SB (2005). Optimising plasticity: Environmental and training associated factors in transplant-mediated brain repair. Reviews in the Neurosciences, 16, 1-21.

13. Döbrössy MD and Dunnett SB (2005). Training specificity, graft development and graft mediated functional recovery in a rodent model of Huntington’s disease. Neuroscience, 132, 543-552.

12. Döbrössy MD and Dunnett SB (2004). Environmental enrichment affects striatal graft morphology and functional recovery. Eur J Neurosci, 19, 159-168.

11. Döbrössy MD, Drapeau E, Aurousseau C, Le Moal M, Piazza PV, and Abrous DN (2003). Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date. Mol Psych, 8, 974-982. doi:10.1038/sj.mp.4001419.

10. Döbrössy MD and Dunnett SB (2003). Motor training effects on recovery of function after striatal lesions and striatal grafts. Exp Neurol, 184 (1), 274-284.

9. Döbrössy MD, Chapman PF, and Dunnett SB (2002). Striatal graft: electrophysiological investigation of synaptic plasticity and circuit reconstruction. Exp Neurol, 175 (2), 445.

8. Döbrössy MD and Dunnett SB (2002). Functional repair of the striatum with striatal grafts. Acta Phys Hungarica, 89,1-3, 207.

7. Döbrössy MD and Dunnett SB (2001). The influence of environment and experience on neural grafts. Nature Reviews Neurosci, 2, 12: 871-879.

6. Döbrössy MD, Le Moal M, Monatron MF, and Abrous, DN (2000). Influence of the environment on the efficacy of intrastriatal dopaminergic grafts. Exp Neurol, 164, 165-172.

5. Döbrössy MD and Dunnett SB (1998). Striatal grafts alleviate deficits in response execution in a lateralised reaction time task. Brain Res Bull, 47(6): 585-593.

4. Brasted PJ, Döbrössy MD and Dunnett SB (1998). Striatal lesions produce impairments in reaction time performance in two different operant chambers. Brain Res Bull, 46, 6: 487-493.

3. Döbrössy MD and Dunnett SB (1997). Unilateral striatal lesions impair response execution on a lateralised choice reaction time task. Behav Brain Res, 87: 159-171.

2. Döbrössy MD, Svendsen CN, and Dunnett SB (1996). Bilateral striatal lesions impair retention of an operant test of short-term memory. Brain Res Bull, 41, 3: 159-165.

1. Döbrössy MD, Svendsen CN, and Dunnett SB (1995). Effects of Bilateral Striatal Lesions on the Acquisition of an Operant Working Memory Task. NeuroReport 6, 15: 2049-2053.

Book chapters

 9. Clinch S, Busse M, Döbrössy MD, Dunnett SB: Rehabilitation training in neural restitution. Functional Neural Transplantation IV: Translations to clinical application. In: Stephen B. Dunnett and Anders Björklund (eds): Progress in Brain Research series. Oxford, UK: Elsevier, 2017.

 8. Döbrössy MD, Pruszak J (2013). Wound Regeneration and Repair: Methods and Protocols (eds Gourdie and Myers): Neural repair with pluripotent stem cells. Humana Press. Methods Mol Biol. 1037:117-44.

 7. Döbrössy MD and Nikkhah G (2012). Progress in Brain Research: Functional Neural Transplantation III (eds. Dunnett and Björklund). Role of experience, training and plasticity in the functional efficacy of striatal transplants. Elsevier.

 6. Döbrössy MD, Büchele F, and Nikkhah G (2011). Excitotoxic lesions of the rodent striatum. In: Contemporary Animal Models of Movement Disorders (eds. E Lane and SB Dunnett). Springer/ Humans.

 5. Pruszak J, Döbrössy MD, Kieninger J, Aravindalochanan K, Urban GA, Nikkhah G (2011). Neural Stem Cells: From Cell Fate and Metabolic Monitoring Toward Clinical Applications. Stem Cell Engineering, Part 4, 435-455.

 4. Döbrössy MD, Brooks S, Trueman R, Brasted PJ and Dunnett SB (2008). Operant Analysis of  Fronto-striatal Function in Rodents. In: Methods of Behaviour Analysis in Neuroscience (Ed. Buccafusco, J.), CRC Press.

 3. Jones-Mazzocchi D, Döbrössy MD and Dunnett SB (2005). Striatal grafts and synaptic plasticity. In: Basal Ganglia VIII (eds. Bolam, J.Paul; Ingham, Cali A.; Magill, Peter J.). London.

 2. Döbrössy MD and Dunnett SB (2005). Plasticity, Cell Transplantation and Brain Repair. In: Synaptic Plasticity: Basic Mechanisms to Clinical Applications. (Eds. Baudry, M., Bi, X., Schreiber, S.), Taylor & Francis.

 1. Brasted PJ, Döbrössy MD, Eagle DM, Nathwani F, Robbins TW, and Dunnett SB (2000). Operant analysis of striatal dysfunction. In: Central Nervous System Diseases: Innovative animal models from Lab to Clinic. (Eds. Emerich, DF, Dean, RL and Sandberg, PR). Humana Press, 249-273.

Lab of Stereotaxy and Interventional Neuroscience

PD Dr. Máté Döbrössy

Group Leader

Department of Stereotactic and Functional Neurosurgery
University Medical Center Freiburg
Phone: +49  (0) 761 - 270 50360
Fax:       +49  (0) 761 - 270 50100
mate.dobrossy@uniklinik-freiburg.de

Prof. Dr. Volker Arnd Coenen

Medical Director