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Division of Stereotactic and Functional Neurosurgery

Recent publications

from members of the Lab of Stereotaxy and Interventional Neuroscience

Serchov, T., Schwarz, I., Theiss, A., Sun, L., Holz, A., Dobrossy, M.D., Schwarz, M.K., Normann, C., Biber, K., and van Calker, D. Enhanced adenosine A1 receptor and Homer1a expression in hippocampus modulates the resilience to stress-induced depression-like behavior. Neuropharmacol 162 (2020).

Thiele, S., Sörensen, A., Weis, J., Braun, F., Meyer, P.T., Coenen, V.A., Döbrössy, M.D., 2020. Deep Brain Stimulation of the Medial Forebrain Bundle in a Rodent Model of Depression: Exploring Dopaminergic Mechanisms with Raclopride and Micro-PET. Stereotact. Funct. Neurosurg. 1–13 (2020) https://doi.org/10.1159/000504860

Ashouri Vajari, D. et al. Medial forebrain bundle DBS differentially modulates dopamine release in the nucleus accumbens in a rodent model of depression. Exp. Neurol. 327, 113224 (2020).

Holz, A., Mulsch, F., Schwarz, M.K., Hollmann, M., Dobrossy, M.D., Coenen, V.A., Bartos, M., Normann, C., Biber, K., van Calker, D., Serchov, T. Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. Neuron 104, 338-352 e337 (2019).

van Calker D, Biber K, Domschke K, Serchov T. The Role of Adenosine Receptors in Mood and Anxiety Disorders. J Neurochem. doi: 10.1111/jnc.14841 (2019)

van Calker, D., Serchov, T., Normann, C., and Biber, K. Recent insights into antidepressant therapy: Distinct pathways and potential common mechanisms in the treatment of depressive syndromes. Neurosci Biobehav Rev 88, 63-72 (2018).

Thiele, S., Furlanetti, L., Pfeiffer, L.-M., Coenen, V. A. & Döbrössy, M. D. The effects of bilateral, continuous, and chronic Deep Brain Stimulation of the medial forebrain bundle in a rodent model of depression. Exp. Neurol. 303, 153–161 (2018).

Cook, A., Pfeiffer, L.-M., Thiele, S., Coenen, V. A. & Döbrössy, M. D. Olfactory discrimination and memory deficits in the Flinders Sensitive Line rodent model of depression. Behav. Processes 143, 25–29 (2017).

Furlanetti, L. L., Coenen, V. A. & Döbrössy, M. D. Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle. Behav. Brain Res. 299, 132–140 (2016).

Serchov, T., Heumann, R., van Calker, D., and Biber, K. Signaling pathways regulating Homer1a expression: implications for antidepressant therapy. Biol Chem 397, 207-214 (2016).

Furlanetti, L. L., Coenen, V. A., Aranda, I. A. & Döbrössy, M. D. Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a hemiparkinsonian rodent model. Exp. Brain Res. doi:10.1007/s00221-015-4375-9 (2015).

Döbrössy, M. D., Furlanetti, L. L. & Coenen, V. A. Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders. Neurosci. Biobehav. Rev. 49, 32–42 (2015).

Furlanetti, L.L., Cordeiro, J.G., Cordeiro, K.K., García, J.A., Winkler, C., Lepski, G.A., Coenen, V.A., Nikkhah, G., Döbrössy, M.D. Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents. Neurorehabil. Neural Repair 1545968315581419. doi:10.1177/1545968315581419 (2015).

Furlanetti, L. L., Döbrössy, M. D., Aranda, I. A. & Coenen, V. A. Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat. Behav. Neurol (2015).

Thiele, S. et al. Long-term characterization of the Flinders Sensitive Line rodent model of human depression: Behavioral and PET evidence of a dysfunctional entorhinal cortex. Behav. Brain Res. 300, 11–24 (2015).

Serchov, T., Clement, H.W., Schwarz, M.K., Lasevoli, F., Tosh, D.K., Idzko, M., Jacobson, K.A., de Bartolomeis, A., Normann, C., Biber, K., and van Calker, D. Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. Neuron 87, 549-562 (2015).

Lab of Stereotaxy and Interventional Neuroscience

PD Dr. Máté Döbrössy

Group Leader

Department of Stereotactic and Functional Neurosurgery
University Medical Center Freiburg
Phone: +49  (0) 761 - 270 50360
Fax:       +49  (0) 761 - 270 50100
mate.dobrossy@uniklinik-freiburg.de

Prof. Dr. Volker Arnd Coenen

Medical Director