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Institut für Virologie


Experimentelle Doktorarbeiten am Institut für Virologie, AG Kochs

Weitere Infos auf der Homepage, Bewerbungen mit CV und Zeugnissen bitte per Email an Georg Kochs.

1) Molekular-biologische Doktorarbeit mit Schwerpunkt antivirale Aktivität der humanen Mx-Proteine

Human MxB: The mode of antiviral action against herpesviruses

Humans express two paralogous Mx genes, MX1 and MX2, that encode the dynamin-like GTPases, MxA and MxB, respectively. MxA is known for its broad antiviral activity, e.g. against influenza A- and vesicular stomatitis virus, whereas MxB has recently been described to block HIV-1 replication (Goujon, 2013). We recently discovered an additional antiviral function of MxB, the restriction of Herpesvirus replication that is distinct from the MxB action against HIV-1. The goal of this project is to define the step in the viral replication cycle that is affected by MxB and to identify possible viral and cellular interaction partners of MxB that would help to understand the mode of MxB antiviral action.
Further reading:
Goujon, C. et al., (2013) Nature 502, 559-62. / Haller et al., (2015) TIM 23, 154-63.
Mitchell, PS et al., (2015) Plos Path. 11, e1005304.


2) Medizinische Doktorarbeit mit Schwerpunkt Influenza A Virus (Dauer ca. 8-12 Monate)

Analysis of virulence factors of Influenza A virus in the mouse model

Influenza A viruses are highly pathogenic in humans and have the capacity to emerge from their animal reservoirs causing zoonotic outbreaks. The aim of this project is the characterization of the non-structural protein NS1 of influenza A virus and its role in viral virulence using the mouse model. We are focused on the effect of NS1 on the induction of interferon. Without NS1-mediated control, viral infection leads to the production of interferons that subsequently induce interferon-stimulated gene products with antiviral activity. Using reverse genetics we manipulate influenza viruses in order to analyze the contribution of functional domains of NS1 for the suppression of the antiviral host defense. The recombinant viruses will be characterized in cell cultures and mice. The goal is to understand the contribution of certain domains of NS1 to virulence and pathogenesis of highly virulent influenza viruses.
Further reading:
Steidle,S. et al., (2010) J. Virol. 84, 12761.
Lohrmann, F., (2013) J. Virol. 87, 11300-303.

Institut für Virologie

Hermann-Herder-Strasse 11
D-79104 Freiburg

Ärztlicher Direktor

Prof. Dr. med. Hartmut Hengel

Sekretariat: Kristina Gendrisch         
Telefon: 0761 203-6534
Telefax: 0761 203-6626
E-Mail: kristina.gendrisch@uniklinik-freiburg.de

Administration: Gudrun Simpson
Telefon: 0761 203-6511
Telefax: 0761 203-6562
E-Mail: gudrun.simpson@uniklinik-freiburg.de

Pforte: Bärbel Barton
Telefon: 0761 203-6510
Telefax: 0761 203-6562
E-Mail: baerbel.barton@uniklinik-freiburg.de