2023
Emerging principles of primary cilia dynamics in controlling tissue organization and function.
J Gopalakrishnan, K Feistel, BM Friedrich, A Grapin-Botton, N Jurisch-Yaksi, E Mass, DU Mick, RU Müller, H May-Simera, B Schermer, M Schmidts, P Walentek, D Wachten. - 2023 EMBO Journal.
Link: https://www.embopress.org/doi/full/10.15252/embj.2023113891
Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion.
R Ventrella, SK Kim, J Sheridan, A Grata, E Bresteau, OA Hassan, EE Suva, P Walentek, BJ Mitchell. - 2023 Development.
The evolutionary history of Brachyury genes in Hydrozoa involves duplications, divergence, and neofunctionalization
Alexandra A. Vetrova, Daria M. Kupaeva, Alena Kizenko, Tatiana S. Lebedeva, Peter Walentek, Nikoloz Tsikolia, Stanislav V. Kremnyov - 2023 Scientific Reports
2022
Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
Hantel F., Liu H., Fechtner L., Neuhaus H., Ding J., Arlt D., Walentek P., Villavicencio-Lorini P., Gerhardt C., Hollemann T., Pfirrmann T. - 2022 Journal of Cell Science
Link: https://journals.biologists.com/jcs/article/135/9/jcs259209/275349
Microridge-like structures anchor motile cilia
Yasunaga T., Wiegel J., Bergen M.D., Helmstädter M., Epting D., Paolini A., Çiçek Ö., Radziwill G., Engel C., Brox T., Ronneberger O., Walentek P., Ulbrich M.H., Walz G. - 2022 Nature Communications
Spectrum of Genetic Variants in a Cohort of 37 Laterality Defect Cases
Antony D, Yilmaz Gulec E, Gezdirici A, Slagter L, Bakey Z, Bornaun H, Tanidir I, Van Dinh T, Brunner HG, Walentek P, Arnold S, Backofen R, Schmidts M. - 2022 FrontGen
Link: https://www.frontiersin.org/articles/10.3389/fgene.2022.861236/abstract
A simple method to generate human airway epithelial organoids with externally orientated apical membranes
Boecking CA, Walentek P, Zlock LT, Sun, DI, Wolters PJ, Ishikawa H, Jin B-J, Haggie PM, Marshall WF, Verkman AS, Finkbeiner WE. - 2022 Am J Physiol Lung Cell Mol Physiol.
Link: https://journals.physiology.org/doi/abs/10.1152/ajplung.00536.2020
Link to press release University Freiburg Medical Center: https://kommunikation.uni-freiburg.de/pm/2022/lungengewebe-aus-dem-labor?set_language=de
2021
The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus
Beckers A, Fuhl F, Ott T, Boldt K, Brislinger MM, Walentek P, Schuster-Gossler K, Hegermann J, Alten L, Kremmer E, Przykopanski A, Serth K, Ueffing M, Blum M, Gossler A. - 2021 Scientific Reports
Signaling Control of Mucociliary Epithelia: Stem Cells, Cell Fates, and the Plasticity of Cell Identity in Development and Disease
Walentek P. - 2021 Cells Tissues Organs
Xenopus epidermal and endodermal epithelia as models for mucociliary epithelial evolution, disease, and metaplasia
Walentek P. - 2021 Genesis
Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling
Tasca A, Helmstädter M, Brislinger MM, Haas M, Mitchell B, Walentek P. - 2021 Developmental Cell
Link: https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30980-1
bioRxiv: https://www.biorxiv.org/content/10.1101/2020.04.16.045401v2
2020
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan
Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz L-O, Hollemann T, Pfirrmann T. - 2020 Autophagy
Link: https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1695399
2019
ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia
Haas M, Gómez Vázquez JL, Sun DI, Tran HT, Brislinger MM, Tasca A, Shomroni O, Vleminckx K, Walentek P. - 2019 Cell Reports
Link: https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31118-0
2018
Katanin-like protein Katnal2 is required for ciliogenesis and brain development in Xenopus embryos
Rankin Willsey H, Walentek P, Exner CRT, Xu Y, Lane AB, Harland RM, Heald R, Santama N. - 2018 Developmental Biology
Link: https://www.sciencedirect.com/science/article/pii/S0012160618302628
Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia
Sun DI, Tasca A, Haas M, Baltazar G, Harland RM, Finkbeiner WE, Walentek P. - 2018 Cells Tissues Organs
Manipulating and Analyzing Cell Type Composition of the Xenopus Mucociliary Epidermis
Walentek P. - 2018 Methods in Molecular Biology - Xenopus
Link: https://link.springer.com/protocol/10.1007%2F978-1-4939-8784-9_18
2017
What we can learn from a tadpole about ciliopathies and airway diseases: Using systems biology in Xenopus to study cilia and mucociliary epithelia
Walentek P, Quigley IK. - 2017 Genesis
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/dvg.23001
Planar Cell Polarity in Ciliated Epithelia
Walentek P, Boutin C, Kodjabachian L. - 2017 Cell Polarity in Development and Disease
Link: https://www.sciencedirect.com/science/article/abs/pii/B9780128024386000073?via%3Dihub
2016
Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis
Walentek P, Quigley IK, Sun DI, Sajjan UK, Kintner C, Harland RM. - 2016 Elife
Ciliary transcription factors in cancer--how understanding ciliogenesis can promote the detection and prognosis of cancer types
Walentek P. - 2016 Journal of Pathology
Link: https://onlinelibrary.wiley.com/doi/full/10.1002/path.4703
2015
ATP4 and ciliation in the neuroectoderm and endoderm of Xenopus embryos and tadpoles
Walentek P, Hagenlocher C, Beyer T, Müller C, Feistel K, Schweickert A, Harland RM, Blum M. - 2015 Data in Brief
Link: https://www.sciencedirect.com/science/article/pii/S235234091500044X
ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia
Walentek P, Beyer T, Hagenlocher C, Müller C, Feistel K, Schweickert A, Harland RM, Blum M. - 2015 Developmental Biology
Link: https://www.sciencedirect.com/science/article/pii/S0012160615001463
The alternative splicing regulator Tra2b is required for somitogenesis and regulates splicing of an inhibitory Wnt11b isoform
Dichmann DS, Walentek P, Harland RM. - 2015 Cell Reports
Link: https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(14)01099-7
2014
miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110
Song R*, Walentek P*, Sponer N*, Klimke A, Lee JS, Dixon G, Harland RM, Wan Y, Lishko P, Lize M, Kessel M, He L. - 2014 Nature
A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles
Walentek P, Bogusch S, Thumberger T, Vick P, Dubaissi E, Beyer T, Blum M, Schweickert A. - 2014 Development
Link: https://journals.biologists.com/dev/article/141/7/1526/46725
microRNAs and cilia. An ancient connection
Walentek P, Song R, He L. - 2014 Cell Cycle
Link: https://www.tandfonline.com/doi/full/10.4161/cc.29827
2013
Ciliogenesis and cerebrospinal fluid flow in the developing Xenopus brain are regulated by foxj1
Hagenlocher C, Walentek P, M Ller C, Thumberger T, Feistel K. - 2013 Cilia
Link: https://ciliajournal.biomedcentral.com/articles/10.1186/2046-2530-2-12
Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development
Walentek P, Schneider I, Schweickert A, Blum M. - 2013 PlosOne
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073646
2012
ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development
Walentek P, Beyer T, Thumberger T, Schweickert A, Blum M. - 2012 Cell Reports
Link: https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(12)00090-3
Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus
Beyer T, Danilchik M, Thumberger T, Vick P, Tisler M, Schneider I, Bogusch S, Andre P, Ulmer B, Walentek P, Niesler B, Blum M, Schweickert A. - 2012 Current Biology
Link: https://www.cell.com/current-biology/fulltext/S0960-9822(11)01309-1
Linking early determinants and cilia-driven leftward flow in left-right axis specification of Xenopus laevis: a theoretical approach
Schweickert A, Walentek P, Thumberger T, Danilchik M. - 2012 Differentiation
Link: https://www.sciencedirect.com/science/article/abs/pii/S0301468111001952
2010
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration
Oviedo NJ, Morokuma J, Walentek P, Kema IP, Gu MB, Ahn JM, Hwang JS, Gojobori T, Levin M. - 2010 Developmental Biology
Link: https://www.sciencedirect.com/science/article/pii/S001216060901402X