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Psychiatric surgery Summit: Surgical Strategies for the Treatment of Psychiatric Diseases

Inaugural meeting of the Center for Deep Brain Stimulation

October 27-29, 2022 | Freiburg im Breisgau

We would like to invite you to the

Inaugural Meeting of the Center for Deep Brain Stimulation – a Psychiatric Surgery Summit: Surgical Strategies for the Treatment of Psychiatric Diseases,

organized by Thomas Schläpfer, Volker Coenen and Bastian Sajonz

Speakers

Baldermann, Juan

Dr. Juan Carlos Baldermann (MD) is a clinician scientist at the University Hospital of Cologne, Germany. He is a certified psychiatrist, dedicating his scientific work to improving neuromodulation for patients with obsessive-compulsive- and tic disorders. To pursue a further specialization in neuropsychiatry, he is currently a research fellow, resident and principal investigator in the department of neurology at the University Hospital of Cologne.

Bergfeld, Isidoor

Isidoor Bergfeld is a neuropsychologist and researcher at the Psychiatry department of the Amsterdam UMC (University of Amsterdam). His research focuses on deep brain stimulation (DBS) and electroconvulsive therapy (ECT) for treatment-resistant psychiatric disorders. Besides the effects of DBS on symptoms, he also studies the effects on cognitive functions and personality features of patients.

Coenen, Volker Arnd

Volker Coenen is since 2013 appointed as the Traugott Riechert Professor of Stereotactic and Functional Neurosurgery (full professorship) and department head at the Medical Center of the University of Freiburg. Volker earned his MD degree from the RWTH Aachen where he started his career in Neurosurgery.  He earned his habilitation at the medical faculty of RWTH Aachen in 2005 followed by a fellowship in Functional and Stereotactic Neurosurgery in Vancouver with Prof. Chris Honey in 2007 and 2008. He was appointed as Full Professor in Stereotaxy and MR based OR techniques at the University of Bonn from 2008 to 2012. Volker has introduced DTI tractographic targeting into the field of Functional Neurosurgery. Together with his colleague Thomas Schläpfer he researches the slMFB as a target for major depression since 2011 in clinical trials. He has authored and co-authored more than 160 papers. His current focus is the anatomical basis of Deep Brain Stimulation mechanisms which he researches with imaging technologies and in translative approaches in different indications.

Denys, Damiaan

Damiaan Denys has a master in philosophy and medicine. He is currently professor of psychiatry at the University of Amsterdam and chair of the department of psychiatry at the AmsterdamUMC. His work is characterized by the combined approach of psychiatry, neuroscience and philosophy. He published over 400 scientific papers and is an active participant in the public debate of complex social matters.

Deuschl, Günther

Günther Deuschl was trained in Munich, Freiburg and Bethesda/USA. Between 1995 -2016 he was chairman and head of the Department of Neurology, UKSH Kiel, Christian-Albrechts-University, Kiel, Germany. He developed with his team a prominent center for movement disorder patients and for advanced therapies particularly deep brain stimulation. Since 2016 he is working as Senior-Professor in Kiel and Zürich. His research interests are focused on DBS and Movement Disorders. He published more than 700 peer-reviewed articles and is among the highly cited researchers in the world (cross-field, top 1%). He is Past Editor of the ‘Movement Disorder Journal’ and Past President of the German Society of Neurology and the International Movement Disorder Society. He was the founding President of the European Academy of Neurology.

Fenoy, Albert J.

Dr. Fenoy has recently moved from UT Houston to Northwell Health In NY as Associate Professor of Neurosurgery and Director of Stereotactic and Functional Neurosurgery.
He is the PI of an NIH R01 exploring the structural, functional, and electrophysiologic connectivity of the DRTt following DBS in ET patients.
He is continuing his clinical trial of DBS in TRD at Northwell.

Fins, Jospeh J.

Joseph J. Fins is The E. William Davis, Jr. M.D. Professor of Medical Ethics and Chief of the Division of Medical Ethics at Weill Cornell Medical College where he is a Tenured Professor of Medicine and chair of the Ethics Committee of New York-Presbyterian Weill Cornell Medical Center. He co-directs, the Consortium for the Advanced Study of Brain Injury (CASBI) at Weill Cornell Medicine and Rockefeller University where he is a member of the adjunct faculty. At Yale Law School, he is the Solomon Center Distinguished Scholar in Medicine, Bioethics and the Law and a Visiting Professor of Law. A developer of clinical pragmatism as a method of moral problem solving for medicine, Professor Fins’ current scholarly interests include: ethical and policy issues in brain injury and disorders of consciousness; civil and disability rights for individuals with severe brain injury; palliative care; research ethics in neurology and psychiatry; medical education; methods of ethics case consultation; the history of medicine; medical humanities; bioethics in the Spanish-speaking world; and more broadly fostering a productive dialogue between the sciences and the humanities. The author of over 500 papers, chapters, essays, and books, his most recent volume is Rights Come to Mind: Brain Injury, Ethics and The Struggle for Consciousness (Cambridge University Press, 2015). Dr. Fins is also the author of A Palliative Ethic of Care: Clinical Wisdom at Life’s End (Jones and Bartlett, 2006). Dr. Fins is a co-author of the 2007 Nature paper describing the first use of deep brain stimulation (DBS) in the minimally conscious state. He is currently a co-investigator on an NIH BRAIN Initiative grant studying DBS in moderate to severe traumatic brain injury and principal investigator on an NIH study entitled, "Cognitive Restoration: Neuroethics and Disability Rights." A Master and past Governor of the American College of Physicians, Dr. Fins is an elected Member of the National Academy of Medicine (formerly the Institute of Medicine) of the National Academies of Sciences, a Fellow of the American Academy of Arts and Sciences, and by Royal Appointment an Academico de Honor (Honored Academic) of the Real Academia Nacional de Medicina de España (the Royal National Academy of Medicine of Spain). In 2022, he was elected to the Association of American Physicians. Professor Fins is President of the International Neuroethics Society, a Past President of the American Society for Bioethics and Humanities, and a member of Board of Trustees of The Hastings Center. Dr. Fins a Trustee Emeritus of Wesleyan University, which has recognized him with an honorary Doctor of Humane Letters.

Goodman, Wayne

Wayne Goodman, MD, D.C and Irene Ellwood Professor and Chair of the Department of Psychiatry and Behavioral Sciences at Baylor College of Medicine, specializes in Obsessive-Compulsive Disorder (OCD) and Deep Brain Stimulation (DBS) for intractable psychiatric illnesses. He is the principal developer of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the gold standard for assessing OCD, and co-founder of the International OCD Foundation, the major advocacy group for patients with OCD. He graduated from Columbia University with a degree in Electrical Engineering, received his medical degree from Boston University School of Medicine and completed his internship, residency, and research fellowship at Yale School of Medicine where he remained on faculty for 7 years.

 

Groppa, Sergiu

Sergiu Groppa is professor of neurology and head of Movement Disorders, Neurostimulation and Imaging at the Clinic of Neurology at the University Medical Center Mainz. After studying medicine at the Universities of Bonn, Innsbruck and Kiel, he was trained as neurologist and clinical neuroscientist at the Universities of Kiel and at King’s College London. His scientific work focuses on mechanisms of brain reorganization for motor and cognitive function and as a principle of adaptation to neurological disorders. He develops paradigms for optimised neuromodulation with deep brain stimulation (DBS) and transcranial magnetic stimulation.

Gross, Robert E.

Robert E. Gross, MD, PhD is Professor of Neurosurgery, holds the MBNA/Bowman Endowed Chair in Neurosurgery, and is Vice-Chairman of the Department of Neurosurgery at Emory University, where he has been on the faculty since 2001. He has a co-appointment in Neurology and program faculty appointments in the Coulter Department of Biomedical Engineering at Emory and Georgia Tech, and the Neuroscience Program of the Graduate Division of Biological and Biomedical Sciences at Emory University. Administrative positions currently held include Director of the Translational Neuroengineering Laboratory, Director of the Emory MD/PhD program, Director of the Emory Neuromodulation and Technology Innovation Center and new Brain Restoration Center, Director of the Stereotactic, Functional and Epilepsy Surgery division of the Department of Neurosurgery, and Director of the Neurosurgery Clinical Research Unit. He is a Past-President of the American Society for Stereotactic and Functional Neurosurgery. He has published more than 218 articles, reviews, comments and book chapters with a H-index of 42, I10-index of 77, having been cited 7263 times. Dr. Gross has been continuously funded from the NIH since 2004, and has received >$1M from industry for clinical trials over the last 5 year. He has or is supervising the doctoral research of 9 PhD students as well as a large number of neurosurgery post-residency fellows, post-doctoral research fellows, neurosurgery and neurology residents, medical students, university students and high school students, not including the 99 MD/PhD students he supervises as Director of the MD/PhD program at Emory. In addition, he is a frequent invited lecturer and course director/co-director. This track record of success reflects his passion for the intersection of clinical neurosurgery and research (translational and clinical), as well as teaching, mentorship, and innovation (reflected in holding 3 US patents).

Hariz, Marwan

Marwan Hariz is born in Bayreuth, Lebanon. Sudied medicine in Reims (France) and in Umeå (Sweden), where he became neurosurgeon and obtained a PhD in 1990. From 2002 to 2018 he was Professor Chair of Functional Neurosurgery at University College London Queen Square and the National Hospital for Neurology and Neurosurgery. He now works at Umeå University Hospital in Northern Sweden. He published more than 300 papers. Main interests in stereotactic brain imaging, surgery for movement disorders and psychiatric illness, and ethics and history of functional neurosurgery. He received the Spiegel and Wycis Award from the WSSFN and the Herbert Olivecrona Award from the Karolinka Institute in Stockholm.

Horn, Andreas

Andreas is interested in connectivity and causality in the brain and focuses on how deep brain stimulation impacts distributed brain networks. He aims to find out how these brain network modulations map onto changes in clinical symptoms and behavior. He is head developer of the Lead-DBS toolbox which has been created to facilitate these types of analyses. Andreas earned his MD from the University of Freiburg and his PhD at Charite Berlin. He now serves as the director for deep brain stimulation research within the center for brain circuit therapeutics at Brigham and Women's Hospital in Boston.

Kellmeyer, Philipp

Dr. Kellmeyer is a neurologist at the University Medical Center Freiburg where he heads the Human-Technology Interaction Lab (2019-2022: Neuroethics and AI Ethics Lab) at the Department of Neurosurgery. He studied human medicine in Heidelberg and Zurich and received a Master of Philosophy from the University of Cambridge (GB). As a neuroscientist he works in the fields of neuroimaging and translational neurotechnology, in particular the clinical application of medical technologies, such as brain-computer interfaces, assistive robots and VR systems. He is a scientific member of the Center BrainLinks-BrainTools at the University of Freiburg and from 2018-2021 he was a Research Fellow at the Freiburg Institute for Advanced Studies (FRIAS) in the “Responsible Artificial Intelligence” research group. In his highly transdisciplinary research at the intersection of neurology, neuroscience / neurotechnology, ethics and social sciences, he works on human-technology interaction in medicine and other health-related contexts. He is also an affiliated researcher at the Institute for Biomedical Ethics and History of Medicine at the University of Zurich, where he also teaches biomedical ethics. He is also a member of the Board of Directors of the International Neuroethics Society (INS).

Lozano, Andreas

Dr. Lozano holds the Alan & Susan Hudson Cornerstone Chair in Neurosurgery at University Health Network, currently holds the distinguished rank of University Professor and is the past Chairman of Neurosurgery at the University of Toronto. He is best known for his work in the field of Deep Brain Stimulation (DBS) and Magnetic Resonance-guided Focused Ultrasound (MRgFUS). Dr. Lozano has approximately 800 manuscript publications, co-edited 10 books and over 100 book chapters, and is the most highly cited neurosurgeon in the world (Clarivate). He has received a number of honors including the Order of Canada, Order of Spain, Doctor Honoris Causa from the University of Sevilla, the Olivecrona Medal, Margolese Brain Prize, Salk Award, Pioneer in Medicine Award, the Speigel and Wycys award and the Dandy Medal.

McIntyre , Cameron

Cameron McIntyre received his B.S. and Ph.D. in Biomedical Engineering from Case Western Reserve University (CWRU) in 1997 and 2001, respectively. The McIntyre Lab is currently at Duke University where he is a Professor of Biomedical Engineering & Neurosurgery. The special expertise of the group resides in the theoretical, experimental, and clinical application of neuromodulation and neurorecording technologies in human patients.

Mosely, Philip

Dr Philip Mosley is a neuropsychiatrist with a special interest in movement disorders and neuromodulation for treatment-resistant psychiatric disorders. He has been the psychiatrist at the largest deep brain stimulation centre in Australia since 2013 (1200 devices implanted). Dr Mosley completed a PhD in neuroscience in 2019 (receiving the Dean’s award for outstanding thesis) and he remains a clinical research fellow at the QIMR Berghofer Medical Research Institute. Dr Mosley has contributed to improving the neuropsychiatric safety of DBS for Parkinson’s disease through individualised assessments of brain connectivity and stimulation field distribution, which resulted in two Brain manuscripts, the Royal Australian and New Zealand College of Psychiatrists (RANZCP) early career psychiatrist prize and the postgraduate medal from the Australian Society of Medical Research. He also conducted the first Australian placebo-controlled trial of DBS for refractory OCD, which he will discuss in this presentation.

van den Munckhof, Peijn

Bio Pepijn van den Munckhof (1973) studied medicine in Groningen and specialized in neurosurgery in Amsterdam. He was trained in deep brain stimulation (DBS) by Andries Bosch and Rick Schuurman. He acted as a co-investigator on clinical trials studying DBS in Parkinson's disease, obsessive-compulsive disorder, depression and anorexia nervosa. He acts as principal investigator of a clinical trial studying the effects of DBS in patients with disorders of consciousness. Current affiliation Department of Neurosurgery, Amsterdam University Medical Centers, Amsterdam, The Netherlands Link to website
https://researchinformation.amsterdamumc.org/en/persons/pepijn-van-den-munckhof

Okun, Michael

Michael S. Okun obtained his M.D. with honors from the University of Florida. He was fellowship trained by Mahlon DeLong, Jerrold Vitek and Ray Watts at Emory University in Atlanta GA before moving to co-found the movement disorders program at the University of Florida with Kelly Foote MD. He is currently Chair of Neurology, Professor and Director of the Norman Fixel Institute for Neurological Diseases at the University of Florida Health College of Medicine. Dr. Okun has served as the National Medical Director/Advisor for the Parkinson’s Foundation since 2006 and as the Medical Advisor for Tyler’s Hope for a Dystonia Cure since its inception and is a co-founder of the DBS Think Tank. Dr. Okun holds the Adelaide Lackner Professorship in Neurology and has published over 500 peer-reviewed articles, 80 review articles and 14 books.  He is a poet (Lessons From the Bedside, 1995) and his book, Parkinson's Treatment: 10 Secrets to a Happier Life was translated into over 20 languages.  His most recent books are Ending Parkinson’s Disease and Living with Parkinson’s Disease. Dr. Okun was recognized in a 2015 White House ceremony by the Obama administration as a Champion of Change for Parkinson’s Disease.

Onur, Ozgür

Prof. Dr. Özgür Onur, MD, is trained in neurology and intensive care at the University Cologne, Department of Neurology and is board certified in both disciplines. Prof. Onur is specialized in neurodegenerative diseases, stroke and care of critically ill. He is board member of the Centre of Memory Disorders at the University Hospital Cologne.
Prof. Onur performed his scientific work at the Research Centre Jülich and the University Hospital Cologne. His research area is the (non-)pharmacological modulation of cognitive processes. He investigated on neural effects of pharmacological challenges, cognitive training, and cognitive stimulation in subjects suffering AD. Further, he performed network analyses using functional imaging techniques to detect changes of network architecture during memory encoding and consolidation in the course of aging and dementia. In the last years he performed research applying Non-Invasive Brain Stimulation as well as Deep Brain Stimulation in Alzheimer´s Disease. In the ADvance II study (Fornix-DBS), he is PI for Germany.

Polosan, Mircea

Dr Mircea Polosan, trained in psychiatry and neurosciences, is Professor of Psychiatry and Head of Psychiatry Department in the University Hospital of Grenoble. He focused his activity on invasive and non invasive brain stimulation techniques for treating refractory psychiatric disorders, as well as on research on physiopathology and psychophysical, electrophysiological, neurofunctional response biomarkers identification. He is currently leading or involved in international DBS trials for OCD and depression.

Regis, Jean

Jean Regis, MD, is Full Professor of Neurosurgery at the Aix Marseille University  (Marseille, France), and Neurosurgeon at the Timone University Hospital where he currently serves as Head the Stereotactic, Functional Neurosurgery and Radiosurgery Department.

His basic research activiy (INSERM UMR 1106) is focused on cerebral cortex gyration modeling and individual brain surgery prediction (The Virtual Brain). His clinical research activity is dedicated to advance imaging applied to surgery and the functional applications of radiosurgery. Since the early 1990' he developpe a special program for the management of hypothalamic hamartomas with severe epilepsy.

Sameer, Seth

Dr. Sameer Sheth is currently Associate Professor, Cullen Foundation Endowed Chair, Vice-Chair of Research, and McNair Scholar in the Department of Neurosurgery, Baylor College of Medicine, Houston, TX. He also holds joint appointments in the Department of Neuroscience and Department of Psychiatry & Behavioral Sciences at Baylor and is an Adjunct Associate Professor in the Department of Electrical and Computer Engineering at Rice University. He graduated summa cum laude from Harvard University with a degree in Physics and Astronomy. He then entered the Medical Scientist Training Program at the UCLA School of Medicine, where he received both his M.D. and Ph.D. degrees. Dr. Sheth trained in neurological surgery at Massachusetts General Hospital and Harvard Medical School. Dr. Sheth specializes in the treatment of patients with movement disorders, epilepsy, and psychiatric disorders. Dr. Sheth is also a neuroscientist, with postdoctoral training in neurophysiology. His research interests are centered on a desire to better understand brain function and develop new therapies for neuropsychiatric conditions. Dr. Sheth runs the Functional and Cognitive Neurophysiology Lab, with funding from the NIH, McNair Foundation, Dana Foundation, and other sources.

Dr. Sameer Sheth is currently Professor, Cullen Foundation Endowed Chair, Vice-Chair of Research, and McNair Scholar in the Department of Neurosurgery, Baylor College of Medicine, Houston, TX. He also holds joint appointments in the Department of Neuroscience and Department of Psychiatry & Behavioral Sciences at Baylor and is an Adjunct Associate Professor in the Department of Electrical and Computer Engineering at Rice University. Dr. Sheth specializes in the treatment of patients with movement disorders, epilepsy, and psychiatric disorders. His research interests are centered on a desire to better understand brain function and develop new therapies for neuropsychiatric conditions.

 

Schläpfer, Thomas

Thomas E. Schlaepfer, MD

  • Professor of Psychiatry and Psychotherapy University of Freiburg, Germany; Head of the Department of Interventional Biological Psychiatry
  • Professor of Psychiatry and Mental Hygiene (part time), The Johns Hopkins University School of Medicine
  • Professor of Psychiatry (part time), University of Florida, Gainesville, FL

 Dr. Schlaepfer received his medical training at the University of Bern, Switzerland. He completed internship and residency training at the University Hospital Bern and the Johns Hopkins Hospital. Before his current position as division head in Freiburg, he completed a Fellowship in Psychiatric Neuroimaging at the Johns Hopkins University and directed the Division of Psychiatric Neuroimaging at the University Hospital Bern, Switzerland. In 2003 he was elected Vice Chair of the Department of Psychiatry and Psychotherapy and Professor of Psychiatry, University Hospital Bonn, Germany. From 2006 to 2014 he acted as Dean of Medical Education of this University.

Dr. Schlaepfer focused the research of his group on translational, functional neuroimaging and clinical effects of neuromodulation interventions (including repetitive transcranial magnetic stimulation, vagus nerve stimulation, magnetic seizure therapy and foremost deep brain stimulation) for treatment resistant major depression. After the first human application ihis group developed the clinical use of magnetic seizure therapy (MST) for depression and most importantly the hypothesis-guided therapeutic use of deep brain stimulation of parts of the human reward system in the same disorder.

Dr. Schlaepfer published more than 200 peer-reviewed papers (150 as first or last author) and about 80 non-peer-reviewed publications. The number of citations is 17000, the h-index is 72. 

Starr, Philip

Dr. Starr is the Dolores Cakebread Professor of Neurological Surgery, at the University of California, San Francisco. He obtained his MD and PhD from Harvard Medical School, did neurosurgical residency at Brigham and Women’s Hospital, and did a fellowship in movement disorders surgery at Emory University with Drs. Roy Bakay, Jerrold Vitek, and Mahlon Delong.   He was recruited to UCSF in 1998 to launch a clinical and research program in deep brain stimulation. Dr. Starr and UCSF neurologist Dr. Jill Ostrem are the directors of a multidisciplinary clinic for comprehensive care of patients with movement disorders.  His NIH funded research addresses:

1) Brain network abnormalities underlying motor and nonmotor features of movement disorders.

2) Mechanisms of therapeutic deep brain stimulation.

3) The use of totally implantable neural interfaces for long term brain recording and adaptive DBS. 

The laboratory website is starrlab.ucsf.edu

Temel, Yasin

Yasin Temel is the chairman of the Academic Neurosurgical Center Limburg (hospital network; 5 hospitals and university department). He is specialized in deep brain stimulation and skull base tumours. Most of his research deals with the mechanisms of action of deep brain stimulation in (pre)clinical models.

Visser- Vandewalle, Veerle

1989-1996: neurosurgical training in Belgium (B)
1996-1999: staff Dep. of Neurosurgery, University Hospital Ghent, B
1999-2012: senior consultant Dep. of Neurosurgery, Maastricht University Hospital, Netherlands
2004: PhD, Maastricht University
2007: extraordinary professorship functional neurosurgery, Maastricht University
2012- : head of the Dep. of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Germany

Ziemann, Ulf

Professor Ulf Ziemann, MD
Director of the Department Neurology & Stroke, Co-Director of the Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany.

Research expertise: Human motor cortex, excitability, plasticity, motor learning, TMS, brain state-dependent stimulation, closed-loop stimulation, neuropharmacology, TMS-EEG.
Clinical expertise: Stroke, neurointensive care, neuroimmunology, clinical neurophysiology.
Current positions: Editor-in-Chief of “Clinical Neurophysiology”, ExCo member of the International Federation of Clinical Neurophysiology (IFCN), Deputy Editor of “Brain Stimulation”, Past-President of the German Society for Clinical Neurophysiology and Functional Imaging (DGKN).
Awards: Richard-Jung Prize of the German Society of Clinical Neurophysiology and Functional Neuroimaging (DGKN), National Institutes of Health (NIH, Bethesda, USA) Merit Award, NIH Fellowship Award for Research Excellence. Clarivate Web of Science Highly Cited Researcher  2020, 2021
Publications: 524 peer-reviewed publications, 42 book chapters, 8 Books, Cumulative IF: 2.301, ISI Citations: 36.128, ISI h-index: 93, Google scholar h-index: 115.