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MEC 2022

Cardiac Mechano-Electric Coupling and Arrhythmias
21-24th September

It has been a great pleasure to welcome you to the 9th International Workshop on Cardiac Mechano-Electric Coupling and Arrhythmias (MEC2022), held from 21-24 September 2022 in Freiburg.

The workshop again attracted over 90 participants and trainees from 13 countries and 4 continents.
In 29 lectures and 6 abstract-selected talks we learned more about new developments, with a focus on the rapidly improving understanding of molecular mechanisms, and their integration at cell, tissue and organ levels, and the latest clinical observations, as well as major technical developments, including time-resolved 3D electron microscopy, super-resolution structure-function mapping in contracting cardiac muscle, and novel high throughput single cell mechanics measurements.
Around 8.5h of discussion time and a dedicated poster session with 52 posters provided ample time for scientific interaction. After a comprehensive review, a poster jury selected 7 trainees for their poster presentations:

Proxime Accessit Awards:
Ana Simon Chica - Stretch-Activated Channels in Cardiac Macrophages –What we Know and What we Don't Know yet
Fazeelat Mazhar - Modelling of Electromechanical Coupling and Mechano-Electric Feedback Effect in Human Atrial Cells
Austin Wellette-Hunsucker - Prior Freezing has Minimal Impact on the Contractile Properties of PermeabilizedHuman Myocardium

First Prize Awards:
Teresa Schiatti - Atrial Tissue Slices: a Biomimetic Model to Investigate Time-Dependent Processes
Ross Bretherton - A p38-MAPK FibroproliferativeResponse is a Central Determinant of Cardiac Remodellingin Inherited Dilated Cardiomyopathy
Joachim Greiner - Reconstruction of Contracting Cardiomyocytes With Nanometer Resolution
Ahmed Ramadan - OptogeneticSuppression of Drug-Induced Early Afterdepolarisationsin the Zebrafish Heart

Congratulations again to the award winners and many thanks to the judges.

We very much look forward to the next edition of MEC in 2025 and hope to welcome you back then.

With my best wishes,
Peter Kohl

Programme

Wednesday, 21 September 2022

   
16:00 – 17:00 Registration
   
Keynote Lectures and Festive Opening
Chair: Ursula Ravens
17:00 – 17:15 Welcome addresses by: Peter Kohl
17:15 – 18:00 Leslie Leinwand Myosin modulation as a treatment for a deadly disease
18:00 – 18:45 Michael Sheetz Appreciating force and shape: the rise of mechanotransduction in cell biology
18:45 – 19:00 Wrap-up
19:00 – 21:00 Reception Prometheus Hall

Thursday, 22 September 2022

                                      
09:00 Registration
09:15 –  09:30 Rémi Peyronnet MEC2022
   

Session 1: Ion Channels From Endomembranes to Sarco- / Plasma-lemma
Chair: Breanne Cameron

09:30 – 10:00 Kristi Anseth Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
10:00 – 10:30 Bailong Xiao The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
10:30 – 11:00 Alexander Quinn Microtubules and TRPA1 in stretch-induced arrhythmias
11:00 – 11:30 Tea (posters on display)
11:30 – 12:00 Timothy Domeier TRPV4 and stretch-induced dysfunction in the aged heart
12:00 – 12:30 Bo Hjorth Bentzen   SK channels and stretch-induced vulnerability to AF
12:30 – 13:00 Aurore Lyon Stretch-activated channels and calcium-contraction coupling: insights from computer modelling
13:00 – 14:30 Lunch (posters on display)
   

Session 2: Scaffolding MEC: Cytoskeleton and Nanodomains
Chair: Ramona Emig

14:30 – 15:00 Eva Rog-Zielinska   Time-resolved 3D EM to investigate mechanics of T-tub content mixing
15:00 – 15:30 Long-Sheng Song   Junctophilin-2 couples cardiac mechanical information with transcriptional reprogramming
15:30 – 16:00 Alexey Glukhov Caveolae-mediated activation of mechanosensitive chloride channels in pulmonary veins triggers atrial arrhythmogenesis
16:00 – 16:30 Tea (posters on display)
   
Session 3: MEC-induced Arrhythmias
Chair: Lutz Hein
16:30 – 17:00 Peter Kohl Commotio cordis: a fresh look
17:00 – 17:15 Bo Han
(Poster 06)
Sustainability of cardiac pacing by mechanical stimulation in the Langendorff-perfused rabbit heart
17:15 – 17:30 Melania Buonocunto (Poster 52) Understanding the contribution of stretch-activated ion channels to cardiac arrhythmogenesis using computational modelling
17:30 – 18:00 Sian Harding 55 years of 'Mechano-Electrical Feedback' -
Laudatio on a pioneer in this field: Ursula Ravens
   
Poster Session
18:00 – 20:00 Posters with refreshments, and nibbles, and more…

Friday, 23 September 2022

    
Session 4: ECM and Mechano-Regulation
Chair: Kate Herum
09:00 – 09:30    Boris Hinz Mechanical regulation of myofibroblast phenoconversion and collagen contraction
09:30 – 10:00 Michele Orini Direct in-vivo assessment of global and regional mechano-electric feedback in the intact human heart
10:00 – 10:30 Pinar Zorlutuna Mechanotransduction at the cardiomyocyte-fibroblast interface
10:30 – 11:00 Coffee (posters on display)
11:00 – 11:30 Rémi Peyronnet Piezo and matrix stiffness sensing
11:30 – 12:00 Neil Turner Channeling the force to reprogram the matrix
12:00 – 13:30              Lunch (posters on display)
    
Session 5: Tissue MEC: From the Roots to Computational Modelling
Chair: Viviane Timmermann
13:30 – 14:00 Adam Feinberg Mechanics of engineered heart tissue
14:00 – 14:30 Elisabetta Cerbai At the roots of atrial myopathy and arrhythmias: interplay between atrial dilation and genetic factors
14:30 – 15:00 Sandeep Pandit Mechanisms by which ranolazine terminates paroxysmal but not persistent atrial fibrillation
15:00 – 15:30 Tea (posters on display)
15:30 – 16:00 David Filgueiras-Rama Atrial remodelling characterization during atrial fibrillation progression
16:00 – 16:15 Eilidh MacDonald
(Poster 14)
Targeting Runx1 protects cardiac structure and function
16:15 – 16:30 Jessi Bak
(Poster 22)
Microtubules and TRPA1 drive mechanically-induced arrhythmias in the rabbit heart
16:30 – 16:45 Leander Stewart
(Poster 13)
Genetic deletion of myofibroblast-specific Piezo1 Protects against hypertension-induced cardiac hypertrophy
16:45 – 17:00 Charles Cox
(Poster 12)
Piezo1 is the cardiac mechanosensor that initiates the cardio-myocyte hypertrophic response to pressure overload in mice
17:15 Meeting Photo

Saturday, 24 September 2022

   
Session 6: Tissue MEC Reloaded: New Approaches
Chair: Eilidh MacDonald
09:00 – 09:30 Vadim Fedorov Distinct fibrotic signatures of human sinoatrial node in non-failing and failing hearts
09:30 – 10:00 Aurelien Forget Tailorable hydrogels for applied mechanobiology
10:00 – 10:30 Jennifer Davis Mechanisms of cardiac stiffness regulations
10:30 – 11:00 Coffee (posters on display)
11:00 – 11:30 Daniel Beard Multi-scale systems analysis of metabolic and mechanical determinants of reserve cardiac power output
11:30 – 12:00 Natalia Trayanova Artificial intelligence in arrhythmia and electrophysiology
12:00 – 13:00 Lunch (posters on display)
   
Session 6: Cool tools
Chair: Leonardo Sacconi
13:00 – 13:30 Boris Martinac High-throughput measurements of the viscoelastic properties of cells
13:30 – 14:00 Andrew McCulloch New tools for cell electrophysiology and clinical arrhythmia mapping
14:00 – 14:30 Juliane Münch Sensing and responding of cardiomyocytes to changes of tissue stiffness
14:30 – 15:00 Tea (posters on display)
                                      
Closing Session
Chair: Peter Kohl
15:00 – 15:15 Michael Sheetz                   What we’ve learned and what we should focus on next in terms of MEC mechanisms
15:15 – 15:30 Natalia Trayanova What we’ve learned and what we should focus on next in terms of MEC clinical relevance
15:30 – 16:00 Discussion, Participant Feedback
17:30 – 00:00 Meeting Dinner and Dance
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