Umweltmedizin am IUK

a full list of our publications can be found at:

http://www.researchgate.net/profile/Evelyn-Lamy-2/research

2019

Tran HTT, Schlotz N, Schreiner M, Lamy E. Short-term dietary intervention with cooked but not raw Brassica leafy vegetables increases telomerase activity in CD8+ lymphocytes in a randomized human trial. Nutrients 2019, 11, 786; doi:10.3390/nu11040786

Odongo GA, Skatchkov I, Herz C, Lamy E. Optimization of the alkaline comet assay for easy repair capacity quantification of oxidative DNA damage in PBMC from human volunteers using aphidicolin block. DNA Repair (Amst). 2019 Mar 14;77:58-64. doi: 10.1016/j.dnarep.2019.03.005.

2018

Tran HTT, Herz C, Ruf P, Stetter R, and Lamy E. Human T2R38 bitter taste receptor expression in resting and activated lymphocytes. Frontiers in Immunology. 11 December 2018 doi: 10.3389/fimmu.2018.02949

Schlotz N, Odongo G, Herz C, Waßmer H, Kühn C, Hanschen F, Neugart S, Binder N, Ngwene B, Schreiner M, Rohn S, Lamy E. Are raw Brassica vegetables healthier than cooked ones? A randomized, controlled crossover intervention trial on the health-promoting potential of Ethiopian Kale. Nutrients 2018, 10, 1622; doi:10.3390/nu10111622

Kühn C, Kupke F, Baldermann S, Klopsch R, Lamy E, Hornemann S, Pfeiffer AFH, Schreiner M, Hanschen FS, Rohn S. Diverse Excretion Pathways of Benzyl Glucosinolate in Humans after Consumption of Nasturtium (Tropaeolum majus L.)-A Pilot Study. Mol Nutr Food Res. 2018 Aug 9:e1800588. doi: 10.1002/mnfr.201800588

Odongo G, Schlotz N, Baldermann S, Neugart S, Huyskens-Keil S, Ngwene B, Trierweiler B, Schreiner M, Lamy E. African nightshade (Solanum scabrum Mill.): impact of cultivation and plant processing on its health promoting potential as determined in a human liver cell model. Nutrients. 2018 Oct 17;10(10). pii: E1532. doi: 10.3390/nu10101532.

Odongo G, Schlotz N, Baldermann S, Neugart S, Ngwene B, Schreiner M and Lamy E. Effects of Amaranthus cruentus L. on aflatoxin B1- and oxidative stress-induced DNA damage in human liver (HepG2) cells. Food Bioscience. 2018 28: 42-48.

Kühn C, von Oesen T, Herz C, Schreiner M, Hanschen FS, Lamy E, Rohn S. In Vitro Determination of Protein Conjugates in Human Cells by LC-ESI-MS/MS after Benzyl Isothiocyanate Exposure. J Agric Food Chem. 2018 Jul 5;66(26):6727-6733.

Fechner J, Kaufmann M, Herz C, Eisenschmidt D, Lamy E, Kroh LW, Hanschen FS. The major glucosinolate hydrolysis product in rocket (Eruca sativa L.), sativin, is 1,3-thiazepane-2-thione: Elucidation of structure, bioactivity, and stability compared to other rocket isothiocyanates. Food Chem. 2018 Sep 30;261:57-65.

2017

Schlotz N, Kim GJ, Jäger S, Günther S and Lamy E. In vitro observations and in silico predictions of xenoestrogen mixture effects in T47D-based receptor transactivation and proliferation assays. Toxicologiy in vitro 2017. doi: 10.1016/j.tiv.2017.08.017

Herz C*, Tran HTT*, Schlotz N, Michels K and Lamy E. Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC. Nature - Sci Rep. 2017 Nov 30;7(1):16631. doi: 10.1038/s41598-017-15978-2, *contributed equally

Schloß S, Hackl T, Herz C, Lamy E, Koch M, Rohn S, Maul R. Detection of a Toxic Methylated Derivative of Phomopsin A Produced by the Legume Infesting Fungus  Diaporthe toxica. J Nat Prod. 2017 Jun 14. doi: 10.1021/acs.jnatprod.6b00662. [Epub ahead of print]

Herz C, Tran HTT, Landerer S, Gaus J, Schlotz N, Lehr L, Schäfer W, Treeck O, Odongo G, Skatchkov I and Lamy E. Normal human immune cells are sensitive to telomerase inhibition by Brassica-derived 3.3-diindolylmethane, partly mediated via ERα/β-AP1 signalling. Mol Nutr Food Res. 2017 Mar 7. 

Odongo G*, Schlotz N*, Herz C Hanschen F, Baldermann S, Neugart S, Trierweiler B, Frommherz L, Franz C., Ngwene B, Luvonga AW, Schreiner, M, Rohn S and Lamy E. The role of plant processing for the cancer preventive potential of Ethiopian kale (Brassica carinata). Food and Nutrition Research. 2017;61(1):1-11, *contributed equally

Herz C, Tran HTT, Marton M, Maul R, Baldermann S, Schreiner M and Lamy E. Evaluation of an aequeous extract from horseradish root (Armoracia rusticana radix) against lipopolysaccharide-induced cellular inflammation reaction.  ECAM. 2017; 2017:1950692       

2016

Kupke F*, Herz C*, Hanschen F, Platz S, Odongo G, Helmig S, Bartolome Rodriguez M, Schreiner M, Rohn S and Lamy E. Cytotoxic and genotoxic potential of  food-borne nitriles in a liver in vitro model. Nature - Scientific Reports, 2016 Nov 24; 6, 37631, *contributed equally                                 

Tran HTT, Márton M-R, Herz C, Maul R, Baldermann S, Schreiner M, Lamy E. Nasturtium (indian cress, tropaeolum majus nanum) dually blocks the cox and lox pathway in primary human immune cells. Phytomedicine 2016;23:611-620

Herz C, Márton MR, Tran HTT, Gründemann C, Schell J, and Lamy E. Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells. Journal of Functional Foods. 2016;23:135-143

Schlotz N, Roulin A, Ebert D, and Martin-Creuzburg D. Combined effects of dietary polyunsaturated fatty acids and parasite exposure on eicosanoid-related gene expression in an invertebrate model. Comparative Biochemistry and Physiology-Part A: Molecular & Integrative Physiology. 2016;201:115-123.

2015

Hanschen FS, Herz C, Schlotz N, Kupke F, Rodríguez MM, Schreiner M, Rohn S, and Lamy E. The Brassica epithionitrile 1-cyano-2,3-epithiopropane triggers cell death in human liver cancer cells in vitro. Molecular Nutrition & Food Research. 2015;59(11):2178-2189                 

Gründemann C, Garcia-Käufer M, Lamy E, Hanschen FS and Huber R. 4-methylthiobutyl isothiocyanate (erucin) from rocket plant dichotomously affects the activity of human immunocompetent cells. Phytomedicine. 2015;22(3):369-78.                                                                                

Platz S, Piberger AL, Budnowski J, Herz C, Schreiner M, Blaut M, Hartwig A, Lamy E, Hanske L und  Rohn S. Bioavailability and biotransformation of sulforaphane and erucin metabolites in various biological matrices determined by LC-MS/MS. Analytical and Bioanalytical Chemistry. 2015;407(7):1819-29

2014

Herz C, Hertrampf A, Zimmermann S, Stetter N, Wagner M, Kleinhans C, Erlacher M,  Schüler J, Platz S, Rohn S, Mersch-Sundermann V and Lamy E. The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumor model of HCC, J Cell Mol Med. 2014 Sep 25.

Hanschen FS, Lamy E, Schreiner M, Rohn S. Reactivity and stability of glucosinolates and their breakdown products in foods. Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11430-50.

Hanschen F, Lamy E, Schreiner M, Rohn S. Reaktivität und Stabilität von Glucosinolaten und ihren Abbauprodukten in Lebensmitteln. Angewandte Chemie. 2014;126(43):11614-11635.

Schlotz N, Pester M, Freese HM, Martin-Creuzburg D. A dietary polyunsaturated fatty acid improves consumer performance during challenge with an opportunistic bacterial pathogen. FEMS Microbiology Ecology. 2014;90(2):467-477.

2013 - 2004

Lamy E, Hertrampf A, Herz C, Schüler J, Erlacher M, Bertele D, Bakare A, Wagner M, Weiland T, Lauer U, Drognitz O, Huber R,  Rohn S, Giesemann T, Mersch-Sunderman V, Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status. PlosOne. 2013 Aug 2;8(8):e70846

Lamy E, Herz C, Lutz-Bonengel S, Hertrampf A, Márton MR, Mersch-Sundermann V. The MAPK pathway signals telomerase modulation in response to isothiocyanate-induced DNA damage of human liver cancer cells. PLoS One. 2013;8(1):e53240

Márton MR, Krumbein A, Platz S, Schreiner M, Rohn S, Rehmers A, Lavric V, Mersch-Sundermann V, Lamy E. Determination of bioactive, free isothiocyanates from a glucosinolate-containing phytotherapeutic agent: A pilot study with in vitro models and human intervention. Fitoterapia. 2013 Mar; 85:25-34.                                                                                       

Lamy E, Oey D, Eißmann F, Herz C, Münstedt K, Tinneberg HR, Mersch-Sundermann V. Erucin and Benzyl Isothiocyanate Suppress Growth of Late Stage Primary Human Ovarian Carcinoma Cells and Telomerase Activity In Vitro. Phytother Res. 2012 Sep 5.

Millet A*, Lamy E*, Jonas D, Stintzing F, Mersch-Sundermann V, Merfort I. Fermentation enhances the biological activity of Allium cepa bulb extracts. (*equal contribution) JAgric Food Chem. 2012 Mar 7;60(9):2148-56.

Lamy E, Garcia-Käufer M, Prinzhorn J, Mersch-Sundermann V. Antigenotoxic action of isothiocyanate-containing mustard as determined by two cancer biomarkers in a human intervention trial. Eur J Cancer Prev. 2012 Jul;21(4):400-6

Fronza M, Lamy E, Günther S, Heinzmann B, Laufer S, Merfort I. Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action. Phytochemistry. 2012 Jun;78:107-19

Lamy E, Goetz V, Erlacher M, Herz C, Mersch-Sundermann V. hTERT: Another brick in the  wall of cancer cells. Mutat Res. Rev. 2012 Dec 31.

Lamy E, Schmitz S, Krumbein A, Mersch-Sundermann V. Isothiocyanate-containing mustard protects human cells against genotoxins in vitro and in vivo. Mutat Res. 2011 Dec 24;726(2):146-50.

Gründemann C, Papagiannopoulos M, Lamy E, Mersch-Sundermann V, Huber R. Immunomodulatory properties of a lemon-quince preparation (Gencydo®) as an indicator of anti-allergic potency. Phytomedicine. 2011 Jun 15;18(8-9):760-8                                                                             

Lamy E, Scholtes C, Herz C, Mersch-Sundermann V. Pharmacokinetics and pharmacodynamics of isothiocyanates. Drug Metab Rev. 2011 Aug;43(3):387-407.

Lamy E, Mersch-Sundermann V. MTBITC mediates cell cycle arrest and apoptosis induction in human HepG2 cells despite its rapid degradation kinetics in the in vitro model.  Environ Mol Mutagen. 2009 Apr;50(3):190-200

Lamy E, Mersch-Sundermann V. Sulphur-containing compounds in food plants: kinetics, biological activity, and mechanisms of action. Environ Mol Mutagen. 2009 Apr;50(3):163

Lamy E, Crössmann C, Saeed A, Schreiner PR, Kotke M, Mersch-Sundermann V. Three structurally homologous isothiocyanates exert "Janus" characteristics in human HepG2 cells. Environ Mol Mutagen. 2009 Apr;50(3):164-70. 

Wu X, Hu Y, Lamy E, Mersch-Sundermann V. Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides: triggers, pathways, and modulators. Environ Mol Mutagen. 2009 Apr;50(3):266-75. 

Lamy E, Schröder J, Paulus S, Brenk P, Stahl T, Mersch-Sundermann V. Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action. Food Chem Toxicol. 2008 Jul;46(7):2415-21.    

Lamy E, Völkel Y, Roos PH, Kassie F, Mersch-Sundermann V. Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion. Int J Hyg Environ Health. 2008 Mar;211(1-2):74-81.

Mersch-Sundermann V, Bahorun T, Stahl T, Neergheen VS, Soobrattee MA, Wohlfarth R, Sobel R, Brunn HE, Schmeiser T, Lamy E, Aruoma OI. Assessment of the DNA damaging potency and chemopreventive effects towards BaP-induced genotoxicity in human derived cells by Monimiastrum globosum, an endemic Mauritian plant.  Toxicol In Vitro. 2006 Dec;20(8):1427-34.

Aruoma OI, Colognato R, Fontana I, Gartlon J, Migliore L, Koike K, Coecke S, Lamy E, Mersch-Sundermann V, Laurenza I, Benzi L, Yoshino F, Kobayashi K, Lee MC. Molecular effects of fermented papaya preparation on oxidative damage, MAP Kinase activation and modulation of the benzo[a]pyrene mediated genotoxicity. Biofactors. 2006;26(2):147-59.                                          

Lamy E, Kassie F, Gminski R, Schmeiser HH, Mersch-Sundermann V. 3-Nitrobenzanthrone (3-NBA) induced micronucleus formation and DNA damage in human hepatoma (HepG2) cells. Toxicol Lett. 2004 Jan 15;146(2):103-9.