The Institute of Anatomy and Cell Biology of the University of Freiburg offers a

Postdoc Position for Electrical and Optical Analysis of Nanopores for Peptide Identification Using Single-Molecule Tools (m/f/d)

Biological and solid state nanopores play an increasing role in molecular diagnostics. The goal of this project is to establish their use for the identification of peptides and their post-translational modifications that are found in a variety of pathological conditions, including cancer, cardiovascular, neurodegenerative, and infectious diseases. Simultaneous observation of the electrical current through a single nanopore and the optical signal from a dye molecule inside the pore will provide characteristic information of the peptide bound in the pore.

As a part of the collaborative research cluster "nEOdiag" funded by the Carl-Zeiss-Stiftung

(https://www.carl-zeiss-stiftung.de/themen-projekte/uebersicht-projekte/detail/nanoporen-basierte-elektrisch-optische-proteindiagnostik-neodiag), the University of Freiburg (https://www.uni-freiburg.de) offers a postdoc position (E13 TV-L) in a fixed-term contract for two years to work on the project

» Optimization of fluorescently doped nanopore proteins for optical-electrical peptide analysis «

The responsibilities of the successful applicants will include:

optimization of the combined electrophysiology/microscopy setup
wet lab work for reconstitution of membrane proteins in lipid bilayers
molecular biology and biochemistry to generate chimeric and mutant proteins
experiments and data analysis
comprehensive presentation of results in group meetings and at conferences
preparation of manuscripts

What we are looking for:

talented and highly motivated candidates with a PhD in physics, chemistry, biophysics or equivalent skills
strong interest in microscopy and electrophysiology
experience in work with lipid bilayers and reconstitution of membrane proteins
background in biophysics, molecular biology, and biochemistry
ability to work independently and in a team

Interested? Applications should include:

Curriculum vitae with your name, address, degree(s) with transcript(s) of grades, research experience, educational and employment history. Please include any awards, distinctions and publications.
Motivation letter
Name and e-mail address of two academic references

The preferred starting date is as soon as possible.