Zu den Inhalten springen

Chronic bacterial infections

Team
Junior Research Group Leader:

Dr. Anne Lößlein 

Physician

Tel +49 761 270 82770 

anne.loesslein@uniklinik-freiburg.de

PhD student

Shiva Fallahianshafiei

 

MD student

Leonhard Wagner

 

Selected Publications

* equal contribution, # corresponding author

Lösslein AK , Goerne T, Elling R, Wengenmayer T, Häcker G, Biever PM. Post-pandemic increase of Group A streptococcal infections in adults: a retrospective cohort study from 2012 to 2024. Infection. 2025 Oct 31. doi: 10.1007/s15010-025-02668-9. Epub ahead of print. PMID: 41171514. DOI: 10.1007/s15010-025-02668-9 

Seidl M, Haghighi EB, Lösslein AK, Hufnagel M, Lohrmann F, Schneider C, Kohlfürst DS, Zenz W, Gorkiewicz G, Feiterna-Sperling C, Krüger R, Bronsert P, Neppl C, Sommer KZ, Stehl V, Boerries M, Kuntz M, Henneke P. Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children. Front Immunol. 2025 Jun 26;16:1597074. 10.3389/fimmu.2025.1597074

Lösslein AK*,#, Staus PI*, Beisert Carneiro C, Wolkewitz M, Häcker G. The burden of nosocomial superinfections in a retrospective cohort study of critically ill COVID-19 patients. BMC Infect Dis. 2025 May 3;25(1):650. 10.1186/s12879-025-10983-7

Lösslein, A. K., Henneke P. (2025) Macrophage Differentiation and Metabolic Adaptation in
Mycobacterial Infections. Annu. Rev. Immunol. 43:15.1–15.28. 10.1146/annurev-immunol-082323-120757 

Mansoori Moghadam, Z., Zhao, B., Raynaud, C., Strohmeier, V., Neuber, J., Lösslein, A. K., Qureshi, S., Gres, V., Ziegelbauer, T., Baasch, S., Schell, C., Warnatz, K., Inohara, N., Nunez, G., Clavel, T., Rosshart, S. P., Kolter, J., & Henneke, P. (2025). Reactive oxygen species regulate early development of the intestinal macrophage-microbiome interface. Blood, blood.2024025240. 10.1182/blood.2024025240 

Lösslein, A.K., Lohrmann, F., Scheuermann, L., Gharun, K., Neuber, J., Kolter, J., Forde, A.J., Kleimeyer, C., Poh, Y.Y., Mack, M., Triantafyllopoulou, A., Dunlap, M.D., Khader, S.A., Seidl, M., Hölscher, A., Hölscher, C., Guan, X.L., Dorhoi, A., Henneke, P., (2021). Monocyte progenitors give rise to multinucleated giant cells. Nat. Commun. 12(1):2027. 10.1038/s41467-021-22103-5

Lösslein A, Henneke P. (2020). Mycobacterial immunevasion – spotlight on the enemy within. J. Leukoc. Biol., 109(1): 9-11. 10.1002/JLB.3CE0520-104R

Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d'Errico P, Baasch S, Amann L, Masuda T, Lösslein A, Gharun K, Meyer-Luehmann M, Waskow C, Franzke CW, Grün D, Lämmermann T, Prinz M, Henneke P. (2019). A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity. 50(6): 1482-1497.e7. 10.1016/j.immuni.2019.05.009

Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Vavra M, Schachtrup K, Illert AL, Gilleron M, Kirschning CJ, Triantafyllopoulou A, Henneke P. (2017). Mycobacteria exploit nitric oxide- induced transformation of macrophages into permissive giant cells. EMBO Rep. 18(12), 2144-2159. 10.15252/embr.201744121