Cutaneous inflammation
Major Focus:
Chronic inflammatory skin diseases represent a major burden for modern health care systems. They affect up to 25% of the population ranging from young babies to elderly. Whereas highly efficient therapies are available for the most common diseases such as psoriasis and atopic eczema other disorders still remain undertreated. However, even highly efficient therapies leave a proportion of patients that do not achieve acceptable treatment outcomes. The pathogenesis of chronic inflammatory skin diseases is complex and defined by an interplay of genetic background, environmental influences and dysbalances in the immune system. These alterations lead to a miscommunication of immune cells with the epithelial compartment and thereby to a disruption of the epithelial barrier. The aim of our research group to decipher communication pathways in health and disease to allow better diagnosis and more efficient treatment of patients. Within this aim, we primarly focus on the understanding of the interaction of adaptive T cells with tissue resident cells such as keratinocytes and fibroblasts and how this interaction can lead to the maintenance of skin barrier integrity or to pathology.
Prof. Dr. med. Kilian Eyerich, PhD – Dermatologist -
Phone: +49 (0)761 270-67160
E-Mail: sabine.acker-heinig@uniklinik-freiburg.de
ORCID: 0000-0003-0094-2674
CV
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Since 2021 |
Full Professor and Medical Director, Department of Dermatology, Medical Center – University of Freiburg |
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2021-2025 |
Guest Professor, Karolinska Institutet, Stockholm |
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2019-2021 |
Professor and Chair for Dermatology and Venerology, Karolinska Institutet, Stockholm |
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2014-2019 |
Heisenberg Professor for Experimental Dermato-immunology, Technical University of Munich |
Team
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Postdocs |
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Dr. Nora Langreder, PhD, Biologist |
Evaluation of key drivers in chronic skin inflammation |
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Dr.Konstantin Leppelmann, MD, Dermatologist |
Regulation of anti-inflammatory processes during skin inflammation |
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Doctoral/Master students |
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Haya Bourhani, Dr. rer. nat. cand. |
Immunometabolism in skin inflammation |
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Carolyn Fode, Dr. med. cand. |
The potential of Jak inhibition for the treatment of inflammatory skin diseases |
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Technician |
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Ann-Kathrin Fritz |
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Alumni |
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2024 |
Emanuele Scala, Dr. rer. nat. |
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2023 |
Menna Mubarak, Dr. rer. nat. |
Key Puclications
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2024 |
Spatial transcriptomics reveals altered lipid metabolism and inflammation-related gene expression of sebaceous glands in psoriasis and atopic dermatitis. Seiringer P, Hillig C, Schäbitz A, Jargosch M, Pilz AC, Eyerich S, Szegedi A, Sochorová M, Gruber F, Zouboulis CC, Biedermann T, Menden MP, Eyerich K, Törőcsik D. Front Immunol. 2024 Feb 16;15:1334844. doi: 10.3389/fimmu.2024.1334844. |
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2024 |
Noninferiority of 16-Week vs 8-Week Guselkumab Dosing in Super Responders for Maintaining Control of Psoriasis: The GUIDE Randomized Clinical Trial. Eyerich K, Asadullah K, Pinter A, Weisenseel P, Reich K, Paul C, Sabat R, Wolk K, Eyerich S, Lauffer F, Angsana J, Taut FJH, Kohler K, Chen Y, Sendecki J, Leung MWL, Wegner S, Personke Y, Gomez M, Krüger N, Tabori S, Schäkel K. JAMA Dermatol. 2024 Jul 31:e242463. doi: 10.1001/jamadermatol.2024.2463 |
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2022 |
Schäbitz A, Hillig C, Mubarak M, Jargosch M, Farnoud A, Scala E, Kurzen N, Pilz AC, Bhalla N, Thomas J, Stahle M, Biedermann T, Schmidt-Weber CB, Theis F, Garzorz-Stark N, Eyerich K, Menden MP, Eyerich S. Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases. Nat Commun. 2022 Dec 13;13(1):7729. doi: 10.1038/s41467-022-35319-w |
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2014 |
Quaranta M*, Knapp B*, Pullabhatla V, Garzorz N, Mattii M, Pennino P, Andres C, Traidl-Hoffmann C, Cavani A, Theis FB, Ring J, Schmidt-Weber CB, Eyerich S*, Eyerich K* Intra-individual genome expression analysis reveals a specific molecular signature of psoriasis and eczema Sci Transl Med. 2014 Jul 9;6(244):244ra90. doi: 10.1126/scitranslmed.3008946. |
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2011 |
Eyerich S*, Onken AT*, Weidinger S, Franke A, Nasorri F, Pennino D, Grosber M, Pfab F, Schmidt-Weber CB, Mempel M, Hein R, Ring J, Cavani A, Eyerich K Mutual Antagonism of the T cell Subsets Causing Psoriasis and Atopic Eczema N Engl J Med. 2011 Jul 21;365(3):231-8. doi: 10.1056/NEJMoa1104200. |