The Statistical Genomics Group (Emmy Noether Group Leader: Dr. Pascal Schlosser) at the Institute of Genetic Epidemiology generates new insights into the (patho-)physiology of complex human traits and diseases, which arise from the combination of genetic predisposition and environmental influences. The proposed project is focused on the development and application of phenome-wide Molecular Causal inference Network analysis by integrating pre-computed molecular prediction models (e.g., cis-heritable plasma proteins, gene expression) with genome-wide association data from complex traits. This effort combines data from large biobanks and consortia (e.g., UK Biobank, FinnGen, All of Us, MVP), accounting for ancestry-specific differences and using multiple protein prediction models.