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Department Neurozentrum

Prof. Dr. Dr. Rumyana Kristeva

e-mail: rumyana.kristeva(at)gmail.com

Before her retirement end of 2014 Professor Rumyana Kristeva was head of the research laboratory „Cortical motor control“ which she  established in 1996 in the Department of Neurology and Neurophysiology of the University Medical Center Freiburg.

The general mission of the laboratory was to understand:

  • the physiology of human voluntary movement and the pathophysiology of certain involuntary movements (in Parkinson’s disease, writer's and musician's cramp, tics and myoclonus) and thus to provide the neurophysiological basis for the brain computer interface;
  • the stochastic resonance in the human sensorimotor system and to implement it for improvement of the motor performance and suppression of tremor

In 2010 Professor Rumyana Kristeva established a bridge between science and society and between science and art with the project “Dance for Parkinson”  (Heiberger et al., 2011).

Currently Rumyana Kristeva takes part in a project of Prof. Dr. Elias Manjarrez (Puebla University, Mexico)   investigating multisensory stochastic resonance and optogenetic noise photostimulation for the improvement of the human sensory perception, sensorimotor performance and cognition as well as in rehabilitation.




Huidobro, N., Mendez-Fernandez, A., Méndez-Balbuena, I., Gutiererez, R., Kristeva, R., and Manjarrez, E. Brownian Optogenetic-Noise-Photostimulation on the Brain Amplifies Somatosensory-Evoked Field Potentials. Front Neurosci. 2017; 11: 464. Epub 2017 Aug 31. doi: 10.3389/fnins.2017.00464





Flores, A., Manilla, S., Huidobro N., De la Torre-Valdovinos B., Kristeva, R., Mendez-Balbuena, I., Galindo F., Trevino, M., Manjarrez, E. Stochastic resonance in the synaptic transmission between hair cells and vestibular primary afferents in development. Neurosci., 13;322:416-29. doi: 10.1016/j.neuroscience.2016.02.051. Epub 2016 Feb 27, 2016.





Méndez-Balbuena, I., Huidobro, N., Silva, M., Flores, A., Trenado, C., Quintanar, L., Arias-Carrión, O., Kristeva, R., and Manjarrez, E. Effect of mechanical tactile noise on amplitude of visual evoked potentials: multisensory stochastic resonance. J. Neurophysiol. 114(4):2132-43. doi: 10.1152/jn.00457., 2015.



Trenado, C., Amtage, F, Huethe, F., Schulte-Mönting, J., Mendez-Balbuena, I., Baker, S.N., Baker, M., Hepp-Reymond, M.C., Manjarrez, E., and Kristeva, R. Suppression of enhanced physiological tremor via stochastic noise: initial observations, Plos One, 9:(11), 2014


Trenado, C., Mendez-Balbuena, I., Manjarrez, E., Huethe, F., Schulte-Mönting, J., Feige, B., Hepp-Reymond, M.C. and Kristeva, R. Enhanced corticomuscular coherence by external stochastic noise, Front. Hum. Neurosci, 2014 May 20;8:325. doi: 10.3389/fnhum.2014.00325. eCollection 2014


Trenado, C., Mikulic, A., Manjarrez, E., Mendez-Balbuena, I., Schulte-Mönting, J., Huethe, F., Hepp-Reymond, M.C., and Kristeva, R. Broad-band Gaussian noise is most effective in improving motor performance and is most pleasant, Front. Hum. Neurosci., 2014 Feb 3;8:22. doi: 10.3389/fnhum.2014.00022. eCollection 2014




Tapia, J.A., Trejo, A., Linares, P., Alva, J.M., Kristeva, R., and Manjarrez, E., Reticular activating system of a central pattern generator: premovement electrical potentials. Physiol Rep. 2013 Oct;1(5):e00129. doi: 10.1002/phy2.129. Epub 2013 Oct 24


Mendez-Balbuena, I. Naranjo, J.R., Wang, X., Andrykiewicz, A., Huethe, F., Schulte-Moenting, J., Hepp-Reymond, M.C., and Kristeva. The strength of the corticospinal coherence depends on the predictability of modulated isometric forces, J Neurophysiol. 2013 Mar;109(6):1579-88. doi: 10.1152/jn.00187         




Mendez-Balbuena, I., Manjarrez, E., Schulte-Mönting, J., Huethe, F., Tapia, J.A. Hepp-Reymond, M.C, and Kristeva, R. Improved sensorimotor performance via stochastic resonance, J Neurosci., 32:(36) 12612-12618, 2012


Mendez-Balbuena, I., Huethe, F., Schulte-Mönting, J., Leonhart, R., Manjarrez, E., Kristeva, R. Corticomuscular coherence reflects interindividual differences in the state of the corticomuscular network during low-level static and dynamic forces. Cereb Cortex, 2012 Mar;22(3):628-38. doi: 10.1093/cercor/bhr147. Epub 2011 Jun




Heiberger, L., Maurer, Ch., Amtage, F., Mendez-Balbuena, I., Schulte-Mönting, J., Hepp-Reymond, M.-C. and Kristeva, R. Impact of a weekly dance class on the functional mobility and on the quality of life of individuals with Parkinson’s disease, Front Aging Neurosci, 3:(14), 2011

Omlor W., Patino L., Mendez-Balbuena I., Schulte-Mönting J., Kristeva R. Corticospinal beta-range coherence is highly dependent on the pre-stationary motor state. J Neurosci. 2011 Jun 1;31(22):8037-45.





Naranjo, J R and Wang, X and Schulte-Mönting, J and Huethe, F and Maurer, C and Hepp-Reymond, M C and Kristeva, R Corticospinal interaction during isometric compensation for modulated forces with different frequencies, BMC Neuroscience, 11:157, 2010





Hepp-Reymond, M.C., Chakarov, V., Schulte-Monting, J.,  Huethe, F., and Kristeva, R. Role of proprioception and vision in handwriting, 79: 365-370, 2009


Chakarov, V., Naranjo,JR, Schulte-Mönting, J., Omlor, W., Huethe, F., and Kristeva, R. Beta-range EEG-EMG coherence with isometric compensation for increasing modulated low-level forces J Neurophysiol 102:1115-1120, 2009





Patino, L., Omlor, W., Chakarov, V., Hepp-Reymond, M.C., and Kristeva, R. Absence of gamma-range corticomuscular coherence during dynamic force in a deafferented patient, J Neurophysiol, 99:(4) 1906-1916, 2008





Andrykiewicz, A., Patino, L., Naranjo, J.R., Witte, M., Hepp-Reymond, M.-C., and Kristeva, R. Corticomuscular synchronization with small and large dynamic force output, BMC Neuroscience, 8:(1), 2007


Omlor, W., Patino, L., Hepp-Reymond, M-C and Kristeva, R Gamma-range cortico-muscular coherence during dynamic force output, Neuroimage, 34: 1191-1198, 2007


Witte, M and Patino, L and Hepp-Reymond, M-C and Kristeva, R Modulation of human corticomuscular beta-range coherence with low-level static forces, Eur J Neurosci, 26:(12) 3564-3570, 2007


Naranjo, J.R., Brovelli, A., Longo, R., Budai, R., Kristeva, R., and Battaglini, P.P. EEG dynamics of the frontoparietal network during reaching preparation in humans. Neuroimage 34: 1673-82, 2007


Omlor, W., Patino, L., Hepp-Reymond, M.C., and Kristeva, R. Gamma-range cortico-muscular coherence during dynamic force output. Neuroimage 34:1191-8, 2007


Kristeva, R., Patino, L., Omlor, W. Beta-range cortical motor synchrony and corticomuscular coherence as a mechanism for effective corticospinal interaction during steady-state motor output. Neuroimage 36: 785-792, 2007




Kristeva, R and Chakarov, V and Wagner, M and Schulte-Mönting, J and Hepp-Reymond, M-C Is the movement-evoked potential mandatory for movement execution? A high-resolution EEG study in a deafferented patient, Neuroimage, 31: 677-685, 2006


Patino, L and Chakarov, V and Schulte-Mönting, J and Hepp-Reymond, M-C and Kristeva, R Oscillatory cortical activity during a motor task in a deafferented patient, Neuroscience Letters, 401: 214-218, 2006


Nirkko, A., and R. Kristeva Brain activation during string playing. In: Music, Motor Control and the Brain. Altenmüller, Kesselring and Wiesendanger (Eds.) Oxford University Press, ISBN 0-19-929872-6, 2006


Patino, L., Chakarov, V., Schulte-Monting, J., Hepp-Reymond, M.C., and Kristeva, R. Oscillatory cortical activity during a motor task in a deafferented patient. Neurosci Lett, 401: 214-218, 2006


Kristeva, R., Chakarov, V., Wagner, M., Schulte-Monting, J., Hepp-Reymond, M.C. Is the movement-evoked potential mandatory for movement execution? A high-resolution EEG study in a deafferented patient. Neuroimage 31: 677-685, 2006


Chakarov, V., Hummel, S., Losch, F., Schulte-Monting, J., and Kristeva, R. Handwriting performance in the absence of visual control in writer's cramp patients: initial observations. BMC Neurol, 6, 14, 2006




Kristeva R., Chakarov V., Losch F., Hummel S., Popa T., and J. Schulte-Mönting Electroencephalographic spectral power in writer’s cramp patients: Evidence for motor cortex malfunctioning during the cramp, NeuroImage 27: 706-714, 2005




Kristeva R., Popa T., Chakarov V., and Hummel, S. Cortico-muscular coupling in a patient with postural myoclonus, Neurosci Let 366: 259-263, 2004





Kristeva-Feige, R. Distributed source modeling in the analysis of movement-related activity. In: M. Jahanshahi and M. Hallett (Eds.) The Bereitschaftspotential: Movement-related cortical potentials. Kluwer Academic/Plenum Publishers, New York, 79-95, 2003


Kristeva, R., Chakarov, V., Schulte-Monting, J., and J. Spreer Activation of cortical areas in music execution and imagining: a high-resolution EEG study, Neuroimage 20: 1872-1883, 2003



Stancak, A., Lücking, C.H., and Kristeva-Feige, R. The size of corpus callosum and functional connectivities of cortical regions in finger and shoulder movements Cogn Brain Res, 13: 61-74, 2002

Kristeva-Feige, R., Fritsch, Ch., Timmer, J., and Lücking, C.H. Effects of attention and precision of exerted force on beta range EEG-EMG synchronization during a maintained motor contraction task. Clin Neurophysiol, 113: 124-131, 2002



Huppertz, H.J., Hof., E., Klisch, J., Wagner, M., Lücking C.H., and Kristeva-Feige, R. Localisation of interictal delta and epileptiform EEG activity associated with focal epileptogenic brain lesions Neuroimage 13: 15-28, 2001


Huppertz H.J., Hoegg., S., C. Sick, Lücking, C.H.. Zentner, J., Schulze-Bonhage, A., and Kristeva-Feige, R. Cortical Current Density Reconstruction of Interictal Epileptiform Activity in Temporal Lobe Epilepsy. Clin Neurophysiol, 112: 1761-1772, 2001.



Feige, B., Aertsen, A., and Kristeva-Feige, R. Dynamic synchronization between multiple cortical motor areas and muscle activity in phasic voluntary movements J Neurophysiol, 84: 2622-2629, 2000

Stancak, A., Feige, B., Lücking, C.H., and Kristeva-Feige, R. Slow cortical potentials and movement-related spectral power changes with proximal and distal voluntary movements, Electroencephalogr Clin Neurophysiol 111: 636-650, 2000


Rossi, S., Pasqualetti, P., Feige, B., Glocker, F.X., Ulivelli, M., Battistini, N., Lücking, C.H., Rossini, P.M. and Kristeva-Feige, R. Effects of repetitive transcranial magnetic stimulation on movement-related cortical activity in humans. Cereb Cortex 10: 802-808, 2000


Hellwig, B., Häußler, S., Lauk, M., Guschlbauer, B., Köster, B., Kristeva-Feige, R., Timmer, J. and C.H. Lücking Tremor-correlated cortical activity detected by electroencephalography Clin Neurophysiol, 111: 806-809, 2000


Stancak, A., C.H. Lücking and R. Kristeva-Feige (2000) Lateralization of movement-related potentials and the size of corpus callosum. NeuroReport, 11:329-332, 2000

Further publications please see Pubmed


Sprecher des Departments
Prof. Dr. Horst Urbach

Prof. Dr. Horst Urbach
Klinik für Neuroradiologie

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