The lab of Dr. Eric Metzger at the Department of Urology, Medical Center – University of Freiburg, is offering a
PhD position - Epigenetic reprogramming of the tumor microenvironment in prostate cancer (m/f/d)
The fully funded PhD student position is available at the Center for Clinical Research, Medical Center, University of Freiburg, Germany. The group led by Dr. Eric Metzger is a multi-disciplinary team with a focus on all aspects of epigenetic regulation including immuno-oncology, stemness, metabolism, signaling, drug development, and chromatin states. The research group is embedded in the Collaborative Research Centre 1479, a research effort of 19 PIs on various aspects on oncogene-driven immune escape.
The Metzger lab combines genome-wide analyses and single cell-omics techniques with in vivo approaches such as genetically modified mouse and 3D organoid models to study the interdependent interaction between tumor and its microenvironment. The aim is to connect basic and translational research with comprehension of human diseases.
The proposed project aims to investigate the functions of the lysine methyltransferase KMT9 (Jia et al, Nat Commun 2025: Wang et al, Nat Commun, 2024, Metzger et al, Nat Struc Mol Biol 2019) in reprogramming the tumor microenvironment in prostate cancer. You will be part of a team, which combines genome-wide analyses, proteomics, metabolomics, and molecular- and cellular biology with epigenetic regulation to identify novel avenues for translation in clinical practice. In particular, we intersect immuno-oncology and immunological approaches with epigenetic information to develop novel therapeutic strategies orchestrating tumor-microenvironment interactions.
Applicants with experience in immuno-oncology and/or immunology are preferred.
We offer:
- a dynamic, highly interactive environment and an international working atmosphere with state-of-the-art facilities
- intensive support and interdisciplinary collaborations
- participation in the CRC1479 “OncoEscape” graduate school
- a 3-year 65% PhD position
Tasks:
- perform genome-wide transcriptome (RNA-seq, scRNA-seq), cistrome (ChIP-seq, CUT&RUN) proteome analyses. Use technologies such as flow cytometry, CODEX imaging. Perfom bioinformatic analysis
- work with prostate tumour cells, organoids and preclinical mouse models
- perform functional T-cell assays, immune checkpoint analyses, and signaling studies
You profile:
- completed Master degree in molecular medicine, biology, biochemistry, or a related field
- experience in immuno-oncology and/or immunology
- interest in translational cancer immunology
- independent, structured work style and good English skills
Application procedure:
To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The application should consist of an up to date CV, a supporting statement, which describes why you would be a suitable candidate for the position, and at least two letters of recommendation.
Your complete online application must be submitted no later than 28th of February (23:59 German time).
For further inquiries, please contact:
eric.metzger@uniklinik-freiburg.de
