The Thimme/Hofmann lab, Department of Medicine II, Medical Center – University of Freiburg, is looking for a
PhD student (m/f/d)
We focus on translational research in the field of tumor immune escape in Hepatocellular carcinoma. Our results contribute to a better understanding of tumor- immune cell interactions with implications for therapeutic strategies.
Job description:
The aim of this project is to comprehensively study the role of FAK for tumor immune escape using patient-derived 3D model systems and high-dimensional immune cell profiling. The project is integrated in the collaborative research center 1479 Oncoescape, a consortium of leading scientists, focusing on the development of rationally designed combination treatment approaches of oncogenic signalling inhibition and immunotherapy.
Your work will give insights into the potential of FAK as a targetable candidate to improve tumor susceptibility to immunotherapy for the continously rising number of patients with hepatocellular carcinoma.
We offer:
- a translational project in a clinically relevant setting with the possibility to implement your own ideas
- working in a dedicated interdisciplinary team of biologists and physicians on exciting research topics and participation in the Collaborative Research Center 1479 (https://www.sfb1479.uni-freiburg.de/)
- participation in a graduate program
- a unique network of excellent partners for continuous support in development of your scientific profile
- professional and efficient supervision supported by a thesis advisory committee
- a good working atmosphere in modern laboratories with cutting-edge equipment
- buddy System for new doctoral researchers
- participation in a wide range of further training opportunities and participation in (inter-)national conferences
- salaries are based on the German academic standards (TV-L E13, 65 %) with attractive employee benefits, e.g. JobTicket
Your work includes but is not limited to:
- autonomous processing of research tasks related to immune escape in hepatocellular carcinoma
- working with 3D ex vivo models including tumor spheroids and organoids
- application of state-of-the-art and cutting-edge methods of cell and molecular biology including immunohistochemistry, imaging mass cytometry, high dimensional FACS
- establishing of new methods to elaborate on subsequent research questions
- presentation of results on regular lab and consortium meetings and (inter-) national conferences
- supervision of students
Prerequisites:
- we are looking for a highly motivated and enthusiastic individual who enjoys translational scientific work in an interdisciplinary and international team
- graduation (M. Sc.) in biology, molecular medicine or related subjects preferentially with focus on oncology and/or immunology
- strong interest in translational research, human immunology and oncology
- distinct working autonomy combined with a high capacity for teamwork
- a careful and focused working habit
- enjoy scientific work
- awareness of careful documentation
- ability to work independently and as a part of an international team
- communication skills in English
- knowledge in presentation skills
If you are interested, please submit your application in German or English (including CV, a motivation letter and contact details of two references).
University Medical Center Freiburg
Clinic for Internal Medicine II
TEXIMMED2-FR
(Translational EXperimental IMmunology lab)
Hugstetter Str. 55, 79106 Freiburg
For further information please contact:
Dr. Fabian Gendrisch
fabian.gendrisch@uniklinik-freiburg.de
