The Institute of Anatomy and Cell Biology, Department of Molecular Embryology at the Albert-Ludwigs-University Freiburg is looking for the research group of Prof. Dr. Christian Schachtrup at the earliest possible date for a
PhD Student (m/f/d)
Our research focuses on the molecular and cellular mechanisms that govern central nervous system (CNS) repair and regeneration. In particular, we study how blood–brain barrier disruption alters the local tissue environment to drive scar formation and impair functional recovery (Akassoglou et al., 2024, Cell; Nath et al., 2024, Nat Commun; Martinez Santamaria et al., 2025, iScience).
Specifically, we investigate how changes in vascular permeability with vascular-derived factors regulate reactive gliosis and fibrotic scar formation, and how these barriers influence neural stem cell behavior, differentiation, and function.
The PhD student will investigate the cellular and molecular mechanisms that regulate fibroblast–immune cell interactions at CNS interfaces following vascular dysfunction.
The successful candidate will be trained in a wide array of state-of-the-art techniques in modern neuroscience and molecular biology, including cell fate mapping using reporter mice, flow cytometry, single-cell RNA sequencing, advanced microscopy, and approaches in cell biology, signaling, and regenerative medicine.
Requirements:
- above-average degree (Master’s or equivalent) in molecular medicine, biology, chemistry, neuroscience, or a related natural science field
- strong interest in neurobiology, vascular biology, and regenerative medicine
- proven ability for independent and structured scientific work
- ideally experience with modern molecular and cellular biology techniques (e.g., flow cytometry, single-cell RNA sequencing, advanced microscopy)
- prior experience with animal models is advantageous but not mandatory
- strong communication skills, motivation, and ability to work in an interdisciplinary team
We offer you:
- a challenging and exciting research project in a dynamic and international research group
- access to state-of-the-art research facilities and cutting-edge technologies
- an inspiring academic environment at the University of Freiburg
- opportunities for international networking and scientific exchange
- structured doctoral training and mentoring
The position is limited to 3 years. Depending on qualifications and the tasks assigned, remuneration will be based on TV-L E13.
Are you interested in a varied and responsible field of activity? Please send us your documents exclusively via our online portal by 30.06.2026.
Albert-Ludwigs-Universität Freiburg
Institute of Anatomy and Cell Biology
Department of Molecular Embryology
Prof. Dr. Christian Schachtrup
Albertstr. 17, 79104 Freiburg
Questions? Then give us a call or send an e-mail:
Prof. Dr. Christian Schachtrup
christian.schachtrup@anat.uni-freiburg.de
0761/203-5101
christian.schachtrup@anat.uni-freiburg.de
0761/203-5101
Please do not send any application documents to this e-mail address.
