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Emerging principles of primary cilia dynamics in controlling tissue organization and function.

J Gopalakrishnan, K Feistel, BM Friedrich, A Grapin-Botton, N Jurisch-Yaksi, E Mass, DU Mick, RU Müller, H May-Simera, B Schermer, M Schmidts, P Walentek, D Wachten. - 2023 EMBO Journal.

Link: https://www.embopress.org/doi/full/10.15252/embj.2023113891

Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion.

R Ventrella, SK Kim, J Sheridan, A Grata, E Bresteau, OA Hassan, EE Suva, P Walentek, BJ Mitchell. - 2023 Development.

Link: https://journals.biologists.com/dev/article/150/17/dev201612/326627/Bidirectional-multiciliated-cell-extrusion-is

The evolutionary history of Brachyury genes in Hydrozoa involves duplications, divergence, and neofunctionalization

Alexandra A. Vetrova, Daria M. Kupaeva, Alena Kizenko, Tatiana S. Lebedeva, Peter Walentek, Nikoloz Tsikolia, Stanislav V. Kremnyov - 2023 Scientific Reports

Link: https://www.nature.com/articles/s41598-023-35979-8


Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components

Hantel F., Liu H., Fechtner L., Neuhaus H., Ding J., Arlt D., Walentek P., Villavicencio-Lorini P., Gerhardt C., Hollemann T., Pfirrmann T. - 2022 Journal of Cell Science

Link: https://journals.biologists.com/jcs/article/135/9/jcs259209/275349

Microridge-like structures anchor motile cilia

Yasunaga T., Wiegel J., Bergen M.D., Helmstädter M., Epting D., Paolini A., Çiçek Ö., Radziwill G., Engel C., Brox T., Ronneberger O., Walentek P., Ulbrich M.H., Walz G. - 2022 Nature Communications

Link: https://www.nature.com/articles/s41467-022-29741-3

Spectrum of Genetic Variants in a Cohort of 37 Laterality Defect Cases

Antony D, Yilmaz Gulec E, Gezdirici A, Slagter L, Bakey Z, Bornaun H, Tanidir I, Van Dinh T, Brunner HG, Walentek P, Arnold S, Backofen R, Schmidts M. - 2022 FrontGen

Link: https://www.frontiersin.org/articles/10.3389/fgene.2022.861236/abstract

A simple method to generate human airway epithelial organoids with externally orientated apical membranes

Boecking CA, Walentek P, Zlock LT, Sun, DI, Wolters PJ, Ishikawa H, Jin B-J, Haggie PM, Marshall WF, Verkman AS, Finkbeiner WE. - 2022 Am J Physiol Lung Cell Mol Physiol.

Link: https://journals.physiology.org/doi/abs/10.1152/ajplung.00536.2020

Link to press release University Freiburg Medical Center: https://kommunikation.uni-freiburg.de/pm/2022/lungengewebe-aus-dem-labor?set_language=de


The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus

Beckers A, Fuhl F, Ott T, Boldt K, Brislinger MM, Walentek P, Schuster-Gossler K, Hegermann J, Alten L, Kremmer E, Przykopanski A, Serth K, Ueffing M, Blum M, Gossler A. - 2021 Scientific Reports

Link: https://www.nature.com/articles/s41598-021-92495-3

Signaling Control of Mucociliary Epithelia: Stem Cells, Cell Fates, and the Plasticity of Cell Identity in Development and Disease

Walentek P. - 2021 Cells Tissues Organs

Link: https://www.karger.com/Article/FullText/514579

Xenopus epidermal and endodermal epithelia as models for mucociliary epithelial evolution, disease, and metaplasia

Walentek P. - 2021 Genesis

Link: https://onlinelibrary.wiley.com/doi/10.1002/dvg.23406

Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling

Tasca A, Helmstädter M, Brislinger MM, Haas M, Mitchell B, Walentek P. - 2021 Developmental Cell

Link: https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30980-1

bioRxiv: https://www.biorxiv.org/content/10.1101/2020.04.16.045401v2


The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan

Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini  P, Walentek P, Klotz L-O, Hollemann T, Pfirrmann T. - 2020 Autophagy

Link: https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1695399


ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia

Haas M, Gómez Vázquez JL, Sun DI, Tran HT, Brislinger MM, Tasca A, Shomroni O, Vleminckx K, Walentek P. - 2019 Cell Reports

Link: https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31118-0

bioRxiv: https://www.biorxiv.org/content/10.1101/682534v1


Katanin-like protein Katnal2 is required for ciliogenesis and brain development in Xenopus embryos

Rankin Willsey H, Walentek P, Exner CRT, Xu Y, Lane AB, Harland RM, Heald R, Santama N. - 2018 Developmental Biology

Link: https://www.sciencedirect.com/science/article/pii/S0012160618302628

Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia

Sun DI, Tasca A, Haas M, Baltazar G, Harland RM, Finkbeiner WE, Walentek P. - 2018 Cells Tissues Organs

Link: https://www.karger.com/Article/FullText/492973

Manipulating and Analyzing Cell Type Composition of the Xenopus Mucociliary Epidermis

Walentek P. - 2018 Methods in Molecular Biology - Xenopus

Link: https://link.springer.com/protocol/10.1007%2F978-1-4939-8784-9_18


What we can learn from a tadpole about ciliopathies and airway diseases: Using systems biology in Xenopus to study cilia and mucociliary epithelia

Walentek P, Quigley IK. - 2017 Genesis

Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/dvg.23001

Planar Cell Polarity in Ciliated Epithelia

Walentek P, Boutin C, Kodjabachian L. - 2017 Cell Polarity in Development and Disease

Link: https://www.sciencedirect.com/science/article/abs/pii/B9780128024386000073?via%3Dihub


Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis

Walentek P, Quigley IK, Sun DI, Sajjan UK, Kintner C, Harland RM. - 2016 Elife

Link: https://elifesciences.org/articles/17557

Ciliary transcription factors in cancer--how understanding ciliogenesis can promote the detection and prognosis of cancer types

Walentek P. - 2016 Journal of Pathology

Link: https://onlinelibrary.wiley.com/doi/full/10.1002/path.4703


ATP4 and ciliation in the neuroectoderm and endoderm of Xenopus embryos and tadpoles

Walentek P, Hagenlocher C, Beyer T, Müller C, Feistel K, Schweickert A, Harland RM, Blum M. - 2015 Data in Brief

Link: https://www.sciencedirect.com/science/article/pii/S235234091500044X

ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia

Walentek P, Beyer T, Hagenlocher C, Müller C, Feistel K, Schweickert A, Harland RM, Blum M. - 2015 Developmental Biology

Link: https://www.sciencedirect.com/science/article/pii/S0012160615001463

The alternative splicing regulator Tra2b is required for somitogenesis and regulates splicing of an inhibitory Wnt11b isoform

Dichmann DS, Walentek P, Harland RM. - 2015 Cell Reports

Link: https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(14)01099-7


miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

Song R*, Walentek P*, Sponer N*, Klimke A, Lee JS, Dixon G, Harland RM, Wan Y, Lishko P, Lize M, Kessel M, He L. - 2014 Nature

Link: https://www.nature.com/articles/nature13413

A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles

Walentek P, Bogusch S, Thumberger T, Vick P, Dubaissi E, Beyer T, Blum M, Schweickert A. - 2014 Development

Link: https://journals.biologists.com/dev/article/141/7/1526/46725

microRNAs and cilia. An ancient connection

Walentek P, Song R, He L. - 2014 Cell Cycle

Link: https://www.tandfonline.com/doi/full/10.4161/cc.29827





Ciliogenesis and cerebrospinal fluid flow in the developing Xenopus brain are regulated by foxj1

Hagenlocher C, Walentek P, M Ller C, Thumberger T, Feistel K. - 2013 Cilia

Link: https://ciliajournal.biomedcentral.com/articles/10.1186/2046-2530-2-12

Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development

Walentek P, Schneider I, Schweickert A, Blum M. - 2013 PlosOne

Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073646


ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development

Walentek P, Beyer T, Thumberger T, Schweickert A, Blum M. - 2012 Cell Reports

Link: https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(12)00090-3

Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus

Beyer T, Danilchik M, Thumberger T, Vick P, Tisler M, Schneider I, Bogusch S, Andre P, Ulmer B, Walentek P, Niesler B, Blum M, Schweickert A. - 2012 Current Biology

Link: https://www.cell.com/current-biology/fulltext/S0960-9822(11)01309-1

Linking early determinants and cilia-driven leftward flow in left-right axis specification of Xenopus laevis: a theoretical approach

Schweickert A, Walentek P, Thumberger T, Danilchik M. - 2012 Differentiation

Link: https://www.sciencedirect.com/science/article/abs/pii/S0301468111001952


Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration

Oviedo NJ, Morokuma J, Walentek P, Kema IP, Gu MB, Ahn JM, Hwang JS, Gojobori T, Levin M. - 2010 Developmental Biology

Link: https://www.sciencedirect.com/science/article/pii/S001216060901402X