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Naturheilkunde am IUK

Aktuelle Publikationen

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Zimmermann-Klemd AM, Reinhardt JK, Morath A, Schamel WW, Steinberger P, Leitner J, Huber R, Hamburger M, Gründemann C: Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds. Front Pharmacol. 2020 Apr 8;11:402. doi: 10.3389/fphar.2020.00402. eCollection 2020. PubMed

Kienle GS, Werthmann PG, Grotejohann B, Kaier K, Steinbrenner I, Voigt-Radloff S, Huber R: A multi-centre, parallel-group, randomised controlled trial to assess the efficacy and safety of eurythmy therapy and tai chi in comparison with standard care in chronically ill elderly patients with increased risk of falling (ENTAiER): a trial protocol. BMC Geriatr. 2020 Mar 17;20(1):108. doi: 10.1186/s12877-020-1503-6. PubMed

Matthes H, Thronicke A, Hofheinz RD, Baars E, Martin D, Huber R, Breitkreuz T, Bar-Sela G, Galun D, Schad F: Statement to an Insufficient Systematic Review on Viscum album L. Therapy. Evid Based Complement Alternat Med. 2020 Feb 18;2020:7091039. doi: 10.1155/2020/7091039. eCollection 2020. PudMed

Lederer AK, Maul-Pavicic A, Hannibal L, Hettich M, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Sehnert B, Salzer U, Klein R, Voll RE, Samstag Y, Huber R: Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids - A randomized, controlled trial. Clin Nutr. 2020 Feb 24. pii: S0261-5614(20)30059-5. doi: 10.1016/j.clnu.2020.02.011. [Epub ahead of print] PubMed

Du Preez CI, Gründemann C, Reinhardt JK, Mumbengegwi DR, Huber R: Immunomodulatory effects of some Namibian plants traditionally used for treating inflammatory diseases. J Ethnopharmacol. 2020 May 23;254:112683. doi: 10.1016/j.jep.2020.112683. Epub 2020 Feb 20. PubMed


Kienle GS, Eran Ben-Arye, Bettina Berger, Cristobal Cuadrado Nahum, Torkel Falkenberg, Kapócs Gabor, Helmut Kiene, David Martin, Ursula Wolf and Henrik Szöke: Contributing to Global Health – Development of a Consensus-based Whole Systems Research Strategy for Anthroposophic Medicine. Evidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 3706143, https://doi.org/10.1155/2019/3706143

Reynel MB, Villegas Y, Kiene H, Werthmann PG, Kienle GS. Bilateral asynchronous renal cell carcinoma with lung metastases: a case report of a patient treated solely with high-dose intravenous and subcutaneous Viscum album extract therapy for a second renal lesion. Anticancer Research, 39: 5597-5604 (2019) doi: 10.21873/anticanres.13754.

Werthmann PG, Kempenich R, Lang-Avérous G, Kienle, GS. Long-term Survival of a Patient With Advanced Pancreatic Cancer Under Adjunct Treatment With Viscum album Extracts – A Case Report. World J Gastroenterol. March 2019. doi:10.3748/wjg.v25.i12.0000

Werthmann PG, Kindermann L, Kienle GS. Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts. Complementary Medicine Research. March 2019:1-4. doi:10.1159/000496866

Werthmann PG, Kempenich R, Kienle GS: Long-term tumor-free survival in a patient with stage IV epithelial ovarian cancer undergoing high-dose chemotherapy and viscum album extract treatment: A case report. Perm J 2019;23:18-025. online

Lederer AK, Maly C, Weinert T, Huber R: Tissue Stiffness is Not Related to Pain Experience: An Individually Controlled Study in Patients with Chronic Neck and Back Pain. Evid Based Complement Alternat Med. 2019 Dec 21;2019:1907168. doi: 10.1155/2019/1907168. eCollection 2019. PubMed

Lederer AK, Hannibal L, Hettich M, Behringer S, Spiekerkoetter U, Steinborn C, Gründemann C, Zimmermann-Klemd AM, Müller A, Simmet T, Schmiech M, Maul-Pavicic A, Samstag Y, Huber R: Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants. Nutrients. 2019 Nov 18;11(11). pii: E2815. doi: 10.3390/nu11112815. PubMed

Oomen-Welke K, Huber R : Intramuscular autologous blood therapy - a systematic review of controlled trials. BMC Complement Altern Med. 2019 Sep 5;19(1):248. doi: 10.1186/s12906-019-2643-0. PubMed

Reinhardt JK, Klemd AM, Danton O, De Mieri M, Smieško M, Huber R, Bürgi T, Gründemann C, Hamburger M : Sesquiterpene Lactones from Artemisia argyi: Absolute Configuration and Immunosuppressant Activity. J Nat Prod. 2019 Jun 28;82(6):1424-1433. doi: 10.1021/acs.jnatprod.8b00791. Epub 2019 Jun 5. PubMed


Müller A., Kousoulas L., Fichtner-Feigl S., Huber R., Lederer AK.: Unbemerkt und doch allgegenwärtig: Komplementärmedizin in der Chirurgie. Angenommen 09/2018, noch nicht erschienen, Chirurgische Praxis

Lederer AK., Haffa D., Makowiec F., Martini V., Fichtner-Feigl S., Huber R., Kousoulas L.: Clinical characteristics and outcomes of renal transplant recipients after abdominal surgical procedures not connected with transplantation. International Journal of Surgery 2018, DOI: 10.1016/j.ijsu.2018.12.002, sowie Kongressbeitrag: Transplantation, Juli 2018, online 

Lederer AK.: Generation Y und die Chirurgie: Alles ist möglich. Deutsches Ärzteblatt 03/2018. online

Lederer AK., Kousoulas L., Fichtner Feigl S., Huber R.: Unbemerkt und doch allgegenwärtig: Komplementärmedizin in der Chirurgie. Kongresszeitung des 135. Kongress der DGCH. 2018

Lederer AK., Schmucker C., Kousoulas L., Fichtner-Feigl S., Huber R.: Naturheilverfahren und Komplementärmedizin in der Chirurgie?. Deutsches Ärzteblatt 2018, DOI: 10.3238/arztebl.2018.0815. online

Werthmann PG, Inter P, Welsch T, Sturm A-K, Grützmann R, Debus M, u. a.: Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report. Medicine. Dezember 2018;97(49):e13243. online

Meyer R, Werthmann PG, Kienle GS: Reduction of the frequency of recurrent diverticulitis episodes under treatment with the integrative medicine therapies Carpellum Mali comp. and Kalium aceticum comp.-A case report. Complement Ther Med. 2018 Oct;40:203-206. doi: 10.1016/j.ctim.2018.03.013. Epub 2018 Apr 10. pubmed/30219450.

Baars EW, Kiene H, Kienle GS, Heusser P, Hamre HJ: An assessment of the scientific status of anthroposophic medicine, applying criteria from the philosophy of science. Complement Ther Med. 2018 Oct;40:145-150. doi: 10.1016/j.ctim.2018.04.010. Epub 2018 Apr 27. pubmed/30219440.

Rentsch G, Steinborn C, Klemd AM, Kienle GS, Gründemann C, Huber R: Investigations on the constitutional types under consideration of anthropometric data, autonomic regulation and immunological parameters. Complement Ther Med. 2018 Oct;40:133-144. doi: 10.1016/j.ctim.2018.04.011. Epub 2018 May 1. pubmed/30219439.

Kienle GS, Mussler M, Fuchs D, Kiene H: On caring and sharing-Addressing psychological, biographical, and spiritual aspects in integrative cancer care: A qualitative interview study on physicians' perspectives. Complement Ther Med. 2018 Oct;40:126-132. doi: 10.1016/j.ctim.2018.04.012. Epub 2018 May 4. pubmed/30219437.

Gutsch J, Werthmann PG, Rosenwald A, Kienle GS: Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under Viscum album Extracts After Resistance to R-CHOP: A Case Report. Anticancer Res. 2018 Sep;38(9):5363-5369. doi: 10.21873/anticanres.12865. pubmed/30194190.

Kienle GS, Mussler M, Fuchs D, Kiene H: The Subjective Dimension of Integrative Cancer Care: A Qualitative Study Exploring the Perspectives, Themes, and Observations of Experienced Doctors from the Area of Anthroposophic Medicine. Explore (NY). 2018 Sep;14(5):342-351. doi: 10.1016/j.explore.2018.03.007. Epub 2018 Aug 1. pubmed/30181043

Werthmann PG, Huber R, Kienle GS: Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report. Head Neck. 2018 Jul;40(7):E77-E81. doi: 10.1002/hed.25320. Epub 2018 Jun 9. pubmed/29885069; PubMed Central PMCID: PMC6055724.

Werthmann PG, Kindermann L, Kienle GS: A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report. Complement Ther Med. 2018 Jun;38:58-60. doi: 10.1016/j.ctim.2018.04.001. Epub 2018 Apr 9. online.

Reynel M, Villegas Y, Kiene H, Werthmann PG, Kienle GS: Reynel M, Villegas Y, Kiene H. Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report. Medicine. November 2018;97(48):e13420. . Medicine. November 2018;97(48):e13420. online.

Grunewald F, Steinborn C, Huber R, Wille R, Meier S, Alresly Z, Lindequist U, Gründemann C: Effects of Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes), the „Iceman Fungus“, on Human Immune Cells. International Journal of Medicinal Mushrooms. online.

Rentsch G, Steinborn C, Klemd AM, Kienle GS, Gründemann C, Huber R: Investigations on the constitutional types under consideration of anthropometric data, autonomous regulation and immunological parameters. Complementary Therapies in Medicine, 2018, In press

von Schönfeld C, Huber R, Trittler R, Kammerer B, Gründemann C: Rosemary has immunosuppressant activity mediated through the STAT3 pathway.  Complementary Therapies in Medicine, In press, corrected proof, Available online 11 March 2018. in press. online

Gründemann C, Stenberg KG, Gruber CW: T20K: An Immunomodulatory Cyclotide on Its Way to the Clinic. International Journal of Peptide Research and Therapeutics pp 1–5| Cite as. in press. online

Stadlbauer S, Steinborn C, Klemd A, Hattori F, Ohmori K, Suzuki K, Huber R, Wolf P, Gründemann C:  1.)   Impact of Green Tea Catechin ECG and Its Synthesized Fluorinated Analogue on Prostate Cancer Cells and Stimulated Immunocompetent Cells. Planta Med. 2018 Feb 21. doi: 10.1055/s-0044-102099. [Epub ahead of print] pubmed/29466808

Steinborn C, Potterat O, Meyer U, Trittler R, Stadlbauer S, Huber R, Gründemann C:  1.)   In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. Planta Med. 2017 Dec 4. doi: 10.1055/s-0043-123075. [Epub ahead of print] pubmed/29202511

Gründemann C, Huber R: Chemoprevention with isothiocyanates - From bench to bedside. Cancer Lett. 2018 Feb 1;414:26-33. doi: 10.1016/j.canlet.2017.10.033. Epub 2017 Oct 27. pubmed/29111351



Steinborn C, Klemd AM, Sanchez-Campillo AS, Rieger S, Scheffen M, Sauer B, Garcia-Käufer M, Urech K, Follo M, Ücker A, Kienle GS, Huber R, Gründemann C:  Viscum album neutralizes tumor-induced immunosuppression in a human in vitro cell model. PLoS One. 2017 Jul 18;12(7):e0181553. doi: 10.1371/journal.pone.0181553. eCollection 2017. pubmed/28719632   Erratum in: PLoS One. 2017 Nov 2;12 (11):e0187786. PMID: 28719632 pubmed/29095922

Merdivan S, Jenett-Siems K, Siems K, Niedermeyer THJ, Schultze N, Steinborn C, Gründemann C, Lindequist U:  Effects of extracts and compounds from Tricholoma populinum Lange on degranulation and IL-2/IL-8 secretion of immune cells. Z Naturforsch C. 2017 Jul 14;72(7-8):277-283. doi: 10.1515/znc-2016-0247. PMID: 28315853. pubmed/28315853

Ben-Arye E, Bonucci M, Daher M, Kebudi R, Saad B, Breitkreuz T, Rassouli M, Rossi E, Gafer N, Nimri O, Hablas M, Kienle GS, Samuels N, Silbermann M: Refugees in Conflict: Creating a Bridge Between Traditional and Conventional Health Belief Models. Oncologist. 2017 Dec 28. pii: theoncologist.2017-0490. doi: 10.1634/theoncologist.2017-0490. pubmed/29284761

Werthmann PG, Saltzwedel G, Kienle GS: Minor regression and long-time survival (56 months) in a patient with malignant pleural mesothelioma under Viscum album and Helleborus niger extracts-a case report. J Thorac Dis. 2017 Dec;9(12):E1064-E1070. doi: 10.21037/jtd.2017.11.56. pubmed/29312767

Lederer AK, Pisarski P, Kousoulas L, Fichtner-Feigl S, Hess C, Huber R: Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review. BMC Surg. 2017 Dec 4;17(1):125. doi: 10.1186/s12893-017-0325-8. pubmed/29202875

Steinborn C, Potterat O, Meyer U, Trittler R, Stadlbauer S, Huber R, Gründemann C: In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. Planta Med. 2017 Dec 4. doi: 10.1055/s-0043-123075. pubmed/29202511

Werthmann PG, Hintze A, Kienle GS: Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract: A case report. Medicine (Baltimore). 2017 Nov;96(46):e8731. doi: 10.1097/MD.0000000000008731. pubmed/29145317

Huber R, Schlodder D, Effertz C, Rieger S, Tröger W: Safety of intravenously applied mistletoe extract - results from a phase I dose escalation study in patients with advanced cancer. BMC Complement Altern Med. 2017 Sep 18;17(1):465. doi: 10.1186/s12906-017-1971-1. pubmed/28923036

Steinborn C, Klemd AM, Sanchez-Campillo AS, Rieger S, Scheffen M, Sauer B, Garcia-Käufer M, Urech K, Follo M, Ücker A, Kienle GS, Huber R, Gründemann C: Viscum album neutralizes tumor-induced immunosuppression in a human in vitro cell model. PLoS One. 2017 Jul 18;12(7):e0181553. doi: 10.1371/journal.pone.0181553. eCollection 2017. pubmed/28719632; Erratum in: PLoS One. 2017 Nov 2;12 (11):e0187786. 

Riley DS, Barber MS, Kienle GS, Aronson JK, von Schoen-Angerer T, Tugwell P, Kiene H, Helfand M, Altman DG, Sox H, Werthmann PG, Moher D, Rison RA, Shamseer L, Koch CA, Sun GH, Hanaway P, Sudak NL, Kaszkin-Bettag M, Carpenter JE, Gagnier JJ: CARE guidelines for case reports: explanation and elaboration document. J Clin Epidemiol. 2017 Sep;89:218-235. doi: 10.1016/j.jclinepi.2017.04.026. Epub 2017 May 18. pubmed/28529185

Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R: Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial. BMC Complement Altern Med. 2017 Mar 28;17(1):172. doi: 10.1186/s12906-017-1676-5. pubmed/28351399

Huber R, Gminski R, Tang T, Weinert T, Schulz S, Linke-Cordes M, Martin I, Fischer H: Pomegranate (Punica granatum) Seed Oil for Treating Menopausal Symptoms: An Individually Controlled Cohort Study. Altern Ther Health Med. 2017 Mar;23(2):28-34. pubmed/28323626

Stock-Schröer B, Huber R, Joos S, Klose P: Evaluation of the current status of Rehabilitation, Physical Medicine and Naturopathy education 10 years after the reform of the Medical Licensure Act - a nationwide survey of German Medical Universities. GMS J Med Educ. 2017 Feb 15;34(1):Doc3. doi: 10.3205/zma001080. eCollection 2017. pubmed/28293670

Merdivan S, Jenett-Siems K, Siems K, Niedermeyer THJ, Schultze N, Steinborn C, Gründemann C, Lindequist U: Effects of extracts and compounds fromTricholoma populinum Lange on degranulationand IL-2/IL-8 secretion of immune cells. Z. Naturforsch. 2017. DOI 10.1515/znc-2016-0247. accepted February11, 2017

Esch, T, Winkler J, Auwärter V, Gnann H, Huber R, Schmidt S: Neurobiological Aspects of Mindfulness in Pain Autoregulation: Unexpected Results from a Randomized-Controlled Trial and Possible Implications for Meditation Research. Front Hum Neurosci. 2017 Jan 26;10:674. pubmed/28184192


Naumann J, Sadaghiani C, Alt F, Huber R: Effects of Sulfate-Rich Mineral Water on Functional Constipation: A Double-Blind, Randomized, Placebo-Controlled Study. Forsch Komplementmed. 23(6) 356-363 (2016) online

Stock-Schröer B, Huber R, Joos S, Klose P: Rehabilitation, Physikalische Medizin und Naturheilverfahren: Stand der Lehre im QB12 an deutschen Medizinischen Fakultäten. Forsch Komplementmed. 23(6) 370-372 (2016) online

Gruber CW, Gründemann C: Exploring nature to treat multiple sclerosis. TheScienceBreaker. online

Lorenz P, Heinrich M, Garcia-Käufer M, Grunewald F, Messerschmidt S, Herrick A, Gruber K, Beckmann C, Knoedler M, Huber R, Steinborn C, Stintzing FC, Gründemann C: Constituents from oak bark (Quercus robur L.) inhibit degranulation and allergic mediator release from basophils and mast cells in vitro. J Ethnopharmacol. 2016 Oct 7. pii: S0378-8741(16)31213-2. doi: 10.1016/j.jep.2016.10.027. [Epub ahead of print] pubmed/27725242

Steinborn C, Diegel C, Garcia-Käufer M, Gründemann C, Huber R: Immunomodulatory effects of metal salts at sub-toxic concentrations. Journal of Applied Toxicology. 2016. (wileyonlinelibrary.com) DOI 10.1002/jat.3390. online        

Eva Roser E, Gründemann C, Engels I, Huber R: Antibacterial in vitro Effects of Preparations from Anthroposophical Medicine. BMC Complementary and Alternative Medicine. 2016 Sep 22;16(1):372. pubmed/27660088

Naumann J, Sadaghiani C, Bureau N, Schmidt S, Huber R: Outcomes from a three-arm randomized controlled trial of frequent immersion in thermoneutral water on cardiovascular risk factors.  BMC Complement Altern Med. 2016 Jul 27;16:250. doi: 10.1186/s12906-016-1241-7. pubmed/27465608

Schläppi M, Ewald C, Kuehn JJ, Weinert T, Huber R: Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study. Integr Cancer Ther. Jul 7. (2016) online

Huber R, Gminski R, Tang T, Weinert T, Schulz S, Linke-Cordes M, Martin I, Fischer H: Pomegranate (Punica granatum L.) seed oil for treating menopausal symptoms – an individually controlled cohort study. Accepted in Alternative Therapies in Health and Medicine 2016

Hoffmann A, Klein SD, Gründemann C, Garcia-Käufer M, Wolf U, Huber R: Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study. Phytother Res. 2016 Jun 10. pubmed/27282490. online

Kienle G; Mussler M, Fuchs D, Kiene H: Individualized Integrative Cancer Care in Anthroposophic Medicine: A qualitative study of the concepts and procedures of expert doctors. Integrative Cancer Therapies 2016. pubmed/27151589

Kienle G, Mussler M, Fuchs D, Kiene H: Intravenous mistletoe treatment in integrative cancer care: A qualitative study exploring the procedures, concepts and observations of expert doctors. Evidence-Based Complementary and Alternative Medicine 2016. pubmed/27239209

Carsten Gründemann, Mandy Arnhold, Stefanie Meier, Christian Bäcker, Manuel Garcia-Käufer, Franziska Grunewald, Carmen Steinborn, Amy Marisa Klemd, Radim Wille, Roman Huber and Ulrike Lindequistc: Effects of Inonotus hispidus extracts and compounds on human immunocompetent cells. Planta Medica 2016. pubmed/27428885

Thell K, Hellinger R, Sahin E, Michenthaler P, Gold-Binder M, Haider T, Kuttke M, Liutkevičiūtė Z,  Göransson U, Gründemann C, Schabbauer G and Gruber CW: Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. PNAS 2016. published ahead of print March 28, 2016, doi:10.1073/pnas.151996011 online

Herz C, Márton MR, Tran HTT, Gründemann C, Schell J, and Lamy E: Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells. Journal of Functional Foods. online


Gründemann C, Hertrampf A, Sauer B, Garcia-Käufer M, Zehl M, and Huber R: Influence of Rheum rhaponticum, Cimicifuga racemosa and Trifolium pratense extracts on breast cancer cell proliferation.  ZPT – Zeitschrift für Phytotherapie 2015; 36: 157–163 online

Gründemann C, Garcia-Käufer M, Sauer B, Scheer R, Merdivan S, Bettin P, Huber R, Lindequist U: Comparative chemical and biological investigations of β-glucan-containing products from shiitake mushrooms.  Journal of Functional Foods, Volume 18, Part A, October 2015, Pages 692–702. online

Gründemann C, Diegel C, Sauer B, Garcia-Käufer M, Huber R: Immunomodulatory effects of preparations from Anthroposophical Medicine for parenteral use. BMC Complement Altern Med. online

Gründemann C: Pharmazeutische Zubereitungen aus Zitrone und Quitte zur Behandlung von allergischem Asthma bronchiale und Heuschnupfen bei Kindern und Jugendlichen. ZPT – Zeitschrift für Phytotherapie 2015; 36: 106–107.  online

Gründemann C, Garcia-Käufer M, Lamy E, Hanschen FS, Huber R: 4-Methylthiobutyl isothiocyanate (Erucin) from rocket plant dichotomously affects the activity of human immunocompetent cells. Phytomedicine. 2015 Mar 15;22(3):369-78. online

Schink M, Garcia-Käufer M, Bertrams J, Duckstein SM, Müller MB, Huber R, Stintzing FC, Gründemann C: Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells. J Ethnopharmacol. 2015 Jan 15;159:129-36. pubmed/25446603



Hempen N, Huber R: Qualität und Sicherheit chinesischer Arzneidrogen in Deutschland - ein Update. Forsch Komplementmed. 2014;21(6):401-412. pubmed/25592951

Seitel E, Gründemann C, Huber R: Antimikrobielle Aktivität von Inhaltsstoffen anthroposophischer Arzneimittel - eine systematische Literaturrecherche. Der Merkurstab; November/Dezember 2014. online

Garcia-Käufer M, Gartiser S, Hafner C, Schiwy S, Keiter S, Gründemann C, Hollert H: Genotoxic and teratogenic effect of freshwater sediment samples from the Rhine and Elbe River (Germany) in zebrafish embryo using a multi-endpoint testing strategy. Environ Sci Pollut Res Int. 2014 Dec 5. pubmed/25471716

Gründemann C, Lengen K, Sauer B, Garcia-Käufer M, Zehl M, Huber R: Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells. BMC Complement Altern Med. 2014 Aug 4;14:283. online

Emerich M, Braeunig M, Clement HW, Lüdtke R, Huber R: Mode of action of cupping--local metabolism and pain thresholds in neck pain patients and healthy subjects. Complement Ther Med. 2014 Feb;22(1):148-58. pubmed/24559830

Hellinger R, Koehbach J, Fedchuk H, Sauer B, Huber R, Gruber CW, Gründemann C: Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol. 2014;151(1):299-306. pubmed/24216163

Gründemann C, Huber R: Wässrig-fermentierte Extrakte aus Citrus limon L. und Cydonia oblonga Mill. - phytochemische Daten und antiallergisches Potential daraus hergestellter Arzneimittel. Der Merkurstab; Juli/August 2014. online


Gründemann C, Thell K, Lengen K, Garcia-Käufer M, Huang YH, Huber R, Craik DJ, Schabbauer G, Gruber CW: Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One. 2013 Jun 26;8(6):e68016. pubmed/23840803

Gründemann C, Garcia-Käufer M, Sauer B, Stangenberg E, Könczöl M, Merfort I, Zehl M, Huber R: Traditionally used Veronica officinalis inhibits proinflammatory mediators via the NF-κB signalling pathway in a human lung cell line. J Ethnopharmacol. 2013 Jan 9;145(1):118-26. pubmed/23142555


Kim KC, Yook JH, Eisenbraun J, Kim BS, Huber R: Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma - a randomized, controlled pilot study. BMC Complement Altern Med. 2012 Oct 3;12:172. pubmed/23033982

Hertrampf A, Gründemann C, Jäger S, Laszcyk M, Giesemann T, Huber R: In Vitro Cytotoxicity of Cyclodextrin-bonded Birch Bark Extract. Planta Med. 2012 Jun;78(9):881-9. pubmed/22573365

Wacker K*, Gründemann C*, Kern Y, Bredow L, Huber R, Reinhard T, Schwartzkopff J: Inhibition of corneal inflammation following keratoplasty by birch leaf extract. Exp Eye Res. 2012 Apr;97(1):24-30. *contributed equally. pubmed/22360995

Gründemann C, Koehbach J, Huber R, Gruber CW: Do plant cyclotides have potential as immunosuppressant peptides? J Nat Prod. 2012 Feb 24;75(2):167-74. pubmed/22272797

Huber R, Stintzing FC, Briemle D, Beckmann C, Meyer U, Gründemann C: In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruits. Planta Med. 2012 Mar;78(4):334-40. pubmed/22193979


Huber R, Lüdtke H, Wieber J, Beckmann C: Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjects. BMC Complement Altern Med. 2011 Nov 24;11:116. pubmed/22114899

Huber R, Bross F, Schempp C, Gründemann C: Arnica and stinging nettle for treating burns - a self-experiment. Complement Ther Med. 2011 Oct;19(5):276-80. pubmed/21944657

Gründemann C, Gruber CW, Hertrampf A, Zehl M, Kopp B, Huber R: An aqueous birch leaf extract of Betula pendula inhibits the growth and cell division of inflammatory lymphocytes. J Ethnopharmacol. 2011 Jul 14;136(3):444-51. pubmed/21619918

Huber R, Emerich M, Braeunig M: Cupping - is it reproducible? Experiments about factors determining the vacuum. Complement Ther Med. 2011 Apr;19(2):78-83. pubmed/21549258

Gründemann C, Papagiannopoulos M, Lamy E, Mersch-Sundermann V, Huber R: Immunomodulatory properties of a lemon-quince preparation (Gencydo®) as an indicator of anti-allergic potency. Phytomedicine. 2011 Jun 15;18(8-9):760-8. pubmed/21256726

Eisenbraun J, Scheer R, Kröz M, Schad F, Huber R: Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract. Phytomedicine. 2011 Jan 15;18(2-3):151-7. pubmed/20724129

2010 und älter

Huber R, Eisenbraun J, Miletzki B, Adler M, Scheer R, Klein R, Gleiter CH: Pharmacokinetics of natural mistletoe lectins after subcutaneous injection. Eur J Clin Pharmacol. Sep;66(9):889-97 (2010) pubmed/20467733

Huber R, Prestel U, Bloss I, Meyer U, Lüdtke R: Effectiveness of subcutaneous injections of a cartilage preparation in osteoarthritis of the knee—–A randomized, placebo controlled phase II study. Complement Ther Med 18(3-4):113-8. (2010) pubmed/20688256

Huber R, Müller M, Naumann J, Schenk T, Lüdtke R: Artichoke leave extract for chronic hepatitis C - A pilot study. Phytomedicine 16(9):801-804 (2009) pubmed/19427774

Huber R: Phytotherapie in der Gastroenterologie. Phytotherapie Austria 2009; 6:4-6. online

Lan L, Gorke S, Rau SJ, Zeisel MB, Hildt E, Himmelsbach K, Carvajal-Yepes M, Huber R, Wakita T, Schmitt-Graeff A, Royer C, Blum HE, Fischer R, Baumert TF: Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner. J Immunol. 2008 Oct 1;181(7):4926-35. pubmed/18802096

Huber R: Phytotherapie bei Colitis ulcerosa. Zeitschrift für Komplementärmedizin 2008; 1:8-11

Klein R, Buck S, Classen K, Rostock M, Huber R: Enhanced in vitro activation of immunocompetent cells in healthy individuals being subcutaneously 'vaccinated' with placebo (physiological saline). Clin Immunol.126(3):322-331 (2008) pubmed/18345549

Lan L, Gorke S, Rau SJ, Zeisel MB, Hildt E, Himmelsbach K, Carvajal-Yepes M, Huber R, Wakita T, Schmitt-Graeff A, Royer C, Blum HE, Fischer R, Baumert TF: Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner. J Immunol. 181(7):4926-35 (2008) pubmed/18802096

Horneber MA, Bueschel G, Huber R, Linde K, Rostock M: Mistletoe therapy in oncology. Cochrane Database Syst Rev. 16;(2):CD003297 (2008) pubmed/18425885

Huber R, Weisser S, Luedtke R: Effects of abdominal hot compresses on indocyanine green elimination--a randomized cross over study in healthy subjects. BMC Gastroenterol. 10;7:27 (2007) online

Huber R, Ditfurth A, Amann F, Güthlin C, Rostock M, Trittler R, Kümmerer K, Merfort I: Tormentil for active ulcerative colitis – an open-label, dose-escalating study. J Clin Gastroenterol. 41(9):834-838 (2007) pubmed/17881930

Huber R, Lüdtke R, Klassen M, Müller-Buscher G, Wolff-Vorbeck G, Scheer R: Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C: an individually controlled cohort study. Eur.J Med Res 6:399-405 (2001) pubmed/11669085

Huber R, Klein R, Lüdtke R, Werner M: Häufigkeit grippaler Infekte bei Gesunden unter Gabe eines lektinreichen und eines lektinarmen Mistelpräparates im Rahmen einer randomisierten, doppelbinden, placebokontrollierten Studie. Forsch Komplementärmed 8:354-358 (2001) online

Huber R, Klein R, Berg PA, Lüdtke R, Werner M: Effects of a lectin- and a viscotoxin-rich mistletoe preparation on clinical and hematological parameters: a placebo controlled evaluation in healthy subjects. J Alternative Compl Med 8:857-866 (2002) pubmed/12614536

Huber R, Nauck M, Lüdtke R, Scharnagl H: Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjects. Forsch Komplementärmed 10.7-10 (2003) pubmed/12624474

Huber R, Koch D, Beiser I, Zschocke I, Luedtke R: Experience and attitudes towards CAM--a survey of internal and psychosomatic patients in a German University Hospital. Altern Ther Health Med. 10(1):32-36 (2004) pubmed/14727497

Huber R, Ludtke R, Beiser I, Koch D: Coping strategies and the request for a consultation on complementary and alternative medicine - a cross-sectional survey of patients in a psychosomatic and three medical departments of a German University Hospital. Forsch Komplementarmed 11(4):207-211 (2004) pubmed/15347903

Huber R, Hockenjos B, Blum HE: DDB treatment of patients with chronic hepatitis. Hepatology. 39(6):1732-1733 (2004) pubmed/15185315

Huber R, Nauck M, Basler N, Haas B, Mattern M, Lüdtke R, Peter KH: Effects of subtotal fasting on plasmatic coagulation, fibrinolytic status and platelet activation. A controlled pilot study in healthy subjects. Nutr Metab Cardiovasc Dis. 15(3):212-218 (2005) pubmed/15955470

Huber R, Futter I, Goedl R, Rostock M, Lüdtke R: Oral enzyme therapy for chronic hepatitis C – a retrospective analysis. Forsch Komplementarmed 12:144-147 (2005) pubmed/15985778

Huber R, Futter I, Lüdtke R: Oral silymarin for chronic hepatitis C - a retrospective analysis comparing three dose regimens. Eur J Med Res. 28;10(2):68-70 (2005) pubmed/15817425

Huber R, Rostock M, Goedl R, Lüdtke R, Urech K, Buck S, Klein R: Mistletoe treatment induces GM-CSF- and IL-5 production by PBMC and increases blood granulocyte- and eosinophil counts: a placebo controlled randomized study in healthy subjects. Eur J Med Res 10:411-418 (2005) online

Rostock M, Huber R, Greiner T, Fritz P, Scheer R, Fiebig HH: Anticancer activity of a lectin-rich mistletoe extract injected intratumorally into human pancreatic cancer xenografts. Anticancer Research 25:1969-1976 (2005) pubmed/16158932

Orlent H, Hansen BE, Willems M, Brouwer JT, Huber R, Kullak-Ublick GA, Gerken G, Zeuzem S, Nevens F, Tielemans WC, Zondervan PE, Lagging M, Westin J, Schalm SW: Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: A randomized phase II trial. J Hepatol. 45(4):539-546. (2006) pubmed/16905220

Huber R, Classen K, Werner M, Klein R: In vitro immunoreactivity towards lectin-rich or viscotoxin-rich mistletoe (Viscum album L.) extracts Iscador applied to healthy individuals. Arzneimittelforschung. 56(6A):447-456 (2006) pubmed/16927525


Mind-Maps® Phytotherapie, Roman Huber, Verlag: Hippokrates;
Auflage: 1., Aufl. (15. Juli 2009), ISBN-13: 978-3830454151

Huber R. Gastroenterologie. In: Lehrbuch Naturheilverfahren, Kraft K, Stange R (Hrsg), 1. Auflage, Hippokrates (2010)


Prof. Dr. med. Roman Huber

FA für Innere Medizin, Gastroenterologie, Zusatzausbildung in Naturheilverfahren, Akupunktur, Ernährungsbeauftragter Arzt, Anthroposophische Medizin (GAÄD)

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