Prof. Dr. med. Philipp Henneke
Prof. Dr. med. Philipp Henneke
Tel.: 0761 270-77640
philipp.henneke@uniklinik-freiburg.de
Affiliation: Center for Pediatrics and Adolescent Medicine, CCI
Innate immunity is - in contrast to the individually developed adaptive immunity - chromosomally encoded and passed on from one generation to the next. It is available right from the beginning of life and particularly important in newborns and during fulminant invasive infections like sepsis and meningitis. The research group "Innate Immunity" investigates receptor-mediated mechanisms underlying cellular innate immunity against bacteria, specifically streptococci (pneumococci, group B streptococci), staphylococci and mycobacteria. Emerging areas of interest are the development and microenvironmental programming of macrophages, and the impact of these dynamic events on mucosal control of bacteria and infection pathogenesis. In order to improve understanding and break new ground, we exploit a variety of methods, including infection models in mice, in vitro models and clinical studies.
Research Keywords: Innate immunity, immunological control of streptococci and staphylococci; macrophages; monocytes; granulocytes; postnatal development of macrophages
Funding: DFG, NIH, ESPID, BMBF, Landesstiftung Baden-Württemberg