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Cancer ResearchDepartment of Thoracic Surgery

Division of Cancer Research

Department of Thoracic Surgery

Molecular Biology of Lung Cancer & Metastasis

Lung cancer is the leading cause of cancer-associated death world-wide. While its etiology based on smoking is well established, the molecular changes leading to this malignant disease are often not understood. This lack of molecular insight into tumorigenesis also frequently precludes the development of innovative and highly specific new drugs.

Metastasis - the development of new tumor nodules in distant organs - is the most frequent cause of death of all solid tumor entities. One of the distant sites most often affected by metastasis is the lung.

In our Division for Cancer Research in the Department of Thoracic Surgery, we hence investigate the mechanisms and networks, the regulation and function of the molecules involved in these essential processes to understand the processes and pathways leading to the development of lung cancer and metastasis to enable the future development of novel therapy approaches based on these mechanisms.

More than 70% of the human Genome (blue) is transcribed into RNA forming the Transcriptome (red), while only less than 2% of the genome are needed to produce all proteins in a human cell constituting the Proteome (yellow).

RNA Biology

A particular emphasis of our research lies on the Molecular Biology of RNA and its associated molecules.

Recent insights into RNA biology induced a paradigm shift towards the recognition of RNAs as functionally important molecules - beyond serving as messengers for protein-encoding genes. A large fraction of the human genome is transcribed into RNA (more than 70%), while only 2% are protein-encoding. Non-protein-coding RNAs execute important functions in the cell. Very short non-coding RNAs, the microRNAs, play important roles in gene regulation. The tumor-suppressive or oncogenic role of many microRNAs and their frequent deregulation in tumors allow a first glimpse of the striking role that non-coding RNAs could play in cancer. Novel long non-coding RNAs (ncRNA, lncRNA, lincRNA) fulfill important functions in epigenetic regulation, chromatin remodeling or splicing. Taken together, the human cell contains many more RNAs than previously anticipated and many of them might just await their discovery as functionally important molecules in cancer.

Our research focuses on long non-coding RNAs (lncRNAs) and their role in cancer. Based on expression profiling using microarrays as well as deep RNA sequencing of the whole transcriptome, we elucidate the cellular and molecular functions of differentially regulated ncRNAs in cancer using innovative techniques like the CRISPR/Cas9 system, in vivo RNA Affinity Purification and our own customized siRNA and CRISPR libraries targeting specifically lung cancer-associated lncRNAs. Our RNAi screens have uncovered numerous lncRNAs controlling several hallmarks of cancer including cancer cell viability, mitosis and migration.

Division of RNA Biology & Cancer - German Cancer Research Center (DKFZ)

Our Division of Cancer Research at the Depatment of Thoracic Surgery in Freiburg closely cooperates with the Division of RNA Biology & Cancer at the German Cancer Research Center (DKFZ) in Heidelberg also headed by Prof. Dr. Sven Diederichs.

Network

We are happy to be part of the following scientific networks in Freiburg:

Collaborative Research Center SFB 850

Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis

Division of Cancer Research

Department of Thoracic Surgery

Center for Translational Cell Research (ZTZ)
Breisacher Str. 115
D-79106 Freiburg

 

 

Prof. Dr. Sven Diederichs

Division Head

Phone:
+49 761 270-77571
E-Mail:
lung-cancer-research
@uniklinik-freiburg.de
 

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