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Cancer ResearchDepartment of Thoracic Surgery

Division of Cancer Research

Department of Thoracic Surgery

Publications

Selected Publications

Research Articles

Review Articles & Book Chapters


ORCID:                 0000-0001-7901-4752
ResearcherID:   J-6237-2012



Selected Publications

Y Sharma*, M Miladi*, S Dukare*, K Boulay*, M Caudron-Herger, M Groß, R Backofen, S Diederichs: "A pan-cancer analysis of synonymous mutations"
Nature Communications (2019) 10: 2569

M Caudron-Herger, SF Rusin, ME Adamo, J Seiler, V Schmid, E Barreau, AN Kettenbach, S Diederichs: "R-DeeP: Proteome-wide and Quantitative Identification of RNA-dependent Proteins by Density Gradient Ultracentrifugation"
Molecular Cell (2019) 75: 184-199

A Goyal, K Myacheva, M Groß, M Klingenberg, B Duran-Arque, S Diederichs: "Challenges of CRISPR / Cas9 applications for long non-coding RNA genes"
Nucleic Acids Research (2017) 45: e12

S Diederichs et al.: "The dark matter of the cancer genome: Aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations"
EMBO Molecular Medicine (2016) 8: 442-457

A Roth, S Diederichs: "RAP and ChIRP about X inactivation"
Nature (2015) 521: 170-171

D Nachmani, T Gutschner, A Reches, S Diederichs*, O Mandelboim*: "RNA binding proteins regulate the expression of the immune activating ligand MICB"
Nature Communications (2014) 5: 4186

T Gutschner*, M Hämmerle*, N Pazaitis*, N Bley, E Fiskin, H Uckelmann, A Heim, M Groß, N Hofmann, R Geffers, B Skawran, T Longerich, K Breuhahn, P Schirmacher, B Mühleck, S Hüttelmaier*, S Diederichs*: "The Insulin-like Growth Factor 2 mRNA-Binding Protein 1 (IGF2BP1) is an important pro-tumorigenic factor in hepatocellular carcinoma"
Hepatology (2014) 59: 1900-1911

M Liu, A Roth, M Yu, R Morris, F Bersani, MN Rivera, J Lu, T Shioda, S Vasudevan, S Ramaswamy, S Maheswaran, S Diederichs*, DA Haber*: "The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis"
Genes & Development (2013) 27: 2543-2548 

M Hämmerle*, T Gutschner*, H Uckelmann, S Ozgur, E Fiskin, M Groß, B Skawran, R Geffers, T Longerich, K Breuhahn, P Schirmacher, G Stoecklin, S Diederichs: "Post-transcriptional destabilization of the liver-specific long non-coding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)"
Hepatology (2013) 58: 1703-1712

J Winter, S Link, D Witzigmann, C Hildenbrand, C Previti, S Diederichs: "Loop-miRs: Active microRNAs generated from single-stranded loop regions"
Nucleic Acids Research (2013) 41: 5503-5512                                                      

T Gutschner, M Hämmerle, M Eißmann, J Hsu, Y Kim, G Hung, AS Revenko, G Arun, M Stentrup, M Groß, M Zörnig, AR MacLeod, DL Spector, S Diederichs: "The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells"
Cancer Research (2013) 73: 1180-1189

T Gutschner, M Baas, S Diederichs: "Non-coding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases"
Genome Research (2011) 21: 1944-1954

J Winter, S Diederichs: "Argonaute proteins regulate microRNA stability"
RNA Biology (2011) 8: 1149-1157

J Winter*, S Jung*, S Keller, RI Gregory, S Diederichs: "Many roads to maturity: microRNA biogenesis pathways and their regulation"
Nature Cell Biology (2009) 11: 228-234

S Diederichs, S Jung, SM Rothenberg, GA Smolen, BG Mlody, DA Haber: "Co-expression of Argonaute-2 enhances RNA Interference towards perfect match binding sites"
Proceedings of the National Academy of Sciences U.S.A. (2008) 105: 9284-9289

S Diederichs, DA Haber: "Dual Role for Argonautes in microRNA Processing and post-transcriptional Regulation of microRNA Expression"
Cell (2007) 131: 1097-1108

S Diederichs, DA Haber: "Sequence Variations of microRNAs in human Cancer: Alterations in predicted secondary Structure do not affect Processing"
Cancer Research (2006) 66: 6097-6104

P Ji*, S Diederichs*, W Wang, S Böing, R Metzger, PM Schneider, N Tidow, B Brandt, H Buerger, E Bulk, M Thomas, WE Berdel, H Serve, C Müller-Tidow: "MALAT-1, a novel non-coding RNA, and Thymosin b4 predict Metastasis and Survival in early-stage Non-Small Cell Lung Cancer"
Oncogene (2003) 22: 8031-8041

... Here, you can find our Top Impact Publications independent of the research topic.

Research Articles

2019

M Roatsch, I Hoffmann, M Abboud, R Hancock, H Tarhonskaya, KF Hsu, S Wilkins, TL Yeh, K Lippl, K Serrer, I Moneke, T Ahrens, D Robaa, S Wenzler, N Barthes, H Franz, W Sippl, S Lassmann, S Diederichs, E Schleicher, C Schofield, A Kawamura, R Schüle, M Jung: "The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases" ACS Chemical Biology (2019) in press

Y Sharma*, M Miladi*, S Dukare*, K Boulay*, M Caudron-Herger, M Groß, R Backofen, S Diederichs: "A pan-cancer analysis of synonymous mutations" Nature Communications (2019) 10: 2569

M Caudron-Herger, SF Rusin, ME Adamo, J Seiler, V Schmid, E Barreau, AN Kettenbach, S Diederichs: "R-DeeP: Proteome-wide and Quantitative Identification of RNA-dependent Proteins by Density Gradient Ultracentrifugation" Molecular Cell (2019) 75: 184-199

I Tiessen, M Abildgaard, M Lubas, H Gylling, C Steinhauer, E Pietras, S Diederichs, L Frankel, A Lund: "A high-throughput screen identifies the long noncoding RNA DRAIC as a regulator of autophagy" Oncogene (2019) 38: 5127-5141

S Dhamija, AC Becker, Y Sharma, K Myacheva, J Seiler, S Diederichs: "LINC00261 and the adjacent gene FOXA2 are epithelial markers and are suppressed during lung cancer tumorigenesis and progression" Non-coding RNA (2019) 5: E2

2018

A Roth, K Boulay, M Groß, M Polycarpou-Schwarz, FA Mallette, M Regnier, O Bida, D Ginsberg, A Warth, PA Schnabel, T Muley, M Meister, H Zabeck, H Hoffmann, S Diederichs: "Targeting LINC00673 expression triggers cellular senescence in lung cancer" RNA Biology (2018) 15: 1499-1511

Q Sun*, V Tripathi*,#, JH Yoon#, DK Singh, Q Hao, KW Min, S Davila, RW Zealy, XL Li, M Polycarpou-Schwarz, E Lehrmann, Y Zhang, KG Becker, SM Freier, Y Zhu, S Diederichs, SG Prasanth, A Lal, M Gorospe, KV Prasanth#: "MIR-100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs" Nucleic Acids Research (2018) 46: 10405-10416

M Klingenberg, M Groß, A Goyal, M Polycarpou-Schwarz,
T Miersch, AS Ernst, J Leupold, N Patil, U Warnken, H Allgayer, T Longerich, P Schirmacher, M Boutros, S Diederichs: "The lncRNA CASC9 and RNA binding protein HNRNPL form a complex and co-regulate genes linked to AKT signaling" Hepatology (2018) 68: 1817-1832

M Polycarpou-Schwarz, M Groß,
P Mestdagh, J Schott, SE Grund, C Hildenbrand, J Rom, S Aulmann, HP Sinn, J Vandesompele, S Diederichs: "The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation" Oncogene (2018) 37: 4750-4768

G Dumbović, J Biayna, J Banús, J Samuelsson, A Roth, S Diederichs, S Alonso, M Buschbeck, M Perucho*, SV Forcales*: "A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer" Nucleic Acids Research (2018) 46: 5504-5524

T Mlambo, S Nitsch, M Hildenbeutel, M Romito, M Müller, C Bossen, S Diederichs, T Cornu, T Cathomen, C Mussolino: "Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells" Nucleic Acids Research (2018) 46: 4456-4468

R Soares, G Maglieri, T Gutschner, S Diederichs, A Lund, B Nielsen, K Holmstrøm: "Evaluation of fluorescence in situ hybridization techniques to study long non-coding RNA expression in cultured cells" Nucleic Acids Research (2018) 46: e4

I Moneke, JT Kaifi, R Kloeser, P Samson, B Haager, S Wiesemann, S Diederichs, B Passlick: "Pulmonary metastasectomy for thyroid cancer as salvage therapy for radioactive iodine-refractory metastases" European Journal of Cardio-Thoracic Surgery (2018) 53: 625-630

M Caudron-Herger, S Diederichs: "Mitochondrial mutations in human cancer: Curation of translation" RNA Biology (2017) 15: 62-69

2017

A Goyal, E Fiskin, T Gutschner, M Polycarpou-Schwarz, M Groß, J Neugebauer, M Gandhi, M Caudron-Herger, V Benes, S Diederichs: "A cautionary tale of sense-antisense gene pairs: Independent regulation despite inverse correlation of expression" Nucleic Acids Research (2017) 45: 12496-12508

F Haderk, R Schulz, M Iskar, LL Cid, T Worst, KV Willmund, A Schulz, U Warnken, J Seiler, A Benner, M Nessling, T Zenz, M Göbel, J Dürig, S Diederichs, J Paggetti, E Moussay, S Stilgenbauer, M Zapatka, P Lichter, M Seiffert: "Tumor-derived exosomes modulate PD-L1 expression in monocytes" Science Immunology (2017) 2: eaah5509

L Nötzold, L Frank, M Gandhi, M Polycarpou-Schwarz, M Groß, M Gunkel, N Beil, H Erfle, N Harder, K Rohr, J Trendel, J Krijgsveld, T Longerich, P Schirmacher, M Boutros, S Erhardt, S Diederichs: "The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells" Scientific Reports (2017) 7: 2265

J Seiler,
M Breinig, M Caudron-Herger, M Polycarpou-Schwarz, M Boutros, S Diederichs: "The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance" Nucleic Acids Research (2017) 45: 5458-5469

K Das, D Eisel, C Lenkl, A Goyal, S Diederichs, E Dickes, W Osen, SB Eichmüller: "Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system" PLoS ONE (2017) 12: e0174077

A Goyal, K Myacheva, M Groß, M Klingenberg, B Duran-Arque, S Diederichs
: "Challenges of CRISPR / Cas9 applications for long non-coding RNA genes" Nucleic Acids Research (2017) 45: e12

2016

A Diaz-Lagares, A Crujeiras, P Lopez-Serra, M Soler, F Setien, A Goyal, J Sandoval, Y Hashimoto, A Martinez-Cardus, A Gomez, H Heyn, C Moutinho, J Espada, A Vidal, M Paúles, M Galan, N Sala, Y Akiyama, M Martínez-Iniesta, L Farré, A Villanueva, M Gross, S Diederichs, S Guil*, M Esteller*: "Epigenetic Inactivation of the p53-Induced Long Noncoding RNA TP53TG1 in Human Cancer" Proc Natl Acad Sci USA (2016) 113: E7535-7544

A Sas-Chen, MR Aure, L Leibovich, S Carvalho, Y Enuka, C Körner, M Polycarpou-Schwarz, S Lavi, N Nevo, Y Kuznetsov, J Yuan, F Azuaje, Oslo Breast Cancer Research Consortium (OSBREAC), I Ulitsky, S Diederichs, S Wiemann, Z Yakhini, VN Kristensen, AL Børresen-Dale, Y Yarden: "LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer" EMBO Molecular Medicine (2016) 8: 1052-1064

S Link*, S Grund*, S Diederichs
: "Alternative splicing affects the subcellular localization of Drosha" Nucleic Acids Research (2016) 44: 5330-5343
 
K Nöske, HJ Stark, L Nevaril, M Berning, L Langbein, A Goyal, S Diederichs, P Boukamp: "Mitotic Diversity in homeostatic human interfollicular epidermis" International Journal of Molecular Sciences (2016) 17: 167 
 
J Haar, M Contrant, K Bernhardt, R Feederle, S Diederichs, S Pfeffer, HJ Delecluse: "The expression of a viral microRNA is regulated by clustering to allow optimal B cell transformation" Nucleic Acids Research (2016) 44: 1326-1341

2015

RM de Guia, AJ Rose, A Sommerfeld, O Seibert, D Strzoda, A Zota, Y Feuchter, A Krones-Herzig, T Sijmonsma, M Kirilov, C Sticht, N Gretz, G Dallinga-Thie, S Diederichs, N Klöting, M Blüher. M Berriel Diaz, S Herzig: "microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis" EMBO Journal (2015) 34: 344-360

2014

T Gutschner*, M Hämmerle*, N Pazaitis*, N Bley, E Fiskin, H Uckelmann, A Heim, M Groß, N Hofmann, R Geffers, B Skawran, T Longerich, K Breuhahn, P Schirmacher, B Mühleck, S Hüttelmaier*, S Diederichs*: "The Insulin-like Growth Factor 2 mRNA-Binding Protein 1 (IGF2BP1) is an important pro-tumorigenic factor in hepatocellular carcinoma" Hepatology (2014) 59: 1900-1911

L Quagliata, MS Matter, S Piscuoglio, L Arabi, C Ruiz, A Procino, M Kovac, F Moretti, Z Makowska, T Boldanova, JB Andersen, M Hämmerle, L Tornillo, MH Heim, S Diederichs, C Cillo*, LM Terracciano*: "IncRNA HOTTIP / HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients" Hepatology (2014) 59: 911-923

D Nachmani, T Gutschner, A Reches, S Diederichs*, O Mandelboim*: "RNA binding proteins regulate the expression of the immune activating ligand MICB" Nature Communications (2014) 5: 4186

2013

M Liu, A Roth, M Yu, R Morris, F Bersani, MN Rivera, J Lu, T Shioda, S Vasudevan, S Ramaswamy, S Maheswaran, S Diederichs*, DA Haber*: "The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis" Genes & Development (2013) 27: 2543-2548 

J Winter, S Diederichs: "Argonaute-3 activates the let-7a passenger strand microRNA" RNA Biology (2013) 10: 1631-1643 

M Hämmerle*, T Gutschner*, H Uckelmann, S Ozgur, E Fiskin, M Groß, B Skawran, R Geffers, T Longerich, K Breuhahn, P Schirmacher, G Stoecklin, S Diederichs: "Post-transcriptional destabilization of the liver-specific long non-coding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)" Hepatology (2013) 58: 1703-1712

M Eißmann, B Schwamb, IM Melzer, J Moser, D Siele, U Köhl, RJ Rieker, DL Wachter, A Agaimy, E Herpel, P Baumgarten, M Mittelbronn, S Rakel, D Kögel, S Böhm, T Gutschner, S Diederichs, M Zörnig: "A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes" PLoS ONE (2013) 8: e64873 

J Winter, S Link, D Witzigmann, C Hildenbrand, C Previti, S Diederichs: "Loop-miRs: Active microRNAs generated from single-stranded loop regions" Nucleic Acids Research (2013) 41: 5503-5512     

T Gutschner, M Hämmerle, M Eißmann, J Hsu, Y Kim, G Hung, AS Revenko, G Arun, M Stentrup, M Groß, M Zörnig, AR Mac Leod, DL Spector, S Diederichs: "The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells" Cancer Research (2013) 73: 1180-1189

T Palm, K Hemmer, J Winter, I Fricke, K Tarbashevich, F Sadegi Shakib, I Rudolph, A Hillje, P De Lucca, L Bahnassawy, R Madel, T Viel, A de Siervi, A Jacobs, S Diederichs, J Schwamborn: "A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop" Nucleic Acids Research (2013) 41: 3699-3712

C Luo, PW Tetteh, PR Merz, E Dickes, A Abukiwan, A Hotz-Wagenblatt, S Holland-Cunz, T Sinnberg, B Schittek, D Schadendorf, S Diederichs, SB Eichmüller: "miR-137 inhibits the invasion of melanoma cells through down-regulation of multiple oncogenic target genes" Journal of Investigative Dermatology (2013) 133: 768-775

2012

M Faryna*, C Konermann*, S Aulmann, J Lorenzo Bermejo, M Brugger, S Diederichs, J Rom, D Weichenhan, R Claus, M Rehli, P Schirmacher, HP Sinn, C Plass, C Gerhäuser: "Genome-wide methylation screen in low-grade breast cancer to identify novel diagnostic and prognostic markers" FASEB Journal (2012) 26: 4937-4950 

M Eißmann*, T Gutschner*, M Hämmerle, S Günther, M Caudron-Herger, M Groß, P Schirmacher, K Rippe, T Braun, M Zörnig*, S Diederichs*: "Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development" RNA Biology (2012) 9: 1076-1087

SE Grund, M Polycarpou-Schwarz, C Luo, SB Eichmüller, S Diederichs: "Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells" Neoplasia (2012) 14: 238-248

A Heinemann, F Zhao, S Pechlivanis, J Eberle, A Steinle, S Diederichs, D Schadendorf, A Paschen: "Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress induced ligand of the natural killer cell receptor NKG2D" Cancer Research (2012) 72: 460-471

2011

T Gutschner, M Baas, S Diederichs: "Non-coding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases" Genome Research (2011) 21: 1944-1954

J Winter, S Diederichs: "Argonaute proteins regulate microRNA stability" RNA Biology (2011) 8: 1149-1157

M Ganzinger, T Noack, S Diederichs, T Longerich, P Knaup: "Service-oriented Data Integration for a Biomedical Research Network" Studies in Health Technology and Informatics (2011) 169: 867-871

C Kahlert, F Klupp, K Brand, F Lasitschka, S Diederichs, J Kirchberg, N Rahbari, S Dutta, U Bork, J Fritzmann, C Reissfelder, M Koch, J Weitz: "Invasion front specific expression and prognostic significance of microRNAs in colorectal liver metastases" Cancer Science (2011) 102: 1799-1807

N Bäumer*, L Tickenbrock*, P Tschanter*, L Lohmeyer, S Diederichs, S Bäumer, BV Skryabin, F Zhang, S Agrawal-Singh, G Koehler, WE Berdel, H Serve, S Koschmieder, C Müller-Tidow: "Inhibitor of CDK interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling" Journal of Biological Chemistry (2011) 286: 28210-28222

2010

P de Souza Rocha Simonini*, A Breiling*, N Gupta, M Malekpour, M Youns, R Omranipour, F Malekpour, S Volinia, CM Croce, H Najmabadi, S Diederichs, Ö Sahin, D Mayer, F Lyko, JD Hoheisel, Y Riazalhosseini: "Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with Estrogen Receptor alpha in breast cancer cells" Cancer Research (2010) 70: 9175-9184

I Surolia*, SP Pirnie*, V Chellappa*, KN Taylor*, A Cariappa*, J Moya, H Liu, DW Bell, D Driscoll, S Diederichs, K Haider, I Netravali, S Le, R Elia, E Dow, A Lee, J Freudenberg, PL De Jager, Y Chretien, A Varki, ME MacDonald, T Gillis, TW Behrens, D Bloch, D Collier, J Korzenik, DK Podolsky, D Hafler, M Murali, B Sands, JH Stone, PK Gregersen, S Pillai: "Functionally defective germline variants of sialic acid acetylesterase in autoimmunity" Nature (2010) 466: 243-247

2008

S Maheswaran*, LV Sequist*, S Nagrath*, L Ulkus, B Brannigan, C Collura, E Inserra, S Diederichs, AJ Iafrate, DW Bell, S Digumarthy, A Muzikansky, D Irimia, J Settleman, RG Tompkins, TJ Lynch, M Toner, DA Haber: "Detecting Epidermal Growth Factor Receptor Mutations in Circulating Tumor Cells from Patients with Non-Small Cell Lung Cancer" New England Journal of Medicine (2008) 359: 366-377

S Diederichs, S Jung, SM Rothenberg, GA Smolen, BG Mlody, DA Haber: "Co-expression of Argonaute-2 enhances RNA Interference towards perfect match binding sites" Proceedings of the National Academy of Sciences U.S.A. (2008) 105: 9284-9289

E Bulk, A Hascher, R Liersch, RM Mesters, S Diederichs, B Sargin, V Gerke, M Hotfilder, J Vormoor, WE Berdel, H Serve, C Müller-Tidow: "Adjuvant therapy with small hairpin RNA prevents NSCLC metastasis development in mice" Cancer Research (2008) 68: 1896-1904

2007

S Diederichs, DA Haber: "Dual Role for Argonautes in microRNA Processing and post-transcriptional Regulation of microRNA Expression" Cell (2007) 131: 1097-1108

GA Smolen, BJ Schott, RA Stewart, S Diederichs, B Muir, HL Provencher, AT Look, DC Sgroi, RT Peterson, DA Haber: "A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors" Genes & Development (2007) 21: 2131-2136

P Ji, N Bäumer, T Yin, S Diederichs, F Zhang, C Beger, K Welte, S Fulda, WE Berdel, H Serve, C Müller-Tidow: "The DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells" International Journal of Cancer (2007) 121: 706-713

2006

S Diederichs, DA Haber: "Sequence Variations of microRNAs in human Cancer: Alterations in predicted secondary Structure do not affect Processing" Cancer Research (2006) 66: 6097-6104

2005

M Böhm, M Eickelmann, Z Li, SW Schneider, V Oji, S Diederichs, GS Barsh, A Vogt, K Stieler, U Blume-Peytavi, TA Luger: "Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of α-melanocyte-stimulating hormone in human dermal papilla cells" Endocrinology (2005) 146: 4635-4646

P Ji, S Agrawal, S Diederichs, N Bäumer, A Becker, T Cauvet, S Kowski, C Beger, K Welte, WE Berdel, H Serve, C Müller-Tidow: "Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells" Oncogene (2005) 24: 2739-2744

S Diederichs, N Bäumer, N Schultz, FK Hamra, MG Schrader, ML Sandstede, WE Berdel, H Serve, C Müller-Tidow: "Expression Patterns of Mitotic and Meiotic Cell Cycle Regulators in Testicular Cancer and Development" International Journal of Cancer (2005) 116: 207-217

C Müller-Tidow*, S Diederichs*, E Bulk, T Pohle, B Steffen, J Schwäble, S Plewka, M Thomas, R Metzger, PM Schneider, C Brandts, WE Berdel, H Serve: "Identification of Metastasis-associated Receptor Tyrosine Kinases in Non-Small Cell Lung Cancer" Cancer Research (2005) 65: 1778-1782

2004

C Müller-Tidow*, P Ji*, S Diederichs, J Potratz, C Beger, M Carrington, G Köhler, T Cauvet, A Yasmeen, E Bulk, HP Koeffler, WE Berdel, H Serve: "Cyclin A1 is induced by p53 following DNA damage and modulates DNA repair by interacting with Ku proteins" Molecular and Cellular Biology (2004) 24: 8917-8928

S Diederichs, E Bulk, B Steffen, P Ji, L Tickenbrock, K Lang, KS Zänker, R Metzger, PM Schneider, V Gerke, M Thomas, WE Berdel, H Serve, C Müller-Tidow: "S100 family members and Trypsinogens are predictors of distant Metastasis and Survival in early-stage Non-Small Cell Lung Cancer" Cancer Research (2004) 64: 5564-5569

S Diederichs, N Bäumer, P Ji, SK Metzelder, GE Idos, T Cauvet, W Wang, M Möller, S Pierschalski, J Gromoll, MG Schrader, HP Koeffler, WE Berdel, H Serve, C Müller-Tidow: "Identification of Interaction Partners and Substrates of the Cyclin A1/CDK2 complex" Journal of Biological Chemistry (2004) 279: 33727-33741

C Müller-Tidow*, B Steffen*, T Cauvet, L Tickenbrock, P Ji, S Diederichs, B Sargin, G Köhler, M Stelljes, E Puccetti, M Ruthardt, S de Vos, SW Hiebert, HP Koeffler, WE Berdel, H Serve: "Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells" Molecular and Cellular Biology (2004) 24: 2890-2904

2003

P Ji*, S Diederichs*, W Wang, S Böing, R Metzger, PM Schneider, N Tidow, B Brandt, H Buerger, E Bulk, M Thomas, WE Berdel, H Serve, C Müller-Tidow: "MALAT-1, a novel non-coding RNA, and Thymosin b4 predict Metastasis and Survival in early-stage Non-Small Cell Lung Cancer" Oncogene (2003) 22: 8031-8041

C Müller-Tidow, C Readhead, AH Cohen, K Asotra, GE Idos, S Diederichs, T Cauvet, R Yang, WE Berdel, H Serve, HP Koeffler: "Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice" International Journal of Molecular Medicine (2003) 11: 311-315

C Müller-Tidow, S Diederichs, MG Schrader, U Vogt, K Miller, WE Berdel, H Serve: "Cyclin A1 is highly expressed in aggressive testicular germ cell tumors" Cancer Letters (2003) 190: 89-95

PM Sincock, IG Ganley, JP Krise, S Diederichs, U Sivars, B O’Connor, L Ding, SR Pfeffer: "Self-Assembly Is Important for TIP47 Function in Mannose 6-Phosphate Receptor Transport" Traffic (2003) 4: 18-25

2002

M Schrader, C Müller-Tidow, S Ravnik, M Müller, W Schulze, S Diederichs, H Serve, K Miller: "Cyclin A1 and gametogenesis in fertile and infertile patients: a potential new molecular diagnostic marker" Human Reproduction (2002) 17: 2338-2343

2001

C Müller-Tidow, K Kügler, S Diederichs, S Klümpen, A Westermann, P Zuo, U Vogt, R Metzger, PM Schneider, WE Berdel, H Serve: "Loss of expression of HDAC-recruiting Methyl-CpG binding domain proteins in human cancer" British Journal of Cancer (2001) 85: 1168-1174

C Müller-Tidow, W Wang, GE Idos, S Diederichs, R Yang, C Readhead, WE Berdel, H Serve, M Saville, R Watson, HP Koeffler: "Cyclin A1 directly interacts with B-myb and Cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function" Blood (2001) 97: 2091-2097

C Müller-Tidow, R Metzger, K Kügler, S Diederichs, GE Idos, M Thomas, B Dockhorn-Dworniczak, PM Schneider, HP Koeffler, WE Berdel, H Serve: "Cyclin E is the Only Cyclin-dependent Kinase 2-associated Cyclin that Predicts Metastasis and Survival in Early Stage Non-Small Cell Lung Cancer" Cancer Research (2001) 61: 647-653

C Müller-Tidow, C Bornemann, S Diederichs, A Westermann, S Klümpen, P Zuo, W Wang, WE Berdel, H Serve: "Analyses of the genomic methylation status of the human Cyclin A1 promoter by a novel real-time PCR-based methodology" FEBS Letters (2001) 490: 75-79

2000

C Müller, C Readhead, S Diederichs, GE Idos, R Yang, N Tidow, H Serve, WE Berdel, HP Koeffler: "Methylation of the Cyclin A1 Promoter Correlates with Gene Silencing in Somatic Cell Lines, while Tissue-Specific Expression of Cyclin A1 is Methylation Independent" Molecular and Cellular Biology (2000) 20: 3316-3329

1999

C Müller, R Yang, GE Idos, N Tidow, S Diederichs, OM Koch, W Verbeek, TP Bender, HP Koeffler: "c-myb Transactivates the Human Cyclin A1 Promoter and Induces Cyclin A1 Gene Expression" Blood (1999) 94: 4255-4262

 

Review Articles & Book Chapters

M Gandhi, M Caudron-Herger, S Diederichs: "RNA motifs and combinatorial prediction of non-coding RNA interaction, stability and localization" Nature Structural & Molecular Biology (2018) 25: 1070-1076

M Klingenberg,
A Matsuda, S Diederichs*, T Patel*: "Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets" Journal of Hepatology (2017) 67: 603-618

S Diederichs, L Bartsch*, JC Berkmann*, K Fröse*, J Heitmann*, C Hoppe*, D Iggena*, D Jazmati*, P Karschnia*, M Linsenmeier*, T Maulhardt*, L Möhrmann*, J Morstein*, SV Paffenholz*, P Röpenack*, T Rückert*, L Sandig*, M Schell*, A Steinmann*, G Voss*, J Wasmuth*, ME Weinberger*, R Wullenkord*: "The dark matter of the cancer genome: Aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations" EMBO Molecular Medicine (2016) 8: 442-457

S Dhamija, S Diederichs: "From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis" International Journal of Cancer (2016) 139: 269-280

A Roth, S Diederichs: "RAP and ChIRP about X inactivation" Nature (2015) 521: 170-171

A Roth, S Diederichs: "Long non-coding RNAs in lung cancer" Current Topics in Microbiology & Immunology (2016) 394: 57-110

S Diederichs: "micro-Terminator: 'Hasta la vista, lncRNA !' " Nature Structural & Molecular Biology (2015) 22: 279-281

G Stoecklin, S Diederichs: "tRNAs: New tricks from old dogs" EMBO Journal (2014) 33: 1981-1983

S Diederichs: "The four dimensions of non-coding RNA conservation" Trends in Genetics (2014) 30: 121-123

H Sültmann, S Diederichs: "Long non-coding RNA: LNCs to cancer" European Urology (2014) 65: 1152-1153

T Gutschner, M Hämmerle, S Diederichs: "MALAT 1 - a paradigm for long noncoding RNA function in cancer" Journal of Molecular Medicine (2013) 91, (7): 791-801

T Gutschner, S Diederichs: "The Hallmarks of Cancer: A long non-coding RNA point of view" RNA Biology (2012) 9: 703-719

S Diederichs: "Non-coding RNA and disease" RNA Biology (2012) 9: 701-702

SK Abd Ellatif, T Gutschner, S Diederichs: "Long Noncoding RNA Function and Expression in Cancer" in Regulatory RNAs, edited by Bibekanand Mallick & Zhumur Ghosh (2012) 197-226

J Winter*, A Roth*, S Diederichs: "RNA meets Disease in Paradise" RNA Biology (2011) 8: 984-987

J Winter, S Diederichs: "microRNA Northern Blotting, Precursor Cloning & Ago2-improved RNA interference" in Methods in Molecular Biology: microRNA & Cancer, edited by Wei Wu (2011) 85-100

J Winter, S Diederichs: "microRNA Biogenesis and Cancer" in Methods in Molecular Biology: microRNA & Cancer, edited by Wei Wu (2011) 3-22

S Grund, S Diederichs: "microRNA Biogenesis and its impact on RNA interference" in RNA Technologies and Their Applications, edited by VA Erdmann & J Barciszewski (2010) 325-354

S Diederichs: "Non-coding RNA in malignant tumors : A new world of tumor biomarkers and target structures in cancer cells" [German] Pathologe (2010) S2: 258-262

J Winter*, S Jung*, S Keller, RI Gregory, S Diederichs: "Many roads to maturity: microRNA biogenesis pathways and their regulation" Nature Cell Biology (2009) 11: 228-234

C Müller-Tidow, S Diederichs, M Thomas, H Serve: "Genome wide screening for prognosis predicting genes in early stage non-small cell lung cancer" Lung Cancer (2004) 45: S145-S150



Asterisks (*) indicate shared first or last or corresponding authorship.
Authors in bold are present or former members of our labs.

Division of Cancer Research

Department of Thoracic Surgery

Center for Translational Cell Research (ZTZ)
Breisacher Str. 115
D-79106 Freiburg

 

 

Prof. Dr. Sven Diederichs

Division Head

Phone:
+49 761 270-77571
E-Mail:
lung-cancer-research
@uniklinik-freiburg.de
 

More than 70% of the human Genome (blue) is transcribed into RNA forming the Transcriptome (red), while only less than 2% of the genome are needed to produce all proteins in a human cell constituting the Proteome (yellow).

RNA Biology

A particular emphasis of our research lies on the Molecular Biology of RNA and its associated molecules.

Recent insights into RNA biology induced a paradigm shift towards the recognition of RNAs as functionally important molecules - beyond serving as messengers for protein-encoding genes. A large fraction of the human genome is transcribed into RNA (more than 70%), while only 2% are protein-encoding. Non-protein-coding RNAs execute important functions in the cell. Very short non-coding RNAs, the microRNAs, play important roles in gene regulation. The tumor-suppressive or oncogenic role of many microRNAs and their frequent deregulation in tumors allow a first glimpse of the striking role that non-coding RNAs could play in cancer. Novel long non-coding RNAs (ncRNA, lncRNA, lincRNA) fulfill important functions in epigenetic regulation, chromatin remodeling or splicing. Taken together, the human cell contains many more RNAs than previously anticipated and many of them might just await their discovery as functionally important molecules in cancer.

Our research focuses on long non-coding RNAs (lncRNAs) and their role in cancer. Based on expression profiling using microarrays as well as deep RNA sequencing of the whole transcriptome, we elucidate the cellular and molecular functions of differentially regulated ncRNAs in cancer using innovative techniques like the CRISPR/Cas9 system, in vivo RNA Affinity Purification and our own customized siRNA and CRISPR libraries targeting specifically lung cancer-associated lncRNAs. Our RNAi screens have uncovered numerous lncRNAs controlling several hallmarks of cancer including cancer cell viability, mitosis and Migration.

An emerging Topic of particular importance in our lab are RNA-Protein complexes, especially the new concept of RNA Dependence: R-DeeP (Mol Cell 2019).