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Cancer ResearchDepartment of Thoracic Surgery

Division of Cancer Research

Department of Thoracic Surgery

Oral Presentations

S Diederichs: "Long non-coding RNAs & RNA-dependent proteins in cancer", University of Bern, Bern, Switzerland, October 2018

S Diederichs: "Proteome-wide and Quantitative Identification of RNA-dependent Proteins", GBM RNA Biochemistry, Bonn, Germany, October 2018

S Diederichs: "Non-coding RNA in Lung Cancer", IASLC, Toronto, Canada, September 2018

M Caudron-Herger, SF Rusin, ME Adamo, J Seiler, V Schmid, AN Kettenbach S Diederichs: "Proteome-wide and quantitative identification of RNA-dependent protein complexes – a novel concept to discover unexpected functions of RNAs", RNA Society Meeting, Berkeley, USA, May 2018

S Diederichs: "Die dunkle Materie des Genoms: Nicht-codierende RNA - Eine neue Welt
in der Krebsforschung", Akademische Mittagspause, Peterskirche, Heidelberg, Germany, April 2018

S Diederichs: "The dark matter of the cancer genome: Long non-coding RNAs and RNA-dependent proteins in Cancer", IBMC Strasbourg, France, June 2018

S Diederichs: "Non-coding RNA and RNA-dependent proteins complexes in human cancer", Institut Marie Curie, Paris, France, February 2018

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", SFB 960, Regensburg, Germany, October 2017

S Diederichs: "Molecular Genetics of Lung Cancer & Metastasis - A non-coding Perspective", 21. Chirurgische Forschungstage Köln, Köln, Germany, September 2017

S Diederichs: "LncRNAs & Ribonucleoproteins in Lung Cancer", Loewe-Symposium; Medical RNomics consortium, University of Giessen, Giessen, Germany, September 2017

S Diederichs: "MALAT1 and beyond - Long non-coding RNAs in Lung Cancer", ISFMS 2017: Non-Coding RNAs and Epigenetics in Cancer, Basel, Switzerland, June 2017

S Diederichs: "Long non-coding RNAs in Metastasis & Migration", SFB850 Cell Migration Symposium, Freiburg, Germany, March 2017

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", F-Tales Meeting, Leuven, Belgium, March 2017

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", Universität Tübingen, Tübingen, Germany, November 2016

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", NCRI Conference Scientific Committee symposium  “Noncoding RNAs in cancer” , Liverpool, GBR, November 2016

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", 3. DGP Nachwuchsakademie, Kloster Johannisberg, Germany, October 2016

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", Perspectives in Vascular Biology 2016",  Frankfurt, Germany, September 2016

S Diederichs: "Long non-coding RNAs in Lung Cancer & Signaling", BIOSS Centre for Biological Signalling Studies University of Freiburg, Freiburg, Germany, September 2016

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", Opening Symposium "Center for Translational Cell research" (ZTZ), Freiburg, Germany, September 2016

S Diederichs: "Success in a scientific team", Helmholtz Akademie Kamingespräch, Berlin, Germany, September 2016 

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", SFB 992 "Medical Epigenetics", Freiburg, Germany, May 2016

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", Center for Chronic Immunodeficiencies (CCI), Freiburg, Germany, April 2016

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", Marie Curie ITN RNAtrain, Fischbachau, Germany, March 2016

S Diederichs: "Long non-coding RNAs - Messages from the dark matter of the cancer genome", Düsseldorf School of Oncology, Düsseldorf, Germany, March 2016

S Diederichs: "Long non-coding RNAs in Cancer" Harvard Medical School / Beth Israel Deaconess Medical Center, Boston, USA, December 2015

S Diederichs: "Long non-coding RNAs in Cancer" Broad Institute, Cambridge, USA, December 2015

S Diederichs: "Long non-coding RNAs in Cancer" Harvard Medical School / Massachusetts General Hospital Cancer Center, Boston, USA, December 2015

S Diederichs: "Long non-coding RNAs in Cancer" Harvard Medical School, Boston, USA, December 2015

S Diederichs: "Long non-coding RNAs in Cancer" Dartmouth College, Hanover, USA, December 2015

S Diederichs: "Long non-coding RNA in Lung Cancer" AACR Conference "Noncoding RNAs and Cancer: Mechanisms to Medicines", Boston, USA, December 2015 (invited speaker)

S Diederichs: "Long non-coding RNA in Cancer" Royal Society Buckhinghamshire , "Long non-coding RNAs: Evolution of new epigenetic and post-transcriptional functions" Buckinghamshire, UK, September 2015 (invited speaker) 

S Diederichs: "Long non-coding RNAs in Cancer", 1st Aegean Conference on Non-Coding RNAs, Kreta, Greece, June 2015 (invited speaker)

S Diederichs: "What junior scientists need for success", Karolinka Institutet Workshop "Career Systems for Academic Excellence in Europe", Stockholm, Sweden, June 2015

S Diederichs: "The IncRNA Malat1 is a marker, active player and therapeutic target in lung cancer metastasis", 99. Jahrestagung DGP, Frankfurt, Germany, May 2015 

S Diederichs: "Long non-coding RNA in Cancer" Netherlands Cancer Institute, Symposium "Epigenetics and non-coding RNA´s in cancer and development", Amsterdam, Netherlands, May 2015 (invited speaker)

S Diederichs: "Nicht-kodierende RNA - Eine neue Welt in der Krebsforschung", Universität des Saarlandes, Vortragsreihe der DPhG, Saarbrücken, Germany, May 2015

S Diederichs: "Long non-coding RNAs and Epigenetics in Lung in Cancer" Keystone Symposium "Long noncoding RNA: From Evolution to Function", Keystone, Colorado, March 2015 (invited speaker)

S Diederichs: "Long non-coding RNAs in Liver Cancer" Marie Curie Workshop "Liver Cancer - From Molecular Pathogenesis to Target Therapies", Mannheim, Germany, March 2015

S Diederichs: "Long non-coding RNAs and Epigenetics in Lung Cancer" German-Catalan-Epigenetics Workshop, Barcelona, Spain, November 2014

S Diederichs: "Long non-coding RNAs in Cancer" RNA Train Berlin MDC, Berlin, Germany, October 2014

S Diederichs: "Non-coding RNA & Cancer", DGP Nachwuchsakademie Eberbach, Eberbach, Germany, October 2014

S Diederichs: "Long non-coding RNAs in Lung Cancer" 26th International IGB Workshop "Decoding non-coding RNAs in development and cancer" Capri, Italy, October 2014 (invited speaker)

S Diederichs: "Long non-coding RNAs in Cancer" MC ITN „RNATrain“, MDC Berlin, Germany, October 2014

S Diederichs: Long non-coding RNAs in cancer" Roche Penzberg, Germany, October 2014 (invited speaker)

S Diederichs: "Long non-coding RNAs in Cancer" Symposium "Free circulating nucleic acids, exosomes and microparticles", German Congress on Laboratory Medicine, Mannheim, Germany, September 2014 (invited speaker)

S Diederichs: "Long non-coding RNAs in Cancer" ESF / EMBO Meeting on non-coding RNA 2014, Pultusk, Polen, September 2014 (co-organizer)

S Diederichs: "Long non-coding RNA & Cancer" 23rd Biennial Congress of the European Association for Cancer Research (EACR), Munich, July 2014 (invited speaker)

S Diederichs: "Long non-coding RNA & Cancer" Max-Planck-Institute for Molecular Genetics, Berlin, Germany, June 2014

S Diederichs: "Long non-coding RNAs in Cancer" "Non-coding RNA - From Basic Mechanisms to Cancer", Heidelberg, Germany, June 2014 (co-organizer)

S Diederichs: "Long non-coding RNA & Cancer" EMBL, Galway, Ireland, June 2014

S Diederichs: "Long non-coding RNA & Cancer" University Vienna, Vienna, Austria, April 2014

S Diederichs: "The dark matter of the genome: Long non-coding RNA & Cancer" Medical University Graz, Graz, Austria, April 2014

S Diederichs: "Long non-coding RNAs in Cancer" 8th Graduate School Meeting "Cell Dynamics and Disease" Münster, April 2014 (invited speaker)

S Diederichs: " Long non-coding RNA & Cancer" Excellence Cluster CECAD Minisymposium, Cologne, April 2014

S Diederichs: "Long non-coding RNA in Cancer" Genomics Research Europe 2013, Barcelona, Spain, October 2013 (invited speaker)

S Diederichs: "Long non-coding RNA in Cancer" Institut d´Investigacío Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain, October 2013

S Diederichs: "Nicht-kodierende RNA" GPOH (Gesellschaft für Pädiatrische Onkologie und Hämatologie) 2. Nachwuchsakademie "Pädiatrische Onkologie", Bad Godesberg, Juli 2013

S Diederichs: "Long non-coding RNAs & Cancer", International Union of Physiological Sciences (IUPS) 2013, Birmingham, United Kingdom, July 2013 (invited speaker)

S Diederichs: " Long non-coding RNA profiling identifies novel oncogenes and therapy response genes in lung cancer" 97. Jahrestagung der Deutschen Gesellschaft für Pathologie, Heidelberg, May 2013

Tony Gutschner: "The non-coding RNA MALAT1 is a critical regulator of lung cancer metastasis"  97. Jahrestagung der Deutschen Gesellschaft für Pathologie, Heidelberg, May 2013

Monika Hämmerle: "Characterization of long non-coding RNAs in hepatocellular carcinoma"  97. Jahrestagung der Deutschen Gesellschaft für Pathologie, Heidelberg, May 2013

S Diederichs: "microRNA Biogenesis, RNAi & long ncRNAs in Cancer" VIB Leuven Symposium "Non-coding Genomic: from Dark Matter to `Golden Secret´", Leuven, Belgium, April 2013 (keynote speaker)

S Diederichs: "The long non-coding RNA landscape of cancer" EMBO Practical Course "Analysis of small non-coding RNAs: From discovery to function",Heidelberg, Germany, April 2013

S Diederichs: "microRNAs and long non-coding RNAs in cancer" Universitätsklinikum Freiburg, April 2013

S Diederichs: "The long non-coding RNA MALAT1 is an essential gene regulator for lung cancer metastasis in a novel human knockout model" American Association for Cancer Research (AACR), "Annual Meeting 2013", Washington, USA, April 2013

S Diederichs: "Long non-coding RNA in cancer" National Institutes of Health, Bethesda, USA, April 2013 

S Diederichs: "Long non-coding RNA in cancer" International Joint Meeting of the German Society for Cell Biology (DGZ) and the German Society for Developmental Biology (GfE),  Heidelberg, Germany, March 2013 (chair)

S Diederichs: "The role of long non-coding RNA in lung cancer" Integrated Biobank of Luxembourg (IBBL)/Partnership for Personalized Medicine (PPM),"Lung Cancer Treatment in the Era of Personalized Medicine", Luxembourg, March 2013 (invited speaker)

S Diederichs: "MALAT1 is an essential gene regulator for lung cancer metastasis in a novel human knockout model" Keystone Symposia on Molecular and Cellular Biology, "Noncoding RNAs in Development and Cancer", Vancouver, Canada, January 2013

S Diederichs: "Non-coding RNA & Cancer" Institut Curie, 2nd Course On Non-Coding Genome - 2012, Paris, France, December 2012 (invited speaker)

S Diederichs: "Non-coding RNAs, Cancer and Genome Editing" Karlsruher Institut für Technologie/Institute of Toxicology and Genetics, Karlsruhe, Germany, November 2012

S Diederichs: "Non coding RNA" German Society of Pathology (DGP) Nachwuchsakademie, Eberbach, Germany, October 2012 (invited speaker)

S Diederichs: "The non-coding RNA MALAT1 is a critical gene regulator for lung cancer metastasis in a novel human knockout model" GBM Study Group RNA Biochemistry, Bonn, Germany, October 2012 (invited speaker)

S Diederichs: "microRNA biogenesis & long non-coding RNAs in Cancer" Cancer Research UK, London, United Kingdom, September 2012

S Diederichs: "Argonautes, microRNA, Biogenesis&RNA Interference" Genomics Research Europe, Frankfurt, Germany, September 2012 (invited speaker)

S Diederichs: "Non-coding RNA - A whole new world of potential diagnostic and prognostic markers" Next Generation Molecular Diagnostics 2012, Prague, Czech Republic, June 2012 (invited speaker)

M Hämmerle, T Gutschner, M Polycarpou-Schwarz, C Hildenbrand, K Breuhahn, T Longerich, P Schirmacher, S Diederichs: "Molecular and functional analysis of long non-coding RNAs in hepatocellular carcinoma" German Society of Pathology (DGP), Berlin, Germany, May 2012

T Gutschner, M Eißmann, M Hämmerle, M Baas, C Hildenbrand, M Groß, M Zörnig, S Diederichs: "MALAT1 is essential for lung cancer metastasis in a novel human knockout model" German Society of Pathology (DGP), Berlin, Germany, May 2012

S Diederichs: "microRNAs & long non-coding RNAs in Cancer" EMBL Course "Analysis of short non-coding RNA", Heidelberg, Germany, April 2012

S Diederichs: "The many roles of Argonaute proteins in microRNA Biogenesis and RNA interference" Genomics Research 2012, Boston, USA, April 2012 (invited speaker)

S Diederichs: "microRNA Biogenesis, long non-coding RNA & Cancer" Yale University, New Haven, USA, April 2012

S Diederichs: "microRNA Biogenesis & long non-coding RNA in Cancer" Memorial Sloan-Kettering Cancer Center, New York, USA, April 2012

S Diederichs: "microRNA Biogenesis & long non-coding RNA in Cancer" University of Utah, Salt Lake City, USA, April 2012

S Diederichs: "microRNA & Cancer" American Association for Cancer Research (AACR), Chicago, USA, April 2012 (chair)

S Diederichs: "The non-coding RNA Landscape of Lung, Liver and Breast Cancer" Keystone Meeting: Non-coding RNAs, Snowbird, USA, April 2012 (invited speaker)

S Diederichs: "microRNA & long non-coding RNA in Cancer" German Society of Cell Biology (DGZ) - Award Lecture, Dresden, Germany, March 2012

S Diederichs: "microRNA, RNAi and long non-coding RNA in Cancer" Tel Aviv University, Tel Aviv, Israel, March 2012

M Hämmerle: "Non-coding RNA in malignant tumors: A new world of tumor biomarkers and target structures in cancer cells" German Society for Endocrinology (DGE), Mannheim, Germany, March 2012 (invited speaker)

S Diederichs: "Long non-coding RNAs & Cancer" X-GEN Targeting Non-Coding RNA, San Diego, USA, March 2012 (invited speaker)

S Diederichs: "The big world of small RNAs and the small world of big RNAs in Cancer" Lectio Magistralis, University of Trento, Italy, February 2012 (invited speaker)

T Gutschner: "Non-coding RNAs and Cell Cycle Regulation - Regulating the Regulator" Heidelberg Forum for Young Life Scientists, Heidelberg, Germany, February 2012

S Diederichs: "Long Non-coding RNA in the nucleus" Epigenetics @ DKFZ, Heidelberg, Germany, January 2012

S Diederichs: "Knocking out noncoding RNAs in human cancer" EMBL Symposium "Zinc Finger Nucleases", Heidelberg, Germany, December 2011 (invited speaker)

S Diederichs: "microRNA, non-coding RNA & Cancer" SFB 902, University of Frankfurt, Frankfurt, Germany, November 2011

S Diederichs: "Non-coding RNA - A whole new world of potential Biomarkers" Molecular Diagnostics of Cancer, Hannover, Germany, October 2011 (invited speaker)

S Diederichs: "Non-coding RNA in Liver Cancer" Visceral Medicine 2011 (DGVS / DGAV), Leipzig, Germany, September 2011 (invited speaker)

S Diederichs: "Long non-coding RNA in Cancer" 12th Young Scientist Meeting of the German Society of Cell Biology (DGZ): "RNA & Disease", Jena, Germany, September 2011 (organizer)

S Diederichs: "Non-coding RNA as molecular marker and functional player in Lung Adenocarcinoma" German Society of Pathology (DGP), Leipzig, Germany, June 2011

M Hämmerle, M Polycarpou-Schwarz, T Gutschner, C Hildenbrand, T Longerich, P Schirmacher, S Diederichs: "Non-coding RNA profiling in hepatocellular carcinoma" German Society of Pathology (DGP), Leipzig, Germany, June 2011

S Diederichs: "microRNA Biogenesis, RNAi and long non-coding RNA in Cancer" University of Calgary, Canada, June 2011

S Diederichs: "microRNA Biogenesis, RNAi and long non-coding RNA in Cancer" University of Lethbridge, Canada, June 2011

S Diederichs: "Small and Long non-coding RNAs in Cancer" International Graduate School for Molecular Medicine, University of Ulm, Germany, April 2011

S Diederichs: "microRNA Biogenesis, RNA interference & Non-coding RNAs in Cancer" University of Regensburg, Germany, February 2011

S Diederichs: "Long non-coding RNAs in the nucleus" Epigenetics @ DKFZ, Heidelberg, Germany, January 2011

S Diederichs: "microRNA Biogenesis, RNA interference & Long Non-coding RNA in Cancer" University of Münster, Germany, December 2010

S Diederichs: "MicroRNA and non-coding RNA in Breast Cancer" COMBATing Breast Cancer, Frankfurt, Germany, November 2010 (invited speaker)

S Diederichs: "Non-coding RNA & Cancer" Max-Delbrück-Center for Molecular Medicine & Berlin Institute for Systems Biology, Berlin, Germany, October 2010

S Diederichs: "microRNA Biogenesis, RNAi & long non-coding RNA in Cancer" SFB571 Seminar, Helmholtz Center Munich, Germany, October 2010

S Diederichs: "Non-coding RNA & Cancer" Mainz Genomics Seminar, Mainz, Germany, October 2010

M Polycarpou-Schwarz, T Gutschner, S Domcke, E Fiskin, M Geigges, J Rom, S Aulmann, P Sinn, S Diederichs: "Long non-coding RNA in Cancer" German Society for Biochemistry and Molecular Biology (GBM) - Study Group RNA Biochemistry, Pforzheim, Germany, October 2010

S Diederichs: "Non-coding RNA: Biomarkers and functional players in Cancer" Systems Genomics 2010, Heidelberg, Germany, September 2010

S Diederichs: "Using Zinc Finger Nucleases in Non-Coding RNA Biology" First European Symposium on Zinc Finger Nucleases, BRIC, Copenhagen, Denmark, September 2010 (invited speaker)

S Diederichs: "Using Zinc Finger Nucleases in Non-Coding RNA Biology" RNAi & miRNA Europe, Dublin, Ireland, September 2010 (invited speaker)

S Diederichs: "Beyond Proteins: Non-coding RNAs as Biomarkers in Cancer" International Society of Oncology and BioMarkers (ISOBM), Munich, Germany, September 2010 (invited speaker)

T Gutschner, M Polycarpou-Schwarz, J Rom, S Aulmann, P Schirmacher, P Sinn, S Diederichs: "Non-coding RNA - A new world beyond proteins of Tumor Markers and Regulators ?" German Society of Pathology (DGP), Berlin, Germany, May 2010

S Diederichs: "Beyond proteins - Non-coding RNA, microRNA & RNA interference in Cancer” German Research Foundation (DFG) - Hinterzartener Kreis, Cadenabbia - Lago di Como, Italy, May 2010 (by invitation only)

S Diederichs: "Argonaute proteins in microRNA Biogenesis & RNA interference" German Society for Cell Biology (DGZ), Regensburg, Germany, March 2010 (invited speaker)

S Diederichs: "MicroRNA Biogenesis & Regulation" DKFZ-Israel Summer School, Ein Gedi, Israel, November 2009 (invited speaker)

S Diederichs: "Argonaute-2 Co-Expression Enhances RNA Interference" RNAi Europe, Berlin, Germany, September 2009 (invited speaker)

S Diederichs: "Argonaute proteins in microRNA Biogenesis & RNA interference" Seminar Series - University Hospital Ulm, Ulm, Germany, September 2009

S Diederichs: "Argonaute proteins in microRNA Biogenesis & RNA interference" DFG Graduate College: Transcription, Chromatin & DNA Repair, Dormagen, Germany, April 2009 (invited speaker)

S Diederichs: "Argonaute proteins in microRNA Biogenesis & RNA interference" Medical University Hannover (MHH), Hannover, Germany, January 2009

S Diederichs: "Argonaute proteins in microRNA Biogenesis & RNA interference" Molecular Cell Biology Kolloquium, University of Lübeck, Lübeck, Germany, November 2008

S Diederichs: "microRNA Biology, RNAi & Cancer" Scientific Seminar, Institute of Pathology, University of Heidelberg, Heidelberg, Germany, November 2008

S Diederichs: "Argonaute proteins in microRNA Processing and Regulation" GBM Study Group RNA Biochemistry Meeting, Kassel, Germany, September 2008 (invited speaker)

S Diederichs: "Dual Role for Argonaute Proteins in microRNA Processing" RNAi Europe Meeting, Stockholm, Sweden, September 2008 (invited speaker)

S Diederichs, DA Haber: "Dual Role for Argonaute Proteins in microRNA Processing and Post-Transcriptional Regulation of microRNA Expression" RNAi World Meeting, Boston, MA, May 2008 (invited speaker)

S Diederichs: "Argonaute Proteins in microRNA Processing and Regulation" Sixth International RNAi & microRNAs Meeting, Boston, MA, April 2008 (invited speaker)

S Diederichs, DA Haber: "Argonaute proteins in microRNA biogenesis" Miami Winter Symposium "Regulatory RNA in Biology and human Health", Miami, FL, February 2008

S Diederichs: "Argonaute proteins & microRNA biogenesis" Blue Seminar Series, European Molecular Biology Laboratory (EMBL), Heidelberg, December 2007

S Diederichs: "Argonaute proteins, microRNA biogenesis & RNA interference" German Cancer Research Center (DKFZ), Heidelberg, December 2007

S Diederichs: "Argonaute proteins & microRNA processing" Max-Planck-Institute for Biophysical Chemistry, Göttingen, December 2007

S Diederichs, DA Haber: "Dual Role for Argonaute proteins in microRNA Processing and Post-Transcriptional Regulation of microRNA Expression" AACR Special Conference "The role of Non-Coding RNAs in Cancer", Cambridge, MA, November 2007 [This presentation was selected for a 2007 AACR Scholar-in-Training Award. ]

S Diederichs
, DA Haber: "Dual role for Argonaute proteins in microRNA processing and regulation" Society for Biochemistry and Molecular Biology (GBM), Hamburg, Germany, September 2007

S Diederichs, DA Haber: "Two novel functions for Argonaute proteins in microRNA Processing and Regulation" Cancer Program Meeting of the Broad Institute of Harvard and MIT, Cambridge, MA, July 2007

S Diederichs: "Two novel functions for Argonaute proteins in microRNA Processing" 2nd microSymposium on small RNAs, Vienna, Austria, May 2007

S Diederichs: "Cancer Research: At the Interface of Medicine and Molecular Biology" German National Academic Merit Foundation Symposium “Future and Frontiers of Research”, Cambridge, MA, January 2007

S Diederichs, N Bäumer, M Möller, S Agrawal, S Pierschalski, WE Berdel, H Serve, C Müller-Tidow: "INCA1 is a novel growth-suppressive CDK inhibitor that blocks B-Myb and E2F activity and is lost in tumors" Annual Meeting German Society for Hematology and Oncology (DGHO), 2004; Onkologie (2004) 27 (S3): 59

S Diederichs, P Ji, R Metzger, S Klümpen, M Möller, PM Schneider, WE Berdel, H Serve, C Müller-Tidow: "Comparative genome-wide analysis of metastasis-associated genes in early-stage non-small cell lung cancer (NSCLC) using high-density oligonucleotide microarray technology" Annual Meeting German Society for Hematology and Oncology (DGHO), 2002; Onkologie (2002) 25 (S4): 139

Division of Cancer Research

Department of Thoracic Surgery

Center for Translational Cell Research (ZTZ)
Breisacher Str. 115
D-79106 Freiburg

 

Prof. Dr. Sven Diederichs

Division Head

Phone:
+49 761 270-77571
E-Mail:
lung-cancer-research
@uniklinik-freiburg.de
 

More than 70% of the human Genome (blue) is transcribed into RNA forming the Transcriptome (red), while only less than 2% of the genome are needed to produce all proteins in a human cell constituting the Proteome (yellow).

RNA Biology

A particular emphasis of our research lies on the Molecular Biology of RNA and its associated molecules.

Recent insights into RNA biology induced a paradigm shift towards the recognition of RNAs as functionally important molecules - beyond serving as messengers for protein-encoding genes. A large fraction of the human genome is transcribed into RNA (more than 70%), while only 2% are protein-encoding. Non-protein-coding RNAs execute important functions in the cell. Very short non-coding RNAs, the microRNAs, play important roles in gene regulation. The tumor-suppressive or oncogenic role of many microRNAs and their frequent deregulation in tumors allow a first glimpse of the striking role that non-coding RNAs could play in cancer. Novel long non-coding RNAs (ncRNA, lncRNA, lincRNA) fulfill important functions in epigenetic regulation, chromatin remodeling or splicing. Taken together, the human cell contains many more RNAs than previously anticipated and many of them might just await their discovery as functionally important molecules in cancer.

Our research focuses on long non-coding RNAs (lncRNAs) and their role in cancer. Based on expression profiling using microarrays as well as deep RNA sequencing of the whole transcriptome, we elucidate the cellular and molecular functions of differentially regulated ncRNAs in cancer using innovative techniques like the CRISPR/Cas9 system, in vivo RNA Affinity Purification and our own customized siRNA and CRISPR libraries targeting specifically lung cancer-associated lncRNAs. Our RNAi screens have uncovered numerous lncRNAs controlling several hallmarks of cancer including cancer cell viability, mitosis and Migration.

An emerging Topic of particular importance in our lab are RNA-Protein complexes, especially the new concept of RNA Dependence: R-DeeP (Mol Cell 2019).