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Abteilung Prächirurgische Epilepsiediagnostik – EpilepsiezentrumKlinik für Neurochirurgie

Connectivity of the human cortex

Brain connectivity is of high relevance for an understanding of physiological brain processing as well as for propagation of epileptic activity and for cognitive impairments related to an epileptic focus. Our knowledge of brain connectivity is mostly based on studies in primates, whereas information on human brain connectivity is very limited.

At the Freiburg epilepsy center, human brain connectivity is studied using both, diffusion tensor imaging (DTI), EEG-fMRI and cortico-cortical evoked potentials (CCEP). CCEP studies are performed in collaboration with the INSERM (University of Grenoble) and in the context of the Human Brain Project (HBP, SEEG-MIP). Research topics are the assessment of physiological information on brain connectivity based on high patient numbers to establish an brain atlas of connectivity, the assessment of biomarkers of brain excitability and epileptogenicity using analyses of the morphology of evoked potentials, and cognitive correlates of brain connectivity alterations in epilepsy.

References:

Probabilistic functional tractography of the human cortex revisited.
Trebaul L, Deman P, Tuyisenge V, Jedynak M, Hugues E, Rudrauf D, Bhattacharjee M, Tadel F, Chanteloup-Foret B, Saubat C, Reyes Mejia GC, Adam C, Nica A, Pail M, Dubeau F, Rheims S, Trébuchon A, Wang H, Liu S, Blauwblomme T, Garcés M, De Palma L, Valentin A, Metsähonkala EL, Petrescu AM, Landré E, Szurhaj W, Hirsch E, Valton L, Rocamora R, Schulze-Bonhage A, Mindruta I, Francione S, Maillard L, Taussig D, Kahane P, David O.
Neuroimage. 2018 Nov 1;181:414-429. doi: 10.1016/j.neuroimage.2018.07.039. Epub 2018 Jul 17.

Association between seizure freedom and default mode network reorganization in patients with unilateral temporal lobe epilepsy.
Ofer I, LeRose C, Mast H, LeVan P, Metternich B, Egger K, Urbach H, Schulze-Bonhage A, Wagner K.
Epilepsy Behav. 2018 Dec 8.

Cognitive and behavioral comorbidities in Rolandic epilepsy and their relation with default mode network's functional connectivity and organization.
Ofer I, Jacobs J, Jaiser N, Akin B, Hennig J, Schulze-Bonhage A, LeVan P.
Epilepsy Behav. 2018 Jan;78:179-186.

Bilateral cingulum fiber reductions in temporal lobe epilepsy with unilateral hippocampal sclerosis.
Urbach H, Egger K, Rutkowski K, Nakagawa JM, Schmeiser B, Reisert M, Brandt A, Steinhoff BJ, Schulze-Bonhage A, Hammen T.
Eur J Radiol. 2017 Sep;94:53-57. doi: 10.1016/j.ejrad.2017.07.015. Epub 2017 Jul 23.

Remote effects of hippocampal damage on default network connectivity in the human brain.
Frings L, Schulze-Bonhage A, Spreer J, Wagner K. J
Neurol. 2009 Dec;256(12):2021-9.

Hippocampal functional connectivity reflects verbal episodic memory network integrity.
Wagner K, Frings L, Halsband U, Everts R, Buller A, Spreer J, Zentner J, Schulze-Bonhage A.
Neuroreport. 2007 Oct 29;18(16):1719-23.

Abteilung Prächirurgische Epilepsiediagnostik

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Ärztlicher Leiter:
Prof. Dr. Schulze-Bonhage
Breisacher Str. 64
D-79106 Freiburg
Telefon: 0761 270 53660
Telefax: 0761 270 50030
E-Mail: epilepsiezentrum@uniklinik-freiburg.de