Publications Dr. Daniel Hornuß

Rinaldi M, Bartoletti M, Cojutti P, Escolà-Vergé L, Fernández-Hidalgo N, Hornuss D, et al. Managing Enterococcus faecium bloodstream infection: a Delphi document on clinical recommendations and research agenda. eClinicalMedicine. 2026 May 1;95:103925. doi:10.1016/j.eclinm.2026.103925

Rieg S, Waibel SM, Giesen R, Kainz L, Strub M, Hornuss D, et al. Implementation of automated alerts for last-resort antibiotics with indication review by infectious diseases specialists: impact on antibiotic prescription quality and costs. Infection. 2026 Aug 12. doi:10.1007/s15010-026-02894-9

Nikolai LA, Hornuss D, Gladstone BP, Walker SV, Vehreschild JJ, Schmauder K, et al. Missed opportunities for antibiotic de-escalation among clinically stable adult patients with bloodstream infection: Secondary analysis of a prospective, multicentre study. International Journal of Antimicrobial Agents. 2026 Oct 1;67(10):107908. doi:10.1016/j.ijantimicag.2026.107908

Mathé P, Graw K, Matzarakis A, Maros ME, Tobys D, Kohlmorgen B, et al. Impact of seasons and heat waves on the incidence of Staphylococcus aureus and Escherichia coli bacteremia – A prospective multicenter study using biometeorological data. PLOS ONE. 2026 Jul 14;21(7):e0352186. doi:10.1371/journal.pone.0352186

Hornuss D, Mathé P, Giesen R, Escolà-Vergé L, Isler B, Bartoletti M, et al. Quality indicators for clinical infectious diseases consultations—results from a hybrid Delphi-nominal group approach and scenario study. Clinical Microbiology and Infection. 2026 Mar 12. doi:10.1016/j.cmi.2026.03.006

Rusignuolo G, Thimme R, Hornuß D. Praktisches Vorgehen bei Leberabszessen. Gastro-News. 2025 Feb;12(1):30–9. doi:10.1007/s15036-024-3815-4

Mathé P, Hornuss D, Giesen R, Camp J, Isler B, Bartoletti M, et al. Early oral switch therapy for infective endocarditis: An international cross-sectional survey on current use in clinical practice. CMI Communications. 2025 Mar 1;2(1):105063. doi:10.1016/j.cmicom.2025.105063

Leibenguth M, Rieg S, Thimme R, Hornuss D. Ambulant erworbene Gastroenteritis. Dtsch Med Wochenschr. 2025 Feb;150(4):133–9. doi:10.1055/a-2301-6781

Gutiérrez-Gutiérrez B, Gallego-Mesa B, Kaasch AJ, Riediger M, Rieg S, Trigo M, et al. Identification and validation of clinical phenotypes in Staphylococcus aureus blood stream infection and their association with mortality (FEN-AUREUS cohort-based study). eClinicalMedicine. 2025 May 1;83:103240. doi:10.1016/j.eclinm.2025.103240

Giesen R, Först G, Fink G, Allen R, Wimmesberger N, Hornuss D, et al. Antimicrobial Stewardship in German non-university hospitals: baseline status and impact of a multifaceted AMS intervention within the prospective ID ROLL OUT study. Infection. 2025 Oct 6. doi:10.1007/s15010-025-02658-x PubMed PMID: 41051691.

Fuchs J, Karl V, Hettich I, Alvarado J, Eckert D, Jaki L, et al. SARS-CoV-2 infection dynamics in a MHCI-mismatched lung transplant recipient. Nat Commun. 2025 Sep 16;16(1):8292. doi:10.1038/s41467-025-63681-y PubMed PMID: 40957936; PubMed Central PMCID: PMC12441153.

Orth HM, Pfau S, Gabriel M, Günther S, Tappe D, Hornuss D, et al. A cluster of Mayaro virus infections in a film team returning from Suriname, February 2024. Eurosurveillance. 2024 Oct 31;29(44):2400679. doi:10.2807/1560-7917.ES.2024.29.44.2400679

Meyer-Schwickerath C, Weber C, Hornuss D, Rieg S, Hitzenbichler F, Hagel S, et al. Complexity of patients with or without infectious disease consultation in tertiary-care hospitals in Germany. Infection. 2024 Apr;52(2):577–82. doi:10.1007/s15010-023-02166-w PubMed PMID: 38277092; PubMed Central PMCID: PMC10955003.

Kraus LM, Overstijns M, Rahal AE, Behringer S, Buttler KJ, Andereggen L, et al. Spontaneous brain abscess formation: challenge of a shifting pathogen spectrum over the last 21 years - a single center experience. Acta Neurochir (Wien). 2024 Nov 14;166(1):453. doi:10.1007/s00701-024-06349-8 PubMed PMID: 39541000; PubMed Central PMCID: PMC11564206.

Hornuss D, Göpel S, Walker SV, Tobys D, Häcker G, Seifert H, et al. Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals: a prospectively evaluated multicentre cohort study from 2016 to 2020 of the R-Net study group. Infection. 2024 Apr 30. doi:10.1007/s15010-024-02249-2 PubMed PMID: 38684586.

Götz V, Mathé P, Agarwal P, Hornuss D, Pfau S, Panning M, et al. Clinical phenotype and outcome of persistent SARS-CoV-2 replication in immunocompromised hosts: a retrospective observational study in the Omicron era. Infection. 2024 Jun;52(3):923–33. doi:10.1007/s15010-023-02138-0 PubMed PMID: 38095753; PubMed Central PMCID: PMC11142974.

Camp J, Nüßle K, Deyhle N, Mathé P, Hornuss D, Grundmann S, et al. Partial oral treatment of infective endocarditis in real-world settings – an in-depth analysis of the prospectively evaluated German DERIVE cohort. CMI Communications. 2024 Nov 1;1(2):105032. doi:10.1016/j.cmicom.2024.105032

Mathé P, Göpel S, Hornuss D, Tobys D, Käding N, Eisenbeis S, et al. Increasing numbers and complexity of Staphylococcus aureus bloodstream infection-14 years of prospective evaluation at a German tertiary care centre with multi-centre validation of findings. Clin Microbiol Infect. 2023 Sep;29(9):1197.e9-1197.e15. doi:10.1016/j.cmi.2023.05.031 PubMed PMID: 37277092.

Hornuß D, Rieg S. [Antibiotic allergies: targeted approach in suspected β‑lactam allergy]. Inn Med (Heidelb). 2023 Apr;64(4):351–61. doi:10.1007/s00108-023-01490-5 PubMed PMID: 36917227.

Hornuss D, Mathé P, Usadel S, Zimmermann S, Müller M, Rieg S. Already current practice? A snapshot survey on doxycycline use for prevention of sexually transmitted infections in parts of the German MSM community. Infection. 2023 Dec;51(6):1831–4. doi:10.1007/s15010-023-02086-9 PubMed PMID: 37608042; PubMed Central PMCID: PMC10665247.

Hornuss D, Daehne T, Goetz V, Mueller M, Usadel S, Lorz A, et al. Transmission characteristics, replication patterns and clinical manifestations of human monkeypox virus—an in-depth analysis of four cases from Germany. Clinical Microbiology and Infection. 2023 Jan 1;29(1):112.e5-112.e9. doi:10.1016/j.cmi.2022.09.012

Bahrs C, Rieg S, Hennigs A, Hitzenbichler F, Brehm TT, Rose N, et al. Short-course versus long-course antibiotic treatment for uncomplicated vancomycin-resistant enterococcal bacteraemia: a retrospective multicentre cohort study. Clin Microbiol Infect. 2023 Feb;29(2):200–7. doi:10.1016/j.cmi.2022.08.023 PubMed PMID: 36087919.

Singh B, Lant S, Cividini S, Cattrall JWS, Goodwin LC, Benjamin L, et al. Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis. PLoS One. 2022;17(6):e0263595. doi:10.1371/journal.pone.0263595 PubMed PMID: 35653330; PubMed Central PMCID: PMC9162376.

Murtha-Lemekhova A, Fuchs J, Teroerde M, Rau H, Frey OR, Hornuss D, et al. Study protocol of REpeat versus SIngle ShoT Antibiotic prophylaxis in major Abdominal Surgery (RESISTAAS I): a prospective observational study of antibiotic prophylaxis practice for patients undergoing major abdominal surgery. BMJ Open. 2022 Sep 19;12(9):e062088. doi:10.1136/bmjopen-2022-062088 PubMed PMID: 36123092; PubMed Central PMCID: PMC9486288.

Murtha-Lemekhova A, Fuchs J, Teroerde M, Chiriac U, Klotz R, Hornuss D, et al. Routine Postoperative Antibiotic Prophylaxis Offers No Benefit after Hepatectomy-A Systematic Review and Meta-Analysis. Antibiotics (Basel). 2022 May 12;11(5):649. doi:10.3390/antibiotics11050649 PubMed PMID: 35625294; PubMed Central PMCID: PMC9138010.

Moneke I, Hornuss D, Serr A, Kern WV, Passlick B, Senbaklavaci O. Lung Abscess and Recurrent Empyema After Infection With Mycoplasma hominis: A Case Report and Review of the Literature. Open Forum Infect Dis. 2022 Jan;9(1):ofab406. doi:10.1093/ofid/ofab406 PubMed PMID: 35028329; PubMed Central PMCID: PMC8753028.

Hornuss D, Giesen R, Rieg S. Osteoartikuläre und rheumatologische Manifestationen sexuell übertragbarer Infektionen. Arthritis und Rheuma. 2022 Apr;42(02):93–9. doi:10.1055/a-1755-4618

Fuchs J, Murtha-Lemekhova A, Pfeiffenberger J, Fichtner A, Günther P, Halama N, et al. Generating evidence for diagnosis and therapy of RarE LIVEr disease: the RELIVE Initiative for systematic reviews and meta-analyses. Syst Rev. 2022 Nov 3;11(1):235. doi:10.1186/s13643-022-02105-0 PubMed PMID: 36329524; PubMed Central PMCID: PMC9635082.

Weigang S, Fuchs J, Zimmer G, Schnepf D, Kern L, Beer J, et al. Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants. Nat Commun. 2021 Nov 4;12(1):6405. doi:10.1038/s41467-021-26602-3 PubMed PMID: 34737266; PubMed Central PMCID: PMC8568958.

Schneider J, Jaenigen B, Wagner D, Rieg S, Hornuss D, Biever PM, et al. Therapy with lopinavir/ritonavir and hydroxychloroquine is associated with acute kidney injury in COVID-19 patients. PLoS One. 2021;16(5):e0249760. doi:10.1371/journal.pone.0249760 PubMed PMID: 33974624; PubMed Central PMCID: PMC8112697.

Hornuss D, Rudi A, Koerner L, Mohr I, Merle U, Wehling C, et al. HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients: A retrospective study. Clin Res Hepatol Gastroenterol. 2021 Mar;45(2):101496. doi:10.1016/j.clinre.2020.07.003 PubMed PMID: 33740476.

Hornuss D, Giesen R, Biever P, Kern WV. [Clinical benefit of Tocilizumab and other immunomodulating agents for treatment of COVID-19]. Dtsch Med Wochenschr. 2021 Nov;146(23):1538–42. doi:10.1055/a-1643-4209 PubMed PMID: 34826840.

Schmid B, Hornuß D, Feuerstein D, Schultheiß M, Damjanovic D. [Pulmonary Sonography in Patients With Suspected COVID-19 - Step-by-Step]. Dtsch Med Wochenschr. 2020 Jul;145(15):1100–4. doi:10.1055/a-1185-6885 PubMed PMID: 32731285.

Lemekhova A, Hornuss D, Polychronidis G, Mayer P, Rupp C, Longerich T, et al. Clinical features and surgical outcomes of fibrolamellar hepatocellular carcinoma: retrospective analysis of a single-center experience. World J Surg Oncol. 2020 May 12;18(1):93. doi:10.1186/s12957-020-01855-2 PubMed PMID: 32397993; PubMed Central PMCID: PMC7218513.

Hornuss D, Laubner K, Monasterio C, Thimme R, Wagner D. [COVID-19 associated pneumonia despite repeatedly negative PCR-analysis from oropharyngeal swabs]. Dtsch Med Wochenschr. 2020 Jun;145(12):844–9. doi:10.1055/a-1170-6061 PubMed PMID: 32403153; PubMed Central PMCID: PMC7356073.

Hornuss D, Lange B, Schröter N, Rieg S, Kern WV, Wagner D. Anosmia in COVID-19 patients. Clin Microbiol Infect. 2020 Oct;26(10):1426–7. doi:10.1016/j.cmi.2020.05.017 PubMed PMID: 32447049; PubMed Central PMCID: PMC7242197.

Wehling C, Hornuss D, Schneider P, Springfeld C, Hoffmann K, Chang DH, et al. Impact of interventions and tumor stage on health-related quality of life in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol. 2019 Nov;145(11):2761–9. doi:10.1007/s00432-019-03005-y PubMed PMID: 31428932.

Pfeiffenberger J, Hornuss D, Houben P, Wehling C, Von Haken R, Lozanovski V, et al. Routine Liver Elastography Could Predict Actuarial Survival after Liver Transplantation. J Gastrointestin Liver Dis. 2019 Sep 12;28(3):271–7. doi:10.15403/jgld-218 PubMed PMID: 31517323.

Stremmel W, Staffer S, Stuhrmann N, Gan-Schreier H, Gauss A, Burger N, et al. Phospholipase A2 of Microbiota as Pathogenetic Determinant to Induce Inflammatory States in Ulcerative Colitis: Therapeutic Implications of Phospholipase A2 Inhibitors. Inflamm Intest Dis. 2018 Mar;2(3):180–7. doi:10.1159/000486858 PubMed PMID: 29922677; PubMed Central PMCID: PMC5988128.

Manzhalii E, Hornuss D, Stremmel W. Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917. World J Gastroenterol. 2016 Jun 21;22(23):5415–21. doi:10.3748/wjg.v22.i23.5415 PubMed PMID: 27340358; PubMed Central PMCID: PMC4910662.

Papatheodorou P, Hornuss D, Nölke T, Hemmasi S, Castonguay J, Picchianti M, et al. Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts. mBio. 2013 Apr 30;4(3):e00244-00213. doi:10.1128/mBio.00244-13 PubMed PMID: 23631918; PubMed Central PMCID: PMC3648903.

Papatheodorou P, Wilczek C, Nölke T, Guttenberg G, Hornuss D, Schwan C, et al. Identification of the cellular receptor of Clostridium spiroforme toxin. Infect Immun. 2012 Apr;80(4):1418–23. doi:10.1128/IAI.06378-11 PubMed PMID: 22252869; PubMed Central PMCID: PMC3318402.