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Cancer ResearchDepartment of Thoracic Surgery

Division of Cancer Research

Department of Thoracic Surgery

Prof. Dr. Sven Diederichs

Division Head
 

Division of Cancer Research

Department of Thoracic Surgery

 

Center for Translational Cell Research (ZTZ)
Breisacher Str. 115, 02.031
D-79106 Freiburg

Phone +49 761 270-77571
E-Mail  sven.diederichs*at*uniklinik-freiburg.de

Publications

 

Scientific Education & Professional Experience

since 01 / 2016
Tenured Full Professor (W3) & Division Head of the Division "Cancer Research", Department of Thoracic Surgery, University Hospital Freiburg, Albert-Ludwigs-University Freiburg

since 01 / 2015
Division Head of the Division "RNA Biology & Cancer", German Cancer Research Center (DKFZ), Heidelberg
 
01 / 2009 - 12 / 2014
Junior Group Leader of the Helmholtz-University-Junior Research Group, German Cancer Research Center (DKFZ) & Institute of Pathology, University of Heidelberg

07 / 2008 - 12 / 2014
Junior Group Leader, German Cancer Research Center DKFZ, Heidelberg

2005 - 2008
Postdoctoral Fellowship in the laboratory of Prof. Dr. Daniel A. Haber, Harvard Medical School / Massachusetts General Hospital Cancer Center, Boston

2002 - 2004
PhD thesis (Dr. rer. nat.) at the University of Münster, Dept. of Medicine, Hematology / Oncology & University of Witten / Herdecke

2001 - 2002
Diploma thesis at the University of Münster, Dept. of Medicine, Hematology / Oncology

1999 - 2001
University of Witten / Herdecke: Biochemistry

1996 - 1999
Eberhard-Karls-Universität Tübingen: Biochemistry

 

Scholarships & Awards

2016
Anniversary Prize of the Federation of European Biochemical Societies (FEBS)

2014
Liver Cancer Research Award of the German Society for Gastrointestinal Diseases (DGVS) & Bayer Health Care

2013
Dr. Hella Bühler Prize - endowed with 100.000 Euros for Cancer Research

2012
Binder Innovation Prize of the German Society of Cell Biology (DGZ)

2010
Karl-Freudenberg-Preis of the Heidelberg Academy of Sciences and Humanities

2008
Presentation Award Miami Winter Symposium “Regulatory RNA in Biology and human Health”

2007
Scholar-in-Training Award of the American Association for Cancer Research (AACR): “The role of Non-Coding RNAs in Cancer”

2005
Young Investigator Award of the German Academy of Scientists Leopoldina

2005
PhD thesis Award of the German Society for Hematology and Oncology (DGHO)

2003
Scholar-in-Training Award of the American Association for Cancer Research (AACR) / Pezcoller Foundation

2002 - 2004
PhD Scholarship Award of the German Academic Merit Foundation (Studienstiftung des deutschen Volkes)
"Characterization of Cyclin A1 interacting proteins and analysis of their role in the pathogenesis of human malignancies"

1997 - 2001
Scholarship Award of the German Academic Merit Foundation (Studienstiftung des deutschen Volkes)

 

Scientific Community

Associate Editor of RNA Biology

Member of the Young Academy of Scientists ("Die Junge Akademie") - established by the National Academy of Sciences Leopoldina and the Berlin-Brandenburg Academy of Sciences (BBAW)

Group Leader "Genetics & Genomics" in the Life Science College of the German Academic Merit Foundation (Studienstiftung des deutschen Volkes)

Member of the selection committee for the German Academic Merit Foundation (Studienstiftung des deutschen Volkes)

Reviewer for multiple international peer-reviewed journals as well as national and international funding agencies

 

Memberships

since 2010
German Society for Pathology (DGP)

since 2007
RNA Society

since 2006
German Society for Biochemistry & Molecular Biology (GBM)

GBM Study Group RNA Biochemistry

since 2003
American Association for Cancer Research (AACR)
(Active Member since 2009)

Division of Cancer Research

Department of Thoracic Surgery

Center for Translational Cell Research (ZTZ)
Breisacher Str. 115
D-79106 Freiburg

 

Prof. Dr. Sven Diederichs

Division Head

Phone:
+49 761 270-77571
E-Mail:
lung-cancer-research
@uniklinik-freiburg.de
 

More than 70% of the human Genome (blue) is transcribed into RNA forming the Transcriptome (red), while only less than 2% of the genome are needed to produce all proteins in a human cell constituting the Proteome (yellow).

RNA Biology

A particular emphasis of our research lies on the Molecular Biology of RNA and its associated molecules.

Recent insights into RNA biology induced a paradigm shift towards the recognition of RNAs as functionally important molecules - beyond serving as messengers for protein-encoding genes. A large fraction of the human genome is transcribed into RNA (more than 70%), while only 2% are protein-encoding. Non-protein-coding RNAs execute important functions in the cell. Very short non-coding RNAs, the microRNAs, play important roles in gene regulation. The tumor-suppressive or oncogenic role of many microRNAs and their frequent deregulation in tumors allow a first glimpse of the striking role that non-coding RNAs could play in cancer. Novel long non-coding RNAs (ncRNA, lncRNA, lincRNA) fulfill important functions in epigenetic regulation, chromatin remodeling or splicing. Taken together, the human cell contains many more RNAs than previously anticipated and many of them might just await their discovery as functionally important molecules in cancer.

Our research focuses on long non-coding RNAs (lncRNAs) and their role in cancer. Based on expression profiling using microarrays as well as deep RNA sequencing of the whole transcriptome, we elucidate the cellular and molecular functions of differentially regulated ncRNAs in cancer using innovative techniques like the CRISPR/Cas9 system, in vivo RNA Affinity Purification and our own customized siRNA and CRISPR libraries targeting specifically lung cancer-associated lncRNAs. Our RNAi screens have uncovered numerous lncRNAs controlling several hallmarks of cancer including cancer cell viability, mitosis and Migration.

An emerging Topic of particular importance in our lab are RNA-Protein complexes, especially the new concept of RNA Dependence: R-DeeP (Mol Cell 2019).