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Experimental Epilepsy ResearchDepartment of Neurosurgery

Publications

Donkels C, Peters M, Fariña Núñez MT, Nakagawa JM, Kirsch M, Vlachos A, Scheiwe C, Schulze‐Bonhage A, Prinz M, Beck J, Haas CA (2020) Oligodendrocyte lineage and myelination are compromised in the gray matter of focal cortical dysplasia type IIa. Epilepsia 61:171-184. (access to article)

 

Heining K, Kilias A, Janz P, Häussler U, Kumar A, Haas CA, Egert U (2019) Bursts with high and low load of epileptiform spikes show context-dependent correlations in epileptic mice. eNeuro 6:0299-18. (access to article )

Tulke S, Haas CA, Häussler U (2019) Expression of brain-derived neurotrophic factor and structural plasticity in the dentate gyrus and CA2 region correlate with epileptiform activity. Epilepsia 60:1234-1247. (access to article)

Böhm T, Joseph K, Kirsch M, Moroni R, Hilger A, Osenberg M, Manke I, Johnston M, Stieglitz T, Hofmann UG, Haas CA, Thiele S. (2019) Quantitative synchrotron X‐ray tomography of the material‐tissue interface in rat cortex implanted with neural probes. Sci Rep 9: 7646. (access to article)

Szczurkowska J, Pischedda F, Pinto B, Manago F, Haas CA, Summa M, Bertorelli R, Papaleo F, Schäfer MK, Piccoli G, Cancedda L (2018). Negr1 and FGFR2 cooperatively regulate cortical development and core behaviors related to autism spectrum disorders in mice. Brain 141:2772-2794 (access to article)

Janz P*, Hauser P*, Heining K, Nestel S, Kirsch M, Egert U, Haas CA (2018) Position- and time-dependent Arc expression links neuronal activity to synaptic plasticity during epileptogenesis. Frontiers Cell Neurosci 12:244 (access to article)

Kamberger R, Göbel-Guéniot K, Gerlach J; Gruschke OG; Hennig J; LeVan P; Haas CA; Korvink JG (2018) Improved method for MR microscopy of brain tissue cultured with the interface method combined with Lenz lenses. Magnetic Resonance Imaging 52: 24-32. (access to article

Kilias A, Häussler U, Heining K, Froriep UP, Haas CA, Egert U (2018) Theta frequency decreases throughout the hippocampal formation in a focal epilepsy model. Hippocampus 28: 375-391. DOI: 10.1002/hipo.22838. (access to article)

Singh K, Loreth D, Pöttker B, Hefti K, Innos J, Schwald K, Hengstler H, Menzel L, Sommer CJ, Radyushkin K, Kretz O, Philips MA, Haas CA, Frauenknecht K, Lilleväli K, Heimrich B, Vasar E, Schaefer MKE (2018)Neuronal growth and behavioral alterations in mice deficient for the psychiatric disease-associated Negr1 gene. Front. Mol. Neurosci. 11:30, doi: 10.3389/fnmol.2018.00030. (access to article)

Dias RB, Rodrigues TM, Rombo DM, Ribeiro FF, Rodrigues J, McGarvey J, Orcinha C, Henley JM, Sebastião AM (2017) Erythopoietin induces homeostatic plasticity at hippocampal synapses. Cereb Cortex 5:1-15. (access to article)

Janz P*, Schwaderlapp N*, Heining K*, Häussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P*, Haas CA* (2017) Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy. *equal contribution. eLife 2017;6:e25742 doi: 10.7554/eLife.25742 (access to article)

Peters M, Wielsch B, Boltze J (2017) The role of SUMOylation in cerebral hypoxia and ischemia. Neurochem. Int. 107:66-77 (access to article)

Nakagawa JM, Donkels C, Fauser S, Schulze-Bonhage A, Prinz M, Zentner J, Haas CA (2017). Characterization of focal cortical dysplasia with balloon cells by layer-specific markers: evidence for differential vulnerability of interneurons. Epilepsia 58(4):635-645. (access to article

Janz P, Savanthrapadian S, Häussler U, Kilias A, Nestel S, Kretz O, Kirsch M, Bartos M, Egert U, Haas CA (2017) Synaptic remodeling of entorhinal input contributes to an aberrant hippocampal network in temporal lobe epilepsy. Cerebral Cortex 27 (3): 2348-2364. PubMed

Donkels C, Pfeifer D, Janz P, Huber S, Nakagawa J, Prinz M, Schulze-Bonhage A, Weyerbrock A, Zentner J, Haas CA (2017) Whole transcriptome screening reveals myelination deficits in dysplastic human temporal neocortex. Cerebral Cortex 27 (2): 1558-1572. PubMed

Orcinha C, Münzner G, Gerlach J, Kilias A, Follo M, Egert U, Haas CA (2016) Seizure-induced motility of differentiated dentate granule cells is prevented by the central Reelin fragment. Frontiers in Cellular Neuroscience 10: 183. Front CN

Gerlach J, Donkels C, Muenzner G, Haas CA (2016) Persistent gliosis interferes with neurogenesis in organotypic hippocampal slice cultures. Frontiers in Cellular Neuroscience 10: 131. Front CN

Egger K, Janz P, Döbrössy M, Bienert T, Reisert M, Obmann M, Glauche V, Haas CA, Harsan L, Urbach H, von Elverfeldt D (2016) Microstructural effects of a neuro-modulating drug evaluated by Diffusion Tensor Imaging. Neuroimage 127: 1-10. PubMed

Häussler U, Rinas K, Kilias A, Egert U, Haas CA (2016) Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy. Hippocampus 26: 577-88. doi:10.1002/hipo.22543. PubMed

Tulke S, Williams P, Hellysaz A, Ilegems E, Wendel M, Broberger C. (2016) Nucleobindin (NUCB1) is a Golgi-resident marker of neurons. Neuroscience 314:179-88. (access to article)

Hornig T, Haas CA, Sturm L, Fiebich B, Tebartz van Elst L (2015) Increased blood-reelin-levels in first episode schizophrenia. PLoS One 10(8):e0134671.PubMed

Winkelmann A, You X, Grünewald N, Haeussler U, Krestel H, Haas CA, Schwarz G, Chen W, Meier J (2015) Identification of a new genomic hot spot of evolutionary diversification of protein function. PLoS One 10:e0125413.PubMed

Bedner P, Dupper A, Hüttmann K, Müller J, Herde MK, Dublin P, Deshpande T, Schramm J, Häussler U, Haas CA, Henneberger C, Theis M, Steinhäuser C (2015) Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain 138:1208–1222.PubMed

Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Häussler U, Jüttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC (2014) Changes in neural network homeostasis trigger neuropsychiatric symptoms. Journal of Clinical Investigation 124:1-18. JCI

Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, Häussler U, Young C, Haas CA, Frotscher M (2014) Epilepsy-induced motility of differentiated neurons. Cerebral Cortex 24:2130-2140. PubMed

2013

Kirchheim F, Tinnes S, Haas CA, Stegen M and Wolfart J (2013). Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy. Front. Cell. Neurosci. 7:248. doi: 10.3389/fncel.2013.00248.PubMed

Marx M, Haas CA, Häussler U (2013) Differential vulnerability of interneurons in the epileptic hippocampus. Front Cell Neurosci., 7:1-17. doi: 10.3389/fncel.2013.00167.Front CN

Dugladze T, Maziashvilia N, Börgers C, Gurgenidze S, Häussler U, Winkelmann A, Haas CA, Meier JC, Vida I, Kopell N, Gloveli T (2013) GABAB autoreceptor-mediated cell-type specific reduction of inhibition in epileptic mice. Proc Natl Acad Sci U S A (in press).PNAS

Fauser S, Häussler U, Donkels C, Huber S, Nakagawa J, Prinz M, Schulze-Bonhage A, Zentner J, Haas CA (2013) Disorganization of neocortical lamination in focal cortical dysplasia is brain-region dependent: Evidence from layer-specific marker expression. Acta Neuropathologica Communications, 1:47.Acta NC

Kierdorf K, Katzmarski N, Haas CA, Prinz M (2013) Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias. PloS One, 8:e58544.PLoS One 

Tinnes S, Ringwald J, Haas CA (2013) TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy. FASEB J., 27:2542-52.PubMed  

2012

Herpfer I, Hezel H, Reichardt W, Clark K, Geiger J, Gross CM, Heyer A, Neagu V, Harsharan Bhatia H, Atas HC, Fiebich BL, Bischofberger J, Haas CA, Lieb K, Normann C (2012) Early life stress differentially modulates morphological and functional brain plasticity in adult mice.PLoS One, 7: e46004.PloS One.  

Sibbe M, Häussler U, Dieni S, Althof D, Haas CA, Frotscher M (2012) Experimental epilepsy affects Notch1 signaling and the stem cell pool in the dentate gyrus. Eur J Neurosci., 36, 3643-3652.PubMed  

Froriep UP, Kumar A, Cosandier-Rimélé D, Häussler U, Kilias A, Haas CA, Egert U.(2012) Altered theta coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy. Epilepsia, 53,1937–1947.PubMed  

Lee AWS, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, Hrabé de Angelis M, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicolson G, Cox RD, Schäfer MKE (2012) Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One, 7: e41537.PloS One 

Bechstein M, Häussler U, Neef M, Hofmann HD, Kirsch M, Haas CA (2012) CNTF-mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsy. Exp Neurol., 236, 141-150.PubMed  

Häussler U, Bielefeld L, Froriep UP, Wolfart J, Haas CA (2012) Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy. Cereb Cortex, 22:26-26.PubMed  

Gross CM, Flubacher A, Tinnes S, Heyer A, Scheller M, Herpfer I, Berger M, Frotscher M, Lieb K, Haas CA (2012) Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: Evidence for corticosterone-mediated action. Hippocampus, 22:409-20.PubMed 

2011

Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM (2011) Stereological estimation of hippocampal mossy cells in two mouse models of temporal lobe epilepsy. Epilepsia, 52, 1579-89.PubMed  

Pallud J, Häussler U, Langlois M, Hamelin S, Devaux B, Deransart C, Depaulis A (2011) Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy. Hippocampus, 21, 334-343.PubMed  

Heinrich C, Lahteinen S, Suzuki F, Laharie, AM, Huber S, Häussler U, Haas CA, Larmet Y, Castren E, Depaulis A (2011) Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiol Dis., 42, 35-47.PubMed  

Tinnes S, Schäfer M, Flubacher A, Münzner G, Frotscher M, Haas CA (2011) Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning. FASEB J., 25, 1002–1013.PubMed 

2010

Wagener R, Dávid C, Zhao S, Haas CA, Staiger J (2010) The somatosensory cortex of reeler mutant mice shows absent layering but intact formation and behavioral activation of columnar somatotopic maps. J Neurosci., 30, 15700-09.PubMed  

Kowalski J, Geuting M, Sebastian P, Dieni S, Laurens J, Zhao S, Drakew A, Haas CA, Frotscher M, Vida I (2010) Proper layering is important for precisely timed activation of hippocampal mossy cells. Cereb Cortex, 20, 2043-54.PubMed  

Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Gotz M, Haas CA, Kempermann G, Taylor V, Giachino C (2010) Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and ageing. Cell Stem Cell, 6, 401-2.PubMed  

Haas CA, Frotscher M (2010) Reelin deficiency causes granule cell dispersion in epilepsy. Exp Brain Res, 200, Special Issue, 141-149.PubMed 

2009

Frotscher M, Chai X, Bock H, Haas CA, Förster E, Zhao S (2009) Role of Reelin in the development and maintenance of cortical lamination. J Neural Transm, 116, 1451-1455.PubMed  

Mantovani M, Moser A, Haas CA, Zentner J, Feuerstein TJ (2009) GABA (A) autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain? Naunyn-Schmied Arch Pharmacol, 380, 45–58.PubMed  

Müller MC, Osswald M, Tinnes S, Häussler U, Jacobi A, Förster E, Frotscher M, Haas CA (2009) Exogenous reelin prevents granule cell dispersion in experimental epilepsy. Exp Neurol., 216, 390-397.PubMed  

Stegen M, Young C, Haas CA, Zentner J, Wolfart J (2009) Increased leak conductance in dentate gyrus granule cells of temporal lobe epilepsy patients with Ammon’s horn sclerosis. Epilepsia, 50, 646-653.PubMed  

Young C, Stegen M, Bernard R, Müller M, Bischofberger J, Veh RW, Haas CA, Wolfart J (2009) Upregulation of inward rectifier K+ (Kir2) Channels in dentate gyrus granule cells in temporal lobe epilepsy. J Physiol (London), 587, 4213-4233.PubMed 

2008

Najm J, Horn D, Wimplinger I, Golden JA, Chizhikov V, Sudi J, Christian SL, Ullmann R, Kuechler A, Haas CA, Flubacher A, Charnas LA, Uyanik G, Frank U, Klopocki E, Dobyns WB, Kutsche K (2008) Mutations of CASK cause a novel X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nature Genetics, 40, 1065-1067.PubMed 

2007

Deller T, Bas Orth C, Del Turco D, Vlachos A, Burbach GJ, Drakew A, Chabanis S, Korte M, Schwegler H, Haas CA, Frotscher M (2007) A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat., 189, 5-16.PubMed  

Fahrner A, Kann G, Flubacher A, Heinrich C, Freiman TM, Zentner J, Frotscher M, Haas CA (2007) Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. Exp Neurol., 203, 320-332.PubMed 

2006

Deller T, Haas CA, Freiman TM, Phinney A, Jucker M, Frotscher M (2006) Lesion-induced axonal sprouting in the central nervous system. Adv Exp Med., 557, 101-21.PubMed  

Heinrich C, Nitta N, Flubacher A, Müller M, Fahrner A, Kirsch M, Freiman T, Suzuki F, Depaulis A, Frotscher M, Haas CA (2006) Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. J Neurosci., 26, 4701-4713.PubMed  

Schwarzacher SW, Vuksic M, Haas CA, Burbach GJ, Sloviter RS, Deller T (2006) Neuronal hyperactivity induces astrocytic expression of neurocan in the adult hippocampus. Glia, 53, 704-714.PubMed 

2005

Bas Orth C, Vlachos A, del Turco D, Burbach GJ, Haas CA, Mundel P, Feng G, Frotscher M, Deller T (2005) Lamina-specific distribution of synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. J Comp Neurol., 487, 227-239.PubMed  

Czarnecki K, Haas CA, Bas Ort C, Deller T, Frotscher M (2005) Postnatal development of synaptopodin expression in the rodent hippocampus: Expression by principal cells and interneurons. J Comp Neurol., 490, 133-144.PubMed 

2004

Haas CA (2004) Neuronale Migrationsstörungen und Epilepsie. Neuroforum, 4/04, 256-260. 

Haas CA and Frotscher M (2004) Migration disorders and epilepsy. Brain Damage and Repair, pp. 391-402. (T Herdegen and JM Delgado-Garcia eds) Luwer Academic Publishers. 

Burbach GJ, Hellweg R, Haas CA, del Turco D, Deicke U, Abramowski D, Jucker M, Staufenbiel M, Deller T (2004) Induction of brain-derived neurotrophic factor (BDNF) in plaque-associated glial cells of aged APP23 transgenic mice. J Neurosci., 24, 2421-2430.PubMed 

2003

Kulik A, Vida I, Luján R, Haas CA, López-Bendito G, Shigemoto R, Frotscher M (2003) Subcellular localization of metabotropic GABAB receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus. J Neurosci., 23, 11026-11035.PubMed  

Frotscher M, Haas CA, Förster E (2003) Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold. Cerebral Cortex, 13, 634 -640.PubMed 

2002

Deller T, Haas CA, Deissenrieder K, del Turco D, Coulin C, Gebhardt C, Drakew A, Mundel P, Frotscher M (2002) The laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine bearing neurons. J Comp Neurol., 453, 33-44.PubMed  

Haas CA, Dudeck O, Kirsch M, Huszka C, Kann G, Pollak S, Zentner J, Frotscher M (2002) Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci., 22, 5797-5802.PubMed  

Streppel M, Azzolin N, Dohm S, Guntinas-Lichius O, Haas CA, Grothe C, Wewers A, Neiss WF, Angelov DN (2002) Focal application of neutralizing antibodies to soluble neurotrophic factors reduces collateral axonal branching after peripheral nerve lesion. Eur J Neurosci., 15, 1327-1342.PubMed 

2001

Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernández-Klett F, Prass K, Bechmann I, de Boer B, Frotscher M, Kreutzberg GW, Persons DA Dirnagl U (2001) Targeting of gene-modified hematopoietic cells to the central nervous system: use of the green fluorescent protein uncovers microglial engraftment. Nature Med., 7, 1356-1361.PubMed 

2000

Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M (2000) Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Eur J Neurosci., 12, 4233-4242.PubMed  

Deller T, Haas CA, Frotscher M (2000) Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion: Role of the extracellular matrix. Ann NY Acad Sci., 911, 207-220.PubMed  

Thon N, Haas CA, Rauch U, Merten T, Frotscher M, Deller T (2000) The chondroitin sulfate proteoglycan brevican is up-regulated by astrocytes after entorhinal cortex lesions in adult rats. Eur J Neurosci., 12, 2547-2558.PubMed  

Haas CA, Deller T, Krsnik Z, Tielsch A, Woods A and Frotscher M (2000) Entorhinal cortex lesion does not alter reelin mRNA expression in the dentate gyrus of young and adult rats. Neuroscience, 97, 25-31.PubMed 

Review Articles

Deller T.,Haas C.A., Freiman T.M., Phinney A., Jucker M. and Frotscher M. (2003) Lesion-induced axonal sprouting in the central nervous system. In: Brain Repair (M. Bähr, ed.). Landes Bioscience, Georgetown.

Deller T.,Haas C.A., and Frotscher M. (2001) Sprouting in the hippocampus after entorhinal cortex lesion is layer-specific but not translaminar: which molecules may be involved? Rest Neurol Neurosci., 19, 159-167.

Frotscher M., Deller T., Heimrich B., Förster E.,Haas C.A. and Naumann T. (1996) Survival, regeneration, and sprouting of central neurons: the rat septohippocampal projection as a model. Ann Anat., 178, 311-315.

Raivich G., Reddington M., Haas C.A. and Kreutzberg G.W. (1995) Peptides in motoneurons (In: Neuropeptides in the Spinal Cord, Eds. F. Nyberg; H.S. Sharma and Z. Wiesenfeld-Hallin) Prog Brain Res., 104, 1-20.

Dumoulin F.L., Raivich G.,Haas C.A., Lazar P., Reddington M., Streit W.J. and Kreutzberg G.W (1992) Calcitonin gene-related peptide and peripheral nerve regeneration. Ann N Y Acad Sci., 657, 351-360.

Book Chapters

Frotscher M.,Haas C.A. (2009) Epilepsy-associated reelin dysfunction induces granule cell dispersion in the dentate gyrus. In: Encyclopedia of Basic Epilepsy Research Oxford. Schwartzkroin PA (ed), Elsevier pp.192-198. (Vol.1)

Haas CA, Frotscher M (2004) Migration disorders and epilepsy. In: Brain Damage and Repair pp. 391-402. (Herdegen T, Delgado-Garcia JM, eds.). Kluwer Academic Publishers.

Deller T, Haas CA, Freiman TM, Phinney A, Jucker M, Frotscher M (2003) Lesion-induced axonal sprouting in the central nervous system. In: Brain Repair (Bähr M, ed.). Landes Bioscience, Georgetown.