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Experimental Epilepsy ResearchDepartment of Neurosurgery

Experimental Epilepsy Research

Department of Neurosurgery

Group outing 2020

Head

Prof. Dr. Carola Haas e-mail

University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.

Latest news

  • Latest publication of our group: Demerath T*, Donkels C*, Reisert M, Heers M, Rau A, Schröter N, Schulze-Bonhage A, Reinacher P, Scheiwe C, Shah MJ, Beck J, Vlachos A, Haas CA, Urbach H (2021) Gray-white matter blurring of the temporal pole associated with hippocampal sclerosis: A microstructural study involving 3T MRI and ultrastructural histopathology. Cerebral Cortex: doi:10.1093/cercor/bhab320. *equal contribution. (access to article)
  • Travel grant: the Hoffmann-La Roche-Stiftung supports Enya Paschen with 1000€ for her participation at the Society for Neuroscience meeting 2021
  • Recent publication of our group: Piret Kleis, Enya Paschen, Ute Haeussler, Yinth Andrea Bernal Sierra, Carola A. Haas (2021) In vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus. bioRxiv. 2021.09.06.459077 doi: 10.1101/2021.09.06.459077 (access to article).
  • Recent publication of our group: Orcinha C, Kilias A, Paschen E, Follo M and Haas CA (2021) Reelin Is Required for Maintenance of Granule Cell Lamination in the Healthy and Epileptic Hippocampus. Front. Mol. Neurosci. 14:730811. doi: 10.3389/fnmol.2021.730811 (access to article).
  • DFG funding for the project: Molecular and cellular characterization of aberrant myelination in focal cortical dysplasia. Juli 2021. Dr. Catharina Donkels (Experimental Epilepsy Research, Dept. of Neurosurgery, Medical Center - University of Freiburg)
  • Prizes: Piret Kleis won the best poster prize at the European Neuroscience Conference by Doctoral Students (ENCODS) 2021
  • Recent publication of our group: Freiman TM*, Häussler U*, Zentner J, Dooskamp S, Beck J, Scheiwe C; Brandt A, Haas CA, Puhahn-Schmeiser B (2021) Hippocampal mossy fiber sprouting into CA2 in temporal lobe epilepsy. Hippocampus 31:580-592. * equal contribution, doi:10.1002/hipo.23323. (access to article)

Main research goals

Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.

The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:

  1. Analysis of human epileptic brain tissue resected for therapeutic purpose,
  2. In vivo disease modeling with mouse MTLE models,
  3. In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.  

We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.

 

Responsible for the Experimental Epilepsy Research's website:
Enya Paschen (e-mail to Webmaster)

 

Updated: June 2021


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