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Experimental Epilepsy ResearchDepartment of Neurosurgery

Experimental Epilepsy Research

Department of Neurosurgery

Head

Prof. Dr. Carola Haas e-mail

University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.

Latest news

  • eLife podcast featuring Prof. Dr. Carola Haas on our recent research paper: Janz et al (2017) Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy.
  • Alfred-Hauptmann-Award for epilepsy research 2017: was bestowed on Prof. Dr. Carola Haas
     Joined award of the german and austrian societies for epileptology and the swiss epilepsy league
  • Latest publication of our group:   Gremmelspacher T, Gerlach J, Hubbe A, Haas CA, Häussler U (2017) Neurogenic processes induced by very short periods of voluntary wheel-running in male mice. Front. Neurosci. 11:385. doi: 10.3389/fnins.2017.00385 (access to article)

Main research goals

Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.

The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:

1) Analysis of human epileptic brain tissue resected for therapeutic purpose,

2) In vivo disease modeling with mouse MTLE models,

3) In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.  

We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.

 

Responsible for the Experimental Epilepsy Research's website:
Susanne Tulke (e-mail to Webmaster)

 

Updated: November 2017


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