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Experimental Epilepsy Research

Department of Neurosurgery

Group outing 2020

Head

Prof. Dr. Carola Haas e-mail

University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.

Latest news

We congratulate on the latest publications: 

Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an “all-or-nothing” communication switch between the spine head and dendrite.

Rosado J, Bui VD, Haas CA, Beck J, Queisser G, Vlachos A

PLOS Computational Biology 18(4): e1010069 access to article

 

Comprehensive multiomic profiling of somatic mutations in malformations of cortical development.

Chung C, Yang X, Bae T, Vong K, Mittal S, Donkels C, Phillips HW, Marsh APL, Breuss MW, Ball LL, Araújo Bernardino Garcia C, George RD, Gu J, Xu M, Barrows C, James KN, Stanley V, Nidhiry A, Khoury S, Howe G, Riley E, Xu X, Copeland B, Wang Y, Kim SH Kang H-C, Schulze-Bonhage A, Haas CA, Urbach H, Prinz M, Gardner C, Gurnett CA, Sattar S, Nespeca M,. Gonda DD, Imai K, Takahashi Y, Chen R, Tsai J-W, Conti V, Guerrini R, Devinsky O, Silva Jr WA,. Machado HR, Mathern G, Abyzov A, Baldassari S, Boulac S, Focal Cortical Dysplasia Neurogenetics Consortium & Brain Somatic Mosaicism Network, Gleeson JG (2022)

BioRxiv 2022.04.07.487401 (2022) access to article

Main research goals

Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.

The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:

  1. Analysis of human epileptic brain tissue resected for therapeutic purpose,
  2. In vivo disease modeling with mouse MTLE models,
  3. In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.  

We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.

 

Responsible for the Experimental Epilepsy Research's website:
Enya Paschen (e-mail to Webmaster)

 

Updated: May 2022


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