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Experimental Epilepsy Research

Department of Neurosurgery

Group outing 2020

Head

Prof. Dr. Carola Haas e-mail

University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.

Latest news

We congratulate: 

Piret Kleis, who received the ILAE Neurobiology Commission Travel Bursary for SfN 2022

Catharina Donkels, who was accepted for the EIRA mentoring programme from the Faculty of Medicine in Freiburg

 

We congratulate on the latest publication:

Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development 

Changuk Chung, Xiaoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil Mittal, Catharina Donkels, H. Westley Phillips, Ashley P. L. Marsh, Martin W. Breuss, Laurel L. Ball, Camila Araújo Bernardino Garcia, Renee D. George, Jing Gu, Mingchu Xu, Chelsea Barrows, Kiely N. James, Valentina Stanley, Anna Nidhiry, Sami Khoury, Gabrielle Howe, Emily Riley, Xin Xu, Brett Copeland, Yifan Wang, Se Hoon Kim, Hoon-Chul Kang, Andreas Schulze-Bonhage, Carola A. Haas, Horst Urbach, Marco Prinz, Corrine Gardner, Christina A. Gurnett, Shifteh Sattar, Mark Nespeca, David D. Gonda, Katsumi Imai, Yukitoshi Takahashi, Robert Chen, Jin-Wu Tsai, Valerio Conti, Renzo Guerrini, Orrin Devinsky, Wilson A. Silva Jr, Helio R. Machado, Gary W. Mathern, Alexej Abyzov, Sara Baldassari, Stéphanie Baulac, Focal Cortical Dysplasia Neurogenetics Consortium, Brain Somatic Mosaicism Network, Joseph G. Gleeson

bioRxiv 2022.04.07.487401 (2022) https://doi.org/10.1101/2022.04.07.487401

 

Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy

Julia Franz, Nicole Barheier, Susanne Tulke, Carola A. Haas, Ute Häussler

bioRxiv 2022.06.02.494518 (2022) https://doi.org/10.1101/2022.06.02.494518

 

Main research goals

Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.

The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:

  1. Analysis of human epileptic brain tissue resected for therapeutic purpose,
  2. In vivo disease modeling with mouse MTLE models,
  3. In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.  

We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.

 

Responsible for the Experimental Epilepsy Research's website:
Enya Paschen (e-mail to Webmaster)

 

Updated: May 2022


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