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Experimental Epilepsy ResearchDepartment of Neurosurgery

Experimental Epilepsy Research

Department of Neurosurgery

Group Retreat 2016

Head

Prof. Dr. Carola Haas e-mail

University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.

Latest news

  • Symposium 55. Jahretagung der Deutschen Gesellschaft für Epileptologie. September, 6.-9. 2020, Freiburg im Breisgau. Brain stimulation as a treatment option in epilepsy: Results from human patients and animal models
  • DFG funding for the project: Identification of functional network nodes in temporal lobe epilepsy. January 2020. Prof Dr. Carola Haas (Experimental Epilepsy Research, Dept. of Neurosurgery, Medical Center - University of Freiburg) and Prof. Dr. Dominik von Elverfeldt (Medical Physics, Dept. of Radiology, Medical Center - University of Freiburg)
  • New preprint of our group: Paschen E, Elgueta C, Heining K, Vieira D, Orcinha C, Häussler U, Bartos M, Egert U, Janz P*, Haas CA*(2020) Optogenetic low-frequency stimulation of dentate granule cells prevents seizure generation in experimental epilepsy. BioRxiv, doi.org/10.1101/2020.01.09.900084. (access to article)
  • Latest publication of our group: Göbel-Guéniot K*, Gerlach J*, Kamberger R, Leupold J, von Elverfeldt D, Hennig J, Korvink JG, Haas CA*, LeVan P* (2020) Histological correlates of diffusion-weighted magnetic resonance microscopy in a mouse model of mesial temporal lobe epilepsy. Front. Neurosci. 14: 543. Brain Imaging Methods; Research Topic Advanced Imaging Methods in Neuroscience. *equal contribution. doi: 10.3389/fnins.2020.00543. (access to article)

Main research goals

Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.

The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:

1) Analysis of human epileptic brain tissue resected for therapeutic purpose,

2) In vivo disease modeling with mouse MTLE models,

3) In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.  

We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.

 

Responsible for the Experimental Epilepsy Research's website:
Susanne Tulke (e-mail to Webmaster)

 

Updated: March 2020


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