Experimental Epilepsy Research
Department of Neurosurgery
Group outing 2020
Head
Prof. Dr. Carola Haas e-mail
University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.
Latest news
Enya Paschen has successfully defended her PhD thesis with the title:
"Physiological and behavioral implications of neuromodulation in experimental epilepsy"
Nicole Gutmann received a Doctoral scholarship from the Studienstiftung des deutschen Volkes for the project:
"Changes in intrinsic properties and network integration of neuronal subpopulations in the subiculum in mesial temporal lobe epilepsy"
Latest publications:
Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI
Schwaderlapp N, Paschen E, LeVan P, von Elverfeldt D, Haas CA
Preprint available: bioRxiv (2023) https://doi.org/10.1101/2023.09.07.556678
On-demand low-frequency stimulation for seizure control: efficacy and behavioural implications
Paschen E, Kleis P, Vieira DM, Heining K, Boehler C, Egert U, Häussler U, Haas CA
Brain (2023) https://doi.org/10.1093/brain/awad299
3D X-ray Histology for the Investigation of Temporal Lobe Epilepsy in a Mouse Model
Rodgers G, Bikis C, Janz P, Tanner C, Schulz G, Thalmann P, Haas CA, Bert Müller B
Microscopy and Microanalysis (2023) https://doi.org/10.1093/micmic/ozad082
Main research goals
Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.
The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:
- Analysis of human epileptic brain tissue resected for therapeutic purpose,
- In vivo disease modeling with mouse MTLE models,
- In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.
We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.
