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Experimental Epilepsy ResearchDepartment of Neurosurgery

Experimental Epilepsy Research

Department of Neurosurgery

Group outing 2020


Prof. Dr. Carola Haas e-mail

University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.

Latest news

  • Press release on our latest publication by Paschen et al., 2020: "Tiefe Hirnstimulation verhindert im Mausmodell epileptische Anfälle" (article in german)
  • Symposium at 14th Göttingen Meeting of the German Neuroscience Society: March 2021. Genetic and environmental factors shaping neuronal network defects and cognitive impairment. Organized by: Häussler, Ute (Freiburg); Sauer, Jonas-Frederic (Freiburg)
    Speakers: Fisher, Elizabeth (London, UK); Hanganu-Opatz, Ileana (Hamburg); Schulz, Jan (Basel, Switzerland); Sigurdsson, Torfi (Frankfurt/M.)
  • Symposium 55. Jahretagung der Deutschen Gesellschaft für Epileptologie. September, 6.-9. 2020, Freiburg im Breisgau. Brain stimulation as a treatment option in epilepsy: Results from human patients and animal models
  • DFG funding for the project: Identification of functional network nodes in temporal lobe epilepsy. January 2020. Prof Dr. Carola Haas (Experimental Epilepsy Research, Dept. of Neurosurgery, Medical Center - University of Freiburg) and Prof. Dr. Dominik von Elverfeldt (Medical Physics, Dept. of Radiology, Medical Center - University of Freiburg)
  • Latest publication of our group: Paschen E, Elgueta C, Heining K, Vieira D, Kleis P, Orcinha C, Häussler U, Bartos M, Egert U, Janz P, Haas CA (2020) Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy. eLife 9:e54518. doi: 10.7554/eLife.54518.

Main research goals

Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.

The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:

  1. Analysis of human epileptic brain tissue resected for therapeutic purpose,
  2. In vivo disease modeling with mouse MTLE models,
  3. In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.  

We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.


Responsible for the Experimental Epilepsy Research's website:
Susanne Tulke (e-mail to Webmaster)


Updated: March 2021

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