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Experimental Epilepsy Research

Department of Neurosurgery

Group outing 2023


Prof. Dr. Carola Haas e-mail

University Medical Center Freiburg
Neurocenter - Department of Neurosurgery
Exp. Epilepsy Research
Breisacher Strasse 64
D-79106 Freiburg i. Brsg.

Latest news

Enya Paschen has successfully defended her PhD thesis with the title:

"Physiological and behavioral implications of neuromodulation in experimental epilepsy"


Latest publications:

Low frequency stimulation for seizure suppression: identification of optimal targets in the entorhinal-hippocampal circuit

Kleis P, Paschen E, Häussler U, Haas CA

Brain Stimulation (2024) https://doi.org/10.1016/j.brs.2024.03.017


Focal cortical dysplasia type II-dependent maladaptive myelination in the human frontal lobe

Donkels D, Huber S, Demerath T, Scheiwe C, Shah MJ, Heers M, Urbach H, Schulze-Bonhage A, Prinz M, Häussler U, Vlachos A, Beck J, Nakagawa JM, Haas CA

Preprint available: bioRxiv (2024) https://doi.org/10.1101/2024.03.02.582894


On-demand low-frequency stimulation for seizure control: efficacy and behavioural implications

Paschen E, Kleis P, Vieira DM, Heining K, Boehler C, Egert U, Häussler U, Haas CA

Brain (2024) https://doi.org/10.1093/brain/awad299


Main research goals

Epilepsy is a brain disease defined as repeated seizures reflecting recurrent, abnormal, and hypersynchronous neuronal discharges. Epilepsy affects 0.5-1% world population, i.e. 50 million people worldwide. In many cases seizures can be controlled by medication though epilepsy cannot be cured yet. However 30% patients with epilepsy suffer seizures that are resistant to pharmacological treatment. In particular focal epilepsies such as mesial temporal lobe epilepsy (MTLE) are often drug resistant. In these cases neurosurgery currently remains the more reliable treatment to control seizures.

The Experimental Epilepsy Research laboratory aims at a better understanding of focal epilepsies with the perspective of developing new tools for treatment and/or intervention. To this end we follow a three-pillar approach involving:

  1. Analysis of human epileptic brain tissue resected for therapeutic purpose,
  2. In vivo disease modeling with mouse MTLE models,
  3. In vitro studies (organotypic hippocampal slice cultures) offering easy accessibility and pharmacological manipulation.  

We use a plethora of molecular, biochemical, electrophysiological and behavioral techniques to investigate the role of correct lamination, synaptic reorganization, neuronal loss and generation of new neurons in the epileptic brain.


Responsible for the Experimental Epilepsy Research's website:
Nicole Gutmann (E-Mail)


Updated: Dec 2023

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