Programme
Wednesday, 21 September 2022
| 16:00 – 17:00 | Registration | |
| Keynote Lectures and Festive Opening Chair: Ursula Ravens | ||
| 17:00 – 17:15 | Welcome addresses by: Peter Kohl | |
| 17:15 – 18:00 | Leslie Leinwand | Myosin modulation as a treatment for a deadly disease |
| 18:00 – 18:45 | Michael Sheetz | Appreciating force and shape: the rise of mechanotransduction in cell biology |
| 18:45 – 19:00 | Wrap-up | |
| 19:00 – 21:00 | Reception Prometheus Hall | |
Thursday, 22 September 2022
| 09:00 | Registration | |
| 09:15 – 09:30 | Rémi Peyronnet | MEC2022 |
Session 1: Ion Channels From Endomembranes to Sarco- / Plasma-lemma | ||
| 09:30 – 10:00 | Kristi Anseth | Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts |
| 10:00 – 10:30 | Tatjana Kleele | Mitochondrial membrane tension governs fission |
| 10:30 – 11:00 | Bailong Xiao | The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
| 11:00 – 11:30 | Tea (posters on display) | |
| 11:30 – 12:00 | Bo Bentzen | SK channels and stretch-induced vulnerability to AF |
| 12:00 – 12:30 | Timothy Domeier | TRPV4 and stretch-induced dysfunction in the aged heart |
| 12:30 – 13:00 | Aurore Lyon | Differentiating the effects of b-adrenergic stimulation and stretch on Ca2+ and force dynamics using a novel electromechanical cardiomyocyte model |
| 13:00 – 14:30 | Lunch (posters on display) | |
Session 2: Scaffolding MEC: Cytoskeleton and Nanodomains | ||
| 14:30 – 15:00 | Eva Rog-Zielinska | Time-resolved 3D EM to investigate mechanics of T-tub content mixing |
| 15:00 – 15:30 | Long-Sheng Song | Junctophilin-2 couples cardiac mechanical information with transcriptional reprogramming |
| 15:30 – 16:00 | Alexey Glukhov | Caveolae-mediated activation of mechanosensitive chloride channels in pulmonary veins triggers atrial arrhythmogenesis |
| 16:00 – 16:30 | Tea (posters on display) | |
| 16:30 – 17:00 | Alexander Quinn | Microtubules and TRPA1 in stretch-induced arrhythmias |
| 17:00 – 17:30 | Two slots for selected talks (à 10+5 min) | |
| 17:30 – 19:30 | Posters with refreshments, and nibbles, and more… | |
Friday, 23 September 2022
| Session 3: ECM and Mechano-Regulation Chair: TBC | ||
| 09:00 – 09:30 | Boris Hinz | Mechanical regulation of myofibroblast phenoconversion and collagen contraction |
| 09:30 – 10:00 | Michele Orini | Direct in-vivo assessment of global and regional mechano-electric feedback in the intact human heart |
| 10:00 – 10:30 | Pinar Zorlutuna | Mechanotransduction at the cardiomyocyte-fibroblast interface |
| 10:30 – 11:00 | Coffee (posters on display) | |
| 11:00 – 11:30 | Rémi Peyronnet | Piezo and matrix stiffness sensing |
| 11:30 – 12:00 | Neil Turner | Channeling the force to reprogram the matrix |
| 12:00 – 13:30 | Lunch (posters on display) | |
| Session 4: Tissue MEC: From the Roots to Computational Modelling Chair: Viviane Timmermann | ||
| 13:30 – 14:00 | Andreu Climent | Ranolazine-mediated attenuation of mechanoelectric feedback in atrial myocyte monolayers |
| 14:00 – 14:30 | Adam Feinberg | Mechanics of engineered heart tissue |
| 14:30 – 15:00 | Elisabetta Cerbai | At the roots of atrial myopathy and arrhythmias: interplay between atrial dilation and genetic factors |
| 15:00 – 15:30 | Tea (posters on display) | |
| 15:30 – 16:00 | Sandeep Pandit | Mechanisms by which ranolazine terminates paroxysmal but not persistent atrial fibrillation |
| 16:00 – 16:30 | David Filgueiras-Rama | Atrial remodelling characterization during atrial fibrillation progression |
| 16:30 – 17:00 | Two slots for selected talks (à 10+5 min) | |
Saturday, 24 September 2022
| Session 5: Tissue MEC Reloaded: new Tools, Technologies, and Theories Chair: Patrick Boyle | ||
| 09:00 – 09:30 | Vadim Fedorov | Distinct fibrotic signatures of human sinoatrial node in non-failing and failing hearts |
| 09:30 – 10:00 | Aurelien Forget | Mechanically defined microenvironment promotes stabilization of microvasculature: novel Piezo-1+monocyte Population |
| 10:00 – 10:30 | Kory Lavine | Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling |
| 10:30 – 11:00 | Coffee (posters on display) | |
| 11:00 – 11:30 | Daniel Beard | Mechano-energetics |
| 11:30 – 12:00 | Natalia Trayanova | Machine learning in arrhythmia and electrophysiology |
| 12:00 – 13:00 | Lunch (posters on display) | |
| Session 6: Cool tools Chair: Ye Chen-Izu | ||
| 13:00 – 13:30 | Boris Martinac | High-throughput measurements of the viscoelastic properties of cells |
| 13:30 – 14:00 | Cesare Terracciano | Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro: the slice model |
| 14:00 – 14:30 | Juliane Münch | Sensing and responding of cardiomyocytes to changes of tissue stiffness |
| 14:30 – 15:00 | Tea (posters on display) | |
| Closing Session Chair: Peter Kohl | ||
| 15:00 – 15:15 | Leslie Leinwand | What we’ve learned and what should we focus on next in terms of mechanisms |
| 15:15 – 15:30 | Michael Sheetz | What we’ve learned and what should we focus on next in terms of clinical relevance |
| 15:30 – 16:00 | Discussion, Participant feedback | |
| 17:30 – 00:00 | Meeting Dinner and Dance | |
| 17:30 – 18:00 | Reception | |