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Programme

Wednesday, 21 September 2022

 
16:00 – 17:00 Registration
Keynote Lectures and Festive Opening
Chair: Ursula Ravens
17:00 – 17:15 Welcome addresses by: Peter Kohl
17:15 – 18:00 Leslie Leinwand Myosin modulation as a treatment for a deadly disease
18:00 – 18:45 Michael Sheetz Appreciating force and shape: the rise of mechanotransduction in cell biology
18:45 – 19:00 Wrap-up
19:00 – 21:00 Reception Prometheus Hall

Thursday, 22 September 2022

                                      
09:00 Registration
09:15 –  09:30 Rémi Peyronnet MEC2022

Session 1: Ion Channels From Endomembranes to Sarco- / Plasma-lemma
Chair: Thomas Eschenhagen

09:30 – 10:00 Kristi Anseth Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
10:00 – 10:30 Tatjana Kleele Mitochondrial membrane tension governs fission
10:30 – 11:00 Bailong Xiao The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
11:00 – 11:30 Tea (posters on display)
11:30 – 12:00 Bo Bentzen SK channels and stretch-induced vulnerability to AF
12:00 – 12:30 Timothy Domeier TRPV4 and stretch-induced dysfunction in the aged heart
12:30 – 13:00 Aurore Lyon Differentiating the effects of b-adrenergic stimulation and stretch on Ca2+ and force dynamics using a novel electromechanical cardiomyocyte model
13:00 – 14:30 Lunch (posters on display)

Session 2: Scaffolding MEC: Cytoskeleton and Nanodomains
Chair: TBC

14:30 – 15:00 Eva Rog-Zielinska Time-resolved 3D EM to investigate mechanics of T-tub content mixing
15:00 – 15:30 Long-Sheng Song Junctophilin-2 couples cardiac mechanical information with transcriptional reprogramming
15:30 – 16:00 Alexey Glukhov Caveolae-mediated activation of mechanosensitive chloride channels in pulmonary veins triggers atrial arrhythmogenesis
16:00 – 16:30 Tea (posters on display)
16:30 – 17:00 Alexander Quinn Microtubules and TRPA1 in stretch-induced arrhythmias
17:00 – 17:30 Two slots for selected talks (à 10+5 min)
17:30 – 19:30 Posters with refreshments, and nibbles, and more…

Friday, 23 September 2022

 
Session 3: ECM and Mechano-Regulation
Chair: TBC
09:00 – 09:30 Boris Hinz Mechanical regulation of myofibroblast phenoconversion and collagen contraction
09:30 – 10:00 Michele Orini Direct in-vivo assessment of global and regional mechano-electric feedback in the intact human heart
10:00 – 10:30 Pinar Zorlutuna Mechanotransduction at the cardiomyocyte-fibroblast interface
10:30 – 11:00 Coffee (posters on display)
11:00 – 11:30 Rémi Peyronnet Piezo and matrix stiffness sensing
11:30 – 12:00 Neil Turner Channeling the force to reprogram the matrix
12:00 – 13:30 Lunch (posters on display)
Session 4: Tissue MEC: From the Roots to Computational Modelling
Chair: Viviane Timmermann
13:30 – 14:00 Andreu Climent Ranolazine-mediated attenuation of mechanoelectric feedback in atrial myocyte monolayers
14:00 – 14:30 Adam Feinberg Mechanics of engineered heart tissue
14:30 – 15:00 Elisabetta Cerbai At the roots of atrial myopathy and arrhythmias: interplay between atrial dilation and genetic factors
15:00 – 15:30 Tea (posters on display)
15:30 – 16:00 Sandeep Pandit Mechanisms by which ranolazine terminates paroxysmal but not persistent atrial fibrillation
16:00 – 16:30 David Filgueiras-Rama Atrial remodelling characterization during atrial fibrillation progression
16:30 – 17:00 Two slots for selected talks (à 10+5 min)
                               

Saturday, 24 September 2022

 
Session 5: Tissue MEC Reloaded: new Tools, Technologies, and Theories
Chair: Patrick Boyle
09:00 – 09:30 Vadim Fedorov Distinct fibrotic signatures of human sinoatrial node in non-failing and failing hearts
09:30 – 10:00 Aurelien Forget Mechanically defined microenvironment promotes stabilization of microvasculature: novel Piezo-1+monocyte Population
10:00 – 10:30 Kory Lavine Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling
10:30 – 11:00 Coffee (posters on display)
11:00 – 11:30 Daniel Beard Mechano-energetics
11:30 – 12:00 Natalia Trayanova Machine learning in arrhythmia and electrophysiology
12:00 – 13:00 Lunch (posters on display)
Session 6: Cool tools
Chair: Ye Chen-Izu
13:00 – 13:30 Boris Martinac High-throughput measurements of the viscoelastic properties of cells
13:30 – 14:00 Cesare Terracciano Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro: the slice model
14:00 – 14:30 Juliane Münch Sensing and responding of cardiomyocytes to changes of tissue stiffness
14:30 – 15:00 Tea (posters on display)
Closing Session
Chair: Peter Kohl
15:00 – 15:15 Leslie Leinwand What we’ve learned and what should we focus on next in terms of mechanisms
15:15 – 15:30 Michael Sheetz What we’ve learned and what should we focus on next in terms of clinical relevance
15:30 – 16:00 Discussion, Participant feedback
17:30 – 00:00 Meeting Dinner and Dance
17:30 – 18:00     Reception