Programme
Wednesday, 21 September 2022
| 16:00 – 17:00 | Registration | |
| Keynote Lectures and Festive Opening Chair: Ursula Ravens | ||
| 17:00 – 17:15 | Welcome addresses by: Peter Kohl | |
| 17:15 – 18:00 | Leslie Leinwand | Myosin modulation as a treatment for a deadly disease |
| 18:00 – 18:45 | Michael Sheetz | Appreciating force and shape: the rise of mechanotransduction in cell biology |
| 18:45 – 19:00 | Wrap-up | |
| 19:00 – 21:00 | Reception Prometheus Hall | |
Thursday, 22 September 2022
| 09:00 | Registration | |
| 09:15 – 09:30 | Rémi Peyronnet | MEC2022 |
Session 1: Ion Channels From Endomembranes to Sarco- / Plasma-lemma | ||
| 09:30 – 10:00 | Kristi Anseth | Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts |
| 10:00 – 10:30 | Bailong Xiao | The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
| 10:30 – 11:00 | Alexander Quinn | Microtubules and TRPA1 in stretch-induced arrhythmias |
| 11:00 – 11:30 | Tea (posters on display) | |
| 11:30 – 12:00 | Timothy Domeier | TRPV4 and stretch-induced dysfunction in the aged heart |
| 12:00 – 12:30 | Bo Hjorth Bentzen | SK channels and stretch-induced vulnerability to AF |
| 12:30 – 13:00 | Aurore Lyon | Stretch-activated channels and calcium-contraction coupling: insights from computer modelling |
| 13:00 – 14:30 | Lunch (posters on display) | |
Session 2: Scaffolding MEC: Cytoskeleton and Nanodomains | ||
| 14:30 – 15:00 | Eva Rog-Zielinska | Time-resolved 3D EM to investigate mechanics of T-tub content mixing |
| 15:00 – 15:30 | Long-Sheng Song | Junctophilin-2 couples cardiac mechanical information with transcriptional reprogramming |
| 15:30 – 16:00 | Alexey Glukhov | Caveolae-mediated activation of mechanosensitive chloride channels in pulmonary veins triggers atrial arrhythmogenesis |
| 16:00 – 16:30 | Tea (posters on display) | |
| Session 3: MEC-induced Arrhythmias Chair: Lutz Hein | ||
| 16:30 – 17:00 | Peter Kohl | Commotio cordis: a fresh look |
| 17:00 – 17:15 | Bo Han (Poster 06) | Sustainability of cardiac pacing by mechanical stimulation in the Langendorff-perfused rabbit heart |
| 17:15 – 17:30 | Melania Buonocunto (Poster 52) | Understanding the contribution of stretch-activated ion channels to cardiac arrhythmogenesis using computational modelling |
| 17:30 – 18:00 | Sian Harding | 55 years of 'Mechano-Electrical Feedback' - Laudatio on a pioneer in this field: Ursula Ravens |
| Poster Session | ||
| 18:00 – 20:00 | Posters with refreshments, and nibbles, and more… | |
Friday, 23 September 2022
| Session 4: ECM and Mechano-Regulation Chair: Kate Herum | ||
| 09:00 – 09:30 | Boris Hinz | Mechanical regulation of myofibroblast phenoconversion and collagen contraction |
| 09:30 – 10:00 | Michele Orini | Direct in-vivo assessment of global and regional mechano-electric feedback in the intact human heart |
| 10:00 – 10:30 | Pinar Zorlutuna | Mechanotransduction at the cardiomyocyte-fibroblast interface |
| 10:30 – 11:00 | Coffee (posters on display) | |
| 11:00 – 11:30 | Rémi Peyronnet | Piezo and matrix stiffness sensing |
| 11:30 – 12:00 | Neil Turner | Channeling the force to reprogram the matrix |
| 12:00 – 13:30 | Lunch (posters on display) | |
| Session 5: Tissue MEC: From the Roots to Computational Modelling Chair: Viviane Timmermann | ||
| 13:30 – 14:00 | Adam Feinberg | Mechanics of engineered heart tissue |
| 14:00 – 14:30 | Elisabetta Cerbai | At the roots of atrial myopathy and arrhythmias: interplay between atrial dilation and genetic factors |
| 14:30 – 15:00 | Sandeep Pandit | Mechanisms by which ranolazine terminates paroxysmal but not persistent atrial fibrillation |
| 15:00 – 15:30 | Tea (posters on display) | |
| 15:30 – 16:00 | David Filgueiras-Rama | Atrial remodelling characterization during atrial fibrillation progression |
| 16:00 – 16:15 | Eilidh MacDonald (Poster 14) | Targeting Runx1 protects cardiac structure and function |
| 16:15 – 16:30 | Jessi Bak (Poster 22) | Microtubules and TRPA1 drive mechanically-induced arrhythmias in the rabbit heart |
| 16:30 – 16:45 | Leander Stewart (Poster 13) | Genetic deletion of myofibroblast-specific Piezo1 Protects against hypertension-induced cardiac hypertrophy |
| 16:45 – 17:00 | Charles Cox (Poster 12) | Piezo1 is the cardiac mechanosensor that initiates the cardio-myocyte hypertrophic response to pressure overload in mice |
| 17:15 | Meeting Photo | |
Saturday, 24 September 2022
| Session 6: Tissue MEC Reloaded: New Approaches Chair: Eilidh MacDonald | ||
| 09:00 – 09:30 | Vadim Fedorov | Distinct fibrotic signatures of human sinoatrial node in non-failing and failing hearts |
| 09:30 – 10:00 | Aurelien Forget | Tailorable hydrogels for applied mechanobiology |
| 10:00 – 10:30 | Jennifer Davis | Mechanisms of cardiac stiffness regulations |
| 10:30 – 11:00 | Coffee (posters on display) | |
| 11:00 – 11:30 | Daniel Beard | Multi-scale systems analysis of metabolic and mechanical determinants of reserve cardiac power output |
| 11:30 – 12:00 | Natalia Trayanova | Artificial intelligence in arrhythmia and electrophysiology |
| 12:00 – 13:00 | Lunch (posters on display) | |
| Session 6: Cool tools Chair: Leonardo Sacconi | ||
| 13:00 – 13:30 | Boris Martinac | High-throughput measurements of the viscoelastic properties of cells |
| 13:30 – 14:00 | Andrew McCulloch | New tools for cell electrophysiology and clinical arrhythmia mapping |
| 14:00 – 14:30 | Juliane Münch | Sensing and responding of cardiomyocytes to changes of tissue stiffness |
| 14:30 – 15:00 | Tea (posters on display) | |
| Closing Session Chair: Peter Kohl | ||
| 15:00 – 15:15 | Michael Sheetz | What we’ve learned and what we should focus on next in terms of MEC mechanisms |
| 15:15 – 15:30 | Natalia Trayanova | What we’ve learned and what we should focus on next in terms of MEC clinical relevance |
| 15:30 – 16:00 | Discussion, Participant Feedback | |
| 17:30 – 00:00 | Meeting Dinner and Dance | |