Publications

2026

Noma, Hisashi; Evrenoglou, Theodoros; Maruo, Kazushi (2026): Bootstrap Calibration of Likelihood‐Ratio Inference for the Hypergeometric–Normal Random‐Effects Model in Rare‐Event Meta‐Analysis. Statistics in Medicine 45(23-24). https://doi.org/10.1002/sim.70776
Tahmasebi, Noosheen R.; Davies, Annabel L.; Papakonstantinou, Theodoros; Rücker, Gerta; Nikolakopoulou, Adriani (2026): A path‐based approach for detecting and assessing inconsistency in network meta‐analysis. Statistics in medicine 45(23-24):e70752. https://doi.org/10.1002/sim.70752
Pathirana, Dilan; Bergmann, Frank T.; Doresic, Domagoj; Lakrisenko, Polina; Persson, Sebastian; Neubrand, Niklas Felix; Timmer, Jens; Kreutz, Clemens; Binder, Harald; Cvijovic, Marija; Weindl, Daniel; Hasenauer, Jan (2026): PEtab Select: Specification standard and supporting software for automated model selection. PLOS Computational Biology 22(9):e1014774. https://doi.org/10.1371/journal.pcbi.1014774
Farhadyar, Kiana; Hackenberg, Maren; Ahrens, Kira; Schenk, Charlotte; Kollmann, Bianca; Tüscher, Oliver; Lieb, Klaus; Plichta, Michael M.; Reif, Andreas; Kalisch, Raffael; Wolkewitz, Martin; Hess, Moritz ; Binder, Harald (2026): A statistical perspective on transformers for small longitudinal cohort data. Statistics in medicine 45(23-24):e70744. https://doi.org/10.1002/sim.70744
Watter, Manuel; Engel, Felix; Kalantari, Aref; Giuliani, Claudia; Schuller, Karin; Franzke, Claus-Werner; Sperandio, Markus; Binder, Harald; Kaier, Klaus (2026): Accelerating metadata annotation in collaborative research centers: A hybrid AI workflow for biomedical entities. Bioinformatics advances 6(1):vbag283. https://doi.org/10.1093/bioadv/vbag283
Faraza, Sofia; Dyrba, Martin; Wolf, Dominik; Fischer, Florian U.; Knaepen, Kristel; Riedel, David; Kollmann, Bianca; Binder, Harald; Mierau, Andreas; Fellgiebel, Andreas; Tüscher, Oliver; Teipel, Stefan J. (2026): Resting state brain activity and association with transfer of cognitive training gains. NeuroImage : reports 6(3):100389. https://doi.org/10.1016/j.ynirp.2026.100389
Kiesswetter, Eva; Gorenflo, Lea; Schwarzer, Guido; Stadelmaier, Julia; Wallerer, Sabina; Marjanovic, Goran; Fink, Jodok Matthias; Lehane, Cornelius; Metzendorf, Maria-Inti; Meerpohl, Jörg J.; Schwingshackl, Lukas; Cochrane Central Editorial Service, [Study Group] (2026): Metabolic and bariatric surgery in adults with obesity and diabetes mellitus: a network meta-analysis. Cochrane library 2026(8):CD015622. https://doi.org/10.1002/14651858.cd015622.pub2
Kaufmann, Masako M.; Hackenberg, Maren; Henzler, William; Backofen, Rolf; Binder, Harald; Cathomen, Toni (2026): Systematic benchmarking of CRISPR-Cas9 off-target prediction tools reveals limitations and implications for preclinical assessment. Human gene therapy. https://doi.org/10.1177/10430342261466407
Schächter, Clemens; Hackenberg, Maren; Pfaffenlehner, Michelle; Tambe Ndonfack, Félix B.; Schmidt, Thorsten; Pechmann, Astrid; Kirschner, Janbernd; Hasenauer, Jan; Binder, Harald (2026): Using latent representations to link disjoint longitudinal data for mixed‐effects regression. Statistics in medicine 45(18-19):e70701. https://doi.org/10.1002/sim.70701
Thiébaut, Anne C. M.; Perperoglou, Aris; Sedki, Mohammed; Ferreira Guerra, Steve; Gustafson, Paul; Harrell, Frank E.; Sauerbrei, Willi; Abrahamowicz, Michal; Freedman, Laurence S. (2026): Methods for adjusting for covariate measurement error in flexible modeling of functional form: designing a blinded, controlled neutral comparison simulation study. Biometrical Journal 68(4):e70155. https://doi.org/10.1002/bimj.70155
Pfaffenlehner, Michelle; Dreßing, Andrea; Knoerzer, Dietrich; Wagner, Markus; Heuschmann, Peter U.; Scherag, André; Binder, Harald; EVA4MII project, [Study Group]; Binder, Nadine (2026): A stakeholder-inclusive conceptual framework for modeling routinely collected health data for therapeutic decision-making illustrated by means of multistate models. BMC medical research methodology 26(1):157. https://doi.org/10.1186/s12874-026-02946-6
Yilmaz, Tayfun; Schwarzer, Guido; Fuchs, Andreas; Siegel, Markus; Mühlenfeld, Nils Malte; Wagner, F. C.; Schmal, Hagen; Izadpanah, K.; Frodl, A. (2026): MRI-guided detection of knee injuries as a concomitant lesion of femoral shaft fractures: a systematic review and meta-analysis. EFORT open reviews 11(7):859-867. https://doi.org/10.1530/eor-2025-0184
Engel, Felix; Giuliani, Claudia; Watter, Manuel; Kalantari, Aref; Schuller, Karin; Binder, Harald; Kaier, Klaus (2026): From manual entry to machine precision : challenges and evolution of metadata schema development in collaborative research centers. BMC Research Notes 19(1):277. https://doi.org/10.1186/s13104-026-07937-w
Lang, Tina; Konietschke, Frank; Rahnenführer, Jörg; Kubiak, René; Brendel, Michael; Binder, Harald; Igl, Bernd‐Wolfgang (2026): Ensuring quality in preclinical research: the importance of being human. Biometrical journal 68(4):e70145. https://doi.org/10.1002/bimj.70145
Evrenoglou, Theodoros; Nikolakopoulou, Adriani; Schwarzer, Guido; Rücker, Gerta; Chaimani, Anna (2026): Producing treatment hierarchies in network meta-analysis using probabilistic models and treatment-choice criteria. Research synthesis methods 17(4):750-769. https://doi.org/10.1017/rsm.2026.10071
Veroniki, Areti Angeliki; Wolfe, Dianna M.; Hutton, Brian; Schwarzer, Guido; McIsaac, Daniel I.; Straus, Sharon E; Jackson, Dan; Tricco, Andrea C. (2026): Analysing complex interventions using component network meta-analysis. The BMJ 393:e083075. https://doi.org/10.1136/bmj-2024-083075
Sousa-Pinto, Bernardo; Vieira, Rafael José; Gil-Mata, Sara; Pereira, Ana Margarida; Duarte, Vítor Henrique; Bognanni, Antonio; Marques-Cruz, Manuel; Jemioło, Paweł; Giovannini, Mattia; di Bona, Danilo; Agarwal, Arnav; Dykewicz, Mark S.; Shamji, Mohamed H.; Torres, Maria Jose; Zuberbier, Torsten; Klimek, Ludger; Chu, Alexandro W. L.; Schünemann, Holger J.; Schwarzer, Guido; Fonseca, João A.; Bousquet, Jean (2026): Treatment dose increase versus co-medication in allergic rhinitis: systematic review with dose-response network meta‐analysis. Allergy. https://doi.org/10.1111/all.70372
Pfaffenlehner, Michelle; Kesselmeier, Miriam; Günther, Kai; Ungethüm, Kathrin; Rücker, Viktoria; Remo, Flavia; Binder, Harald; Scherag, André; Heuschmann, Peter U.; Binder, Nadine (2026): Evidenzgenerierung und methodische Beratung durch das Projekt "EVAluationsforschung auf der Grundlage von Daten aus der klinischen Routineversorgung für die Medizininformatik-Initiative" (EVA4MII). Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 69(6):698-706. https://doi.org/10.1007/s00103-026-04243-5
Menger, Jonatan; Krissmer, Sonia M.; Kreutz, Clemens; Binder, Harald; Hackenberg, Maren (2026): mmContext : an open framework for multimodal contrastive learning of omics and text data. Bioinformatics 42(6):btag338. https://doi.org/10.1093/bioinformatics/btag338
Butz, Elena; Steinbrenner, Inga; Schultheiss, Ulla T.; Behning, Charlotte; Binder, Harald; Hansmann, Helena; Gronwald, Wolfram; Oefner, Peter J.; Schaeffner, Elke; Eckardt, Kai-Uwe; Köttgen, Anna; Sekula, Peggy (2026): Systematic evaluation of plasma and urine metabolites to predict the risk of adverse kidney-related outcomes in chronic kidney disease: the GCKD study. Kidney medicine 8(7):101409. https://doi.org/10.1016/j.xkme.2026.101409
Koromila, Georgia; Dyrba, Martin; Wolf, Dominik; Fischer, Florian; Knaepen, Kristel; Kollmann, Bianca; Binder, Harald; Mierau, Andreas; Riedel, David; Fellgiebel, Andreas; Tüscher, Oliver; Teipel, Stefan; Faraza, Sofia (2026): Resting-state brain activity and association with physical activity. Frontiers in aging neuroscience 18:1765112. https://doi.org/10.3389/fnagi.2026.1765112
Torbahn, Gabriel; Schoene, Daniel; Galicia Ernst, Isabel; Schwingshackl, Lukas; Rücker, Gerta; Knüttel, Helge; Kemmler, Wolfgang; Sieber, Cornel; Batsis, John A.; Villareal, Dennis T.; Stroebele-Benschop, Nanette; Volkert, Dorothee; Kiesswetter, Eva (2026): Effects of lifestyle interventions in older people with obesity (Effective SLOPE): a systematic review with network meta-analyses. Obesity reviews 27(10):e70123. https://doi.org/10.1111/obr.70123
Kiesswetter, Eva; Schwarzer, Guido; Stadelmaier, Julia; Lohner, Szimonetta; Grummich, Kathrin; Dagnelie, Pieter C.; Beck, Anne Marie; Beelen, Janne; Botella-Carretero, Jose I.; Faxén-Irving, Gerd; Hickson, Mary; Iff, Samuel; Johansen, Antony; Sharma, Yogesh; Sorensen, Janice M.; Kaegi-Braun, Nina; Wunderle, Carla; Bongaerts, Brenda; Meerpohl, Jörg J.; Norman, Kristina; Schuetz, Philipp; Torbahn, Gabriel; Visser, Marjolein; Volkert, Dorothee; Schwingshackl, Lukas (2026): Oral nutritional interventions in hospitalised older people at nutritional risk: a network meta-analysis of individual participant data. Cochrane library 2026(3):CD015468. https://doi.org/10.1002/14651858.cd015468.pub2
Brunn, Niklas; Hackenberg, Maren; Fullio, Camila L.; Vogel, Tanja; Binder, Harald (2026): Sparse dimensionality reduction for analyzing single-cell-resolved interactions. Bioinformatics advances 6(1):vbag047. https://doi.org/10.1093/bioadv/vbag047
Behrens, Max; Stolz, Daiana; Papakonstantinou, Eleni; Nolde, Janis M.; Bellerino, Gabriele; Rohde, Angelika; Hess, Moritz ; Binder, Harald (2026): Contrasting global and patient‐specific regression models via a neural network representation. Biometrical journal 68(2):e70126. https://doi.org/10.1002/bimj.70126
Letzkus, Johannes J.; Sprekeler, Henning; Binder, Harald; Boedecker, Joschka; Diester, Ilka; Elgueta, Claudio; Grosser, Sabine; Haberl, Matthias; Kulik, Akos; Larkum, Matthew E.; Leibold, Christian; Madry, Christian; Monyer, Hannah; Poulet, James F.A.; Sauer, Jonas-Frederic; Schmoranzer, Jan; Schreiber, Susanne; Veit, Julia; Viana da Silva, Silvia; Vlachos, Andreas; Vida, Imre; Geiger, Jörg R. P.; Bartos, Marlene (2026): A population approach to cortical GABAergic interneuron function. Neuron 114(7):1176-1180. https://doi.org/10.1016/j.neuron.2026.01.028
Karakioulaki, Meropi; Yang, Hanning; Hess, Moritz ; Binder, Harald; Eyerich, Kilian; Has, Cristina (2026): Systemic inflammation in recessive dystrophic epidermolysis bullosa: a five-year longitudinal study. British journal of dermatology 195(1):146-157. https://doi.org/10.1093/bjd/ljag082
Farmakis, Ioannis T.; Binder, Harald; Evrenoglou, Theodoros; Schwarzer, Guido; Barco, Stefano (2026): Reperfusion strategies for acute pulmonary embolism: design and rationale of RECONNECT-PE – a living systematic review and meta-analysis. American heart journal 295:107365. https://doi.org/10.1016/j.ahj.2026.107365
Petropoulou, Maria; Rücker, Gerta; Schwarzer, Guido (2026): Network meta-analysis with dose-response relationships. BMC medical research methodology 26(1):17. https://doi.org/10.1186/s12874-025-02754-4
Kaier, Klaus; Engel, Felix; Benadi, Gita; Giuliani, Claudia; Watter, Manuel; Kalantari, Aref; Schuller, Karin; Franzke, Claus-Werner; Sperandio, Markus; Binder, Harald (2026): Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. Bmc research notes 19:43. https://doi.org/10.1186/s13104-026-07632-w
Schoenthaler, Martin; Hempen, Noah; Weymann, Maria; Bargen, Maximilian Ferry von; Glienke, Maximilian; Elsässer, Antonia; Behrens, Max; Binder, Harald; Binder, Nadine (2026): Challenges and solutions in determining urolithiasis caseloads using the digital infrastructure of a clinical data warehouse. PLOS One 21(1):e0341068. https://doi.org/10.1371/journal.pone.0341068
Watter, Manuel; Giuliani, Claudia; Benadi, Gita; Engel, Felix; Binder, Harald; Kaier, Klaus (2026): Automated identification of contextually relevant biomedical entities with grounded LLMs. Scientific reports 16(1):1952. https://doi.org/10.1038/s41598-026-35492-8
Mohr, Katharina; Christodoulou, Konstantinos C.; Barco, Stefano; Valerio, Luca; Neusius, Thomas; Keller, Karsten; Hobohm, Lukas; Vosseler, Markus; Uphaus, Timo; Hahn, Marianne; Klok, Frederikus A.; Binder, Harald; Konstantinides, Stavros; Rognoni, Carla (2026): Impact of catheter-directed thrombolysis on the socio-economic burden of pulmonary embolism in germany: a cost-effectiveness analysis. European heart journal - quality of care and clinical outcomes 12(4):516-525. https://doi.org/10.1093/ehjqcco/qcag003
Bonnet, Hillary; Higgins, Julian P.T.; Chaimani, Anna; Evrenoglou, Theodoros; Ghosn, Lina; Graña, Carolina; Perrodeau, Elodie; Yaacoub, Sally; Rada, Gabriel; Bergman, Hanna; Buckley, Brian; Cogo, Elise; Villanueva, Gemma; Henschke, Nicholas; Assi, Rouba; Riveros, Carolina; Cornish, Rosie; Spiga, Francesca; Minozzi, Silvia; Tovey, David; Ravaud, Philippe; Boutron, Isabelle (2026): Including nonrandomized evidence in living systematic reviews: lessons learned from the COVID-NMA initiative. Journal of clinical epidemiology 190:112071. https://doi.org/10.1016/j.jclinepi.2025.112071
Nedelcu, Andrea; Oerther, Benedict; Benkendorff, Alexander; Dieckbreder, Stephan; Schwarzer, Guido; Agrotis, Georgios; Schoots, Ivo; El Matine, Rami; Eisenblätter, Michel; Sigle, August; Engel, Hannes; Bamberg, Fabian; Benndorf, Matthias (2026): PI-RADS version 2.1 for prostate MRI interpretation: associations of study quality and cancer detection metrics - a systematic review and meta-analysis. American journal of roentgenology 226(2):e2533583. https://doi.org/10.2214/ajr.25.33583
Hackenberg, Maren; Pechmann, Astrid; Kreutz, Clemens; Kirschner, Janbernd; Binder, Harald (2026): A statistical approach to latent dynamic modeling with differential equations. The American statistician 80(1):89-99. https://doi.org/10.1080/00031305.2025.2539999

2025

Engelhardt, Svenja Ursula; Buroh, Sabine; Schwarzer, Guido; Kerschbaumer, Andreas; Braner, Axel; Herber, Mathilde; Machado, Pedro M.; Kiely, Patrick D.W.; Finzel, Stephanie (2025): Clinical and imaging features of haemochromatosis arthropathy : a systematic literature review and meta-analysis to inform the development of EULAR classification criteria. EULAR rheumatology open 1(3):260-268. https://doi.org/10.1016/j.ero.2025.08.005
Siemens, Waldemar; Borenstein, Michael; Evrenoglou, Theodoros; Meerpohl, Jörg J.; Schwarzer, Guido (2025): Beyond prediction intervals in meta-analysis: reporting the expected proportion of comparable studies with clinically relevant benefit or harm. BMC medical research methodology 25(1):275. https://doi.org/10.1186/s12874-025-02733-9
Amdal, Cecilie Delphin; Sauerbrei, Willi; Bjordal, Kristin; Pe, Madeline (2025): SISAQOL-IMI consensus-based guidelines to design, analyse, interpret, and present patient-reported outcomes in cancer clinical trials. The Lancet Oncology 26(12):e683-e693. https://doi.org/10.1016/s1470-2045(25)00520-0
Schächter, Clemens; Hackenberg, Maren; Treppner, Martin; Raum, Hanne; Boedecker, Joschka; Binder, Harald (2025): scSpecies: enhancement of network architecture alignment in comparative single-cell studies. Genome biology 26(1):397. https://doi.org/10.1186/s13059-025-03866-2
Giuliani, Claudia; Benadi, Gita; Engel, Felix; Werner, Jonas; Watter, Manuel; Schwarzer, Guido; Groß, Olaf; Zeiser, Robert; Binder, Harald; Kaier, Klaus (2025): Identifying biomedical entities for datasets in scientific articles: 4-step cache-augmented generation approach using gpt-4o and pubtator 3.0. JMIR formative research 9:v9i3-4e73822. https://doi.org/10.2196/73822
Panagiotopoulou, Kanella; Evrenoglou, Theodoros; Schmid, Christopher H.; Metelli, Silvia; Chaimani, Anna (2025): Meta-analysis models relaxing the random-effects normality assumption: methodological systematic review and simulation study. BMC medical research methodology 25(1):231. https://doi.org/10.1186/s12874-025-02658-3
Dobler, Dennis; Binder, Harald; Boulesteix, Anne-Laure; Igelmann, Jan‐Bernd; Köhler, David; Mansmann, Ulrich; Pauly, Markus; Scherag, André; Schmid, Matthias; Al Tawil, Amani; Weber, Susanne (2025): ChatGPT as a tool for biostatisticians: a tutorial on applications, opportunities, and limitations. Statistics in medicine 44(23-24):e70263. https://doi.org/10.1002/sim.70263
Warth, Rieka von der; Nicolay, Nils H. ; Binder, Harald; Boerries, Melanie; Zöller, Daniela; Grosu, Anca-Liga; Farin-Glattacker, Erik (2025): Exploring feature preferences for a treatment-accompanying app in patients undergoing radiation therapy: cross-sectional study. JMIR cancer 11:v11i5Se68411. https://doi.org/10.2196/68411
Eck, Jonas; Schwarzer, Guido; Frodl, Andreas; Fuchs, Andreas; Yilmaz, Tayfun; Schmal, Hagen; Izadpanah, Kaywan; Siegel, Markus (2025): The dynamic reconstruction of the medial patellofemoral ligament shows good subjective outcomes but high rates of recurrent instability: a systematic review and meta-analysis. EFORT open reviews 10(10):756-762. https://doi.org/10.1530/eor-2024-0179
Karakioulaki, Meropi; Kwarteng, Nana-Adjoa; Nikolakopoulou, Adriani; Yang, Hanning; Hess, Moritz ; Binder, Harald; Eyerich, Kilian; Has, Cristina (2025): Tissue and systemic inflammation in dystrophic epidermolysis bullosa: a systematic review and meta-analysis. Orphanet journal of rare diseases 20(1):479. https://doi.org/10.1186/s13023-025-04034-2
Ullmann, Theresa; Heinze, Georg; Abrahamowicz, Michal; Perperoglou, Aris; Sauerbrei, Willi; Schmid, Matthias; Dunkler, Daniela; Binder, Harald (2025): A systematic categorization of performance measures for estimated non‐linear associations between an outcome and continuous predictors. WIREs Computational Statistics 17(3):e70042. https://doi.org/10.1002/wics.70042
Ortner, Julia; Ewijk, Reyn van; Velthuis, Louis; Labenz, Christian; Arslanow, Anita; Nguyen-Tat, Marc; Wörns, Marcus-Alexander; Reichert, Matthias Christian; Farin-Glattacker, E.; Binder, Harald; Fichtner, Urs Alexander; Graf, Erika; Stelzer, Dominikus; Galle, Peter R.; Lammert, Frank (2025): Evaluating a population-based screening programme for early detection of liver fibrosis and cirrhosis in primary care in Germany: a cost assessment study. BMJ open 15(9):e090442. https://doi.org/10.1136/bmjopen-2024-090442
Brunn, Niklas; Hackenberg, Maren; Fullio, Camila L.; Vogel, Tanja; Binder, Harald (2025): Sparse dimensionality reduction for analyzing single-cell-resolved interactions. Bioinformatics advances vbaf230. https://doi.org/10.1093/bioadv/vbaf230
Fischer, Florian U.; Kollmann, Bianca; Wolf, Dominik; Sebastian, Alexandra; Knaepen, Kristel; Riedel, David; Mierau, Andreas; Ruffini, Nicolas; Endres, Kristina; Winter, Jennifer; Strüder, Heiko; Bischof, Gerard N.; Faraza, Sofia; Baier, Bernhard; Binder, Harald; Drzezga, Alexander; Teipel, Stefan J.; Fellgiebel, Andreas; Tüscher, Oliver (2025): Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study. Frontiers in aging neuroscience 17:1587395. https://doi.org/10.3389/fnagi.2025.1587395
Gärtner, Jan Rupert; Appenzeller-Herzog, Christian; Piechotta, Vanessa; Schwarzer, Guido; Remi, Constanze; Suter, Katja; Böhlke, Christopher (2025): Pharmacological antiemetic prophylaxis and treatment for opioid-induced nausea and vomiting (OINV) in patients treated for cancer pain and cancer-related breathlessness. Cochrane library 2025(8):CD016207. https://doi.org/10.1002/14651858.cd016207
Sekula, Peggy; Steinbrenner, Inga; Schultheiß, Ulla Teresa; Valveny, Neus; Rebora, Paola; Halabi, Susan; Cadarette, Suzanne M.; Riley, Richard D.; Collins, Gary S.; Sauerbrei, Willi; Gail, Mitchell H. (2025): Design aspects for prognostic factor studies. BMJ Open 15(8):e095065. https://doi.org/10.1136/bmjopen-2024-095065
Rücker, Gerta; Schwarzer, Guido (2025): Trials and triangles: network meta-analysis of multi-arm trials with correlated arms. Research synthesis methods 16(6):961-974. https://doi.org/10.1017/rsm.2025.10026
Frosch, Maximilian; Shimizu, Takashi; Wogram, Emile; Amann, Lukas; Gruber, Lars; Groisman, Ayelén I.; Fliegauf, Maximilian; Schwabenland, Marius; Chhatbar, Chintan; Zechel, Sabrina; Rosewich, Hendrik; Gärtner, Jutta; Quintana, Francisco J.; Buescher, Joerg M.; Blank, Thomas; Binder, Harald; Stadelmann, Christine; Letzkus, Johannes J.; Hopf, Carsten; Masuda, Takahiro; Knobeloch, Klaus-Peter; Prinz, Marco (2025): Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis. Nature 646(8086):913-924. https://doi.org/10.1038/s41586-025-09477-y
Kipruto, Edwin; Sauerbrei, Willi (2025): Unraveling similarities and differences between non-negative garrote and adaptive lasso: a simulation study in low- and high-dimensional data. Stats 8(3):70. https://doi.org/10.3390/stats8030070
Kirch, Claudia; Binder, Harald; Lederer, Johannes (2025): Challenges and opportunities for statistics in the era of data science. Harvard data science review 7(2). https://doi.org/10.1162/99608f92.abf14c9d
Lusa, Lara; Kappenberg, Franziska; Collins, Gary S.; Schmid, Matthias; Sauerbrei, Willi; Rahnenführer, Jörg (2025): Evaluation of changes in prediction modelling in biomedicine using systematic reviews. BMC medical research methodology 25(1):167. https://doi.org/10.1186/s12874-025-02605-2
Kipruto, Edwin; Sauerbrei, Willi (2025): Evaluating prediction performance : a simulation study comparing penalized and classical variable selection methods in low-dimensional data. Applied Sciences 15(13):7443. https://doi.org/10.3390/app15137443
Hackenberg, Maren; Canal Guitart, Laia; Backofen, Rolf; Binder, Harald (2025): Evaluating discrepancies in dimensionality reduction for time-series single-cell RNA-sequencing data. Briefings in bioinformatics 26(3):bbaf287. https://doi.org/10.1093/bib/bbaf287
Marciniak, Marta Anna; Rohde, Judith; Yuen, Kenneth S. L.; Binder, Harald; Walter, Henrik; Wieser, Matthias J.; Kalisch, Raffael; Roelofs, Karin; Kleim, Birgit (2025): Development of Powerly, unguided mobile app intervention preventing postpartum depression and anxiety & study protocol of randomized clinical trial. Internet Interventions 41:100843. https://doi.org/10.1016/j.invent.2025.100843
Wigle, Augustine; Béliveau, Audrey; Salanti, Georgia; Rücker, Gerta; Schwarzer, Guido; Mavridis, Dimitris; Nikolakopoulou, Adriani (2025): Precision of treatment hierarchy: a metric for quantifying certainty in treatment hierarchies from network meta‐analysis. Statistics in medicine 44(13-14):e70176. https://doi.org/10.1002/sim.70176
Sauerbrei, Willi; Ambrogi, Federico; De Bin, Riccardo; Boulesteix, Anne-Laure; Goetghebeur, Els; Huebner, Marianne (2025): Commentary: Regression models-efforts are required to improve statistical practice and teaching. Statistics in medicine 44(13-14):e10341. https://doi.org/10.1002/sim.10341
Drees, Philipp; Binder, Harald; Konstantinides, Stavros (2025): Enhanced recovery and abbreviated length of anticoagulation for thromboprophylaxis after primary hip arthroplasty rationale and design of the ENABLE-hip trial. Journal of thrombosis and thrombolysis. https://doi.org/10.1007/s11239-025-03110-5
Stefaan Dejonckheere, Cas; Nour, Younéss; Sahlmann, Joerg; Engelhart, Michael; Hammi, Abdelkhalek; Barth, Simeon Ari; Schimek-Jasch, Tanja; Adebahr, Sonja; Hecht, Markus; Waller, Cornelius; Schmid, Severin; Miederer, Matthias; Brose, Alexander; Binder, Harald; König, Jochem; Rimner, Andreas; Grosu, Anca-Liga; Nestle, Ursula; Gkika, Eleni (2025): Impact of estimated dose of radiation to immune cells (EDRIC) in locally advanced Non-Small-Cell lung Cancer: a secondary analysis of the multicenter randomized PET-Plan trial. Radiotherapy and oncology 208:110907. https://doi.org/10.1016/j.radonc.2025.110907
Bschor, Tom; Unger, Josephine; Nagel, Lea; Schwarzer, Guido; Baethge, Christopher (2025): Negative effects during placebo treatment: a systematic review and meta-analysis. JAMA psychiatry 82(6):618. https://doi.org/10.1001/jamapsychiatry.2025.0336
Hecht, Manuel; Blümle, Anette; Binder, Harald; Schumacher, Martin; Binder, Nadine (2025): Investigator-initiated versus industry-sponsored trials - visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT). BMC medical research methodology 25(1):80. https://doi.org/10.1186/s12874-025-02535-z
Akturk, Zekeriya; Hapfelmeier, Alexander; Fomenko, Alexey; Dümmler, Daniel; Eck, Stefanie; Olm, Michaela; Gehrmann, Jan; Schrottenberg, Victoria von; Rehder, Rahel; Dawson, Sarah; Löwe, Bernd; Rücker, Gerta; Schneider, Antonius; Linde, Klaus (2025): Generalized Anxiety Disorder 7-item (GAD-7) and 2-item (GAD-2) scales for detecting anxiety disorders in adults. Cochrane library 2025(3):CD015455. https://doi.org/10.1002/14651858.cd015455
Rimner, Andreas; Stefaan Dejonckheere, Cas; Sahlmann, Joerg; Barth, Simeon Ari; Schimek-Jasch, Tanja; Adebahr, Sonja; Hecht, Markus; Waller, Cornelius; Schmid, Severin; Stolz, Daiana; Miederer, Matthias; Brose, Alexander; Binder, Harald; König, Jochem; Grosu, Anca-Liga; Nestle, Ursula; Gkika, Eleni (2025): Impact of different mediastinal staging modalities on target volume delineation in locally advanced non-small cell lung cancer: a secondary analysis of the multicenter randomized PET-Plan trial. International journal of radiation oncology, biology, physics 122(5):1217-1226. https://doi.org/10.1016/j.ijrobp.2025.02.041
Hackenberg, Maren; Brunn, Niklas; Vogel, Tanja; Binder, Harald (2025): Infusing structural assumptions into dimensionality reduction for single-cell RNA sequencing data to identify small gene sets. Communications biology 8(1):414. https://doi.org/10.1038/s42003-025-07872-9
Thomassen, Doranne; Roychoudhury, Satrajit; Amdal, Cecilie Delphin; Reynders, Dries; Musoro, Jammbe Z.; Sauerbrei, Willi; Goetghebeur, Els; Cessie, Saskia le (2025): Handling missing values in patient-reported outcome data in the presence of intercurrent events. BMC medical research methodology 25(1):56. https://doi.org/10.1186/s12874-025-02510-8
Schramm, Elisabeth; Elsaesser, Moritz; Müller, Julia; Kwarteng, Nana-Adjoa; Evrenoglou, Theodoros; Cuijpers, Pim; Efthimiou, Orestis; Klein, Daniel N.; Keller, Martin B.; Furukawa, Toshi A.; Nikolakopoulou, Adriani (2025): Efficacy of psychotherapy versus pharmacotherapy, or their combination, in chronic depression: study protocol for a systematic review and network meta-analysis using aggregated and individual patient data. BMJ open 15(2):e089356. https://doi.org/10.1136/bmjopen-2024-089356
Sousa-Pinto, Bernardo; Neumann, Ignacio; Vieira, Rafael José; Bognanni, Antonio; Marques-Cruz, Manuel; Gil-Mata, Sara; Mordue, Simone; Nevill, Clareece; Baio, Gianluca; Whaley, Paul; Schwarzer, Guido; Steele, James; Stewart, Gavin; Schünemann, Holger J.; Azevedo, Luís F. (2025): Quantitative assessment of inconsistency in meta-analysis using decision thresholds with two new indices. Journal of clinical epidemiology 181:111725. https://doi.org/10.1016/j.jclinepi.2025.111725
Fostitsch, Arina Jocelyn; Schwarzer, Guido; Buchgeister, Maria; Surbeck, Werner; Lahmann, Claas; Spiegelhalder, Kai; Frase, Lukas; Spieler, Derek (2025): The association between sleep quality and telomere attrition: a systematic review and meta-analysis comprising 400,212 participants. Sleep medicine reviews 80:102073. https://doi.org/10.1016/j.smrv.2025.102073
Christodoulou, Konstantinos C.; Mohr, Katharina; Uphaus, Timo; Jägersberg, Max; Valerio, Luca; Farmakis, Ioannis T.; Hobohm, Lukas; Binder, Harald; Konstantinides, Stavros; Keller, Karsten (2025): Hospital costs of intracranial haemorrhage in patients with acute pulmonary embolism: possible implications for emerging therapies. Thrombosis and haemostasis 125(10):1048-1051. https://doi.org/10.1055/a-2511-4599
Siemens, Waldemar; Elm, Erik von; Binder, Harald; Böhringer, Daniel; Eisele-Metzger, Angelika; Gartlehner, Gerald; Hanegraaf, Piet; Metzendorf, Maria-Inti; Mosselman, Jacob-Jan; Nowak, Artur; Qureshi, Riaz; Thomas, James; Waffenschmidt, Siw; Labonté, Valérie; Meerpohl, Jörg J. (2025): Opportunities, challenges and risks of using artificial intelligence for evidence synthesis. BMJ evidence-based medicine 30(6):381-384. https://doi.org/10.1136/bmjebm-2024-113320
Pfaffenlehner, Michelle; Behrens, Max; Zöller, Daniela; Ungethüm, Kathrin; Günther, Kai; Rücker, Viktoria; Reese, Jens-Peter; Heuschmann, Peter U.; Kesselmeier, Miriam; Remo, Flavia; Scherag, André; Binder, Harald; Binder, Nadine (2025): Methodological challenges using routine clinical care data for real-world evidence: a rapid review utilizing a systematic literature search and focus group discussion. BMC medical research methodology 25(1):8. https://doi.org/10.1186/s12874-024-02440-x
Rühle, Alexander; Weymann, Maria; Behrens, Max; Zamboglou, Constantinos; Grosu, Anca-Liga; Binder, Harald; Nicolay, Nils H. (2025): Predicting cisplatin tolerability in older adults with head and neck cancer – insights for improved chemoradiation outcomes. Radiotherapy and oncology 204:110697. https://doi.org/10.1016/j.radonc.2024.110697
Emprechtinger, Robert; Schwarzer, Guido; Schreder, Gunther; Toelch, Ulf; Gartlehner, Gerald (2025): Assessing the effectiveness of metahelper: a randomized controlled trial of a web application for statistical transformations in meta-analysis. Journal of clinical epidemiology 179:111640. https://doi.org/10.1016/j.jclinepi.2024.111640
Hackenberg, Maren; Pfaffenlehner, Michelle; Behrens, Max; Pechmann, Astrid; Kirschner, Janbernd; Binder, Harald (2025): Investigating a domain adaptation approach for integrating different measurement instruments in a longitudinal clinical registry. Biometrical journal 67(1):e70023. https://doi.org/10.1002/bimj.70023
Mohr, Katharina; Mildenberger, Philipp; Neusius, Thomas; Christodoulou, Konstantinos C.; Farmakis, Ioannis T.; Kaier, Klaus; Barco, Stefano; Klok, Frederikus A.; Hobohm, Lukas; Keller, Karsten; Becker, Dorothea; Abele, Christina; Bruch, Leonhard; Ewert, Ralf; Schmidtmann, I.; Wild, Philipp S.; Rosenkranz, Stephan; Konstantinides, Stavros; Binder, Harald; Valerio, Luca (2025): Estimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study. European heart journal 11(3):334-342. https://doi.org/10.1093/ehjqcco/qcae050
Korinthenberg, Rudolf; Bast, Thomas; Haberlandt, Edda; Stephani, Ulrich; Strzelczyk, Adam; Rücker, Gerta (2025): Kortikosteroide und adrenocorticotropes Hormon bei Epilepsien der frühen Kindheit jenseits des Säuglingsalters : Bericht über einen systematischen Review mit Metaanalyse. Clinical epileptology 38(2):169-176. https://doi.org/10.1007/s10309-024-00685-6

2024

Fichtner, Urs Alexander; Knaus, Jochen; Graf, Erika; Koch, Georg; Sahlmann, Joerg; Stelzer, Dominikus; Wolkewitz, Martin; Binder, Harald; Weber, Susanne (2024): Exploring the potential of large language models for integration into an academic statistical consulting service–the EXPOLS study protocol. PLOS ONE 19(12):e0308375. https://doi.org/10.1371/journal.pone.0308375
Burkhardt, Barbara; Hummel, Johanna; Rücker, Gerta; Stiller, Brigitte (2024): Inotropes for the prevention of low cardiac output syndrome and mortality for paediatric patients undergoing surgery for congenital heart disease: a network meta-analysis. Cochrane library 2024(11):CD013707. https://doi.org/10.1002/14651858.cd013707.pub2
Thomassen, Doranne; Roychoudhury, Satrajit; Amdal, Cecilie Delphin; Reynders, Dries; Musoro, Jammbe Z.; Sauerbrei, Willi; Goetghebeur, Els; Cessie, Saskia le (2024): The role of the estimand framework in the analysis of patient-reported outcomes in single-arm trials: a case study in oncology. BMC medical research methodology 24(1):290. https://doi.org/10.1186/s12874-024-02408-x
Farhadyar, Kiana; Bonofiglio, Federico; Hackenberg, Maren; Behrens, Max; Zöller, Daniela; Binder, Harald (2024): Combining propensity score methods with variational autoencoders for generating synthetic data in presence of latent sub-groups. BMC medical research methodology 24(1):198. https://doi.org/10.1186/s12874-024-02327-x
Zapf, Antonia; Frömke, Cornelia; Hardt, Juliane; Rücker, Gerta; Voeltz, Dina; Hoyer, Annika (2024): Meta‐analysis of diagnostic accuracy studies with multiple thresholds: comparison of approaches in a simulation study. Biometrical journal 66(7):e202300101. https://doi.org/10.1002/bimj.202300101
Kipruto, Edwin; Sauerbrei, Willi (2024): Post‐estimation shrinkage in full and selected linear regression models in low‐dimensional data revisited. Biometrical journal 66(7):e202300368. https://doi.org/10.1002/bimj.202300368
Schipper, Sivan; Nigam, Kabir; Schmid, Yasmin; Piechotta, Vanessa; Ljuslin, Michael; Beaussant, Yvan; Schwarzer, Guido; Böhlke, Christopher (2024): Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases. Cochrane library 2024(9):CD015383. https://doi.org/10.1002/14651858.cd015383.pub2
Stelzer, Dominikus; Binder, Harald; Glattacker, Manuela; Graf, Erika; Hahn, M.; Hollenbeck, Markus; Kaier, Klaus; Kowall, Bernd; Kuklik, Nils; Metzner, Gloria; Mueller, N.; Seiler, Lisa K.; Stolpe, Stefan; Blume, Cornelia A. (2024): Update to the study protocol: minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): a multicentre, stepped-wedge, cluster-randomised controlled trial. Trials 25(1):586. https://doi.org/10.1186/s13063-024-08394-1
Gkika, Eleni; Stefaan Dejonckheere, Cas; Sahlmann, Joerg; Barth, Simeon Ari; Schimek-Jasch, Tanja; Adebahr, Sonja; Hecht, Markus; Miederer, Matthias; Brose, Alexander; Binder, Harald; König, Jochem; Grosu, Anca-Liga; Nestle, Ursula; Rimner, Andreas (2024): Impact of mediastinal tumor burden and lymphatic spread in locally advanced non-small-cell lung cancer: a secondary analysis of the multicenter randomized PET-Plan trial. Radiotherapy and oncology 200:110521. https://doi.org/10.1016/j.radonc.2024.110521
Oerther, Benedict; Nedelcu, Andrea; Engel, Hannes; Schmucker, Christine; Schwarzer, Guido; Brugger, Timo S.; Schoots, Ivo; Eisenblätter, Michel; Sigle, August; Gratzke, Christian; Bamberg, Fabian; Benndorf, Matthias (2024): Update on PI-RADS version 2.1 diagnostic performance benchmarks for prostate MRI: systematic review and meta-analysis. Radiology 312(2):e233337. https://doi.org/10.1148/radiol.233337
Heinze, Georg; Baillie, Mark; Lusa, Lara; Sauerbrei, Willi; Schmidt, Carsten Oliver; Harrell, Frank E.; Huebner, Marianne (2024): Regression without regrets -initial data analysis is a prerequisite for multivariable regression. BMC medical research methodology 24(1):178. https://doi.org/10.1186/s12874-024-02294-3
Hamza, Tasnim; Schwarzer, Guido; Salanti, Georgia (2024): crossnma: an R package to synthesize cross-design evidence and cross-format data using network meta-analysis and network meta-regression. BMC medical research methodology 24(1):169. https://doi.org/10.1186/s12874-023-02130-0
Rücker, Gerta; Papakonstantinou, Theodoros; Nikolakopoulou, Adriani; Schwarzer, Guido; Galla, Tobias; Davies, Annabel L. (2024): Shortest path or random walks? A framework for path weights in network meta‐analysis. Statistics in medicine 43(22):4287-4304. https://doi.org/10.1002/sim.10177
Kunzler, Angela M.; Voigt-Radloff, Sebastian; Binder, Harald; Grundmann, Hajo; Hengel, Hartmut; Kern, Winfried V.; Maun, Andy; Schmucker, Christine; Schwingshackl, Lukas; Zöller, Daniela; Meerpohl, Jörg J. (2024): Informing pandemic management in Germany with trustworthy, living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem (CEOsys). Journal of clinical epidemiology 173:111456. https://doi.org/10.1016/j.jclinepi.2024.111456
Fomenko, Alexey; Dähne, Theo; Weibel, Stephanie; Panning, Marcus; Grummich, Kathrin; Schlesinger, Sabrina; Rücker, Gerta; Hengel, Hartmut (2024): Test accuracy of rapid diagnostic tests and reverse‐transcription polymerase chain reaction against virus isolation in cell culture for assessing SARS‐CoV‐2 infectivity: systematic review and meta‐analysis. Reviews in medical virology 34(4):e2569. https://doi.org/10.1002/rmv.2569
Kiesswetter, Eva; Stadelmaier, Julia; Schwarzer, Guido; Marjanovic, Goran; Fink, Jodok Matthias; Lehane, Cornelius; Metzendorf, Maria-Inti; Dias, Sofia; Schmucker, Christine; Schwingshackl, Lukas (2024): Bariatric surgery in adults with obesity and diabetes mellitus: a network meta-analysis. Cochrane database of systematic reviews 2024(1):CD015622. https://doi.org/10.1002/14651858.cd015622
Stelzer, Dominikus; Binder, Harald; Glattacker, Manuela; Graf, Erika; Hahn, M.; Hollenbeck, Markus; Kaier, Klaus; Kowall, Bernd; Kuklik, Nils; Metzner, Gloria; Mueller, N.; Seiler, Lisa K.; Stolpe, Susanne; Blume, Cornelia A. (2024): Minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): study protocol for a multicentre, stepped-wedge, cluster-randomised controlled trial. Trials 25(1):368. https://doi.org/10.1186/s13063-024-08182-x
Henssler, Jonathan; Schmidt, Yannick; Schmidt, Urszula; Schwarzer, Guido; Bschor, Tom; Baethge, Christopher (2024): Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysis. The lancet 11(7):526-535. https://doi.org/10.1016/s2215-0366(24)00133-0
Bschor, Tom; Nagel, Lea; Unger, Josephine; Schwarzer, Guido; Baethge, Christopher (2024): Differential outcomes of placebo treatment across 9 psychiatric disorders : a systematic review and meta-analysis. JAMA psychiatry 81(8):757. https://doi.org/10.1001/jamapsychiatry.2024.0994

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