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Institut für Medizinische Biometrie und Statistik (IMBI)
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Dr. Erika Graf

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Publikationen

2026

  • Schramm, Elisabeth; Zehender, Nadine; Breuninger, Christoph; Hegerl, Ulrich; Elsner, Anne; Maun, Andy; Schmölz, Marina; Roick, Christiane; Sahlmann, Joerg; Grodd, Marlon; Domschke, Katharina; Elsaesser, Moritz; Graf, Erika (2026): Efficacy of an online self-help programme with automated or individualised psychological support versus treatment as usual for caregivers of people with depression: a randomised, controlled, open-label, superiority trial. The lancet regional health - europe 62:101560. https://doi.org/10.1016/j.lanepe.2025.101560
  • Grosu, Anca-Liga; Weber, Wolfgang A.; Graf, Erika; Mix, Michael; Nestle, Ursula; Schimek-Jasch, Tanja; Wiehle, Rolf; Mader, Irina; Würtemberger, Urs; Beck, Jürgen; Meyer, Philipp Tobias; Urbach, Horst; Popp, Ilinca; Schneider-Fuchs, Sabine; Prinz, Marco (2026): O-(2-[18F]fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01) : a multicentre, open-label, randomised trial. The lancet oncology 27(2):169-180. https://doi.org/10.1016/s1470-2045(25)00642-4

2025

  • Ortner, Julia; Ewijk, Reyn van; Velthuis, Louis; Labenz, Christian; Arslanow, Anita; Nguyen-Tat, Marc; Wörns, Marcus-Alexander; Reichert, Matthias Christian; Farin-Glattacker, E.; Binder, Harald; Fichtner, Urs Alexander; Graf, Erika; Stelzer, Dominikus; Galle, Peter R.; Lammert, Frank (2025): Evaluating a population-based screening programme for early detection of liver fibrosis and cirrhosis in primary care in Germany: a cost assessment study. BMJ open 15(9):e090442. https://doi.org/10.1136/bmjopen-2024-090442
  • Gkika, Eleni; Firat, Elke; Adebahr, Sonja; Graf, Erika; Popp, Ilinca; Eichhorst, Alexandra; Radicioni, Gianluca; Lo, Simon S.; Spohn, Simon; Nestle, Ursula; Nicolay, Nils H. ; Niedermann, Gabriele; Grosu, Anca-Liga; Duda, Dan G. (2025): A prospective study of immune responses in patients with lung metastases treated with stereotactic body radiotherapy with or without concurrent systemic treatment. Radiotherapy and oncology 207:110889. https://doi.org/10.1016/j.radonc.2025.110889
  • Schramm, Elisabeth; Elsaesser, Moritz; Zehender, Nadine; Reif, Andreas; Lahmann, Claas; Feuchtinger, Manon; Deuschle, Michael; Kahl, Kai G.; Hillert, Andreas; Thiel, Nicola; Piosczyk, Hannah; Mack, Simon; Bausch, Johannes; Graf, Erika (2025): Interpersonal vs. supportive group psychotherapy for depression attributed to work stress: study protocol of the multicentre, cluster-randomised, controlled IPT-Work trial. BMC psychiatry 25(1):149. https://doi.org/10.1186/s12888-025-06594-w

2024

  • Fichtner, Urs Alexander; Knaus, Jochen; Graf, Erika; Koch, Georg; Sahlmann, Joerg; Stelzer, Dominikus; Wolkewitz, Martin; Binder, Harald; Weber, Susanne (2024): Exploring the potential of large language models for integration into an academic statistical consulting service–the EXPOLS study protocol. PLOS ONE 19(12):e0308375. https://doi.org/10.1371/journal.pone.0308375
  • Stelzer, Dominikus; Binder, Harald; Glattacker, Manuela; Graf, Erika; Hahn, M.; Hollenbeck, Markus; Kaier, Klaus; Kowall, Bernd; Kuklik, Nils; Metzner, Gloria; Mueller, N.; Seiler, Lisa K.; Stolpe, Stefan; Blume, Cornelia A. (2024): Update to the study protocol: minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): a multicentre, stepped-wedge, cluster-randomised controlled trial. Trials 25(1):586. https://doi.org/10.1186/s13063-024-08394-1
  • Stelzer, Dominikus; Binder, Harald; Glattacker, Manuela; Graf, Erika; Hahn, M.; Hollenbeck, Markus; Kaier, Klaus; Kowall, Bernd; Kuklik, Nils; Metzner, Gloria; Mueller, N.; Seiler, Lisa K.; Stolpe, Susanne; Blume, Cornelia A. (2024): Minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): study protocol for a multicentre, stepped-wedge, cluster-randomised controlled trial. Trials 25(1):368. https://doi.org/10.1186/s13063-024-08182-x
  • Sekandarzad, Asieb; Graf, Erika; Prager, Eric Peter; Luxenburger, Hendrik; Staudacher, Dawid; Wengenmayer, Tobias; Bettinger, Dominik; Supady, Alexander (2024): Cytokine adsorption in patients with acute‐on‐chronic liver failure (CYTOHEP) — Aasingle center, open‐label, three‐arm, randomized, controlled intervention pilot trial. Artificial organs 48(10):1150-1161. https://doi.org/10.1111/aor.14774
  • Dreher, Matthias; Witte, Torsten; Hoeper, Kirsten; Assmann, Gunter; Proft, Fabian; Poddubnyy, Denis; Murawski, Niels; Triantafyllias, Konstantinos; Grodd, Marlon; Graf, Erika; Fichtner, Urs Alexander; Binder, Harald; Zeidler, Jan; Hoeper, Juliana Rachel; Callhoff, Johanna; Karberg, Kirsten; Trautwein, Anna; Tibyampansha, Dativa; Wojnowski, Leszek; Schmidt, Reinhold E.; Schwarting, Andreas (2024): Rheuma-VOR study: optimising healthcare of rheumatic diseases by multiprofessional coordinating centres. Annals of the rheumatic diseases 83(2):184-193. https://doi.org/10.1136/ard-2023-224205

2023

  • Teipel, Stefan J.; Spottke, Annika; Boecker, Henning; Daamen, Marcel; Graf, Erika; Sahlmann, Joerg; Buchert, Ralph; Mohnike, Wolfgang; Mohnike, Konrad; Kurth, Jens; Jessen, Frank; Krause, Bernd-J. (2023): Patient‐related benefits of amyloid PET imaging in dementia: Rationale and design of the German randomized coverage with evidence development study ENABLE. Alzheimer's & dementia 9(3):e12383. https://doi.org/10.1002/trc2.12383
  • Gkika, Eleni; Firat, Elke; Adebahr, Sonja; Graf, Erika; Popp, Ilinca; Radicioni, Gianluca; Lo, Simon S.; Nestle, Ursula; Nicolay, Nils H. ; Niedermann, Gabriele; Duda, Dan G.; Grosu, Anca-Ligia (2023): Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer. npj precision oncology 7(1):24. https://doi.org/10.1038/s41698-023-00358-z

2022

  • Schramm, Elisabeth; Breuninger, Christoph; Zehender, Nadine; Hegerl, Ulrich; Elsner, Anne; Maun, Andy; Schmölz, Marina; Roick, Christiane; Grodd, Marlon; Graf, Erika (2022): An online program with individualized vs automated support for significant others of depressed individuals – study protocol of a randomized controlled trial. BMC psychiatry 22(1):511. https://doi.org/10.1186/s12888-022-04035-6
  • Selaskowski, Benjamin; Staerk, Christian; Braun, Niclas; Matthies, Swantje D.; Graf, Erika; Colla, Michael; Jacob, Christian; Sobanski, Esther; Alm, Barbara; Rösler, Michael; Retz, Wolfgang; Retz-Junginger, Petra; Kis, Bernhard; Abdel-Hamid, Mona; Huss, Michael; Jans, Thomas; Tebartz van Elst, Ludger; Berger, Mathias; Lux, Silke; Mayr, Andreas; Philipsen, Alexandra (2022): Multimodal treatment efficacy differs in dependence of core symptom profiles in adult Attention-Deficit/Hyperactivity Disorder: An analysis of the randomized controlled COMPAS trial. Journal of psychiatric research 151:225-234. https://doi.org/10.1016/j.jpsychires.2022.03.049
  • Labenz, Christian; Arslanow, Anita; Nguyen-Tat, Marc; Nagel, Michael; Wörns, Marcus-Alexander; Reichert, Matthias Christian; Heil, Franz Josef; Mainz, Dagmar; Zimper, Gundula; Römer, Barbara; Binder, Harald; Farin, Erik; Fichtner, Urs Alexander; Graf, Erika; Stelzer, Dominikus; Ewijk, Reyn van; Ortner, Julia; Velthuis, Louis; Lammert, Frank; Galle, Peter R. (2022): Structured early detection of asymptomatic liver cirrhosis: results of the population-based liver screening program SEAL. Journal of hepatology 77(3):695-701. https://doi.org/10.1016/j.jhep.2022.04.009
  • Sekandarzad, Asieb; Weber, Enya; Prager, Eric Peter; Graf, Erika; Bettinger, Dominik; Wengenmayer, Tobias; Supady, Alexander (2022): Cytokine adsorption in patients with acute-on-chronic liver failure (CYTOHEP)—a single center, open-label, three-arm, randomized, controlled intervention trial. Trials 23:222. https://doi.org/10.1186/s13063-022-06139-6
  • Stelzer, Dominikus; Graf, Erika; Köster, Ingrid; Ihle, Peter; Günster, Christian; Dröge, Patrik; Klöss, Andreas; Mehl, Claudia; Farin, Erik; Geraedts, Max; Schubert, Ingrid; Siegel, Achim; Vach, Werner (2022): Assessing the effect of a regional integrated care model over ten years using quality indicators based on claims data – the basic statistical methodology of the INTEGRAL project. BMC health services research 22(1):247. https://doi.org/10.1186/s12913-022-07573-7
  • LeBlanc, Marissa; Rueegg, Corina S.; Bekiroğlu, Nural; Esterhuizen, Tonya M.; Fagerland, Morten W.; Falk, Ragnhild S.; Frøslie, Kathrine F.; Graf, Erika; Heinze, Georg; Held, Ulrike; Holst, René; Lange, Theis; Mazumdar, Madhu; Myrberg, Ida H.; Posch, Martin; Sergeant, Jamie C.; Vach, Werner; Vance, Eric A.; Weedon‐Fekjær, Harald; Zucknick, Manuela (2022): Statistical advising: Professional development opportunities for the biostatistician. Statistics in medicine 41(5):847-859. https://doi.org/10.1002/sim.9290

2021

  • Farin-Glattacker, E.; Schubert, Ingrid; Stelzer, Dominikus; Siegel, Achim; Köster, Ingrid; Mehl, Claudia; Ihle, Peter; Günster, Christian; Dröge, Patrik; Klöss, Andreas; Graf, Erika; Geraedts, Max (2021): 10-Jahres-Evaluation der populationsbezogenen integrierten Versorgung Gesundes Kinzigtal: die INTEGRAL-Studie. Deutsches Ärzteblatt 118:27-28. https://doi.org/10.3238/arztebl.m2021.0163
  • Schubert, Ingrid; Stelzer, Dominikus; Siegel, Achim; Köster, Ingrid; Mehl, Claudia; Ihle, Peter; Günster, Christian; Dröge, Patrik; Klöss, Andreas; Farin-Glattacker, Erik; Graf, Erika; Geraedts, Max (2021): Ten-year evaluation of the population-based integrated health care system „Gesundes Kinzigtal“. Deutsches Ärzteblatt international 118:465-472. https://doi.org/10.3238/arztebl.m2021.0163
  • Köster, Ingrid; Mehl, Claudia; Siegel, Achim; Graf, Erika; Stelzer, Dominikus; Farin, Erik; Geraedts, Max; Schubert, Ingrid (2021): Operationalisierung von Qualitätsindikatoren mittels Routinedaten am Beispiel der Evaluation der „Integrierten Versorgung Gesundes Kinzigtal“. Das Gesundheitswesen. https://doi.org/10.1055/a-1585-1735
  • Supady, Alexander; Weber, Enya; Rieder, Marina; Lother, Achim; Niklaus, Tim; Zahn, Timm; Frech, Franziska; Müller, Sissi; Kuhl, Moritz; Benk, Christoph; Maier, Sven; Trummer, Georg; Fluegler, Annabelle; Krüger, Kirsten; Sekandarzad, Asieb; Stachon, Peter; Zotzmann, Viviane; Bode, Christoph; Biever, Paul M.; Staudacher, Dawid; Wengenmayer, Tobias; Graf, Erika; Duerschmied, Daniel (2021): Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial. The lancet. Respiratory medicine 9(7):755-762. https://doi.org/10.1016/s2213-2600(21)00177-6
  • Lücke, Caroline; Jenkner, Carolin; Graf, Erika; Matthies, Swantje D.; Borel, Patricia; Sobanski, Esther; Alm, Barbara; Rösler, Michael; Retz, Wolfgang; Jacob, Christian; Colla, Michael; Huss, Michael; Jans, Thomas; Kis, Bernhard; Abdel-Hamid, Mona; Müller, Helge H. O.; Lam, Alexandra P.; Berger, Mathias; Tebartz van Elst, Ludger; Philipsen, Alexandra (2021): Long-term improvement of quality of life in adult ADHD- results of the randomized multimodal COMPAS trial. International journal of mental health 1-21. https://doi.org/10.1080/00207411.2021.1910172
  • Bablok, Isabella; Binder, Harald; Stelzer, Dominikus; Kaier, Klaus; Graf, Erika; Wangler, Julian; Jansky, Michael; Löhr, Michael; Schulz, Michael; Kockläuner, Marie; Geschke, Katharina; Wuttke-Linnemann, Alexandra; Fellgiebel, Andreas; Farin, Erik (2021): Primary dementia care based on the individual needs of the patient: study protocol of the cluster randomized controlled trial, DemStepCare. BMC geriatrics 21:222. https://doi.org/10.1186/s12877-021-02114-z

2020

  • Braune, Jan; Keller, Laura; Schiller, Florian; Graf, Erika; Rafei-Shamsabadi, D.; Wehrle, Julius; Follo, Marie; Philipp, Ulrike; Hussung, Saskia; Pfeifer, Dietmar; Mix, Michael; Duyster, Justus; Fritsch, Ralph; Bubnoff, Dagmar von; Meiss, Frank; Bubnoff, Nikolas von (2020): Circulating tumor DNA allows early treatment monitoring in BRAF- and NRAS-mutant malignant melanoma. JCO Precision oncology 4:20-31. https://doi.org/10.1200/po.19.00174
  • Kis, Bernhard; Lücke, Caroline; Müller, Helge H. O.; Philipsen, Alexandra; Abdel-Hamid, Mona; Heßmann, Philipp; Graf, Erika; Berger, Mathias; Matthies, Swantje D.; Borel, Patricia; Sobanski, Esther; Alm, Barbara; Rösler, Michael; Retz, Wolfgang; Jacob, Christian; Colla, Michael; Tebartz van Elst, Ludger; Huss, Michael; Jans, Thomas (2020): Safety profile of methylphenidate under long-term treatment in adult ADHD patients - results of the COMPAS study. Pharmacopsychiatry 53(06):263-271. https://doi.org/10.1055/a-1207-9851
  • Geissler, Julia M.; Graf, Erika; Hennighausen, Klaus; Haack-Dees, Barbara; Schneider-Momm, Katja Kerstin; Matthies, Swantje; Philipsen, Alexandra; Jans, Thomas (2020): Does helping mothers in multigenerational ADHD also help children in the long run? 2-year follow-up from baseline of the AIMAC randomized controlled multicentre trial. European child & adolescent psychiatry 29(10):1425-1439. https://doi.org/10.1007/s00787-019-01451-0
  • Geraedts, Max; Mehl, Claudia; Schmitz, Jutta; Siegel, Achim; Graf, Erika; Stelzer, Dominikus; Farin, Erik; Ihle, Peter; Köster, Ingrid; Dröge, Patrik; Günster, Christian; Haas, Nathalie; Gröne, Oliver; Schubert, Ingrid (2020): Entwicklung eines Indikatorensets zur Evaluation der Integrierten Versorgung Gesundes Kinzigtal. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen 150-152:54-64. https://doi.org/10.1016/j.zefq.2020.04.001
  • Grosu, Anca-Ligia; Frings, Lars; Bentsalo, Iryna; Oehlke, Oliver; Brenner, Franziska; Bilger, Angelika; Fennell, Jamina Tara; Rothe, Thomas; Schneider-Fuchs, Sabine; Graf, Erika; Schmoor, Claudia; Beck, Jürgen; Becker, Gerhild; Bock, Michael; Egger, Karl; Urbach, Horst; Lahmann, Claas; Popp, Ilinca (2020): Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) - a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG). BMC cancer 20(1):532. https://doi.org/10.1186/s12885-020-07011-z
  • Chiabudini, Marco; Schumacher, Martin; Graf, Erika (2020): Comparison of complex modeling strategies for prediction of a binary outcome based on a few, highly correlated predictors. Biometrical journal 62(3):568-582. https://doi.org/10.1002/bimj.201800243

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