Prof. Dr. Harald Binder

Publikationen

2026

Pathirana, Dilan; Bergmann, Frank T.; Doresic, Domagoj; Lakrisenko, Polina; Persson, Sebastian; Neubrand, Niklas Felix; Timmer, Jens; Kreutz, Clemens; Binder, Harald; Cvijovic, Marija; Weindl, Daniel; Hasenauer, Jan (2026): PEtab Select: Specification standard and supporting software for automated model selection. PLOS Computational Biology 22(9):e1014774. https://doi.org/10.1371/journal.pcbi.1014774
Farhadyar, Kiana; Hackenberg, Maren; Ahrens, Kira; Schenk, Charlotte; Kollmann, Bianca; Tüscher, Oliver; Lieb, Klaus; Plichta, Michael M.; Reif, Andreas; Kalisch, Raffael; Wolkewitz, Martin; Hess, Moritz ; Binder, Harald (2026): A statistical perspective on transformers for small longitudinal cohort data. Statistics in medicine 45(23-24):e70744. https://doi.org/10.1002/sim.70744
Watter, Manuel; Engel, Felix; Kalantari, Aref; Giuliani, Claudia; Schuller, Karin; Franzke, Claus-Werner; Sperandio, Markus; Binder, Harald; Kaier, Klaus (2026): Accelerating metadata annotation in collaborative research centers: A hybrid AI workflow for biomedical entities. Bioinformatics advances. https://doi.org/10.1093/bioadv/vbag283
Pfaffenlehner, Michelle; Dreßing, Andrea; Knoerzer, Dietrich; Wagner, Markus; Heuschmann, Peter U.; Scherag, André; Binder, Harald; EVA4MII project, [Study Group]; Binder, Nadine (2026): A stakeholder-inclusive conceptual framework for modeling routinely collected health data for therapeutic decision-making illustrated by means of multistate models. BMC medical research methodology 26(1):157. https://doi.org/10.1186/s12874-026-02946-6
Faraza, Sofia; Dyrba, Martin; Wolf, Dominik; Fischer, Florian U.; Knaepen, Kristel; Riedel, David; Kollmann, Bianca; Binder, Harald; Mierau, Andreas; Fellgiebel, Andreas; Tüscher, Oliver; Teipel, Stefan J. (2026): Resting state brain activity and association with transfer of cognitive training gains. NeuroImage : reports 6(3):100389. https://doi.org/10.1016/j.ynirp.2026.100389
Kaufmann, Masako M.; Hackenberg, Maren; Henzler, William; Backofen, Rolf; Binder, Harald; Cathomen, Toni (2026): Systematic benchmarking of CRISPR-Cas9 off-target prediction tools reveals limitations and implications for preclinical assessment. Human gene therapy. https://doi.org/10.1177/10430342261466407
Schächter, Clemens; Hackenberg, Maren; Pfaffenlehner, Michelle; Tambe Ndonfack, Félix B.; Schmidt, Thorsten; Pechmann, Astrid; Kirschner, Janbernd; Hasenauer, Jan; Binder, Harald (2026): Using latent representations to link disjoint longitudinal data for mixed‐effects regression. Statistics in medicine 45(18-19):e70701. https://doi.org/10.1002/sim.70701
Butz, Elena; Steinbrenner, Inga; Schultheiss, Ulla T.; Behning, Charlotte; Binder, Harald; Hansmann, Helena; Gronwald, Wolfram; Oefner, Peter J.; Schaeffner, Elke; Eckardt, Kai-Uwe; Köttgen, Anna; Sekula, Peggy (2026): Systematic evaluation of plasma and urine metabolites to predict the risk of adverse kidney-related outcomes in chronic kidney disease: the GCKD study. Kidney medicine 8(7):101409. https://doi.org/10.1016/j.xkme.2026.101409
Engel, Felix; Giuliani, Claudia; Watter, Manuel; Kalantari, Aref; Schuller, Karin; Binder, Harald; Kaier, Klaus (2026): From manual entry to machine precision: challenges and evolution of metadata schema development in collaborative research centers. BMC Research Notes 19(1):277. https://doi.org/10.1186/s13104-026-07937-w
Lang, Tina; Konietschke, Frank; Rahnenführer, Jörg; Kubiak, René; Brendel, Michael; Binder, Harald; Igl, Bernd‐Wolfgang (2026): Ensuring quality in preclinical research: the importance of being human. Biometrical journal 68(4):e70145. https://doi.org/10.1002/bimj.70145
Karakioulaki, Meropi; Yang, Hanning; Hess, Moritz ; Binder, Harald; Eyerich, Kilian; Has, Cristina (2026): Systemic inflammation in recessive dystrophic epidermolysis bullosa: a five-year longitudinal study. British journal of dermatology 195(1):146-157. https://doi.org/10.1093/bjd/ljag082
Pfaffenlehner, Michelle; Kesselmeier, Miriam; Günther, Kai; Ungethüm, Kathrin; Rücker, Viktoria; Remo, Flavia; Binder, Harald; Scherag, André; Heuschmann, Peter U.; Binder, Nadine (2026): Evidenzgenerierung und methodische Beratung durch das Projekt "EVAluationsforschung auf der Grundlage von Daten aus der klinischen Routineversorgung für die Medizininformatik-Initiative" (EVA4MII). Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 69(6):698-706. https://doi.org/10.1007/s00103-026-04243-5
Menger, Jonatan; Krissmer, Sonia M.; Kreutz, Clemens; Binder, Harald; Hackenberg, Maren (2026): mmContext : an open framework for multimodal contrastive learning of omics and text data. Bioinformatics 42(6):btag338. https://doi.org/10.1093/bioinformatics/btag338
Koromila, Georgia; Dyrba, Martin; Wolf, Dominik; Fischer, Florian; Knaepen, Kristel; Kollmann, Bianca; Binder, Harald; Mierau, Andreas; Riedel, David; Fellgiebel, Andreas; Tüscher, Oliver; Teipel, Stefan; Faraza, Sofia (2026): Resting-state brain activity and association with physical activity. Frontiers in aging neuroscience 18:1765112. https://doi.org/10.3389/fnagi.2026.1765112
Farmakis, Ioannis T.; Binder, Harald; Evrenoglou, Theodoros; Schwarzer, Guido; Barco, Stefano (2026): Reperfusion strategies for acute pulmonary embolism: design and rationale of RECONNECT-PE – a living systematic review and meta-analysis. American heart journal 295:107365. https://doi.org/10.1016/j.ahj.2026.107365
Brunn, Niklas; Hackenberg, Maren; Fullio, Camila L.; Vogel, Tanja; Binder, Harald (2026): Sparse dimensionality reduction for analyzing single-cell-resolved interactions. Bioinformatics advances 6(1):vbag047. https://doi.org/10.1093/bioadv/vbag047
Behrens, Max; Stolz, Daiana; Papakonstantinou, Eleni; Nolde, Janis M.; Bellerino, Gabriele; Rohde, Angelika; Hess, Moritz ; Binder, Harald (2026): Contrasting global and patient‐specific regression models via a neural network representation. Biometrical journal 68(2):e70126. https://doi.org/10.1002/bimj.70126
Letzkus, Johannes J.; Sprekeler, Henning; Binder, Harald; Boedecker, Joschka; Diester, Ilka; Elgueta, Claudio; Grosser, Sabine; Haberl, Matthias; Kulik, Akos; Larkum, Matthew E.; Leibold, Christian; Madry, Christian; Monyer, Hannah; Poulet, James F.A.; Sauer, Jonas-Frederic; Schmoranzer, Jan; Schreiber, Susanne; Veit, Julia; Viana da Silva, Silvia; Vlachos, Andreas; Vida, Imre; Geiger, Jörg R. P.; Bartos, Marlene (2026): A population approach to cortical GABAergic interneuron function. Neuron 114(7):1176-1180. https://doi.org/10.1016/j.neuron.2026.01.028
Kaier, Klaus; Engel, Felix; Benadi, Gita; Giuliani, Claudia; Watter, Manuel; Kalantari, Aref; Schuller, Karin; Franzke, Claus-Werner; Sperandio, Markus; Binder, Harald (2026): Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. Bmc research notes 19:43. https://doi.org/10.1186/s13104-026-07632-w
Mohr, Katharina; Christodoulou, Konstantinos C.; Barco, Stefano; Valerio, Luca; Neusius, Thomas; Keller, Karsten; Hobohm, Lukas; Vosseler, Markus; Uphaus, Timo; Hahn, Marianne; Klok, Frederikus A.; Binder, Harald; Konstantinides, Stavros; Rognoni, Carla (2026): Impact of catheter-directed thrombolysis on the socio-economic burden of pulmonary embolism in germany: a cost-effectiveness analysis. European heart journal - quality of care and clinical outcomes 12(4):516-525. https://doi.org/10.1093/ehjqcco/qcag003
Hackenberg, Maren; Pechmann, Astrid; Kreutz, Clemens; Kirschner, Janbernd; Binder, Harald (2026): A statistical approach to latent dynamic modeling with differential equations. The American statistician 80(1):89-99. https://doi.org/10.1080/00031305.2025.2539999
Schoenthaler, Martin; Hempen, Noah; Weymann, Maria; Bargen, Maximilian Ferry von; Glienke, Maximilian; Elsässer, Antonia; Behrens, Max; Binder, Harald; Binder, Nadine (2026): Challenges and solutions in determining urolithiasis caseloads using the digital infrastructure of a clinical data warehouse. PLOS One 21(1):e0341068. https://doi.org/10.1371/journal.pone.0341068
Watter, Manuel; Giuliani, Claudia; Benadi, Gita; Engel, Felix; Binder, Harald; Kaier, Klaus (2026): Automated identification of contextually relevant biomedical entities with grounded LLMs. Scientific reports 16(1):1952. https://doi.org/10.1038/s41598-026-35492-8

2025

Schächter, Clemens; Hackenberg, Maren; Treppner, Martin; Raum, Hanne; Boedecker, Joschka; Binder, Harald (2025): scSpecies: enhancement of network architecture alignment in comparative single-cell studies. Genome biology 26(1):397. https://doi.org/10.1186/s13059-025-03866-2
Giuliani, Claudia; Benadi, Gita; Engel, Felix; Werner, Jonas; Watter, Manuel; Schwarzer, Guido; Groß, Olaf; Zeiser, Robert; Binder, Harald; Kaier, Klaus (2025): Identifying biomedical entities for datasets in scientific articles: 4-step cache-augmented generation approach using gpt-4o and pubtator 3.0. JMIR formative research 9:v9i3-4e73822. https://doi.org/10.2196/73822
Dobler, Dennis; Binder, Harald; Boulesteix, Anne-Laure; Igelmann, Jan‐Bernd; Köhler, David; Mansmann, Ulrich; Pauly, Markus; Scherag, André; Schmid, Matthias; Al Tawil, Amani; Weber, Susanne (2025): ChatGPT as a tool for biostatisticians: a tutorial on applications, opportunities, and limitations. Statistics in medicine 44(23-24):e70263. https://doi.org/10.1002/sim.70263
Warth, Rieka von der; Nicolay, Nils H. ; Binder, Harald; Boerries, Melanie; Zöller, Daniela; Grosu, Anca-Liga; Farin-Glattacker, Erik (2025): Exploring feature preferences for a treatment-accompanying app in patients undergoing radiation therapy: cross-sectional study. JMIR cancer 11:v11i5Se68411. https://doi.org/10.2196/68411
Frosch, Maximilian; Shimizu, Takashi; Wogram, Emile; Amann, Lukas; Gruber, Lars; Groisman, Ayelén I.; Fliegauf, Maximilian; Schwabenland, Marius; Chhatbar, Chintan; Zechel, Sabrina; Rosewich, Hendrik; Gärtner, Jutta; Quintana, Francisco J.; Buescher, Joerg M.; Blank, Thomas; Binder, Harald; Stadelmann, Christine; Letzkus, Johannes J.; Hopf, Carsten; Masuda, Takahiro; Knobeloch, Klaus-Peter; Prinz, Marco (2025): Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis. Nature 646(8086):913-924. https://doi.org/10.1038/s41586-025-09477-y
Karakioulaki, Meropi; Kwarteng, Nana-Adjoa; Nikolakopoulou, Adriani; Yang, Hanning; Hess, Moritz ; Binder, Harald; Eyerich, Kilian; Has, Cristina (2025): Tissue and systemic inflammation in dystrophic epidermolysis bullosa: a systematic review and meta-analysis. Orphanet journal of rare diseases 20(1):479. https://doi.org/10.1186/s13023-025-04034-2
Ullmann, Theresa; Heinze, Georg; Abrahamowicz, Michal; Perperoglou, Aris; Sauerbrei, Willi; Schmid, Matthias; Dunkler, Daniela; Binder, Harald (2025): A systematic categorization of performance measures for estimated non‐linear associations between an outcome and continuous predictors. WIREs Computational Statistics 17(3):e70042. https://doi.org/10.1002/wics.70042
Ortner, Julia; Ewijk, Reyn van; Velthuis, Louis; Labenz, Christian; Arslanow, Anita; Nguyen-Tat, Marc; Wörns, Marcus-Alexander; Reichert, Matthias Christian; Farin-Glattacker, E.; Binder, Harald; Fichtner, Urs Alexander; Graf, Erika; Stelzer, Dominikus; Galle, Peter R.; Lammert, Frank (2025): Evaluating a population-based screening programme for early detection of liver fibrosis and cirrhosis in primary care in Germany: a cost assessment study. BMJ open 15(9):e090442. https://doi.org/10.1136/bmjopen-2024-090442
Christodoulou, Konstantinos C.; Mohr, Katharina; Uphaus, Timo; Jägersberg, Max; Valerio, Luca; Farmakis, Ioannis T.; Hobohm, Lukas; Binder, Harald; Konstantinides, Stavros; Keller, Karsten (2025): Hospital costs of intracranial haemorrhage in patients with acute pulmonary embolism: possible implications for emerging therapies. Thrombosis and haemostasis 125(10):1048-1051. https://doi.org/10.1055/a-2511-4599
Mohr, Katharina; Hobohm, Lukas; Kaier, Klaus; Farmakis, Ioannis T.; Valerio, Luca; Barco, Stefano; Abele, Christina; Münzel, Thomas; Neusius, Thomas; Konstantinides, Stavros; Binder, Harald; Keller, Karsten (2025): Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism. Clinical research in cardiology 114(10):1246-1257. https://doi.org/10.1007/s00392-024-02437-y
Brunn, Niklas; Hackenberg, Maren; Fullio, Camila L.; Vogel, Tanja; Binder, Harald (2025): Sparse dimensionality reduction for analyzing single-cell-resolved interactions. Bioinformatics advances vbaf230. https://doi.org/10.1093/bioadv/vbaf230
Fischer, Florian U.; Kollmann, Bianca; Wolf, Dominik; Sebastian, Alexandra; Knaepen, Kristel; Riedel, David; Mierau, Andreas; Ruffini, Nicolas; Endres, Kristina; Winter, Jennifer; Strüder, Heiko; Bischof, Gerard N.; Faraza, Sofia; Baier, Bernhard; Binder, Harald; Drzezga, Alexander; Teipel, Stefan J.; Fellgiebel, Andreas; Tüscher, Oliver (2025): Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study. Frontiers in aging neuroscience 17:1587395. https://doi.org/10.3389/fnagi.2025.1587395
Hackenberg, Maren; Canal Guitart, Laia; Backofen, Rolf; Binder, Harald (2025): Evaluating discrepancies in dimensionality reduction for time-series single-cell RNA-sequencing data. Briefings in bioinformatics 26(3):bbaf287. https://doi.org/10.1093/bib/bbaf287
Kirch, Claudia; Binder, Harald; Lederer, Johannes (2025): Challenges and opportunities for statistics in the era of data science. Harvard data science review 7(2). https://doi.org/10.1162/99608f92.abf14c9d
Marciniak, Marta Anna; Rohde, Judith; Yuen, Kenneth S. L.; Binder, Harald; Walter, Henrik; Wieser, Matthias J.; Kalisch, Raffael; Roelofs, Karin; Kleim, Birgit (2025): Development of Powerly, unguided mobile app intervention preventing postpartum depression and anxiety & study protocol of randomized clinical trial. Internet Interventions 41:100843. https://doi.org/10.1016/j.invent.2025.100843
Rimner, Andreas; Stefaan Dejonckheere, Cas; Sahlmann, Joerg; Barth, Simeon Ari; Schimek-Jasch, Tanja; Adebahr, Sonja; Hecht, Markus; Waller, Cornelius; Schmid, Severin; Stolz, Daiana; Miederer, Matthias; Brose, Alexander; Binder, Harald; König, Jochem; Grosu, Anca-Liga; Nestle, Ursula; Gkika, Eleni (2025): Impact of different mediastinal staging modalities on target volume delineation in locally advanced non-small cell lung cancer: a secondary analysis of the multicenter randomized PET-Plan trial. International journal of radiation oncology, biology, physics 122(5):1217-1226. https://doi.org/10.1016/j.ijrobp.2025.02.041
Drees, Philipp; Binder, Harald; Konstantinides, Stavros (2025): Enhanced recovery and abbreviated length of anticoagulation for thromboprophylaxis after primary hip arthroplasty rationale and design of the ENABLE-hip trial. Journal of thrombosis and thrombolysis. https://doi.org/10.1007/s11239-025-03110-5
Stefaan Dejonckheere, Cas; Nour, Younéss; Sahlmann, Joerg; Engelhart, Michael; Hammi, Abdelkhalek; Barth, Simeon Ari; Schimek-Jasch, Tanja; Adebahr, Sonja; Hecht, Markus; Waller, Cornelius; Schmid, Severin; Miederer, Matthias; Brose, Alexander; Binder, Harald; König, Jochem; Rimner, Andreas; Grosu, Anca-Liga; Nestle, Ursula; Gkika, Eleni (2025): Impact of estimated dose of radiation to immune cells (EDRIC) in locally advanced Non-Small-Cell lung Cancer: a secondary analysis of the multicenter randomized PET-Plan trial. Radiotherapy and oncology 208:110907. https://doi.org/10.1016/j.radonc.2025.110907
Mohr, Katharina; Mildenberger, Philipp; Neusius, Thomas; Christodoulou, Konstantinos C.; Farmakis, Ioannis T.; Kaier, Klaus; Barco, Stefano; Klok, Frederikus A.; Hobohm, Lukas; Keller, Karsten; Becker, Dorothea; Abele, Christina; Bruch, Leonhard; Ewert, Ralf; Schmidtmann, I.; Wild, Philipp S.; Rosenkranz, Stephan; Konstantinides, Stavros; Binder, Harald; Valerio, Luca (2025): Estimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study. European heart journal 11(3):334-342. https://doi.org/10.1093/ehjqcco/qcae050
Hecht, Manuel; Blümle, Anette; Binder, Harald; Schumacher, Martin; Binder, Nadine (2025): Investigator-initiated versus industry-sponsored trials - visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT). BMC medical research methodology 25(1):80. https://doi.org/10.1186/s12874-025-02535-z
Hackenberg, Maren; Brunn, Niklas; Vogel, Tanja; Binder, Harald (2025): Infusing structural assumptions into dimensionality reduction for single-cell RNA sequencing data to identify small gene sets. Communications biology 8(1):414. https://doi.org/10.1038/s42003-025-07872-9
Johar, Hamimatunnisa; Atasoy, Seryan; Beutel, Manfred E.; Brähler, Elmar; Schomerus, Georg; Binder, Harald; Peters, Annette; Zöller, Daniela; Fleischer, Toni; Otten, Danielle; Kampling, Hana; Kruse, Johannes; Ladwig, Karl-Heinz (2025): Gender-differential association between loneliness and alcohol consumption: a pooled analysis of 17,808 individuals in the multi-cohort GESA Consortium. International journal of mental health and addiction 23(1):1-23. https://doi.org/10.1007/s11469-023-01121-y
Siemens, Waldemar; Elm, Erik von; Binder, Harald; Böhringer, Daniel; Eisele-Metzger, Angelika; Gartlehner, Gerald; Hanegraaf, Piet; Metzendorf, Maria-Inti; Mosselman, Jacob-Jan; Nowak, Artur; Qureshi, Riaz; Thomas, James; Waffenschmidt, Siw; Labonté, Valérie; Meerpohl, Jörg J. (2025): Opportunities, challenges and risks of using artificial intelligence for evidence synthesis. BMJ evidence-based medicine 30(6):381-384. https://doi.org/10.1136/bmjebm-2024-113320
Pfaffenlehner, Michelle; Behrens, Max; Zöller, Daniela; Ungethüm, Kathrin; Günther, Kai; Rücker, Viktoria; Reese, Jens-Peter; Heuschmann, Peter U.; Kesselmeier, Miriam; Remo, Flavia; Scherag, André; Binder, Harald; Binder, Nadine (2025): Methodological challenges using routine clinical care data for real-world evidence: a rapid review utilizing a systematic literature search and focus group discussion. BMC medical research methodology 25(1):8. https://doi.org/10.1186/s12874-024-02440-x
Rühle, Alexander; Weymann, Maria; Behrens, Max; Zamboglou, Constantinos; Grosu, Anca-Liga; Binder, Harald; Nicolay, Nils H. (2025): Predicting cisplatin tolerability in older adults with head and neck cancer – insights for improved chemoradiation outcomes. Radiotherapy and oncology 204:110697. https://doi.org/10.1016/j.radonc.2024.110697
Hackenberg, Maren; Pfaffenlehner, Michelle; Behrens, Max; Pechmann, Astrid; Kirschner, Janbernd; Binder, Harald (2025): Investigating a domain adaptation approach for integrating different measurement instruments in a longitudinal clinical registry. Biometrical journal 67(1):e70023. https://doi.org/10.1002/bimj.70023
Farmakis, Ioannis T.; Kaier, Klaus; Hobohm, Lukas; Mohr, Katharina; Valerio, Luca; Barco, Stefano; Konstantinides, Stavros; Binder, Harald (2025): Healthcare resource utilisation and associated costs after low-risk pulmonary embolism: pre-specified analysis of the Home Treatment of Pulmonary Embolism (HoT-PE) study. Clinical research in cardiology 114(2):168-176. https://doi.org/10.1007/s00392-023-02355-5

2024

Fichtner, Urs Alexander; Knaus, Jochen; Graf, Erika; Koch, Georg; Sahlmann, Joerg; Stelzer, Dominikus; Wolkewitz, Martin; Binder, Harald; Weber, Susanne (2024): Exploring the potential of large language models for integration into an academic statistical consulting service–the EXPOLS study protocol. PLOS ONE 19(12):e0308375. https://doi.org/10.1371/journal.pone.0308375
Farhadyar, Kiana; Bonofiglio, Federico; Hackenberg, Maren; Behrens, Max; Zöller, Daniela; Binder, Harald (2024): Combining propensity score methods with variational autoencoders for generating synthetic data in presence of latent sub-groups. BMC medical research methodology 24(1):198. https://doi.org/10.1186/s12874-024-02327-x
Stelzer, Dominikus; Binder, Harald; Glattacker, Manuela; Graf, Erika; Hahn, M.; Hollenbeck, Markus; Kaier, Klaus; Kowall, Bernd; Kuklik, Nils; Metzner, Gloria; Mueller, N.; Seiler, Lisa K.; Stolpe, Stefan; Blume, Cornelia A. (2024): Update to the study protocol: minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): a multicentre, stepped-wedge, cluster-randomised controlled trial. Trials 25(1):586. https://doi.org/10.1186/s13063-024-08394-1
Gkika, Eleni; Stefaan Dejonckheere, Cas; Sahlmann, Joerg; Barth, Simeon Ari; Schimek-Jasch, Tanja; Adebahr, Sonja; Hecht, Markus; Miederer, Matthias; Brose, Alexander; Binder, Harald; König, Jochem; Grosu, Anca-Liga; Nestle, Ursula; Rimner, Andreas (2024): Impact of mediastinal tumor burden and lymphatic spread in locally advanced non-small-cell lung cancer: a secondary analysis of the multicenter randomized PET-Plan trial. Radiotherapy and oncology 200:110521. https://doi.org/10.1016/j.radonc.2024.110521
Kunzler, Angela M.; Voigt-Radloff, Sebastian; Binder, Harald; Grundmann, Hajo; Hengel, Hartmut; Kern, Winfried V.; Maun, Andy; Schmucker, Christine; Schwingshackl, Lukas; Zöller, Daniela; Meerpohl, Jörg J. (2024): Informing pandemic management in Germany with trustworthy, living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem (CEOsys). Journal of clinical epidemiology 173:111456. https://doi.org/10.1016/j.jclinepi.2024.111456
Stelzer, Dominikus; Binder, Harald; Glattacker, Manuela; Graf, Erika; Hahn, M.; Hollenbeck, Markus; Kaier, Klaus; Kowall, Bernd; Kuklik, Nils; Metzner, Gloria; Mueller, N.; Seiler, Lisa K.; Stolpe, Susanne; Blume, Cornelia A. (2024): Minimisation of dialysis risk in hospital patients with chronic kidney disease (MinDial): study protocol for a multicentre, stepped-wedge, cluster-randomised controlled trial. Trials 25(1):368. https://doi.org/10.1186/s13063-024-08182-x
Marciniak, Marta Anna; Shanahan, Lilly; Yuen, Kenneth S. L.; Veer, Ilya M.; Walter, Henrik; Tüscher, Oliver; Kobylińska, Dorota; Kalisch, Raffael; Hermans, Erno J.; Binder, Harald; Kleim, Birgit (2024): Burst versus continuous delivery design in digital mental health interventions: evidence from a randomized clinical trial. Digital health 10:1-14. https://doi.org/10.1177/20552076241249267
Schwartz, Oliver; Pfaffenlehner, Michelle; Behrens, Max; Lochmüller, H.; Kirschner, Janbernd; Pechmann, Astrid (2024): Clinical effectiveness of newborn screening for spinal muscular atrophy : a nonrandomized controlled trial. JAMA pediatrics 178(6):540-547. https://doi.org/10.1001/jamapediatrics.2024.0492
Pooseh, Shakoor; Kalisch, Raffael; Köber, Göran; Binder, Harald; Timmer, Jens (2024): Intraindividual time-varying dynamic network of affects: linear autoregressive mixed-effects models for ecological momentary assessment. Frontiers in psychiatry 15:1213863. https://doi.org/10.3389/fpsyt.2024.1213863
Mohr, Katharina; Keeling, Brent; Kaier, Klaus; Neusius, Thomas; Rosovsky, Rachel P.; Moriarty, John M.; Rosenfield, Kenneth; Abele, Christina; Farmakis, Ioannis T.; Keller, Karsten; Barco, Stefano; Channick, Richard N.; Giri, Jay S.; Lookstein, Robert A.; Todoran, Thomas M.; Christodoulou, Konstantinos C.; Hobohm, Lukas; Lanno, Michelle; Reed, Jamie; Binder, Harald; Konstantinides, Stavros; Valerio, Luca; Secemsky, Eric A. (2024): Modelling costs of interventional pulmonary embolism treatment: implications of US trends for a European healthcare system. European heart journal 13(6):501-505. https://doi.org/10.1093/ehjacc/zuae019
Zöller, Daniela; Haverkamp, Christian; Makoudjou, Adeline; Sofack, Ghislain N.; Kiefer, Saskia; Gebele, Denis; Pfaffenlehner, Michelle; Boeker, Martin; Binder, Harald; Karki, Kapil; Seidemann, Christian; Schmeck, Bernd; Greulich, Timm; Renz, Harald; Schild, Stefanie; Seuchter, Susanne A.; Tibyampansha, Dativa; Buhl, Roland; Rohde, Gernot; Trudzinski, Franziska C.; Bals, Robert; Janciauskiene, Sabina; Stolz, Daiana; Fähndrich, Sebastian Wolfgang (2024): Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning. Respiratory research 25(1):38. https://doi.org/10.1186/s12931-023-02607-y
Dreher, Matthias; Witte, Torsten; Hoeper, Kirsten; Assmann, Gunter; Proft, Fabian; Poddubnyy, Denis; Murawski, Niels; Triantafyllias, Konstantinos; Grodd, Marlon; Graf, Erika; Fichtner, Urs Alexander; Binder, Harald; Zeidler, Jan; Hoeper, Juliana Rachel; Callhoff, Johanna; Karberg, Kirsten; Trautwein, Anna; Tibyampansha, Dativa; Wojnowski, Leszek; Schmidt, Reinhold E.; Schwarting, Andreas (2024): Rheuma-VOR study: optimising healthcare of rheumatic diseases by multiprofessional coordinating centres. Annals of the rheumatic diseases 83(2):184-193. https://doi.org/10.1136/ard-2023-224205
Marciniak, Marta Anna; Shanahan, Lilly; Myin-Germeys, Inez; Veer, Ilya M.; Yuen, Kenneth S. L.; Binder, Harald; Walter, Henrik; Hermans, Erno J.; Kalisch, Raffael; Kleim, Birgit (2024): Imager — a mobile health mental imagery‐based ecological momentary intervention targeting reward sensitivity: a randomized controlled trial. Applied psychology 16(2):576-596. https://doi.org/10.1111/aphw.12505

2023

Sprave, Tanja; Pfaffenlehner, Michelle; Stoian, Raluca; Christofi, Eleni; Rühle, Alexander; Zöller, Daniela; Fabian, Alexander; Fahrner, Harald; Binder, Harald; Schäfer, Henning Sebastian; Gkika, Eleni; Grosu, Anca-Liga; Heinemann, Felix E.; Nicolay, Nils H. (2023): App-controlled treatment monitoring and support for patients with head and neck cancer undergoing radiotherapy: results from a prospective randomized controlled trial. Journal of medical internet research 25:e46189. https://doi.org/10.2196/46189
Wulffen, Clemens von; Marciniak, Marta Anna; Rohde, Judith; Kalisch, Raffael; Binder, Harald; Tüscher, Oliver; Kleim, Birgit (2023): German version of the mobile agnew relationship measure: translation and validation study. Journal of medical internet research 25:e43368. https://doi.org/10.2196/43368
Asmuth, Erik G. J. von; Neven, Benedicte; Albert, Michael H.; Mohseny, Alexander B.; Schilham, Marco; Binder, Harald; Putter, Hein; Lankester, Arjan C. (2023): Predicting patient death after allogeneic SCT for inborn errors using machine learning (PREPAD): an EBMT IEWP study. Transplantation and cellular therapy 29(12):775.e1-775.e8. https://doi.org/10.1016/j.jtct.2023.09.007
Bögemann, Sophie A.; Riepenhausen, Antje; Puhlmann, Lara M. C.; Köber, Göran; Binder, Harald; Kalisch, Raffael; Hermans, Erno J.; Walter, Henrik (2023): Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: research protocol of the DynaM-INT study. BMC psychology 11(1):245. https://doi.org/10.1186/s40359-023-01249-5
Wackerhagen, Carolin; Veer, Ilya M.; Leeuwen, Judith M. C. van; Reppmann, Zala; Riepenhausen, Antje; Köber, Göran; Pooseh, Shakoor; Binder, Harald; Timmer, Jens; Hendler, Talma; Kobylińska, Dorota; Hermans, Erno J.; Kalisch, Raffael; Walter, Henrik (2023): Dynamic modelling of mental resilience in young adults: protocol for a longitudinal observational study (DynaM-OBS). JMIR Research Protocols 12:e39817. https://doi.org/10.2196/39817
Appiah, Bismark; Fullio, Camila L.; Ossola, Chiara; Bertani, Ilaria; Restelli, Elena; Cheffer, Arquimedes; Polenghi, Martina; Haffner, Christiane; Garcia‐Miralles, Marta; Zeis, Patrice; Treppner, Martin; Bovio, Patrick Piero; Schlichtholz, Laura; Mas‐Sanchez, Aina; Zografidou, Lea; Winter, Jennifer; Binder, Harald; Grün, Dominic; Kalebic, Nereo; Taverna, Elena; Vogel, Tanja (2023): DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression. EMBO reports 24(8):e56233. https://doi.org/10.15252/embr.202256233
Fichtner, Urs Alexander; Arslanow, Anita; Binder, Harald; Galle, Peter R.; Labenz, Christian; Lammert, Frank; Ortner, Julia; Stelzer, Dominikus; Velthuis, Louis; Farin, Erik (2023): How do (false) positively screened patients experience a screening programme for liver cirrhosis or fibrosis in Germany? A qualitative study. Health expectations 26(5):1923-1930. https://doi.org/10.1111/hex.13800
Grandt, Caine Lucas; Brackmann, Lara Kim; Foraita, Ronja; Schwarz, Heike; Hummel-Bartenschlager, Willempje; Hankeln, Thomas; Kraemer, Christiane; Zahnreich, Sebastian; Drees, Philipp; Mirsch, Johanna; Spix, Claudia; Blettner, Maria; Schmidberger, Heinz; Binder, Harald; Hess, Moritz ; Galetzka, Danuta; Marini, Federico; Poplawski, Alicia; Marron, Manuela (2023): Gene expression variability in long-term survivors of childhood cancer and cancer-free controls in response to ionizing irradiation. Molecular medicine 29(1):41. https://doi.org/10.1186/s10020-023-00629-2
Rahnenführer, Jörg; De Bin, Riccardo; Benner, Axel; Ambrogi, Federico; Lusa, Lara; Boulesteix, Anne-Laure; Migliavacca, Eugenia; Binder, Harald; Michiels, Stefan; Sauerbrei, Willi; McShane, Lisa M. (2023): Statistical analysis of high-dimensional biomedical data: a gentle introduction to analytical goals, common approaches and challenges. BMC medicine 21(1):182. https://doi.org/10.1186/s12916-023-02858-y
Marciniak, Marta Anna; Shanahan, Lilly; Binder, Harald; Kalisch, Raffael; Kleim, Birgit (2023): Positive prospective mental imagery characteristics in young adults and their associations with depressive symptoms. Cognitive therapy and research 47(4):695-706. https://doi.org/10.1007/s10608-023-10378-5
Prochaska, Jürgen H.; Jünger, Claus; Schulz, Andreas; Arnold, Natalie; Müller, Felix; Heidorn, Marc William; Baumkötter, Rieke; Zahn, Daniela; Koeck, Thomas; Tröbs, Sven-Oliver; Lackner, Karl J.; Daiber, Andreas; Binder, Harald; Shah, Sanjiv J.; Gori, Tommaso; Münzel, Thomas; Wild, Philipp S. (2023): Effects of empagliflozin on left ventricular diastolic function in addition to usual care in individuals with type 2 diabetes mellitus - results from the randomized, double-blind, placebo-controlled EmDia trial. Clinical research in cardiology 112(7):911-922. https://doi.org/10.1007/s00392-023-02164-w
Fichtner, Urs Alexander; Horstmeier, Lukas M.; Brühmann, Boris A.; Binder, Harald; Knaus, Jochen (2023): Needs assessment towards research data management at the Medical Faculty of the University of Freiburg – Data of the BE-KONFORM study. Data in brief 48:109084. https://doi.org/10.1016/j.dib.2023.109084
Köber, Göran; Kalisch, Raffael; Puhlmann, Lara M. C.; Chmitorz, Andrea; Schick, Anita; Binder, Harald (2023): Deep learning and differential equations for modeling changes in individual‐level latent dynamics between observation periods. Biometrical journal 65(6):2100381. https://doi.org/10.1002/bimj.202100381
Langhans, Marco; Popp, Ilinca; Grosu, Anca-Ligia; Shusharina, Nadya; Binder, Harald; Baltas, Dimos; Bortfeld, Thomas (2023): Recurrence analysis of glioblastoma cases based on distance and dose information. Radiotherapy and oncology 183:109600. https://doi.org/10.1016/j.radonc.2023.109600
Grodd, Marlon; Refisch, Lukas; Lorenz, Fabian; Fischer, Martina; Lottes, Matthäus; Hackenberg, Maren; Kreutz, Clemens; Grabenhenrich, Linus; Binder, Harald; Wolkewitz, Martin (2023): Prognosemodelle zur Steuerung von intensivmedizinischen COVID-19-Kapazitäten in Deutschland. Medizinische Klinik, Intensivmedizin und Notfallmedizin 118(2):125-131. https://doi.org/10.1007/s00063-022-00903-x
Heinrich, Sophia; Austgen, Thomas; Castven, Darko; Hess, Moritz ; Labenz, Christian; Kirstein, Martha M.; Zimpel, Carolin; Stockhoff, Lena; Maasoumy, Benjamin; Heinrich, Bernd; Wedemeyer, Heiner; Galle, Peter Robert; Binder, Harald; Nguyen-Tat, Marc; Marquardt, Jens Uwe (2023): Markers of cell death predict therapy response in patients with cirrhosis and hepatorenal syndrome. United european gastroenterology journal 11(1):92-102. https://doi.org/10.1002/ueg2.12337
Fichtner, Urs Alexander; Horstmeier, Lukas Maximilian; Brühmann, Boris A.; Watter, Manuel; Binder, Harald; Knaus, Jochen (2023): The role of data sharing in survey dropout: a study among scientists as respondents. Journal of documentation 79(4):864-879. https://doi.org/10.1108/jd-06-2022-0135
Arnold, Natalie; Hermanns, Iris M.; Schulz, Andreas; Hahad, Omar; Schmitt, Volker H.; Panova-Noeva, Marina; Prochaska, Jürgen H.; Binder, Harald; Pfeiffer, Norbert; Beutel, Manfred; Lackner, Karl J.; Münzel, Thomas; Wild, Philipp S. (2023): Renin, aldosterone, the aldosterone-to-renin ratio, and incident hypertension among normotensive subjects from the general population. Cardiovascular research 119(1):294-301. https://doi.org/10.1093/cvr/cvac019

2022

Schnabel, Renate B.; Magnussen, Christina; Schulz, Andreas; Ojeda, Francisco; Schmitt, Volker H.; Arnold, Natalie; Sinning, Christoph R.; Beutel, Manfred E.; Schmidtmann, I.; Pfeiffer, Norbert; Leuschner, Anja; Lackner, Karl J.; Gori, Tommaso; Benjamin, Emelia J.; Binder, Harald; Wild, Philipp S.; Blankenberg, Stefan; Münzel, Thomas (2022): Non-invasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population. Cardiovascular research 118(3):904-912. https://doi.org/10.1093/cvr/cvab087
Timmer, Antje; Weberschock, Tobias; Rothenbacher, Dietrich; Varghese, Julian; Berger, Ursula; Schlattmann, Peter; Dugas, Martin; Kopp-Schneider, Annette; Winter, Alfred; Binder, Harald (2022): Digitalisierung, evidenzbasierte Medizin, Prävention und Forschungskompetenz : die Rolle der Medical Data Sciences im neuen Medizin-Curriculum. GMS Medizinische Informatik, Biometrie und Epidemiologie 18(2):Doc06. https://doi.org/10.3205/mibe000239
Fleischer, Toni; Ulke, Christine; Ladwig, Karl-Heinz; Linkohr, Birgit; Johar, Hamimatunnisa; Atasoy, Seryan; Speerforck, Sven; Kruse, Johannes; Zöller, Daniela; Binder, Harald; Otten, Danielle; Brähler, Elmar; Beutel, Manfred E.; Tibubos, Ana Nanette; Grabe, Hans Jörgen; Schomerus, Georg (2022): Geschlechts- und regionalspezifische Unterschiede von Kindesvernachlässigung und Gewalt vor der deutschen Wiedervereinigung. Ergebnisse aus GESA, einem Multi-Kohorten Konsortium. Psychotherapie, Psychosomatik, medizinische Psychologie 72(12):550-557. https://doi.org/10.1055/a-1926-7428
Brombacher, Eva; Hackenberg, Maren; Kreutz, Clemens; Binder, Harald; Treppner, Martin (2022): The performance of deep generative models for learning joint embeddings of single-cell multi-omics data. Frontiers in molecular biosciences 9:962644. https://doi.org/10.3389/fmolb.2022.962644
Grandt, Caine Lucas; Brackmann, Lara Kim; Poplawski, Alicia; Schwarz, Heike; Hummel-Bartenschlager, Willempje; Hankeln, Thomas; Kraemer, Christiane; Marini, Federico; Zahnreich, Sebastian; Schmitt, Iris; Drees, Philipp; Mirsch, Johanna; Grabow, Desiree; Schmidberger, Heinz; Binder, Harald; Hess, Moritz ; Galetzka, Danuta; Marron, Manuela (2022): Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study. Molecular medicine 28(1):105. https://doi.org/10.1186/s10020-022-00520-6
Schönthaler, Martin; Fichtner, Urs Alexander; Boeker, Martin; Zöller, Daniela; Binder, Harald; Prokosch, Hans-Ulrich; Praus, Friederike; Walther, Tabea; Glienke, Maximilian; Horki, Petar; Gratzke, Christian; Farin-Glattacker, Erik (2022): A nationwide registry for recurrent urolithiasis in the upper urinary tract – The RECUR study protocol. BMC health services research 22(1):1060. https://doi.org/10.1186/s12913-022-08375-7
Köber, Göran; Pooseh, Shakoor; Engen, Haakon; Chmitorz, Andrea; Kampa, Miriam; Schick, Anita; Sebastian, Alexandra; Tüscher, Oliver; Wessa, Michèle; Yuen, Kenneth S. L.; Walter, Henrik; Kalisch, Raffael; Timmer, Jens; Binder, Harald (2022): Individualizing deep dynamic models for psychological resilience data. Scientific reports 12:8061. https://doi.org/10.1038/s41598-022-11650-6
Barsch, Maryam; Salié, Henrike; Schlaak, Alexandra Emilia; Zhang, Zhen; Hess, Moritz ; Mayer, Lena Sophie; Tauber, Catrin; Otto-Mora, Patricia; Nilsson, Tobias; Wischer, Lara; Winkler, Frances; Schmitt-Gräff, Annette; Bronsert, Peter; Hofmann, Maike; Neumann-Haefelin, Christoph; Böttler, Tobias Elmar; Fichtner-Feigl, Stefan; Bettinger, Dominik; Binder, Harald; Schultheiss, Michael; Thimme, Robert; Bengsch, Bertram (2022): T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma. Journal of Hepatology 77(2):397-409. https://doi.org/10.1016/j.jhep.2022.02.032
Ludt, Annekathrin; Ustjanzew, Arsenij; Binder, Harald; Strauch, Konstantin; Marini, Federico (2022): Interactive and reproducible workflows for exploring and modeling RNA‐seq data with pcaExplorer, ideal, and geneTonic. Current protocols 2(4):e411. https://doi.org/10.1002/cpz1.411
Labenz, Christian; Arslanow, Anita; Nguyen-Tat, Marc; Nagel, Michael; Wörns, Marcus-Alexander; Reichert, Matthias Christian; Heil, Franz Josef; Mainz, Dagmar; Zimper, Gundula; Römer, Barbara; Binder, Harald; Farin, Erik; Fichtner, Urs Alexander; Graf, Erika; Stelzer, Dominikus; Ewijk, Reyn van; Ortner, Julia; Velthuis, Louis; Lammert, Frank; Galle, Peter R. (2022): Structured early detection of asymptomatic liver cirrhosis: results of the population-based liver screening program SEAL. Journal of hepatology 77(3):695-701. https://doi.org/10.1016/j.jhep.2022.04.009
Wieringen, Wessel N. van; Binder, Harald (2022): Sequential learning of regression models by penalized estimation. Journal of computational and graphical statistics 31(3):877-886. https://doi.org/10.1080/10618600.2022.2035231
Refisch, Lukas; Lorenz, Fabian; Riedlinger, Torsten; Taubenböck, Hannes; Fischer, Martina; Grabenhenrich, Linus; Wolkewitz, Martin; Binder, Harald; Kreutz, Clemens (2022): Data-driven prediction of COVID-19 cases in Germany for decision making. BMC medical research methodology 22(1):116. https://doi.org/10.1186/s12874-022-01579-9
Binder, Nadine; Dette, Holger; Franz, Julia; Zöller, Daniela; Suarez-Ibarrola, Rodrigo; Gratzke, Christian; Binder, Harald; Miernik, Arkadiusz (2022): Data mining in urology: understanding real-world treatment pathways for lower urinary tract systems via exploration of big data. European urology focus 8(2):391-393. https://doi.org/10.1016/j.euf.2022.03.019
Atasoy, Seryan; Johar, Hamimatunnisa; Fleischer, Toni; Beutel, Manfred; Binder, Harald; Brähler, Elmar; Schomerus, Georg; Zöller, Daniela; Kruse, Johannes; Ladwig, Karl-Heinz (2022): Depression mediates the association between childhood emotional abuse and the onset of type 2 diabetes: Findings from German multi-cohort prospective studies. Frontiers in psychiatry 13:825678. https://doi.org/10.3389/fpsyt.2022.825678
Hackenberg, Maren; Harms, Philipp; Pfaffenlehner, Michelle; Pechmann, Astrid; Kirschner, Janbernd; Schmidt, Thorsten; Binder, Harald (2022): Deep dynamic modeling with just two time points: can we still allow for individual trajectories?. Biometrical journal 64(8):1426-1445. https://doi.org/10.1002/bimj.202000366
Otten, Danielle; Ernst, Mareike; Tibubos, Ana Nanette; Brähler, Elmar; Fleischer, Toni; Schomerus, Georg; Wild, Philipp S.; Zöller, Daniela; Binder, Harald; Kruse, Johannes; Johar, Hamimatunnisa; Atasoy, Seryan; Grabe, Hans Jörgen; Ladwig, Karl-Heinz; Münzel, Thomas; Völzke, Henry; König, Jochem; Beutel, Manfred E. (2022): Does social support prevent suicidal ideation in women and men? Gender-sensitive analyses of an important protective factor within prospective community cohorts. Journal of affective disorders 306:157-166. https://doi.org/10.1016/j.jad.2022.03.031

2021

Marciniak, Marta Anna; Shanahan, Lilly; Rohde, Judith; Ehrt, Yamina; Schulz, Ava; Wackerhagen, Carolin; Kobylińska, Dorota; Tüscher, Olivier; Binder, Harald; Walter, Henrik; Kalisch, Raffael; Kleim, Birgit (2021): Stand-Alone KVT-basierte Interventionen via Smartphone zur Förderung der psychischen Gesundheit. Nervenheilkunde 40(07):558-566. https://doi.org/10.1055/a-1488-4943
Czauderna, Carolin; Poplawski, Alicia; O´Rourke, Colm J.; Castven, Darko; Pérez-Aguilar, Benjamín; Becker, Diana; Heilmann-Heimbach, Stefanie; Odenthal, Margarete; Amer, Wafa; Schmiel, Marcel; Drebber, Uta; Binder, Harald; Ridder, Dirk A.; Schindeldecker, Mario; Straub, Beate Katharina; Galle, Peter R.; Andersen, Jesper Bøje; Thorgeirsson, Snorri S.; Park, Young Nyun; Marquardt, Jens U. (2021): Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis. JCI insight 6(17):e146196. https://doi.org/10.1172/jci.insight.146196

2020

Weber, Matthias; Striaukas, Jonas; Schumacher, Martin; Binder, Harald (2020): Network-constrained covariate coefficient and connection sign estimation. SSRN eLibrary 2020(01):3530820. https://doi.org/10.2139/ssrn.3530820

Alle Publikationen

Prof. Dr. Harald Binder

Kontakt

Bibliographie

Webseiten

Institutionelle Zugehörigkeiten

Publikationen

2026

2025

2024

2023

2022

2021

2020