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Institut für Prävention und Tumorepidemiologie



Leseva MN, Binder AM, Ponsonby A-L, Vuillermin P, Saffery R, Michels KB, et al. Differential gene expression and limited epigenetic dysregulation at the materno-fetal interface in preeclampsia. Hum Mol Genet. 15 2020;29(2):335–50.

Schikowski T, Wigmann C, Fuks KB, Schipf S, Heier M, Neuhauser H, et al. [Blood pressure measurement in the NAKO German National Cohort (GNC) - differences in methods, distribution of blood pressure values, and awareness of hypertension compared to other population-based studies in Germany]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. April 2020;63(4):452–64.

Stiemsma LT, Nakamura RE, Nguyen JG, Michels KB. Does Consumption of Fermented Foods Modify the Human Gut Microbiota? J Nutr. 1. Juli 2020;150(7):1680–92.

Dragano N, Reuter M, Greiser KH, Becher H, Zeeb H, Mikolajczyk R, et al. [Socio-demographic and employment-related factors in the German National Cohort (GNC; NAKO Gesundheitsstudie)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. März 2020;63(3):267–78.

Schmidt CO, Günther K-P, Goronzy J, Albrecht K, Chenot J-F, Callhoff J, et al. [Frequencies of musculoskeletal symptoms and disorders in the population-based German National Cohort (GNC)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. April 2020;63(4):415–25.

Schmid D, Willett WC, Ding M, Michels KB. Maternal and Infant Anthropometric Characteristics and Breast Cancer Incidence in the Daughter. Sci Rep. 13. Februar 2020;10(1):2550.

Karrasch S, Peters A, Meisinger C, Ferland M, Jaeschke L, Pischon T, et al. [Lung function in the German National Cohort: methods and initial results]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. März 2020;63(3):322–31.

Fischer B, Sedlmeier AM, Hartwig S, Schlett CL, Ahrens W, Bamberg F, et al. [Anthropometric measures in the German National Cohort-more than weight and height]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. März 2020;63(3):290–300.

Michels KB, De Vivo I, Calafat AM, Binder AM. In utero exposure to endocrine-disrupting chemicals and telomere length at birth. Environ Res. März 2020;182:109053.

Goldberg M, Tawfik H, Kline J, Michels KB, Wei Y, Cirillo P, et al. Body size at birth, early-life growth and the timing of the menopausal transition and natural menopause. Reprod Toxicol. März 2020;92:91–7.

Nimptsch K, Jaeschke L, Chang-Claude J, Kaaks R, Katzke V, Michels KB, et al. [Self-reported cancer in the German National Cohort (NAKO Gesundheitsstudie): assessment methods and first results]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. April 2020;63(4):385–96.

Kluttig A, Zschocke J, Haerting J, Schmermund A, Gastell S, Steindorf K, et al. [Measuring physical fitness in the German National Cohort-methods, quality assurance, and first descriptive results]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. März 2020;63(3):312–21.

Chavarro JE, Martín-Calvo N, Yuan C, Arvizu M, Rich-Edwards JW, Michels KB, et al. Association of Birth by Cesarean Delivery With Obesity and Type 2 Diabetes Among Adult Women. JAMA Netw Open. 1. April 2020;3(4):e202605.

Hassenstein MJ, Aarabi G, Ahnert P, Becher H, Franzke C-W, Fricke J, et al. [Self-reported infections in the German National Cohort (GNC) in the context of the current research landscape]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. April 2020;63(4):404–14.

Leitzmann M, Gastell S, Hillreiner A, Herbolsheimer F, Baumeister SE, Bohn B, et al. [Physical activity in the German National Cohort (NAKO): use of multiple assessment tools and initial results]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. März 2020;63(3):301–11.

Wolf K, Kraus U, Dzolan M, Bolte G, Lakes T, Schikowski T, et al. [Nighttime transportation noise annoyance in Germany: personal and regional differences in the German National Cohort Study]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. März 2020;63(3):332–43.

Schmid D, Song M, Zhang X, Willett WC, Vaidya R, Giovannucci EL, et al. Yogurt consumption in relation to mortality from cardiovascular disease, cancer, and all causes: a prospective investigation in 2 cohorts of US women and men. Am J Clin Nutr. 01 2020;111(3):689–97.

Holtfreter B, Samietz S, Hertrampf K, Aarabi G, Hagenfeld D, Kim T-S, et al. [Design and quality control of the oral health status examination in the German National Cohort (GNC)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. April 2020;63(4):426–38.

Langer S, Horn J, Kluttig A, Mikolajczyk R, Karrasch S, Schulz H, et al. [Occurrence of bronchial asthma and age at initial asthma diagnosis-first results of the German National Cohort]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. April 2020;63(4):397–403.

Schipf S, Schöne G, Schmidt B, Günther K, Stübs G, Greiser KH, et al. [The baseline assessment of the German National Cohort (NAKO Gesundheitsstudie): participation in the examination modules, quality assurance, and the use of secondary data]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. März 2020;63(3):254–66.

Jaeschke L, Steinbrecher A, Greiser KH, Dörr M, Buck T, Linseisen J, et al. [Assessment of self-reported cardiovascular and metabolic diseases in the German National Cohort (GNC, NAKO Gesundheitsstudie): methods and initial results]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. April 2020;63(4):439–51.

Jaeschke L, Steinbrecher A, Boeing H, Gastell S, Ahrens W, Berger K, et al. Factors associated with habitual time spent in different physical activity intensities using multiday accelerometry. Sci Rep. 21 2020;10(1):774.


Binder N, Blümle A, Balmford J, Motschall E, Oeller P, Schumacher M. Cohort studies were found to be frequently biased by missing disease information due to death. J Clin Epidemiol. 2019 Jan;105:68-79.

Michels KB, Binder N, Courant F, Franke AA, Osterhues A. Urinary excretion of sex steroid hormone metabolites after consumption of cow milk: a randomized crossover intervention trial. Am J Clin Nutr. 2019 Feb 1;109(2):402-410.

Knüppel S, Clemens M, Conrad J, Gastell S, Michels KB, Leitzmann M, Krist L, Pischon T, Krause G, Ahrens W, Ebert N, Jöckel KH, Kluttig A, Obi N, Kaaks R, Lieb W, Schipf S, Brenner H, Heuer T, Harttig U, Linseisen J, Nöthlings U, Boeing H. Design and characterization of dietary assessment in the German National Cohort. Eur J Clin Nutr. 2019 Jan 15. doi: 10.1038/s41430-018-0383-8. [Epub ahead of print]

Terry MB, Cohn BA, Goldberg M, Flom JD, Wei Y, Houghton LC, Tehranifar P, McDonald JA, Protacio A, Cirillo P, Michels KB. Do Birth Weight and Weight Gain During Infancy and Early Childhood Explain Variation in Mammographic Density in Women in Midlife? Results From Cohort and Sibling Analyses. Am J Epidemiol. 2019 Feb 1;188(2):294-304.


Klett H, Balavarca Y, Toth R, Gigic B, Habermann N, Scherer D, Schrotz-King P, Ulrich A, Schirmacher P, Herpel E, Brenner H, Ulrich CM, Michels KB, Busch H, Boerries M. Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles. Epigenetics. 2018;13(4):386-397.

Leseva MN, Grand RJ, Klett H, Boerries M, Busch H, Binder AM, Michels KB. Differences in DNA Methylation and Functional Expression in Lactase Persistent and Non-persistent Individuals. Sci Rep. 2018 Apr 4;8(1):5649.

Skierka AS, Michels KB. Ethical principles and placebo-controlled trials - interpretation and implementation of the Declaration of Helsinki's placebo paragraph in medical research. BMC Med Ethics. 2018 Mar 15;19(1):24.

Binder AM, Corvalan C, Mericq V, Pereira A, Santos JL, Horvath S, Shepherd J, Michels KB. Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls. Epigenetics. 2018;13(1):85-94.

Accomando WP Jr, Michels KB. Multiplexed Reduced Representation Bisulfite Sequencing with Magnetic Bead Fragment Size Selection. Methods Mol Biol. 2018;1708:137-159.

Michels KB, Binder AM. Considerations for Design and Analysis of DNA Methylation Studies. Methods Mol Biol. 2018;1708:31-46.

Schlotz N, Odongo GA, Herz C, Waßmer H, Kühn C, Hanschen FS, Neugart S, Binder N, Ngwene B, Schreiner M, Rohn S, Lamy E. Are Raw Brassica Vegetables Healthier Than Cooked Ones? A Randomized, Controlled Crossover Intervention Trial on the Health-Promoting Potential of Ethiopian Kale. Nutrients. 2018 Nov 2;10(11).


Akmatov MK, Koch N, Vital M, Ahrens W, Flesch-Janys D, Fricke J, Gatzemeier A, Greiser H, Günther K, Illig T, Kaaks R, Krone B, Kühn A, Linseisen J, Meisinger C, Michels K, Moebus S, Nieters A, Obi N, Schultze A, Six-Merker J, Pieper DH, Pessler F. Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study - findings from Pretest 1 of the German National Cohort. Sci Rep. 2017 May 12;7(1):1855. 

Barrow TM, Klett H, Toth R, Böhm J, Gigic B, Habermann N, Scherer D, Schrotz-King P, Skender S, Abbenhardt-Martin C, Zielske L, Schneider M, Ulrich A6, Schirmacher P, Herpel E, Brenner H, Busch H, Boerries M, Ulrich CM, Michels KB. Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study. J Pathol. 2017 Nov;243(3):366-375.

Tserga A, Binder AM, Michels KB. Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism. FASEB J. 2017 Dec;31(12):5149-5158.

van Otterdijk SD, Binder AM, Szarc Vel Szic K, Schwald J, Michels KB. DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome. PLoS One. 2017 Jul 20;12(7).

Ding M, Yuan C, Gaskins AJ, Field AE, Missmer SA, Michels KB, Hu F, Zhang C, Gillman MW, Chavarro J. Smoking during pregnancy in relation to grandchild birth weight and BMI trajectories. PLoS One. 2017 Jul 12;12(7).

Purdue-Smithe AC, Whitcomb BW, Szegda KL, Boutot ME, Manson JE, Hankinson SE, Rosner BA, Troy LM, Michels KB, Bertone-Johnson ER. Vitamin D and calcium intake and risk of early menopause. Am J Clin Nutr. 2017 Jun;105(6):1493-1501.

Gaskins AJ, Pereira A, Quintiliano D, Shepherd JA, Uauy R, Corvalán C, Michels KB. Dairy intake in relation to breast and pubertal development in Chilean girls. Am J Clin Nutr. 2017 May;105(5):1166-1175.

Trudel-Fitzgerald C, Zhou ES, Poole EM, Zhang X, Michels KB, Eliassen AH, Chen WY, Holmes MD, Tworoger SS, Schernhammer ES. Sleep and survival among women with breast cancer: 30 years of follow-up within the Nurses' Health Study. Br J Cancer. 2017 Apr 25;116(9):1239-1246.

Harris HR, Willett WC, Vaidya RL, Michels KB. An Adolescent and Early Adulthood Dietary Pattern Associated with Inflammation and the Incidence of Breast Cancer. Cancer Res. 2017 Mar 1;77(5):1179-1187.

Flom JD, Cohn BA, Tehranifar P, Houghton LC, Wei Y, Protacio A, Cirillo P, Michels KB, Terry MB. Earlier age at menarche in girls with rapid early life growth: cohort and within sibling analyses. Ann Epidemiol. 2017 Mar;27(3):187-193.e2.

Ester WA, Houghton LC, Lumey LH, Michels KB, Hoek HW, Wei Y, Susser ES, Cohn BA, Terry MB. Maternal and Early Childhood Determinants of Women's Body Size in Midlife: Overall Cohort and Sibling Analyses. Am J Epidemiol. 2017 Feb 15:1-10.

Tehranifar P, Cohn BA, Flom JD, Protacio A, Cirillo P, Lumey LH, Michels KB, Terry MB. Early life socioeconomic environment and mammographic breast density. BMC Cancer. 2017 Jan 10;17(1):41.

Powe CE, Tobias DK, Michels KB, Chen WY, Eliassen AH, Manson JE, Rosner B, Willett WC, Hu FB, Zhang C, Rich-Edwards JW, Rexrode KM. History of Gestational Diabetes Mellitus and Risk of Incident Invasive Breast Cancer among Parous Women in the Nurses' Health Study II Prospective Cohort. Cancer Epidemiol Biomarkers Prev. 2017 Mar;26(3):321-327.

Binder N, Manderscheid L, Schumacher M. The combined association of alcohol consumption with dementia risk is likely biased due to lacking account of death cases. Eur J Epidemiol. 2017 Jul;32(7):627-629.


LaRocca J, Binder AM, McElrath TF, Michels KB. First trimester urine concentrations of phthalate metabolites and and phenols and placenta miRNA expression in a cohort of U.S. women. Environ Health Perspect 2016;124:380-7.

Bao W, Michels KB, Tobias DK, Li S, Chavarro JE, Gaskins AJ, Vaag AA, Hu FB, Zhang C. Parental smoking during pregnancy and the risk of gestational diabetes in the daughter. Int J Epidemiol 2016;45:160-169.

Houghton LC, Ester WA, Lumey LH, Michels KB, Wei Y, Cohn BA, Susser E, Terry MB. Maternal weight gain in excess of pregnancy guidelines is related to daughters being overweight 40 years later. Am J Obstet Gynecol 2016; pii: S0002-9378(16)00334-3.

Dougan MM, Field AE, Rich-Edwards JW, Hankinson SE, Glynn RJ, Willett WC, Michels KB. Is grand-parental smoking associated with adolescent obesity? A three-generation study. Int J Obes 2016;40:531-537.

McDonald JA, Michels KB, Cohn BA, Tehranifar P, and Terry MB.  Alcohol Intake from Early Adulthood to Midlife and Mammographic Density.  Cancer Causes Control 2016;27:493-502.

Harris HR, Willett WC, Vaidya RL, Michels KB. Adolescent dietary patterns and premenopausal breast cancer incidence. Carcinogenesis 2016;37:376-84.


Dougan M, Willett WC, Michels KB. Prenatal vitamin intake during pregnancy and offspring obesity. Int J Obesity 2015;39:69-74.

Cook MB, Guenel P, Gapstur SM, van den Brandt PA, Michels KB, Casagrande JT, Cooke R, Van Den Eeden SK, Ewertz M, Falk RT, Gaudet MM, Gkiokas G, Habel LA, Hsing AW, Johnson K, Kolonel LN, La Vecchia C, Lynge E, Lubin JH, McCormack VA, Negri E, Olsson H, Parisi D, Petridou ET, Riboli E, Sesso HD, Swerdlow A, Thomas DB, Willett WC, Brinton LA. Tobacco and alcohol in relation to male breast cancer: an analysis of the male breast cancer pooling project consortium. Cancer Epidemiol Biomarkers Prev 2015;24:520-31.

Carwile JL, Willett WC, Spiegelman D, Hertzmark E, Rich-Edwards J, Frazier AL, Michels KB. Sugar-sweetened beverage consumption and age at menarche in a prospective study of U.S. girls. Human Reproduction 2015;30:675-683.

Barrow TM, Barault L, Ellsworth RE, Harris HR, Binder Am, Valente AL, Shriver CD, Michels KB. Aberrant methylation of imprinted genes is associated with negative hormone receptor status in invasive breast cancer. Int J Cancer 2015;137:537-47.

Dougan MM, Hankinson SE, DeVivo I, Tworoger SS, Glynn RJ, Michels KB. A prospective study of body size throughout the life course and the incidence of endometrial cancer among pre- and postmenopausal women. Int J Cancer 2015;37:625-637.

Devore EE, Kim S, Ramin CA, Wegrzyn LR, Massa J, Holmes MD, Michels KB, Tamimi RM, Forman JP, Schernhammer ES. Antihypertensive medication use and incident breast cancer in women. Breast Cancer Res Treat 2015;150:219-229.

Brinton LA, Key TJ, Kolonel LN, Michels KB, Sesso HD, Ursin G, Van Den Eeden SK, Wood SN, Falk RT, Parisi D, Guillemette C, Caron P, Turcotte V, Habel LA, Isaacs CJ, Riboli E, Weiderpass E, Cook MB. Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer. J Clin Oncol 2015;33:2041-2050.

Charlton BM, Wu K, Zhang X, Giovannucci E, Fuchs CS, Missmer SA, Rosner BA, Hankinson SE, Willett WC, Michels KB. Oral contraceptive use and colorectal cancer in the Nurses’ Health Study I and II. Cancer Epidemiol Biomarkers Prev 2015;24:1214-1221.

Carwile JL, Willett WC, Wang M, Rich-Edwards J, Frazier AL, Michels KB. Milk consumption after age 9 years does not predict age at menarche. J Nutr 2015;145:1900-1908.

Binder AM, LaRocca J, Lesseur C, Marsit C, Michels KB. Epigenome-wide and transcriptome-wise analyses reveal gestational diabetes is associated with alterations in the human leukocyte antigen complex. Clin Epigenetics 2015;7:79.

Arem H, Brinton LA, Moore SC, Gapstur SM, Habel LA, Johnson K, Kolonel LN, McCormack VA, Michels KB, Sesso HD, Ursin G, Van Den Eeden SK, Weiderpass E, Cook MB, Matthews CE. Physical activity and risk of male breast cancer. Cancer Epidemiol Biomarkers Prev 2015;24:1898-1901.


Freese J, Feller S, Harttig U, Kleiser C, Linseisen J, Fischer B, Leitzmann MF, Six-Merker J, Michels KB, Nimptsch K, Steinbrecher A, Pischon T, Heuer T, Hoffmann I, Jacobs G, Boeing H, Nöthlings U. Development and evaluation of a short 24-h food list as part of a blended dietary assessment strategy in large-scale cohort studies. Eur J Clin Nutr 2014;68:324-9.

Sievers C, Akmatov MK, Kreienbrock L, Hille K, Ahrens W, Günther K, Flesch-Janys D, Obi N, Michels KB, Fricke J, Greiser KH, Kaaks R, Peter HH, Pessler F, Nieters A, Krause G. Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : findings of a multicenter study. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1283-91.  

Winkler V, Leitzmann M, Obi N, Ahrens W, Edinger T, Giani G, Linseisen J, Löffler M, Michels K, Nöthlings U, Schipf S, Kluttig A, Wichmann HE, Hoffmann B, Jöckel KH, Becher H. Response in individuals with and without foreign background and application to the National Cohort in Germany: which factors have an effect? Int J Public Health. 2014 Jun;59(3):555-63.  

Kühn A, Nieters A, Köttgen A, Goek ON, Michels K, Nöthlings U, Jacobs G, Meisinger C, Pessler F, Akmatov MF, Kühnisch J, Moebus S, Glocker E, Naus S, Keimling M, Leitzmann M, Linseisen J, Sarioglu H, von Toerne C, Hauck SM, Wallaschofski H, Wichmann HE, Illig T. Feasibility and quality development of biomaterials in the pretest studies of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1255-63.

Michels KB. Contralateral mastectomy for women with hereditary breast cancer. BMJ 2014;348:g1379.

Brinton LA, Cook MB, McCormack V, Johnson KC, Olsson H, Casagrande JT, Cooke R, Falk RT, Gapstur SM, Gaudet MM, Gaziano JM, Gkiokas G, Guénel P, Henderson BE, Hollenbeck A, Hsing AW, Kolonel LN, Isaacs C, Lubin JH, Michels KB, Negri E, Parisi D, Petridou ET, Pike MC, Riboli E, Sesso HD, Snyder K, Swerdlow AJ; The European Rare Cancer Study Group, Trichopoulos D, Ursin G, van den Brandt PA, Van Den Eeden SK, Weiderpass E, Willett WC, Ewertz M, Thomas DB. Anthropometric and Hormonal Risk Factors for Male Breast Cancer: Male Breast Cancer Pooling Project Results. J Natl Cancer Inst 2014;106(3):djt465.

Klar M, Michels KB. Cesarean section and placental disorders in subsequent pregnancies - a meta-analysis. J Perinat Med 2014;42:573-581.

Izzi B, Binder AM, Michels KB. Pyrosequencing evaluation of widely-available bisulfite conversion methods: considerations for application. Med Epigenet 2014;2:28-36.

Non AL, Binder AM, Kubzansky LD, Michels KB. Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy. Epigenetics 2014;9:964-972.

LaRocca J, Binder AM, McElrath T, Michels KB. The impact of first trimester phthalate and phenol exposure on IGF2/H19 genomic imprinting and birth outcomes. Environ Res 2014;133:396-406.

Jaddoe VW, de Jonge LL, van Dam RM, Willett WC, Harris H, Stampfer MJ, Hu FB, Michels KB. Fetal exposure to parental smoking and the risk of type II diabetes in adult women. Diabetes Care 2014;37:2966-73.


Faupel-Badger JM, Arcaro KF, Balkam JJ, Eliassen AH, Hassiotou F, Lebrilla CB, Michels KB, Palmer JR, Schedin P, Stuebe AM, Watson CJ, Sherman ME. Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop. J Natl Cancer Inst 2013;105:166-74.

De Jonge LL, Harris HR, Rich-Edwards JW, Willett WC, Forman MR, Jaddoe VWV, Michels KB. Parental smoking in pregnancy and the risk of adult-onset hypertension. Hypertension 2013;61:494-500.

Boynton-Jarrett R, Wright RJ, Putnam FW, Lividoti Hibert E, Michels KB, Forman MR, Rich-Edwards J. Childhood abuse and age at menarche. J Adolesc Health 2013;52:241-247.

Barault L, Ellsworth RE, Harris HR, Valente AL, Shriver CD, Michels KB. Leukocyte DNA as surrogate for the evaluation of imprinted Loci methylation in mammary tissue DNA. PLoS ONE 2013;8:e55896.

Charlton BM, Carwile JL, Michels KB, Feldman S. A cervical abnormalities risk prediction model: can we use clinical information to predict which patients with ASCUS/LSIL Pap tests will develop CIN2/3 or AIS? J Lower Genital Tract Dis 2013;17:242-247.

Rancourt RC, Harris HR, Barault LB, Michels KB. The prevalence of loss of imprinting of H19 and IGF2 at birth. FASEB 2013;27:3335-3343.

Harris HR, Willett WC, Michels KB. Parental smoking during pregnancy and risk of overweight and obesity in the daughter. Int J Obesity 2013; doi: 10.1038/ijo.2013.101.

Palmsten K, Huybrechts KF, Mogun H, Kowal MK, Williams PL, Michels KB, Setoguchi S, Hernández-Díaz S. Harnessing the Medicaid Analytic eXtract (MAX) to Evaluate Medications in Pregnancy: Design Considerations. PLoS ONE 2013;8(6):e67405.

Osterhues A, Ali N, Michels KB. The role of folic acid fortification in neural tube defects: a review. Crit Rev Food Sci Nutr 2013; 53:1180-1190.

Palmsten K, Huybrechts KF, Michels KB, Williams PL, Mogun H, Setoguchi S, Hernández-Díaz S. Antidepressant use and risk for preeclampsia among women enrolled in Medicaid. Epidemiology 2013;24:682-691.

Carwile JL, Willett WC, Michels KB. Consumption of low-fat dairy products may delay natural menopause. J Nutr 2013;143:1642-1650.

Palmsten K, Hernández-Díaz S, Huybrechts KF, Williams PL, Michels KB, Achtyes E, Mogun H, Setoguchi S. Antidepressant use near delivery and risk of postpartum hemorrhage in a nationwide US cohort of low income women. BMJ 2013;347:f4877.

Michels KB, Binder AM, Dedeurwaerder S, Epstein CB, Greally JM, Gut I, Houseman EA, Izzi B, Kelsey KT, Meissner A, Milosavljevic A, Siegmund KD, Bock C, Irizarry RA. Recommendations for the design and analysis of epigenome-wide association studies. Nature Methods 2013;10:949-955.

Binder AM, Michels KB. The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach. BMC Bioinformatics 2013;14:353.


Michels KB, Terry KL, Eliassen AH, Hankinson SE, Willett WC. Adult weight change and incidence of premenopausal breast cancer. Int J Cancer 2012;130:902-9.

Gu F, Kraft P, Rice M, Michels KB. Leptin and leptin receptor genes in relation to premenopausal breast cancer incidence and grade in Caucasian women. Breast Cancer Res Treat 2012; 131:17-25.

Non AL, Binder AM, Barault L, Rancourt RC, Kubzansky LD, Michels KB. DNA methylation of stress-related genes and LINE-1 repetitive elements across the healthy human placenta. Placenta 2012;33:183-7.

Michels KB. Marking the epigenome – in search of the fingerprints of intrauterine nutritional deficiencies. Int J Epidemiol 2012;41:123-125.

Michels KB. The rise and fall of breast cancer rates. BMJ 2012; 344:d8003.

Michels KB, Saracci R, Lynch J, Pearce N. The Education Corner: updates on new and established core concepts and methods in epidemiology. Int J Epidemiol 2012;41:333-334.

Rothman KJ, Michels KB. The continuing unethical use of placebo controls. In: Miller FG, Kaptchuck TJ, Colloca L, Crouch RA, editors. Pursuing the Placebo: Landmark Studies. Baltimore: John Hopkins University Press; 2012.

Rancourt RC, Harris HR, Michels KB. Methylation levels at imprinting control regions are not altered with ovulation induction or in vitro fertilization in a birth cohort. Human Reproduction 2012;27:2208-16.


Xue F, Michels KB. Breast cancer may originate in utero: the importance of the intrauterine environment for breast cancer development. In: Tot T, editor. Breast Cancer: A Lobar Disease. London: Springer; 2011.

Harris HR, Willett WC, Terry KL, Michels KB. Body fat distribution and risk of premenopausal breast cancer in the Nurses Health Study II. J Natl Cancer Inst 2011;103:273-8.

Xue F, Willett WC, Rosner BA, Hankinson SE, Michels KB. Cigarette smoking and the incidence of breast cancer. Arch Intern Med 2011;171:125-33.

Michels KB, Willett WC. Etiology of cancer: dietary factors. In: DeVita VT, Lawrence TS, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. Philadelphia: Lippincott; 2011.

Jones PA, Michels KB. Epigenetics of cancer. In: DeVita VT, Lawrence TS, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. Philadelphia: Lippincott; 2011.

Wilson KM, Willett WC, Michels KB. Mothers’ pre-pregnancy BMI and weight gain during pregnancy and risk of breast cancer in daughters. Breast Cancer Res Treat 2011;130:273-9.

Mirzaei F, Michels KB, Munger KL, O’Reilly E, Chitnis T, Giovannucci E, Ascherio A. Gestational vitamin D and the risk of Multiple Sclerosis in the offspring. Ann Neurol 2011;70:30-40.

Carwile J, Michels KB. Urinary bisphenol A and obesity: NHANES 2003-2006. Environ Res 2011;111:825-30.

Harris HR, Tworoger SS, Hankinson SE, Rosner BA, Michels KB.  Plasma leptin levels and risk of breast cancer in premenopausal women. Cancer Prev Res 2011;4:1449-56.

Boynton-Jarrett R, Rich-Edwards J, Fredman L, Hibert EL, Michels KB, Forman MR, Wright RJ. Gestational weight gain and daughters’ age at menarche. J Womens Health 2011;20:1193-200.

Harris HR, Tamimi RM, Willett WC, Hankinson SE, Michels KB. Body size across the lifecourse, mammographic density, and risk of breast cancer. Am J Epidemiol 2011;174:909-18.

Michels KB, Harris HR, Barault L. Birthweight, maternal weight trajectories, and global DNA methylation of LINE-1 repetitive elements. PLoS ONE 2011;6(9):e25254.

Stuebe AM, Schwarz EB, Grewen K, Rich-Edwards J, Michels KB, Foster EM, Curhan G, Forman J. Duration of lactation and incidence of maternal hypertension: a longitudinal cohort study. Am J Epidemiol 2011; 174:1147-58.

Michels KB. Medical Detectives. In: Shephard JM, Kosslyn SM, Hammonds EM, editors. The Harvard Sampler. Cambridge, Massachusetts: Harvard University Press; 2011.

Terry MB, Schaefer CA, Flom JD, Wei Y, Tehranifar P, Liao Y, Buka S, Michels KB. Prenatal smoke exposure and mammographic density in mid-life. J Develop Origins Health Dis 2011;2:340-352.

Carwile JL, Ye X, Zhou X, Calafat AM, Michels KB. Canned soup consumption and urinary bisphenol A: a randomized crossover trial. JAMA 2011;306:2218-20.


Ogunleye AA, Xue F, Michels KB. Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res Treat 2010;119:477-84.

Michels KB. The promises and challenges of epigenetic epidemiology. Exp Gerontol 2010;45:297-301.

Tse AC, Michels KB. Maternal and offspring benefits of breast-feeding. In: Symonds ME, Ramsay MM, editors. Maternal-Fetal Nutrition During Pregnancy and Lactation. Cambridge: Cambridge University Press; 2010.

Stephansson O, Granath F, Ekbom A, Michels KB. Risk of breast cancer among daughters of mothers with diabetes: a population-based cohort study. Breast Cancer Res 2010;12:R14.

Michels KB. The design and conduct of population studies of diet and health outcomes. Old Herborn University Seminar Monograph 23; 2010:87-91.

de Haan MC, Michels KB, Peeters PHM, van Noord PAH, Hennekam FAM, van der Schouw YT. Age of mother and grandmother in relation to a subjects’ breast cancer risk. Br J Cancer 2010;102:1400-4.

Palmsten K, Buka SL, Michels KB. Maternal pregnancy-related hypertension and risk for hypertension in offspring later in life. Obstet Gynecol 2010;116:858-64.

Maslova E, Bhattacharya S, Lin SW, Michels KB. Caffeine consumption during pregnancy and risk of preterm birth: a meta-analysis. Am J Clin Nutr 2010;92:1120-32.

Nielsen TS, Khan G, Davis J, Michels KB, Hilakivi-Clarke L. Prepubertal exposure to cow’s milk reduces susceptibility to carcinogen-induced mammary tumorigenesis in rats. Int J Cancer 2010; 128:12-20.

Xue F, Michels KB. Caloric Restriction and Cancer. In: Berger NA, editor. Cancer and Energy Balance, Epidemiology and Overview. Springer Science; 2010.


Michels KB, Willett WC. Self-administered semiquantitative food frequency questionnaires: Patterns, predictors, and interpretation of omitted items. Epidemiology 2009;20:295-301.

Stuebe AM, Michels KB, Willett WC, Manson JE, Rexrode K, Rich-Edwards JW. Duration of lactation and incidence of myocardial infarction in middle to late adulthood. Am J Obstet Gynecol 2009;200:138e1-8.

Caughey RW, Michels KB. Birth weight and childhood leukemia: a meta-analysis and review of the available evidence. Int J Cancer; 2009;124:2658-70.

Michels KB, Willett WC. The Women’s Health Initiative randomized controlled dietary modification trial: a post-mortem. Breast Cancer Res Treat 2009;114:1-6.

Chavarro JE, Michels KB, Isaq S, Rosner BA, Sampson L, Willey C, Tocco P, Willett WC, Chumlea WC. Validity of maternal recall of preschool diet after 43 years. Am J Epidemiol 2009;169:1148-57.

Gardener H, Munger KL, Chitnis T, Michels KB, Spiegelman D, Ascherio A. Prenatal and perinatal factors and risk of multiple sclerosis. Epidemiology 2009;20:611-18.

Stuebe AM, Forman MR, Michels KB. Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter. Int J Obesity 2009;33:743-52.

Michels KB, zur Hausen H. HPV vaccine for all. Lancet 2009;374:268-70.

Stuebe AM, Willett WC, Xue F, Michels KB. Lactation and incidence of premenopausal breast cancer, a longitudinal study. Arch Intern Med 2009;169:1364-71.

Carwile JL, Luu HT, Bassett LS, Driscoll DA, Yuan C, Chang JY, Ye X, Calafat AM, Michels KB. Polycarbonate bottle use and urinary bisphenol A concentrations. Environ Health Perspect 2009;117:1368-72.

Osterhues A, Holzgreve W, Michels KB. Shall we put the world on folate? Lancet 2009;374:959-61.

Chavarro JE, Rosner BA, Sampson L, Willey C, Tocco P, Willett WC, Chumlea WC, Michels KB. Validity of high school diet recall 48 years later. Am J Epidemiol 2009; 170:1563-70.

Institut für Prävention und Tumorepidemiologie


Sabine Frank
Elsässerstr. 2
79110 Freiburg

Tel. +49 761 270-77360
Fax +49 761 270-77340

E-Mail: sabine.frank@uniklinik-freiburg.de

NAKO Studienzentrum
Elsässerstr. 2
79110 Freiburg

Tel. +49 761 270-73190
Fax +49 761 270-77340

E-Mail: nako@uniklinik-freiburg.de