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Institute of Microbiology and Hygiene

Prof. Dr. med. Georg Häcker

Group Leader

Telephone Lab:+49 761 203 5362
Telephone Secretary+49 761 203 6532
Fax:+49 761 203 6651
E-mailgeorg.haecker@uniklinik-freiburg.de

 

 

 

CV

1983Qualification to enter university
1990Medical Examination
1991Doctoral degree (Dr. med., University of Ulm)
1992Approbation (Licence to practise as a medical doctor)
1993-1995Visiting Scientist, Walter and Eliza Hall Institute (Scholarship from the German Research Council, DFG)
1995Research Officer, Walter and Eliza Hall Institute for Medical Research, Melbouren, Australia
1998Habilitation (qualification to join faculty / teaching qualification) in Medical Microbiology and Immunology, Faculty for Medicine, Technical University Munich
1998-2000Privatdozent, Institute for Medical Microbiology, TUM
2000-2009Professor, Institute for Medical Microbiology, Immunology and Hygiene, TUM
2002Specialist Examination (Medical Microbiology and Epidemiology of Infectious Diseases), (Bavarian College of Medical Doctors)
07/2009Full professor and Chair, Department of Medical Microbiology and Hygiene, University of Freiburg, Germany

 

 

 

Who is who?

NamePositionTelefon E-Mail
Prof. Georg HäckerAG-Leiter203- 6531georg.haecker@uniklinik-freiburg.de
Dr. rer. nat. Arnim WeberWiss. Angestellter203- 5362arnim.weber@uniklinik-freiburg.de
Collins KontchouBiol. Doktorand203- 5358collins.kontchou@uniklinik-freiburg.de
Isabel MölterBiol. Doktorandin203- 5358isabel.moelter@uniklinik-freiburg.de
Dr. rer. nat. Michaela OhmerBiol. Doktorandin203- 6546michaela.ohmer@uniklinik-freiburg.de
Aris RoukounakisBiol. Doktorand203- 5358aris.roukounakis@uniklinik-freiburg.de
Dominik BrokatzkyBiol. Doktorand203- 5358dominik.brokatzky@uniklinik-freiburg.de
Constanze EttlBiol. Doktorandin203- 5358constanze.ettl@uniklinik-freiburg.de
Svenja BarthBiol. Doktorandin203- 5358svenja.barth@uniklinik-freiburg.de
Sophie KrügerMTLA203- 5363sophie.krueger@uniklinik-freiburg.de
Arlena MetzBTA203- 5358arlena.metz@uniklinik-freiburg.de

SIGNALLING PATHWAYS – CELL DEATH AND OTHER WAYS OF RESPONDING TO SIGNALS

Life of a multi-cellular organism is determined by interactions between its cells and interactions of these cells with outside factors. In this staggering complexity we focus on a few aspects: Cell death: we are particularly interested in apoptosis as one response the cell has to respond to changes in the microenvironment. We know a lot about apoptosis but there is also a lot we don’t know, which is obviously what we are trying to learn. We use a number of cellular systems and molecular situations to understand how apoptosis is initiated and implemented in mammalian cells. A more detailed description of what we are doing at the moment is given here

Neutrophil granulocytes (neutrophils) are the first professional line of immune reaction and defence in most forms of infection (especially but not exclusively in infections with pyogenic bacteria): invading microorganisms are typically sensed by non-professional immune cells (for instance keratinocytes in the skin) and by tissue resident myeloid cells (such as macrophages). This detection causes them to secrete chemoattractants that cause neutrophils to go from the blood into the infected tissues. In this part of our work we focus mainly on neutrophils (with some attention given also to other immune cells). Neutrophils are relatively short-lived outside tissues and not easy to work with. We use mostly a system where we differentiate mouse neutrophils from progenitor cells and are studying signals determining neutrophil fate as well as signal implementation in the cells. We address questions of survival, differentiation and neutrophil contribution to immune reactions. More is given here.

Chlamydial infections, especially genital infections with Chlamydia trachomatis are a problem whose huge dimensions have only recently started to become apparent. In probably any population of young, sexually active individuals (that is people who do not engage in particularly risky behaviour) at any time there are about 5 % (one in 20) actively infected with C. trachomatis. The acute infection is typically very mild and often (especially in women) not even noticed. The problem is that the infection can stay on for long times and, in women, ascend into the pelvic regions. One of the worst possibilities is unfortunately not uncommon, namely that the prolonged infection causes infertility: the woman cannot conceive children the natural way. Chlamydia has a fascinatingly sophisticated way of growing inside human cells. We are particularly interested in a number of biological aspects of the infection: disturbance of apoptosis by Chlamydia, chlamydial proteolysis in the host cell (which we believe is required for nutrient acquisition by the bacteria), and Chlamydia-induced inflammation. Here you will find more details.

Center for Microbiology and Hygiene

Institute for Microbiology and Hygiene
Hermann-Herder-Str. 11
D-79104 Freiburg
Email: georg.haecker@uniklinik-freiburg.de

 

www.uniklinik-freiburg.de/mikrobiologie  

 

Assistant

Kerstin Jost
Telefon:  +49 761 203 6532
Telefax:  +49 761 203 6651
Email: kerstin.jost@uniklinik-freiburg.de 

 

Receptionist

Frau Bärbel Barton
Telefon:  +49 761 203 6510
Telefax:  +49 761 203 6562