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Genetics of Brain Tumors

News from 26.09.2016: Central switch for frequent brain tumor type found

Due to a novel data analysis, Dr. Carro's laboratory has discovered a central control mechanism for certain brain tumors. With these findings the hope for new therapeutic approaches in the treatment of glioblastomas is growing.

A detailed description of the mode of operation of this central switch can be found here (only in German).

Title of the original study: Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma

DOI: 10.1016/j.ebiom.2016.08.050

Link to original study (in English): www.sciencedirect.com/science/article/pii/S2352396416304078

Popular science article in Scientia: Dr Maria Stella Carro – Making Maps of Shifting Sands


Brain tumor formation upon intracranial injection in mice

Our laboratory is dedicated to understanding the mechanisms of brain tumor formation with a particular focus on human gliomas. This incredibly challenging disease highlights both the application of cutting edge scientific medicine and its limitations as these tumors evade the most targeted therapies. Yet, advances in genome-wide analyses, an ever-increasing production of molecularly targeted/immune directed therapies, and building momentum for understanding the stem-cell component of this disease all mark the present as a time of great promise for new treatment benefits to arise.

Brain tumor isolated cells

Our lab is highly collaborative in nature as we work within the neuro-oncology field to offer patients new hope, educate and train the next generation of neuro-oncology scientists, and advance the general body of knowledge concerning the origins and nature of brain tumors.

Head of Genetics of Brain Tumors group

Head: Dr. Maria Stella Carro
Department of Neurosurgery
Breisacher Str. 64
D-79106 Freiburg