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Abteilung für Orale BiotechnologieDepartment für Zahn-, Mund- und Kieferheilkunde

65. Stolz B, Mader M, Volk L, Steinberg T, Mülhaupt R. Cryo‐3D Printing of Hierarchically Porous Polyhydroxymethylene Scaffolds for Hard Tissue Regeneration. Macromolecular Materials and Engineering. 2020:2000541.

64. Rabel K, Kohal R-J, Steinberg T, Tomakidi P, Rolauffs B, Adolfsson E, Palmero P, Fürderer T, Altmann B: Controlling osteoblast morphology and proliferation via surface micro-topographies of implant biomaterials. Scientific Reports 2020, 10(1):12810.

63. Stolz B, Mönkemeyer F, Mader M, Schmidt S, Volk L, Steinberg T, Bruchmann B, Mülhaupt R: Polyhydroxymethylenes as Multifunctional High Molecular Weight Sugar Alcohols Tailored for 3D Printing and Medical Applications. Macromolecular Chemistry and Physics 2020, n/a(n/a):2000132.

62. Kojima T, Husari A, Dieterle MP, Fontaine S, Prucker O, Tomakidi P, et al. PnBA/PDMAA-Based Iron-Loaded Micropillars Allow for Discrete Cell Adhesion and Analysis of Actuation-Related Molecular Responses. Advanced Materials Interfaces. 2020;7(7):1901806.

61. Belgardt E, Steinberg T, Husari A, Dieterle MP, Hulter-Hassler D, Jung B, Tomakidi P: Force-responsive Zyxin modulation in periodontal ligament cells is regulated by YAP rather than TAZ. Cellular signalling 2020, 72:109662.


60. Husari A, Steinberg T, Dieterle MP, Prucker O, Ruhe J, Jung B, Tomakidi P: On the relationship of YAP and FAK in hMSCs and osteosarcoma cells: Discrimination of FAK modulation by nuclear YAP depletion or YAP silencing. Cell Signal 2019, 63:109382.

59. Wein M, Huelter-Hassler D, Nelson K, Fretwurst T, Nahles S, Finkenzeller G, Altmann B, Steinberg T: Differential osteopontin expression in human osteoblasts derived from iliac crest and alveolar bone and its role in early stages of angiogenesis. J Bone Miner Metab 2019, 37:105-117.

58. Strassburg S, Caduc M, Stark GB, Jedrusik N, Tomakidi P, Steinberg T, Simunovic F, Finkenzeller G: In vivo evaluation of an electrospun gelatin nonwoven mat for regeneration of epithelial tissues. J Biomed Mater Res A 2019, 107:1605-1614.

57. Jedrusik N, Steinberg T, Husari A, Volk L, Wang X, Finkenzeller G, Strassburg S, Tomakidi P: Gelatin nonwovens-based epithelial morphogenesis involves a signaling axis comprising EGF-receptor, MAP kinases ERK 1/2, and beta1 integrin. J Biomed Mater Res A 2019, 107:663-677.

56. Proksch S, Kirsch K, Vach K, Hellwig E, Tomakidi P: Comparative differentiation analysis of distinct oral tissue-derived cells in response to osteogenic stimulation. Clinical oral investigations 2018:1-13.

55. Jerg A, Schulz S, Tomakidi P, Hellwig E, Polydorou O: Modulation of gingival cell response towards dental composites. Dental Materials 2018, 34:412-426.

54. Jedrusik N, Meyen C, Finkenzeller G, Stark GB, Meskath S, Schulz SD, Steinberg T, Eberwein P, Strassburg S, Tomakidi P: Nanofibered Gelatin-Based Nonwoven Elasticity Promotes Epithelial Histogenesis. Adv Healthc Mater 2018, 7:e1700895.

53. Husari A, Hulter-Hassler D, Steinberg T, Schulz SD, Tomakidi P: Disruption of adherens junction and alterations in YAP-related proliferation behavior as part of the underlying cell transformation process of alcohol-induced oral carcinogenesis. Biochim Biophys Acta Mol Cell Res 2018, 1865:209-219.

52. Fretwurst T, Gad LM, Steinberg T, Schmal H, Zeiser R, Amler A-K, Nelson K, Altmann B: Detection of major histocompatibility complex molecules in processed allogeneic bone blocks for use in alveolar ridge reconstruction. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 2018.

51. Hulter-Hassler D, Wein M, Schulz SD, Proksch S, Steinberg T, Jung BA, Tomakidi P: Biomechanical strain-induced modulation of proliferation coincides with an ERK1/2-independent nuclear YAP localization. Exp Cell Res 2017, 361:93-100.

50. Huelter-Hassler D, Tomakidi P, Steinberg T, Jung BA: Orthodontic strain affects the Hippo-pathway effector YAP concomitant with proliferation in human periodontal ligament fibroblasts. Eur J Orthod 2017, 39:251-257.

49. Ehrenmann M, Tomakidi P, Hellwig E, Schulz SD, Polydorou O: Effects of low-dose Bisphenol A on calcium ion influx and on genes of proliferation and differentiation in immortalized human gingival cells in vitro: The role of estrogen receptor beta. Dent Mater 2017, 33:1021-1032.

48. Altmann B, Rabel K, Kohal RJ, Proksch S, Tomakidi P, Adolfsson E, Bernsmann F, Palmero P, Furderer T, Steinberg T: Cellular transcriptional response to zirconia-based implant materials. Dent Mater 2017, 33:241-255.

47. Altmann B, Karygianni L, Al‐Ahmad A, Butz F, Bächle M, Adolfsson E, Fürderer T, Courtois N, Palmero P, Follo M: Assessment of Novel Long‐Lasting Ceria‐Stabilized Zirconia‐Based Ceramics with Different Surface Topographies as Implant Materials. Advanced Functional Materials 2017, 27:1702512.

46. Karygianni L, Proksch S, Schneider S, Vach K, Hellwig E, Steinberg T, Schulz SD, Tchorz JP, Altenburger MJ: The effects of various mixing solutions on the biocompatibility of mineral trioxide aggregate. Int Endod J 2016, 49:561-573.

45. Buskermolen JK, Reijnders CM, Spiekstra SW, Steinberg T, Kleverlaan CJ, Feilzer AJ, Bakker AD, Gibbs S: Development of a Full-Thickness Human Gingiva Equivalent Constructed from Immortalized Keratinocytes and Fibroblasts. Tissue Eng Part C Methods 2016, 22:781-791.

44. Zou P, Laird D, Riga EK, Deng Z, Dorner F, Perez-Hernandez H-R, Guevara-Solarte DL, Steinberg T, Al-Ahmad A, Lienkamp K: Antimicrobial and cell-compatible surface-attached polymer networks–how the correlation of chemical structure to physical and biological data leads to a modified mechanism of action. Journal of Materials Chemistry B 2015, 3:6224-6238.

43. Wein M, Fretwurst T, Nahles S, Duttenhoefer F, Tomakidi P, Steinberg T, Nelson K: Pilot investigation of the molecular discrimination of human osteoblasts from different bone entities. J Craniomaxillofac Surg 2015, 43:1487-1493.

42. Tuna T, Wein M, Swain M, Fischer J, Att W: Influence of ultraviolet photofunctionalization on the surface characteristics of zirconia-based dental implant materials. Dental Materials 2015, 31:e14-e24.

41. Tuna T, Wein M, Altmann B, Steinberg T, Fischer J, Att W: Effect of ultraviolet photofunctionalisation on the cell attractiveness of zirconia implant materials. Eur Cell Mater 2015, 29:82-94; discussion 95-86.

40. Schulz SD, Ruppell C, Tomakidi P, Steinberg T, Reichl FX, Hellwig E, Polydorou O: Gene expression analysis of conventional and interactive human gingival cell systems exposed to dental composites. Dent Mater 2015, 31:1321-1334.

39. Schulz SD, Laquai T, Kümmerer K, Bolek R, Mersch-Sundermann V, Polydorou O: Elution of monomers from provisional composite materials. International Journal of Polymer Science 2015, 2015.

38. Proksch S, Bittermann G, Vach K, Nitschke R, Tomakidi P, Hellwig E: hMSC-Derived VEGF Release Triggers the Chemoattraction of Alveolar Osteoblasts. Stem Cells 2015, 33:3114-3124.

37. Laird D, El-Baba MD, Charpin-El Hamri G, Eberwein P, Nelson K, Tomakidi P, Steinberg T: In vitro and in vivo biocompatibility evaluation of a novobiocin stimulus-responsive poly (ethylene glycol)-based hydrogel designed for soft tissue regeneration. Journal of Bioactive and Compatible Polymers 2015, 30:319-339.

36. Eberwein P, Laird D, Schulz S, Reinhard T, Steinberg T, Tomakidi P: Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors. Biochim Biophys Acta 2015, 1853:2183-2198.

35. Tomakidi P, Schulz S, Proksch S, Weber W, Steinberg T: Focal adhesion kinase (FAK) perspectives in mechanobiology: implications for cell behaviour. Cell Tissue Res 2014, 357:515-526.

34. Schulz S, Beck D, Laird D, Steinberg T, Tomakidi P, Reinhard T, Eberwein P: Natural corneal cell-based microenvironment as prerequisite for balanced 3D corneal epithelial morphogenesis: a promising animal experiment-abandoning tool in ophthalmology. Tissue Eng Part C Methods 2014, 20:297-307.

33. Schulz S, Angarano M, Fabritius M, Mulhaupt R, Dard M, Obrecht M, Tomakidi P, Steinberg T: Nonwoven-based gelatin/polycaprolactone membrane proves suitability in a preclinical assessment for treatment of soft tissue defects. Tissue Eng Part A 2014, 20:1935-1947.

32. Proksch S, Strobel SL, Vach K, Abouassi T, Tomakidi P, Ratka-Kruger P, Hellwig E: Melatonin as a candidate therapeutic drug for protecting bone cells from chlorhexidine-induced damage. J Periodontol 2014, 85:e379-389.

31. Proksch S, Steinberg T, Vach K, Hellwig E, Tomakidi P: Shaping oral cell plasticity to osteogenic differentiation by human mesenchymal stem cell coculture. Cell Tissue Res 2014, 356:159-170.

30. Polydorou O, Rueppell C, Schulz S, Tomakidi P, Hellwig E: The effect of composite materials on gingival cells. Dental Materials 2014:e133.

29. Fretwurst T, Spanou A, Nelson K, Wein M, Steinberg T, Stricker A: Comparison of four different allogeneic bone grafts for alveolar ridge reconstruction: a preliminary histologic and biochemical analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 2014, 118:424-431.

28. Altmann B, Lochner A, Swain M, Kohal RJ, Giselbrecht S, Gottwald E, Steinberg T, Tomakidi P: Differences in morphogenesis of 3D cultured primary human osteoblasts under static and microfluidic growth conditions. Biomaterials 2014, 35:3208-3219.

27. Al-Ahmad A, Zou P, Solarte DL, Hellwig E, Steinberg T, Lienkamp K: Development of a standardized and safe airborne antibacterial assay, and its evaluation on antibacterial biomimetic model surfaces. PLoS One 2014, 9:e111357.

26. Schulz S, Steinberg T, Beck D, Tomakidi P, Accardi R, Tommasino M, Reinhard T, Eberwein P: Generation and evaluation of a human corneal model cell system for ophthalmologic issues using the HPV16 E6/E7 oncogenes as uniform immortalization platform. Differentiation 2013, 85:161-172.

25. Muller K, Engesser R, Schulz S, Steinberg T, Tomakidi P, Weber CC, Ulm R, Timmer J, Zurbriggen MD, Weber W: Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res 2013, 41:e124.

24. Muller K, Engesser R, Metzger S, Schulz S, Kampf MM, Busacker M, Steinberg T, Tomakidi P, Ehrbar M, Nagy F, et al: A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells. Nucleic Acids Res 2013, 41:e77.

23. Moers K, Steinberg T, Schlunck G, Reinhard T, Tomakidi P, Eberwein P: Substrate elasticity as biomechanical modulator of tissue homeostatic parameters in corneal keratinocytes. Exp Cell Res 2013, 319:1889-1901.

22. Gubeli RJ, Laird D, Ehrbar M, Ritter BS, Steinberg T, Tomakidi P, Weber W: Pharmacologically tunable polyethylene-glycol-based cell growth substrate. Acta Biomater 2013, 9:8272-8278.

21. Angarano M, Schulz S, Fabritius M, Vogt R, Steinberg T, Tomakidi P, Friedrich C, Mülhaupt R: Layered gradient nonwovens of in situ crosslinked electrospun collagenous nanofibers used as modular scaffold systems for soft tissue regeneration. Advanced Functional Materials 2013, 23:3277-3285.

20. Altmann B, Kohal RJ, Steinberg T, Tomakidi P, Bachle-Haas M, Wennerberg A, Att W: Distinct cell functions of osteoblasts on UV-functionalized titanium- and zirconia-based implant materials are modulated by surface topography. Tissue Eng Part C Methods 2013, 19:850-863.

19. Al-Ahmad A, Laird D, Zou P, Tomakidi P, Steinberg T, Lienkamp K: Nature-inspired antimicrobial polymers--assessment of their potential for biomedical applications. PLoS One 2013, 8:e73812.

18. Schulz SD, Konig A, Steinberg T, Tomakidi P, Hellwig E, Polydorou O: Human gingival keratinocyte response to substances eluted from silorane composite material reveal impact on cell behavior reflected by RNA levels and induction of apoptosis. Dent Mater 2012, 28:e135-142.

17. Schulz S, Tomakidi P, Mauth C, Kohal R, Steinberg T: Interactive fibroblast-keratinocyte co-cultures: an in vivo-like test platform for dental implant-based soft tissue integration. Tissue Eng Part C Methods 2012, 18:785-796.

16. Proksch S, Steinberg T, Stampf S, Schwarz U, Hellwig E, Tomakidi P: Crosstalk on cell behavior in interactive cocultures of hMSCs with various oral cell types. Tissue Eng Part A 2012, 18:2601-2610.

15. Proksch S, Steinberg T, Schulz S, Sauerbier S, Hellwig E, Tomakidi P: Environmental biomechanics substantiated by defined pillar micropatterns govern behavior of human mesenchymal stem cells. Cell Transplant 2012, 21:2455-2469.

14. Proksch S, Steinberg T, Keller C, Wolkewitz M, Wiedmann-Al-Ahmad M, Finkenzeller G, Hannig C, Hellwig E, Al-Ahmad A: Human saliva exposure modulates bone cell performance in vitro. Clin Oral Investig 2012, 16:69-77.

13. Woertche E, Deibler M, Schulz S, Steinberg T, Kemkemer R, Tomakidi P: Kinetic fingerprint discriminates similar cell populations subjected to uniaxial cyclic tensile strain on flexible substrates. Soft Matter 2011, 7:8612-8618.

12. Weisse S, Heydt M, Maier T, Schulz S, Spatz JP, Grunze M, Haraszti T, Rosenhahn A: Flow conditions in the vicinity of microstructured interfaces studied by holography and implications for the assembly of artificial actin networks. Phys Chem Chem Phys 2011, 13:13395-13402.

11. Steinberg T, Ziegler N, Alonso A, Kohl A, Mussig E, Proksch S, Schulz S, Tomakidi P: Strain response in fibroblasts indicates a possible role of the Ca(2+)-dependent nuclear transcription factor NM1 in RNA synthesis. Cell Calcium 2011, 49:259-271.

10. Hellmann JK, Munter S, Kudryashev M, Schulz S, Heiss K, Muller AK, Matuschewski K, Spatz JP, Schwarz US, Frischknecht F: Environmental constraints guide migration of malaria parasites during transmission. PLoS Pathog 2011, 7:e1002080.

9. Eberwein P, Steinberg T, Schulz S, Zimmermann D, Accardi R, Beck D, Reinhard T, Tomakidi P: Expression of keratinocyte biomarkers is governed by environmental biomechanics. Eur J Cell Biol 2011, 90:1029-1040.


8. Ziegler N, Alonso A, Steinberg T, Woodnutt D, Kohl A, Mussig E, Schulz S, Tomakidi P: Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression. BMC Cell Biol 2010, 11:10.

7. Pommerencke T, Westphal K, Ernst C, Safferling K, Dickhaus H, Steinberg T, Tomakidi P, Grabe N: Spatial quantification and classification of skin response following perturbation using organotypic skin cultures. Bioinformatics 2010, 26:2760-2766.

6. Mussig E, Schulz S, Spatz JP, Ziegler N, Tomakidi P, Steinberg T: Soft micropillar interfaces of distinct biomechanics govern behaviour of periodontal cells. Eur J Cell Biol 2010, 89:315-325.

5. Mussig E, Tomakidi P, Steinberg T: Gingival fibroblasts established on microstructured model surfaces: their influence on epithelial morphogenesis and other tissue-specific cell functions in a co-cultured epithelium: an in-vitro model. J Orofac Orthop 2009, 70:351-362.

4. Dannewitz B, Tomakidi P, Syagailo Y, Kohl A, Staehle HJ, Eickholz P, Komposch G, Steinberg T: Elevation of collagen type I in fibroblast-keratinocyte cocultures emphasizes the decisive role of fibroblasts in the manifestation of the phenotype of cyclosporin A-induced gingival overgrowth. J Periodontal Res 2009, 44:62-72.

3. Pommerencke T, Steinberg T, Dickhaus H, Tomakidi P, Grabe N: Nuclear staining and relative distance for quantifying epidermal differentiation in biomarker expression profiling. BMC Bioinformatics 2008, 9:473.

2. Mussig E, Steinberg T, Schulz S, Spatz JP, Ulmer J, Grabe N, Kohl A, Komposch G, Tomakidi P: Connective‐Tissue Fibroblasts Established on Micropillar Interfaces are Pivotal for Epithelial‐Tissue Morphogenesis. Advanced Functional Materials 2008, 18:2919-2929.

1. Mussig E, Steinberg T, Kohl A, Chamulitrat W, Komposch G, Tomakidi P: Discrimination of epithelium-like and fibroblast-like phenotypes derived from ethanol-treated immortalised human gingival keratinocytes in epithelial equivalents. Cell Tissue Res 2008, 332:57-71.

Universitätsklinikum Freiburg

Department für Zahn-, Mund- und Kieferheilkunde

Abteilung Orale Biotechnologie


Prof. Dr. Pascal Tomakidi (PhD)

Tel.: +49 761 270 4745

E-Mail: pascal.tomakidi@uniklinik-freiburg.de


Prof. Dr. Thorsten Steinberg

Tel.: +49 761 270 47460

Fax: +49 761 270 47440

E-Mail: thorsten.steinberg@uniklinik-freiburg.de