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Abteilung Stereotaktische und Funktionelle Neurochirurgie

Prof. Dr. med. Volker Arnd Coenen

Lebenslauf / Curriculum vitae

Ärztlicher Leiter
Abteilung Stereotaktische und Funktionelle Neurochirurgie

Klinik für Neurochirurgie
Universitätsklinikum Freiburg (i.Br.)

Dienstlich:
Abteilung Stereotaktische und Funktionelle Neurochirurgie
Universitätsklinikum Freiburg
Breisacher Straße 64
D – 79106 Freiburg (i.Br.)
stereotaxie@uniklinik-freiburg.de
Sekretariat: Telefon +49 761 270 50630
                        Telefax +49 761 270 50100

Lebenslauf

Ausbildung/Arbeitserfahrung:

1991 Abitur
1991 -1992 Zivildienst
1992 - 1998 Studium der Humanmedizin. Rheinisch Westfälische Technische Hochschule (RWTH) Aachen
1998 Approbation als Arzt
1999 - 2000 Arzt im Praktikum, Neurochirurgische Klinik, Universitätsklinikum Aachen (Prof. Dr. med. J.M. Gilsbach)
2000 Arzt im Praktikum, Klinik für Anästhesiologie, Universitätsklinikum Aachen, 6-monatige Rotation, Intensivmedizin (Prof. Dr. med. R. Rossaint)
2000 – 2005 Assistenzarzt, Neurochirurgische Klinik, Universitätsklinikum Aachen
2002 Fachkunde für den Rettungsdienst
4 -2005 Facharzt für Neurochirurgie
9 -2005 Oberarzt
2005 - 2008 Leiter des Bereichs Funktionelle Stereotaxie, Neurochirurgische Klinik, UK-Aachen
2007 - 2008 Fellowship "Functional and stereotactic neurosurgery" Surgical Center for Movement Disorders, University of British Columbia, Vancouver, BC, Canada (Christopher R. Honey, M.D., D.phil.)
2008 - 9/2012 Ärztlicher Leiter (W2-Professur) des FE Stereotaxie und MR-basierte Operationsverfahren / Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Bonn
10 - 12/2012 Ärztlicher Leiter (W2-Professur) der Division Stereotaxie und Funktionelle Neurochirurgie / Klinik und Poliklinik für Neurochirurgie, UK Bonn
seit 1/2013 Ärztlicher Leiter (W3-Professur) der Abteilung Stereotaktische und Funktionelle Neurochirurgie
Klinik für Neurochirurgie, Universitätsklinikum Freiburg

Promotion/Habilitation

5-2000 Promotion: "Morphologie und Morphometrie des Temporallappens und des Unterhorns des Seitenventrikels bei Schizophrenie – in-vivo Kernspinstudie" Institut für Anatomie I der RWTH Aachen, Prof. Dr. med. D. Graf v. Keyserlingk
7-2005 Habilitation: "Projektion individueller Faserbahnen in den neurochirurgischen Operationssitus" Neurochirurgische Klinik, Medizinische Fakultät der RWTH AACHEN, Univ. Prof. Dr. med. J.M. Gilsbach

Auslandsaufenthalte:

1995 Department of Neurology, Royal Devon and Exeter Hospital, Exeter, Great Britain (Dr. Chr. Gardner-Thorpe
1996 Department of Neurosurgery, Derriford Hospital, Plymouth, Great Britain (Mr. K. El-Shunnar)
1997 Department of Neurosurgery, University of Virginia Health Sciences Center, Virginia, USA (Prof. Dr. J.A. Jane sr.)
1998 Department of Neurosurgery, University of Virginia Health Sciences Center, Virginia, USA (Prof. Dr. J.A. Jane sr.)
2007 – 2008 Fellowship "functional and stereotactic neurosurgery" Surgical Center for Movement Disorders, University of British Columbia, Vancouver, BC, Canada (Christopher R. Honey, M.D., d.phil.)

Stipendien/Preise:

5-2013 Long Term Effects of Deep Brain Stimulation of the Medial Forebrain Bundle (slMFB DBS) for treatment resistant depression “Best oral presentation“ WSSFN 16th quadrenial meeting Tokio, Japan
9-2012 Deep Brain stimulation of the medial forebrain bundle for the treatment of depression: Results from the FORESEE trial. “Best oral presentation“ 20th bi-annual meeting of the European society for stereotactic and functional neurosurgery (ESSFN), Lissabon, Portugal
9-2010 The medial forebrain bundle and its role in the circuitry of depression. “Best oral presentation“ 19th bi-annual meeting of the European society for stereotactic and functional neurosurgery (ESSFN), Athen, Griechenland
2007 - 2008 Stipendium der Wilhelm Tönnis -Stiftung der DGNC (Deutsche Gesellschaft für Neurochirurgie), dotiert mit 10.000 €
2001 "Kurt Decker Preis" der Deutschen Gesellschaft für Neuroradiologie für die Arbeit: Timo Krings, Volker A. Coenen, Hubertus Axer et al: Three-dimensional visualization of motor cortex and pyramidal tracts employing functional and diffusion weighted MRI. Methods, applications and limitations.
1993 -1998 Stipendiat der Studienstiftung des Deutschen Volkes, Bonn

Mitgliedschaften:

  • Deutsche Gesellschaft für Neurochirurgie (DGNC). (Ordentliches Mitglied)
  • European Association of Neurosurgical Societies (EANS)
  • The Movement Disorders Society
  • Deutsche Gesellschaft für Computer-und Robotterassistierte Chirurgie (CURAC)
  • European Society for Stereotactic and Functional Neurosurgery (ESSFN)
  • World Society for Functional and Stereotactic Neurosurgery (WSFSN)
  • Arbeitsgemeinschaft Tiefe Hirnstimulation, Kiel (Gründungsmitglied)

Dauerhafte Reviewtätigkeit bei Fachzeitschriften:

  • Neurosurgery (USA)
  • Clinical Neurology and Neurosurgery
  • Acta Neurochirurgica (Wien)
  • Central European Neurosurgery
  • Journal of Neurology Neurosurgery and Psychiatry (London, GB)
  • International Journal of Medical Robotics and Computer Assisted Surgery (GB)
  • Epilepsia
  • Neuroimage

Stand: März 2019

[58] Coenen VA, Schlaepfer TE, Bewernick B, Kilian H, Kaller CP, Urbach H, Li M, Reisert M: Frontal white matter architecture predicts efficacy of deep brain stimulation in major depression. Transl Psychiat, 2019; 9 (1) (online): 197. Epub

[57] Coenen VA, Schlaepfer TE, Varkuti B, Schuurman PR, Reinacher PC, Voges J, Zrinzo L, Blomstedt P, Fenoy AJ, Hariz M: Surgical decision making for deep brain stimulation should not be based on aggregated normative data mining. Brain Stimul, 2019 (in Druck). Epub

[56] Coenen VA, Schlaepfer TE, Reinacher PC, Mast H, Urbach H, Reisert M: Machine learning-aided personalized DTI tractographic planning for deep brain stimulation of the superolateral medial forebrain bundle using HAMLET. Acta Neurochir, 2019; 161 (8):1559-1569. Epub

[55] Coenen VA, Bewernick BH, Kayser S, Kilian H, Boström J, Greschus S, Hurlemann R, Klein ME, Spanier S, Sajonz B, Urbach H, Schlaepfer TE: Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial. Neuropsychopharmacol, 2019; 44 (7): 1224-1232. Epub

[54] Reinacher PC, Várkuti B, Krüger MT, Piroth T, Egger K, Roelz R, Coenen VA: Automatic Segmentation of the Subthalamic Nucleus: A Viable Option to Support Planning and Visualization of Patient-Specific Targeting in Deep Brain Stimulation. Oper Neurosurg, 2019 (in Druck). Epub

[53] Coenen VA, Rijntjes M, Sajonz B, Piroth T, Prokop T, Jost W, Trippel M, Urbach H, Reinacher PC: Bilateral Globus Pallidus Internus Deep Brain Stimulation in a Case of Progressive Dystonia in Mohr-Tranebjaerg Syndrome with Bilateral Cochlear Implants. J Neurol Surg Part A, 2019; 80 (1): 44-48. Epub

[52] Coenen VA, Sajonz B, Reisert M, Bostroem J, Bewernick B, Urbach H, Jenkner C, Reinacher PC, Schlaepfer TE, Mädler B: Tractography-assisted deep brain stimulation of the superolateral branch of the medial forebrain bundle (slMFB DBS) in major depression. Neuroimage-clin, 2018; 20: 580-593. Epub

[51] Coenen VA, Schumacher LV, Kaller C, Schlaepfer TE, Reinacher PC, Egger K, Urbach H, Reisert M: The anatomy of the human medial forebrain bundle: Ventral tegmental area connections to reward-associated subcortical and frontal lobe regions. Neuroimage-clin, 2018; 18: 770-783. Epub

[50] Reinacher PC, Amtage F, Rijntjes M, Piroth T, Prokop T, Jenkner C, Kätzler J, Coenen VA: One Pass Thalamic and Subthalamic Stimulation for Patients with Tremor-Dominant Idiopathic Parkinson Syndrome (OPINION): Protocol for a Randomized, Active-Controlled, Double-Blinded Pilot Trial. JMIR Res Protoc, 2018; 7 (1) (online): e36. Epub

[49] Beeker T, Schlaepfer TE, Coenen VA: Autonomy in Depressive Patients Undergoing DBS-Treatment: Informed Consent, Freedom of Will and DBS' Potential to Restore It. Front Integr Neurosci., 2017; 11 (online): 11. Epub 

[48] Allert N, Barbe MT, Timmermann L, Coenen VA: Rapid battery depletion and loss of therapy due to a short circuit in bipolar DBS for essential tremor. Acta Neurochir, 2017;159 (5): 795-798. Epub

[47] Coenen VA, Varkuti B, Parpaley Y, Skodda S, Prokop T, Urbach H, Li M, Reinacher PC: Postoperative neuroimaging analysis of DRT deep brain stimulation revision surgery for complicated essential tremor. Acta Neurochir, 2017; 159 (5): 779-787. Epub

[46] Coenen VA, Jenkner C, Honey CR, Mädler B: Electrophysiologic Validation of Diffusion Tensor Imaging Tractography during Deep Brain Stimulation Surgery. Am J Neuroradiol, 2016, 37 (8): 1470-1478. Epub

[45] Coenen VA, Schlaepfer TE, Goll P, Reinacher PC, Voderholzer U, Tebartz van Elst L, Urbach H, Freyer T: The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder. Cns Spectrums, 2016. (online): 1-8. Epub

[44] Allert N, Gippert SM, Sajonz BE, Nelles C, Bewernick B, Schlaepfer TE, Coenen VA: Arachnophobia alleviated by subthalamic nucleus stimulation for Parkinson's disease. J Neural Transm, 2016; 123 (6): 631-635. Epub

[43] Coenen VA, Rijntjes M, Prokop T, Piroth T, Amtage F, Urbach H, Reinacher PC: One-pass deep brain stimulation of dentato-rubro-thalamic tract and subthalamic nucleus for tremor-dominant or equivalent type Parkinson's disease. Acta Neurochir, 2016; 158 (4): 773-781. Epub

[42] Coenen VA, Amtage F, Volkmann J, Schläpfer TE. Deep Brain Stimulation in Neurological and Psychiatric Disorders. Dtsch Arztebl Int. 2015 Aug 3;112(31-32):519-26. 

[41] Coenen VA, Kieselbach K, Mader I, Reinacher PC: Diffusion tensor magnetic resonance imaging (DTI) tractography-guided deep brain stimulation in neuropathic pain. Acta Neurochir, 2015; 157 (4): 739-741. 

[40] Döbrössy MD, Furlanetti LL, Coenen VA: Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders. Neurosci Biobehav R, 2015; 49 (2): 32-42. 

[39] Furlanetti LL, Döbrössy MD, Aranda IA, Coenen VA: Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat. Behav Neurol, 2015 (online): 256196. Epub

[38] Marek M, Paus S, Allert N, Mädler B, Klockgether T, Urbach H, Coenen VA: Ataxia and tremor due to lesions involving cerebellar projection pathways: a DTI tractographic study in six patients. J Neurol, 2015; 262 (1): 54-58.

[37] Sajonz BE, Mädler B, Herberhold S, Paus S, Allert N, Coenen VA: Stimulation induced hypogeusia in thalamic deep brain stimulation for tremor: an underestimated yet common side effect. J Neurol Neurosurg Psychiatry, 2016; 87: 565-567. Epub

[36] Coenen VA, Allert N, Paus S, Kronenbürger M, Urbach H, Mädler B: Modulation of the Cerebello-thalamo-cortical Network in Thalamic Deep Brain Stimulation for Tremor: A Diffusion Tensor Imaging Study. Neurosurgery, 2014; 75 (6): 657-670.

[35] Panksepp J, Wright JS, Döbrössy MD, Schlaepfer TE, Coenen VA: Affective Neuroscience Strategies for Understanding and Treating Depression: From Preclinical Models to Three Novel Therapeutics. Clinical Psychological Science, 2014; 2 (4): 472-494.

[34] Coenen VA, Allert N, Paus S, Kronenbürger M, Urbach H, Mädler B: Modulation of the Cerebello-thalamo-cortical Network in Thalamic Deep Brain Stimulation for Tremor: A Diffusion Tensor Imaging Study. Neurosurgery, 2014; 75 (6): 657-670.

[33] Schlaepfer TE, Bewernick BH, Kayser S, Hurlemann R, Coenen VA. Deep brain stimulation of the human reward system for major depression - rationale, outcomes and outlook. Neuropsychopharmacology. 2014 May;39(6):1303-14. doi: 10.1038/npp.2014.28. Epub 2014 Feb 11.

[32] Coenen VA, Mädler B, Schlaepfer TE. Reply to: Medial Forebrain Bundle Stimulation-Speed Access to an Old or Entry into a New Depression Neurocircuit? Biol Psychiatry. 2013 Dec 15;74(12):e45-6. doi: 10.1016/j.biopsych.2013.06.017. Epub 2013 Aug 2.

[31] Schlaepfer TE, Bewernick BH, Kayser S, Mädler B, Coenen VA. Rapid effects of deep brain stimulation for treatment-resistant major depression. Biol Psychiatry. 2013 Jun 15;73(12):1204-12. doi:10.1016/j.biopsych.2013.01.034. Epub 2013 Apr 3. Review.

[30] Schulze-Bonhage A, Coenen VA. [Treatment of epilepsy: peripheral and central stimulation techniques]. Nervenarzt. 2013 Apr;84(4):517-28; quiz 529. doi: 10.1007/s00115-013-3749-0. German.

[29] Coenen VA, Schlaepfer TE, Allert N, Mädler B. Diffusion tensor imaging and neuromodulation: DTI as key technology for deep brain stimulation. Int Rev Neurobiol. 2012;107:207-34. doi: 10.1016/B9780-12-404706-8.00011-5. Review.

[28] Coenen VA, Panksepp J, Hurwitz TA, Urbach H, Mädler B. Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression. J Neuropsychiatry Clin Neurosci. 2012 Mar 1;24(2):223-36.

[27] Mädler B, Coenen VA. Explaining clinical (side) effects of deep brain stimulation through simplified target specific modeling of the volume of activated tissue. AJNR Am J Neuroradiol. 2012 Jun;33(6):1072-80. Epub 2012 Feb 2.

[26] Sajonz B, Mädler B, Herberhold S, Paus S, Coenen VA. A case of tremor reduction and almost complete ageusia under bilateral thalamic (VIM) deep brain stimulation in essential tremor--a therapeutic dilemma. Acta Neurochir (Wien). 2011 Dec;153(12):2361-3. Epub 2011 Oct 8.

[25] Coenen VA, Abdel Rahman A, McMaster J, Bogod N, Honey CR. Minimizing brain shift during functional neurosurgical procedures -A simple burr hole technique that can decrease CSF loss and intracranial air. Cent Eur Neurosurg. 2011 Nov;72(4):181-5. Epub 2011 Jul 7.

[24] Coenen VA, Allert N, Mädler B. A role of diffusion tensor imaging fiber tracking in deep brain stimulation surgery: DBS of the dentato-rubro-thalamic tract (drt) for the treatment of therapy refractory tremor. Acta Neurochir (Wien). 2011 Aug;153(8):1579-85; discussion 1585. doi: 10.1007/s00701-011-1036-z. Epub 2011 May 8.

[23] Allert N, Kelm D, Spottke A, Coenen VA. Role of dysphagia in evaluating Parkinson patients for subthalamic nucleus stimulation: a case report. J Neural Transm. 2011 Feb 27. [Epub ahead of print]

[22] Allert N, Miskiewicz AA, Coenen VA. [Deep brain stimulation for Parkinson's disease and camptocormia? A case report]. Fortschr Neurol Psychiatr. 2011 Feb;79(2):97-101. Epub 2011 Jan 20. German.

[21] Rohde V, Coenen VA. Intraoperative 3-dimensional ultrasound for resection control during brain tumour removal: preliminary results of a prospective randomized study. Acta Neurochir Suppl. 2011;109:187-90.

[20] Coenen VA, Mädler B, Schiffbauer H, Urbach H, Allert N. Individual fiber anatomy of the subthalamic region revealed with DTI – A concept to identify the DBS target for tremor suppression. Neurosurgery. 2011 Apr;68(4):1069-75; discussion 1075-6. doi: 10.1227/NEU.0b013e31820a1a20. Erratum in: Neurosurgery. 2011 Jun;68(6):E1780-1.

[19] Coenen VA, Schlaepfer TE, Maedler B, Panksepp J. Cross-species affective functions of the medial forebrain bundle-Implications for the treatment of affective pain and depression in humans. Neurosci Biobehav Rev. 2011 Oct;35(9):1971-81. doi: 10.1016/j.neubiorev.2010.12.009. Epub 2010 Dec 22. Review.

[18] Schoene-Bake C, Parpaley Y, Weber B, Panksepp J, Hurwitz T, Coenen VA. Tractographic analysis of historical lesion-surgery for depression. Neuropsychopharmacology, Epub 25 august 2010

[17] Coenen VA, Honey CR, Hurwitz T, Rahman AA, McMaster J, Bürgel U, Mädler B: Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson's disease. Neurosurgery. 2009 Jun;64(6):1106-14; discussion 1114-5.

[16] Vertinsky AT*, Coenen VA*, Lang DJ, Kolind S, Honey CR, Li D, RauscherA: Localization of the Subthalamic Nucleus: Optimization with Susceptibility-Weighted Phase MR Imaging. AJNR Am J Neuroradiol. 2009 Jun 9. [Epub ahead of print]

* equally contributing

[15] Bürgel U, Mädler B, Honey CR, Thron A, Gilsbach J, Coenen VA: Fiber tracking with distinct software tools results in a clear diversity in anatomical fiber tract portrayal. Cen Eur Neurosurg. 2009 Feb;70(1):27-35. Epub 2009 Feb 3.

[14] Coenen VA, Gielen FLH, Castro-Prado F, Abdel Rahman AY, Honey CR: Noradrenergic modulation of subthalamic nucleus activity in human -Metoprolol reduces spiking activity in microelectrode recordings during deep brain stimulation surgery for Parkinson disease. Acta Neurochirurgica 150:757-62, 2008.

[13] Coenen VA, Prescher A, Schmidt T, Picozzi P, Gielen FLH: What is dorsolateral in the subthalamic nucleus (STN)? – An anatomical consideration on the ambiguous description of one of today’s principle targets for deep brain stimulation (DBS) surgery. 2007. Acta Neurochirurgica 150:1063-65, 2008.

[12] Rohde V, Hans FJ, Dammert S, Gilsbach JM, Coenen VA: How useful is the 3-dimensional, surgeon´s perspective-adjusted visualisation of the vessel anatomy during aneurysm surgery? A prospective clinical trial. Neurosurgical Review 30:209-216, 2007.

[11] Coenen VA, Fromm C, Kronenbürger M, Rohde I, Reinacher PC, Becker R, Marks B, Gilsbach JM, Rohde V: Electrophysiological proof of diffusion weighted imaging derived depiction of the deep-seated pyramidal tract in human. Zentralbl Neurochir. 67(3):117-22, 2006.

[10] Rohde V, Spangenberg P, Mayfrank L, Gilsbach JM, Coenen VA: Advanced neuronavigation in skull base tumors and vascular lesions. MIN -Minimally Invasive Neurosurgery 48:13-18, 2005.

[09] Coenen VA, Gilsbach JM, Dammert S, Thron A, Rohde V: The value of navigated computed tomographic angiography (CTA) for the microneurosurgical management of small cerebrovascular malformations – Neuroradiology, 47(1):66-72, 2005. Epub 2005 Jan 11.

[08] Coenen VA, Krings T, Weidemann J, Hans FJ, Reinacher P, Gilsbach JM, Rohde V: Sequential visualization of brain and fiber tract deformation during intracranial surgery with 3D-Ultrasound (3DUS): An approach to evaluate the effect of brain shift Neurosurgery 56 (ONS Suppl.1): ONS-133-ONS144, 2005.

[07] Coenen VA, Huber KK, Krings T, Weidemann J, Gilsbach JM, Rohde V: Diffusion-weighted imaging guided resection of intracerebral lesions involving the optic radiation. Neurosurgical Review 28:188-195, 2005.

[06] Coenen VA, Gielen F, Rohde I, Fromm C, Kronenbürger M, Dammert S, Rohde V: Subthalamic nucleus stimulation for advanced Parkinson’s disease: How to find a far medial STN. MIN -Minimally Invasive Neurosurgery 47(6):373-7, 2004.

[05] Rohde V, Coenen VA: Endoscopy and Neuronavigation for the management of hydrocephalus, ventricular tumros and intracranial cysts: Personal experience in 81cases. Bulgarian Neurosurgery, 8(1):22-27, 2003.

[04] Coenen VA, Krings T, Axer H, Weidemann J, Kränzlein H, Hans FJ, Thron A, Gilsbach JM, Rohde V: Intraoperative three-dimensional visualization of the pyramidal tract in a neuronavigation system (PTV) reliably predicts true position of principle motor pathways. Surg Neurol: 60(5):381-390, 2003.

[03] Coenen VA, Krings T, Weidemann J, Spangenberg P, Gilsbach JM, Rohde V: Diffusionsgewichtete MRT kombiniert mit navigiertem 3D-Ultraschall und fMRT zur Entfernung eines Kavernoms der Sehstrahlung. Zentralbl Neurochir: 64: 133-137, 2003.

[02] Coenen VA, Krings T, Mayfrank L, Polin RS, Reinges MHT, Thron A, Gilsbach JM: 3D-Visualization of the Pyramidal Tract in a Neuronavigation System during Brain Tumor Surgery: First Experiences and Technical Note. Neurosurgery: 49(1), 86-93, 2001.

[01] Coenen VA, Apperson Hansen C, Kassell NF, Polin RS: Endovascular treatment for symptomatic cerebral vasospasm after subarachnoid hemorrhage: transluminal balloon angioplasty compared with intraarterial papaverine. Neurosurgical Focus:5(4):Article 6, 1998.

[57] Hosp JA, Coenen VA, Rijntjes M, Egger K, Urbach H, Weiller C, Reisert M: Ventral tegmental area connections to motor and sensory cortical fields in humans. Brain Struct Funct, 2019 (in Druck). Epub

[56] Holz A, Mülsch F, Schwarz MK, Hollmann M, Döbrössy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, Serchov T: Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. Neuron, 2019 (in Druck). Epub

[55] Kunz L, Wang L, Lachner-Piza D, Zhang H, Brandt A, Dümpelmann M, Reinacher PC, Coenen VA, Chen D, Wang WX, Zhou W, Liang S, Grewe P, Bien CG, Bierbrauer A, Navarro Schröder T, Schulze-Bonhage A, Axmacher N: Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation. Sci Adv, 2019; 5 (7) (online): eaav8192. Epub

[54] Reinacher PC, Altenmüller DM, Krüger MT, Schulze-Bonhage A, Urbach H, Trippel M, Coenen VA, Delev D: Simultaneous Frame-assisted Stereotactic Placement of Subdural Grid Electrodes and Intracerebral Depth Electrodes. J Neurol Surg Part A, 2019 (in Druck). Epub

[53] Koy A, Bockhorn N, Kühn AA, Schneider GH, Krause P, Lauritsch K, Witt K, Paschen S, Deuschl G, Krauss JK, Saryyeva A, Runge J, Borggraefe I, Mehrkens JH, Horn A, Vesper J, Schnitzler A, Siegert S, Freilinger M, Eckenweiler M, Coenen VA, Tadic V, Voges J, Pauls KAM, Wirths J, Timmermann L, Hellmich M; GEPESTIM consortium: Adverse events associated with deep brain stimulation in patients with childhood-onset dystonia. Brain Stimul, 2019 (in Druck). Epub

[52] Reich MM, Horn A, Lange F, Roothans J, Paschen S, Runge J, Wodarg F, Pozzi NG, Witt K, Nickl RC, Soussand L, Ewert S, Maltese V, Wittstock M, Schneider GH, Coenen V, Mahlknecht P, Poewe W, Eisner W, Helmers AK, Matthies C, Sturm V, Isaias IU, Krauss JK, Kühn AA, Deuschl G, Volkmann J: Probabilistic mapping of the antidystonic effect of pallidal neurostimulation: a multicentre imaging study. Brain 2019 May 1;142(5):1386-1398. Epub

[51] Kilian HM, Meyer DM, Bewernick BH, Spanier S, Coenen VA, Schlaepfer TE: Discontinuation of Superolateral Medial Forebrain Bundle Deep Brain Stimulation for Treatment-Resistant Depression Leads to Critical Relapse. Biol Psychiat, 2019; 85 (6): e23-e24. Epub

[50] Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Priller J, Stadelmann C, Prinz M: Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature, 2019; 566(7744): 388-392. Epub

[49] Roelz R, Scheiwe C, Coenen VA, Reinacher PC: A novel rescue therapy for cerebral vasospasm: Cisternal Nimodipine application via stereotactic catheter ventriculocisternostomy. J Clin Neurosci, 2019; 63:244-248. Epub

[48] Lehtimäki K, Coenen VA, Gonçalves Ferreira A, Boon P, Elger C, Taylor RS, Ryvlin P, Gil-Nagel A, Gielen F, Brionne TC, Abouihia A, Beth G: The Surgical Approach to the Anterior Nucleus of Thalamus in Patients With Refractory Epilepsy: Experience from the International Multicenter Registry (MORE). Neurosurgery, 2019; 84 (1): 141-150. Epub

[47] Duman IE, Coenen VA, Doostkam S, Urbach H: Teaching Neuroimages: Inflammatory CAA. Clin Neuroradiol, 2018 (in Druck). Epub

[46] Ashouri Vajari D, Vomero M, Erhardt JB, Sadr A, Ordonez JS, Coenen VA, Stieglitz T: Integrity Assessment of a Hybrid DBS Probe that Enables Neurotransmitter Detection Simultaneously to Electrical Stimulation and Recording. Micromachines-basel, 2018; 9(10) (online): 510. Epub

[45] Krüger MT, Coenen VA, Jenkner C, Urbach H, Egger K, Reinacher PC: Combination of CT angiography and MRI in surgical planning of deep brain stimulation. Neuroradiology, 2018; 60 (11): 1151-1158. Epub

[44] Krüger MT, Coenen VA, Egger K, Shah M, Reinacher PC: Development of a Standardized Cranial Phantom for Training and Optimization of Functional Stereotactic Operations. Stereot Funct Neuros, 2018; 96 (3): 190-196. Epub

[43] Bewernick BH, Kilian HM, Schmidt K, Reinfeldt RE, Kayser S, Coenen VA, Markett S, Schlaepfer TE: Deep brain stimulation of the supero-lateral branch of the medial forebrain bundle does not lead to changes in personality in patients suffering from severe depression. Psychol Med, 2018; 48(16):2684-2692. Epub

[42] Roelz R, Scheiwe C, Urbach H, Coenen VA, Reinacher P: Stereotactic Catheter Ventriculocisternostomy for Clearance of Subarachnoid Hemorrhage in Patients with Coiled Aneurysms. Operative Neurosurgery, 2018; 14 (3): 231-235. Epub

[41] Nakagawa JM, Trippel M, Doostkam S, Mader I, Coenen VA, Reinacher PC: The stereotactic suboccipitaltranscerebellar approach to lesions of the brainstem and the cerebellum. Clin Neurol Neurosur, 2018; 166: 10-15. Epub

[40] Völker M, Fiederer LDJ, Berberich S, Hammer J, Behncke J, Kršek P, Tomášek M, Marusic P, Reinacher PC, Coenen VA, Helias M, Schulze-Bonhage A, Burgard W, Ball T: The dynamics of error processing in the human brain as reflected by high-gamma activity in noninvasive and intracranial EEG. Neuroimage, 2018; 173: 564-579. Epub

[39] Thiele S, Furlanetti L, Pfeiffer LM, Coenen VA, Döbrössy MD: The effects of bilateral, continuous, and chronic Deep Brain Stimulation of the medial forebrain bundle in a rodent model of depression. Exp Neurol, 2018, 303:153-161. Epub

[38] Weber J, Piroth T, Rijntjes M, Jung B, Reinacher PC, Weiller C, Coenen VA, Klebe S: Atypical Presentation of Rapid-onset Dystonia-parkinsonism (DYT12) Unresponsive to Deep Brain Stimulation of the Subthalamic Nucleus. Mov Disord Clin Pract, 2018; 5 (4): 427-429. Epub

[37] Kuhner A, Schubert T, Cenciarini M, Wiesmeier IK, Coenen VA, Burgard W, Weiller C, Maurer C: Correlations between Motor Symptoms across Different Motor Tasks, Quantified via Random Forest Feature Classification in Parkinson's Disease. Front Neurol, 2017; 8 (online): 607. Epub

[36] Reinacher PC, Coenen VA, Kraeutle R, Scheiwe C, Jabbarli R, Roelz R: Feasibility of stereotactic catheter ventriculocisternostomy for cisternal lavage therapy in patients with subarachnoid hemorrhage. Clin Neurol Neurosur, 2017; 163: 94-102. Epub

[35] Roelz R, Coenen VA, Scheiwe C, Niesen WD, Egger K, Csok I, Kraeutle R, Jabbarli R, Urbach H, Reinacher PC: Stereotactic Catheter Ventriculocisternostomy for Clearance of Subarachnoid Hemorrhage: A Matched Cohort Study. Stroke, 2017; 48(10):2704-2709. Epub

[34] Roelz R, Scheiwe C, Urbach H, Coenen VA, Reinacher P. Stereotactic Catheter Ventriculocisternostomy for Clearance of Subarachnoid Hemorrhage in Patients with Coiled Aneurysms. Oper Neurosurg (Hagerstown), 2017 (in Druck) Epub

[33] Reinacher PC, Krüger MT, Coenen VA, Shah M, Roelz R, Jenkner C, Egger K: Determining the Orientation of Directional Deep Brain Stimulation Electrodes Using 3D Rotational Fluoroscopy. Am J Neuroradiol, 2017; 8 (6): 1111-1116. Epub

[32] Bewernick BH, Kayser S, Gippert SM, Switala C, Coenen VA, Schlaepfer TE: Deep brain stimulation to the medial forebrain bundle for depression- long-term outcomes and a novel data analysis strategy. Brain Stimul, 2017; 10 (3): 664-671. Epub

[31] Koy A, Weinsheimer M, Pauls KA, Kühn AA, Krause P, Huebl J, Schneider GH, Deuschl G, Erasmi R, Falk D, Krauss JK, Lütjens G, Schnitzler A, Wojtecki L, Vesper J, Korinthenberg R, Coenen VA, Visser-Vandewalle V, Hellmich M, Timmermann L, GEPESTIM Consortium: German registry of paediatric deep brain stimulation in patients with childhood-onset dystonia (GEPESTIM). Eur J Paediatr Neuro, 2017; 21 (1): 136-146. Epub

[30] Thiele S, Spehl TS, Frings L, Braun F, Ferch M, Meyer PT, Rezvani A, Furlanetti LL, Coenen VA, Döbrössy MD: Long-term characterization of the Flinders Sensitive Line rodent model of depression: Behavioral and PET evidence of a dysfunctional entorhinal cortex. Behav Brain Res, 2016; 300: 11-24.

[29] Roelz R, Strohmaier D, Jabbarli R, Kraeutle R, Egger K, Coenen VA, Weyerbrock A, Reinacher PC: Residual Tumor Volume as Best Outcome Predictor in Low Grade Glioma - A Nine-Years Near-Randomized Survey of Surgery vs. Biopsy. Scientific Reports, 2016; 6 (online): 32286. Epub

[28] Rauschendorf MA, Jost M, Stock F, Zimmer A, Rösler B, Rijntjes M, Piroth T, Coenen VA, Reinacher PC, Meyer PT, Frings L, Weiller C, Fischer J, Klebe S: Novel compound heterozygous synaptojanin-1 mutation causes l-dopa-responsive dystonia-parkinsonism syndrome. Mov Disord. 2017; 32(3):478-480. Epub

[27] Gippert SM, Switala C, Bewernick BH, Kayser S, Bräuer A, Coenen VA, Schlaepfer TE: Deep brain stimulation for bipolar disorder-review and outlook. Cns Spectrums, 2016 (online): 1-4. Epub

[26] El Tahry R, Hirsch M, Van Rijckevorsel K, Santos SF, de Tourtchaninoff M, Rooijakkers H, Coenen VA, Schulze-Bonhage A: Early experiences with tachycardia-triggered vagus nerve stimulation using the AspireSR stimulator. Epileptic Disord, 2016; 18 (2): 155-162. Epub

[25] Furlanetti LL, Coenen VA, Döbrössy MD: Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain Stimulation of the medial forebrain bündle. Behav Brain Res, 2016; 299: 132-134. Epub

[24] Hirsch M, Coenen VA, Heiland DH, Lützen N, Staszewski O, Schulze-Bonhage A. [Epilepsy-associated tumors of the central nervous system : Epilepsy surgery and oncological aspects]. Nervenarzt. 2016; 87 (4): 402-410. Epub .

[23] Boon P, Vonck K, van Rijckevorsel K, Tahry RE, Elger CE, Mullatti N, Schulze-Bonhage A, Wagner L, Diehl B, Hamer H, Reuber M, Kostov H, Legros B, Noachtar S, Weber YG, Coenen VA, Rooijakkers H, Schijns OE, Selway R, Van Roost D, Eggleston KS, Van Grunderbeek W, Jayewardene AK, McGuire RM. A prospective, multicenter study of cardiac-based seizure detection to activate vagus nerve stimulation. Seizure. 2015 Nov;32:52-61. Epub .

[22] Mormann F, Niediek J, Tudusciuc O, Quesada CM, Coenen VA, Elger CE, Adolphs R. Neurons in the human amygdala encode face identity, but not gaze direction.Nat Neurosci. 2015 Oct 19. (in Druck). Epub .

[21] Kronenbuerger M, Nolte KW, Coenen VA, Burgunder JM, Krauss JK, Weis J: Brain alterations with deep brain stimulation: New insight from a neuropathological case series. Mov Disord., 2015; 30 (8): 1125-1130.

[20] Roelz R, Van Velthoven V, Reinacher P, Coenen VA, Mader I, Urbach H, Meckel S: Unilateral contrast-enhancing pontomedullary lesion due to an intracranial dural arteriovenous fistula with perimedullary spinal venous drainage: the exception that proves the rule. J Neurosurg, 2015. (in Druck)

[19] Heber IA, Coenen VA, Reetz K, Schulz JB, Hoellig A, Fimm B, Kronenbuerger M. Cognitive effects of deep brain stimulation for essential tremor: evaluation at 1 and 6 years. J Neural Transm. 2013 Nov;120(11):1569-77.

[18] Wüllner U, Standop J, Kaut O, Coenen VA, Kalenka A, Wappler F. [Parkinson's disease. Perioperative management and anesthesia]. Anaesthesist. 2012 Feb;61(2):97-105. Review. German.

[17] Möddel G, Coenen VA, Elger CE. [Invasive neurostimulation as adjunct treatment for epilepsy]. Nervenarzt. 2012 Aug;83(8):1001-5. German.

[16] Kronenbuerger M, Zobel S, Ilgner J, Finkelmeyer A, Reinacher P, Coenen VA, Wilms H, Kloss M, Kiening K, Daniels C, Falk D, Schulz JB, Deuschl G, Hummel T. Effects of deep brain stimulation of the cerebellothalamic pathways on the sense of smell. Exp Neurol. 2010 Mar;222(1):144-52. Epub 2010 Jan 4.

[15] Fimm B, Heber IA, Coenen VA, Fromm C, Noth J, Kronenbuerger M. Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease. Mov Disord. 2009 Jun 16. [Epub ahead of print]

[14] Kronenbuerger M, Konczak J, Ziegler W, Buderath P, Frank B, Coenen VA, Kiening K, Reinacher P, Noth J, Timmann D. Balance and Motor Speech Impairment in Essential Tremor. Cerebellum. 2009 May 19. [Epub ahead of print]

[13] Kronenbuerger M, Tronnier VM, Gerwig M, Fromm C, Coenen VA, Reinacher P, Kiening KL, Noth J, Timmann D: Thalamic deep brain stimulation improves eyeblink conditioning deficits in essential tremor. Exp Neurol. 2008 Jun;211(2):387-96. Epub 2008 Feb 21.

[12] Fellows SJ, Kronenburger M, Allert N, Coenen VA, Fromm C, Noth J, Weiss PH. The effect of subthalamic nucleus deep brain stimulation on precision grip abnormalities in Parkinson's disease. Parkinsonism Relat Disord. 2006 Apr;12(3):149-54.

[11] Krings T, Coenen VA, Weinzierl M, Reinges MH, Mull M, Thron A, Rohde V: Spinal dural arteriovenous fistula associated with a spinal perimedullary fistula: case report. J Neurosurg Spine. 2006 Mar;4(3):241-5.

[10] Weinzierl MR, Coenen VA, Korinth MC, Gilsbach JM, Rohde V: Endoscopic transtentorial ventriculocystostomy and cystoventriculoperitoneal shunt in a neonate with Dandy-Walker malformation and associated aqueductal obstruction. Pediatr Neurosurg. 2005 Sep-Oct;41(5):272-7.

[09] Kronenbuerger M, Fromm C, Block F, Coenen VA, Rohde I, Rohde V, Noth J: On-demand deep brain stimulation for essential tremor: A report on four cases. Movement Disorders 2006 Mar;21(3):401-5

[08] Spangenberg P, Coenen VA, Gilsbach JM, Rohde V: Virtual placement of posterior C1-C2 transarticular screw fixation. Neurosurg Rev. 2005 Nov 1;:1-4 [Epub ahead of print]

[07] Reinges MHT, Schoth F, Coenen VA, Krings T: Imaging of postthalamic visual fiber tracts by anisotropic diffusion weighted MRI and diffusion tensor imaging: principlesand applications. European Journal of Radiology 49:91–104, 2004.

[06] Axer H, Gäßel D, Steinhauer M, Stöhr P, John A, Coenen VA, Jansen RH, Keyserlingk DGv: Microwave dielectric measurements and tissue characteristics of the human brain: potential in localizing intracranial tissues. Phys. Med. Biol. 47: 1793 -1803, 2002.

[05] Möller-Hartmann W, Krings T, Coenen VA, Mayfrank L, Weidemann J, Kränzlein H, Thron A. Preoperative assessment of motor cortex and pyramidal tracts in central cavernoma employing functional and diffusion-weighted magnetic resonance imaging. Surg Neurol 58:302– 8, 2002.

[04] Krings T, Coenen VA, Axer H, Möller-Hartmann W, Mayfrank L, Weidemann J, Kränzlein H, Gilsbach JM, Thron A: Three-dimensional visualization of motor cortex and pyramidal tracts employing functional and diffusion weighted MRI. Methods, applications and limitations. Klin Neuroradiol 105-21, 2001.

[03] Krings T, Coenen VA, Axer H, Reinges MH, Holler M, Graf von Keyserlingk D, Gilsbach JM, Thron A: In vivo 3D visualization of normal pyramidal tracts in human subjects using diffusion weighted magnetic resonance imaging and a neuronavigation system. Neurosci. Lett.:307(3):192-196, 2001.

[02] Polin RS, Coenen VA, Apperson Hansen C, Shin P, Baskaya MK, Nanda A, Kassell NF: Efficacy of trans luminal angioplasty for the management of symptomatic cerebral vasospams following aneurysmal subarachnoid hemmorrhage. J Neurosurg: 284-290, 2000.

[01] Niemann K, Hammers A, Coenen VA, Thron A, Klosterkötter J: Evidence of a smaller left hippocampus and left temporal horn in both patients with first episode schizophrenia and normal controls. Psychiatry Reserach: Neuroimaging Section 99: 93-110, 2000.

[3] Coenen VA, Honey CR: Ablative Procedures in Depression. Eds Lozano A, R Tasker, Gildenberg: Textbook of Stereotactic and Functional Neurosurgery, 2nd Edition, 2009, Springer.

[2] Coenen VA, Baskaya MK, Gilsbach JM, Polin RS: Carotid-Cavernous Fistulas. In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. Available at www.medlink.com. 2000-2004.

[1] Niemann K, Spetzger U, Coenen VA, Huetter BO, Kueker W, Keyserlingk DGv: Anatomically guided neuron-avigation: first experience with the sulcuseditor, in Hellwig D, Bauer BL (eds): Minimally Invasive Techniques for Neurosurgery. Current Status and Future Perspectives. Berlin Heidelberg. Springer, 1998, pp 215-221.

 

 

 

 

Stereotaktische und Funktionelle Neurochirurgie

Prof. Dr. Volker Arnd Coenen

Ärztlicher Leiter

Abteilung Stereotaktische und Funktionelle Neurochirurgie
Klinik für Neurochirurgie
Neurozentrum
Universitätsklinikum Freiburg
Breisacher Str. 64
D-79106 Freiburg
Telefon: 0761 270-50630
Telefax: 0761 270-50100
E-Mail:   stereo@uniklinik-freiburg.de