Selected publications 1974 - 2021
Haller, O., Staeheli P., Schwemmle M., and Kochs G:
Mx GTPases: dynamin-like antiviral machines of innate immunity
Trends in Microbiology, 23: 154-163 (2015) (review)
>PubMed
| Haller, O.: Dynamins are forever: MxB inhibits HIV-1 Cell Host Microbe 14: 371-373 (2013) >PubMed |
| Mänz, B., Dornfeld, D., Götz, V., Zell, R., Zimmermann, P., Haller, O., Kochs, G., Schwemmle, M.: Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein. PloS Pathog. e1003279 (2013) >PubMed Adaptive mutations in the nucleoprotein of pandemic influenza A strains were found to confer a degree of resistance to human MxA.
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| Mitchell, P.S., Patzina, C., Emerman, M., Haller, O., Malik, H.S., Kochs, G.: Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. Cell Host Microbe. 12: 598-604 (2012) >PubMed An evolution-guided approach revealed that the loop L4 of MxA has recurrently evolved under positive selection in primates and is the determinant of antiviral specificity for certain viruses. |
| Gao, S., Von der Malsburg, A., Dick, A., Faelber, K., Schröder, G.F., Haller, O., Kochs, G., Daumke, O.: Structure of myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity. 35: 514-525 (2011) >PubMed Description of the crystal structure of the dynamin-like MxA GTPase providing insight into its antiviral action as a molecular machine. Preview by Sadler, A.J., and Williams B.R.G.: „Dynamiting viruses with MxA“, Immunity 35: 491 – 493 (2011). |
| Gao, S., Von der Malsburg, A., Paeschke, S., Behlke, J., Haller, O., Kochs, G., Daumke, O.: Structural basis of oligomerization in the stalk region of dynamin-like MxA Nature. 465: 502-506 (2010) >PubMed First description of the architecture of a dynamin-like large GTPase oligomer. |
| Grimm, D., Staeheli, P., Hufbauer, M., Koerner, I., Martínez-Sobrido, L., Solórzano, A., García-Sastre, A., Haller, O., Kochs, G.: Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc Natl Acad Sci USA. 104: 6806-6811 (2007). >PubMed Demonstration that highly pathogenic influenza viruses escape the innate host response by high speed of replication. |
| Kochs, G., Janzen, Ch., Hohenberg, H. & Haller, O.: Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc Natl Acad Sci USA. 99: 3153-3158 (2002). >PubMed Evidence that human MxA missorts nucleocapsid proteins in infected cells. |
| Bouloy, M., Janzen, C., Vialat, P., Khun, H., Pavlovic, J., Huerre, M. & Haller, O.: Genetic evidence for an interferon- antagonistic function of Rift Valley fever virus nonstructural protein NSs. J. Virol. 75: 1371 – 1377 (2001). >PubMed First description of the interferon-antagonistic function of a nonstructural protein in bunyaviruses. |
| Kochs, G. & Haller, O.: Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. Proc Natl Acad Sci USA. 96: 2082-2086 (1999). >PubMed Evidence that human MxA recognizes viral nucleocapsids in living cells. |
| Arnheiter, H. & Haller, O.: Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon induced Mx proteins. EMBO J. 7: 1315-1320, (1988). >PubMed Demonstration that the antiviral ” intracellular immunity” mediated by the mouse Mx protein can be neutralized by antibodies in living cells. |
| Stäheli, P., Haller, O., Boll, W., Lindenmann, J. & Weissmann, C.: Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell. 44: 147-158 (1986). >PubMed Cloning of an interferon-stimulated gene with specific antiviral function with intrinsic antiviral activity. Editors´choice of The Journal of Infectious Diseases: D. R. Spriggs, “Mx Genes, Interferon, and Enlightment”, J.Inf. Dis, 154, 381-382 (1986). |
| Stäheli, P. & Haller, O.: Interferon-induced human protein with homology to protein Mx of influenza virus resistant mice. Mol Cell Biol. 5: 2150-2153 (1985). >PubMed Description of a human ortholog of mouse Mx. |
| Horisberger, M.A., Stäheli, P. & Haller, O.: Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci USA. 80: 1910-1914 (1983). >PubMed Identification of the Mx protein. |
| Haller, O., Arnheiter, H., Lindenmann, J. & Gresser, I.: Host gene influences sensitivity to interferon action selectively for influenza virus. Nature. 283: 660-662 (1980). >PubMed Demonstration that the antiviral activity of interferon is governed in a virus-specific way by host genes (now called ISGs, for interferon-stimulated genes). |
| Haller, O., Arnheiter, H., Gresser, I. & Lindenmann, J.: Genetically determined, interferon-dependent resistance to influenza virus in mice. J Exp Med. 149: 601-612 (1979). >PubMed Demonstration that Mx-mediated resistance to influenza viruses depends on interferon. |
| Haller, O., Hansson, M., Kiessling, R. & Wigzell, H.: Role of non-conventional, natural killer cells in resistance against syngeneic tumor cells in vivo. Nature. 270: 609-611 (1977). >PubMed Evidence for a role of NK cells in suppressing tumor cell growth in vivo. Editorial by R. W. Baldwin “Immune surveillance revisited”, Nature, 270, 557 (1977). |
| Haller, O., Kiessling, R., Oern, A. & Wigzell, H.: Generation of natural killer cells: An autonomous function of the bone marrow. J Exp Med. 145: 1411-1416 (1977). >PubMed Evidence that Natural Killer (NK) cells originate from bone marrow precursor cells. |
| Haller, O. & Lindenmann, J.: Athymic (nude) mice express gene for myxovirus resistance. Nature. 250: 679-680 (1974). >PubMed Experimental evidence showing that (i) Mx resistance to influenza virus is intact in the immunocompromised host and that (ii) the IgG response against the viral hemagglutinin depends on T cell help. |
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