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Institute of Virology

Herpes- and adenoviruses

Herpes- and adenoviruses are wide spread pathogens in vertebrates. After a mainly symptomless primary infection they establish latency or persistence. However, in susceptible individuals such as immune-compromised patients, newborns, young children, in elderly, or during pregnancy they can provoke fatal diseases either in the context of primary infection or after reactivation from latency.

We use the BAC-technology for the construction of recombinant herpes- and adenovirus genomes. We developed tools, which aid construction and modification recombinant viruses for basic research, gene therapy vector development, and construction of new class of vaccines. We are investigating viral genes, which modulate the host cells and immune responses allowing efficient viral escape of host control.

Recently, we established a new recombinant adeno-associated virus based replicon technology which allows high-throughput assessment of in vitro growth properties of large DNA viruses. This allows easy and fast testing of viral drug resistance and screening for new antivirals. We attempt to identify antiviral compounds with new mode of action targeting viral protein-protein interactions, kinases, and proteases of both viral and host origin. Recently, we established a new recombinant adeno-associated virus based replicon technology which allows high-throughput assessment of in vitro growth properties of large DNA viruses. This allows easy and fast testing of viral drug resistance and screening for new antivirals. We attempt to identify antiviral compounds with new mode of action targeting viral protein-protein interactions, kinases, and proteases of both viral and host origin.

Institute of Virology

Hermann-Herder-Strasse 11
D-79104 Freiburg

Head

Prof. Dr. med. Hartmut Hengel
hartmut.hengel@uniklinik-freiburg.de

Team Leader

Zsolt Ruzsics

Zsolt Ruzsics (Ph.D.)
Phone: +49 761 203 6633
Fax: +49 761 203 6626

Investigators

Hans-Gerhard Burgert


André Riedel