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Herpes- and adenovirus genetics

Herpes- and adenoviruses are wide spread pathogens in vertebrates. After a mainly symptomless primary infection they establish latency or persistence. However, in susceptible individuals such as immune-compromised patients, newborns, young children, in elderly, or during pregnancy they can provoke fatal diseases either in the context of primary infection or after reactivation from latency.

We use the BAC-technology for the construction of recombinant herpes- and adenovirus genomes. We developed tools, which aid construction and modification recombinant viruses for basic research, gene therapy vector development, and construction of new class of vaccines. We are investigating viral genes, which modulate the host cells and immune responses allowing efficient viral escape of host control.

We are member of CRC/TRR 359 Perinatal Development of Immune Cell Topology (PILOT)

Institute of Virology

Hermann-Herder-Strasse 11
D-79104 Freiburg


Prof. Dr. med. Hartmut Hengel

Zsolt Ruzsics

If you are interested in our projects, please contact me.

Zsolt Ruzsics (M.D.)

Phone: +49 761 203 6633
Fax: +49 761 203 6626