PD Dr. Ute Häussler
- Research interests
Focal epilepsies with structural correlate: mesial temporal lobe epilepsy (MTLE), focal cortical dysplasia (FCD)
Embedding of the epileptic focus into brain-wide networks
Role of the hippocampal CA2 region in mesial temporal lobe epilepsy (MTLE)
Structural plasticity of inhibitory interneurons in focal epilepsies
- Publications (PubMed)
Kleis P, Paschen E, Häussler U, Haas CA (2024) Low frequency stimulation for seizure suppression: identification of optimal targets in the entorhinal-hippocampal circuit. Brain Stimulation. doi: 10.1016/j.brs.2024.03.017. (access to article)
Donkels D, Huber S, Demerath T, Scheiwe C, Shah MJ, Heers M, Urbach H, Schulze-Bonhage A, Prinz M, Häussler U, Vlachos A, Beck J, Nakagawa JM, Haas CA (2024) Focal cortical dysplasia type II-dependent maladaptive myelination in the human frontal lobe. bioRxiv. doi: 10.1101/2024.03.02.582894 (access to article)
Häussler U, Neres J, Vandenplas C, Eykens C, Kadiu I, Schramm C, Fleurance R, Stanley P, Godard P, de Mot L, van Eyll J, Knobeloch KP, Haas CA, Dedeurwaerdere S (2024) Downregulation of ubiquitin-specific protease 15 (USP15) does not provide therapeutic benefit in experimental mesial temporal lobe epilepsy. Molecular Neurobiology. doi: 10.1007/s12035-023-03692-2 (access to article)
Paschen E, Kleis P, Vieira DM, Heining K, Böhler C, Egert U, Häussler U, Haas CA (2024) On-demand low-frequency stimulation for seizure control: efficacy and behavioral implications. Brain. doi: 10.1093/brain/awad299 (access to article)
Franz J*, Barheier N*, Tulke S, Wilms H, Haas CA, Häussler U (2023) Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy. Front. Cell. Neurosci. 17:1142507. (access to article)
Kilias A, Tulke S, Barheier N, Ruther P, Häussler U (2023) Integration of the CA2 region in the hippocampal network during epileptogenesis. Hippocampus 33: 223-240. (access to article)
Kleis P, Paschen E, Häussler U, Bernal Sierra YA, Haas CA (2022) Long-term in vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus. BMC Biology 20:18. doi: 10.1186/s12915-021-01210-1 (access to article)
Freiman TM*, Häussler U*, Zentner J, Dooskamp S, Beck J, Scheiwe C; Brandt A, Haas CA, Puhahn-Schmeiser B (2021) Hippocampal mossy fiber sprouting into CA2 in temporal lobe epilepsy. Hippocampus. doi: 10.1002/hipo.23323. (access to article)
Paschen E, Elgueta C, Heining K, Vieira D, Kleis P, Orcinha C, Häussler U, Bartos M, Egert U, Janz P, Haas CA (2020) Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy. eLife 9:e54518. doi: 10.7554/eLife.54518. (access to article)
Heining K, Kilias A, Janz P, Häussler U, Kumar A, Haas CA, Egert U (2019) Bursts with high and low load of epileptiform spikes show context-dependent correlations in epileptic mice. eNeuro 6:0299-18. (access to article)
Tulke S, Haas CA, Häussler U (2019) Expression of brain-derived neurotrophic factor and structural plasticity in the dentate gyrus and CA2 region correlate with epileptiform activity. Epilepsia 60:1234-1247. (access to article)
Kilias A, Häussler U, Heining K, Froriep UP, Haas CA, Egert U (2018) Theta frequency decreases throughout the hippocampal formation in a focal epilepsy model. Hippocampus 28: 375-391. DOI: 10.1002/hipo.22838. (access to article)
Gremmelspacher T, Gerlach J, Hubbe A, Haas CA, Häussler U (2017) Neurogenic processes induced by very short periods of voluntary wheel-running in male mice. Front. Neurosci. 11:385. doi: 10.3389/fnins.2017.00385 (access to article)
Janz P*, Schwaderlapp N*, Heining K*, Häussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P*, Haas CA* (2017) Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy. *equal contribution. eLife 2017;6:e25742 doi: 10.7554/eLife.25742 (access to article)
Janz P, Savanthrapadian S, Häussler U, Kilias A, Nestel S, Kretz O, Kirsch M, Bartos M, Egert U, Haas CA (2017) Synaptic remodeling of entorhinal input contributes to an aberrant hippocampal network in temporal lobe epilepsy. Cerebral Cortex 27 (3): 2348-2364. (access to article)
Häussler U, Rinas K, Kilias A, Egert U, Haas CA (2016) Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy. Hippocampus 26: 577-88. doi:10.1002/hipo.22543. (access to article)
Winkelmann A, You X, Grünewald N, Häussler U, Krestel H, Haas CA, Schwarz G, Chen W, Meier J (2015) Identification of a new genomic hot spot of evolutionary diversification of protein function. PLoS One 10:e0125413. (access to article)
Bedner P, Dupper A, Hüttmann K, Müller J, Herde MK, Dublin P, Deshpande T, Schramm J, Häussler U, Haas CA, Henneberger C, Theis M, Steinhäuser C (2015) Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain 138; 1208-1222. (access to article)
Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Häussler U, Juttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC (2014) Changes in neural network homeostasis trigger neuropsychiatric symptoms. The Journal of Clinical Investigation 124:696-711. (access to article)
Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, Häussler U, Young C, Haas CA, Frotscher M (2014) Epilepsy-Induced Motility of Differentiated Neurons. Cerebral Cortex 24:2130-2140. (access to article)
Marx M, Haas CA, Häussler U (2013) Differential vulnerability of interneurons in the epileptic hippocampus. Frontiers in Cellular Neuroscience 7:167. (access to article)
Fauser S, Häussler U, Donkels C, Huber S, Nakagawa J, Prinz M, Schulze-Bonhage A, Zentner J, Haas CA (2013) Disorganization of neocortical lamination in focal cortical dysplasia is brain-region dependent: evidence from layer-specific marker expression. Acta Neuropathologica Communications 1:47. (access to article)
Dugladze T, Maziashvili N, Borgers C, Gurgenidze S, Häussler U, Winkelmann A, Haas CA, Meier JC, Vida I, Kopell NJ, Gloveli T (2013) GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice. Proceedings of the National Academy of Sciences of the United States of America 110:15073-15078. (access to article)
Sibbe M, Häussler U, Dieni S, Althof D, Haas CA, Frotscher M (2012) Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus. The European Journal of Neuroscience 36:3643-3652. (access to article)
Häussler U, Bielefeld L, Froriep UP, Wolfart J, Haas CA (2012) Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy. Cerebral Cortex 22:26-36. (access to article)
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