Klinik für Neurochirurgie

Main research domain
Brain tumour biology, Ex-vivo Human Brain Organotypic Models and Next generation
Sequencing, Microenvironment studies, Neuroscience.

Current and previous positions

Feb 2023-Present:
Independent Group Leader: “3D-Brain Models (3D-BM) for Neurodegenerative Diseases, Department of Neurosurgery, University Clinic of Freiburg

3D-Brain Models Lab | Universitätsklinikum Freiburg (uniklinikfreiburg.de)

Sep 2018 - Jan 2023:
Junior PI at Department of Neurosurgery, University Clinic of Freiburg.

Oct 2021- July 2022:
Freiburg Institute of Advanced Studies (FRIAS) Junior Fellow

Sep 2018 - Dec 2022:
Post-doctoral research Scientist at Department of Neurosurgery. University Clinic of Freiburg.

Apr 2017 – Sep 2018:
Post-doctoral research scientist at “Sections for Neuroelectronic Systems; University Clinic of Freiburg.

June 2016-Dec 2017:
Post-doctoral research scientist at “FMP- Leibniz Institute Berlin”

Education

Oct 2012- Mar 2016:
Ph.D., Department of Biophysics and Biochemistry, University Autonoma de Barcelona, Spain (Grade: Summa/Excellent cum Laude)

2007- 2009:
Master’s in Bioinformatics, Chennai, India (Grade: University Rank Holder)

2004- 2007:
Bachelor’s in Chemistry, Chennai, India. (Grade: A+)

Academic appointments:

1.Currently reviewer for multiple internationally renowned journals, such as Journal of Neuroinflammation, Neuro-oncology, BMC Cancer, Cellular and Molecular Neurobiology and Journal of Neuro-oncology.
2. Editorial role for Frontiers in Oncology and Frontiers in Immunology.

Achievements, Awards and Funding

Feb 2024-Aug 2024: Internal Research Funding from University Hospital Freiburg to “Explore the microenvironment of Meningioma using 3D Brain Models” (25.000 € for 6 months)
Oct 2023-Oct 2024: Advancement award for Neuro-Oncology 2023, Stiftung Sibylee Assmus. (20.000 €)
July 2023- Aug 2025: DFG Research Grant (280.275 €)
2023: AIRC grant in collaboration with Dr. Eleonora Vannini (500.000 € for 5 Years)
2022: EANO Youngster Award 2022 for Outstanding publication in the field of NeuroOncology
2021: Fellowship from Freiburg Institute of Advanced Studies (FRIAS), Freiburg, Germany (20.000 €)
2016: AGAUR Thesis prize award of 3000 € provided for outstanding doctoral candidates in Barcelona, Spain.
2012: FI-DGR AGAUR EU grant provided for outstanding individuals to conduct PhD in Spain (80.000€ for 3 years)

Conference/Workshop Organization

2022: Chief Organizer for International conference “Vis à vis in the Brain: The Neuron-Glia Interface” in Freiburg (Sep 9th-11th 2022)
(https://www.uniklinik-freiburg.de/ngi-freiburg.html#c219979)
2023: Organization in progress for 2^nd Neuron-Glia Interface meeting (Sep 13-15^th 2023)

Selected Publications:

Cancer Neuroscience:

1. Ravi. V.M…et al., Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma. Cancer Cell (2022) IF: 38.55
2. Ravi. V.M, ...... et al., T-cell dysfunction in Glioblastoma Microenvironment in mediated by myeloid cells releasing Interleukin-10. Nature communications (2022) IF:17.7
3. Heiland D.H* & Ravi. V.M.*…. et al., “Tumor Associated Astrocytes aid the evolution of immunosuppressive environment in Glioblastoma. Nature Communications (2019) IF:17.7 (*Equally contributed)
4. M. Schneider, L. Vollmer, A-L. Pothoff, Ravi. V.M. et al., Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. Neuro-oncology (2021) IF:13.029

Neuroscience:

5. d’Errico P, Ziegler-Waldkirch… Ravi. V.M et al., Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nature Neuroscience (2021) IF: 28.77

Immunology:

6. Buehler M, Yi.X, Ge. W, … Ravi V.M. et al., „Quantitative proteomic landscape of primary and recurrent glioblastoma reveals a protumorigenic role for FBXO2 dependent glioma microenvironment interactions”. Neuroncology (2022)   IF 13.029
7. Meister H, Look T, Roth P.... Ravi V.M. et al., “Multifunctional mRNA-based CART cells display promising Antitumor activity against Glioblastoma. (Clinical Cancer Research) (2022) IF 13.8
 

Selected Talks/Workshops:

2021: “Environmental effect of microglial depletion in human organotypic brain slice cultures” in DGNC
2021: “Spatially Resolved multi-omics deciphers bidirectional tumor-host interdependence in Glioblastoma” in EMBL workshop (Invited by 10X Genomics)
2022: “The role of Aging in Glioblastoma” in SNOG-Helsinki, Finland
2022: “Personalized therapeutic approach in translational Neurooncology” in DGNC, Germany
2022: Invited talk at EANO 2022
2022: Invited Talk by Frontline Genomics “Spatial Heterogeneity in Glioblastoma”
2022: Invited Talk by NOA, Heidelberg, Germany “Räumliche und zeitliche Heterogenität des Glioblastoms“
2023: Invited Talk by IGBMC Strassbourg; 10X User Day Meeting.

Sincerely,

Vidhya M. Ravi

Full Publication List: (2016-2023)

*IF- Impact factor

1. Wang L.Y, Ravi. V.M et al., “Helical unwinding and side chain unlocking unravel the outward open conformation of the melibiose transporter”. Scientifics Reports (2016) IF: 4.99
2. Heiland D.H* & Ravi. V.M.* et al. “Tumor Associated Astrocytes aid the evolution of immunosuppressive environment in Glioblastoma. Nature Communications (2019) IF: 17.69
3. Ravi. V.M, Joseph K…Heiland D.H. „ Human Organotypic Brain Slice culture: a novel framework for environmental research in neuro-oncology. Life Science Alliance (2019) IF 5.19
4. Wurum J, Behringer SP, Ravi V.M. et al., „ Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma”. Cancers (2019) IF 6.5
5. M. Schneider, L. Vollmer, A-L. Pothoff, Ravi. V.M…et al., Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. Neuro-oncology (2021) IF 13.0
6. d’Errico P, Ziegler-Waldkirch… Ravi. V.M et al., Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nature Neuroscience (2021) IF 28.7
7. Maier JP*, Ravi V.M* et al., Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. Cell death and Disease (2021) IF 12.07
8. Ravi. V.M, ...... et al., T-cell dysfunction in Glioblastoma Microenvironment in mediated by myeloid cells releasing Interleukin-10. Nature communications (2022) IF 17.6
9. Ravi. V.M…et al., Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma. Cancer Cell (2022) IF 38.55
10. Buehler M, Yi.X, Ge. W, … Ravi V.M. et al., „Quantitative proteomic landscape of primary and recurrent glioblastoma reveals a protumorigenic role for FBXO2 dependent glioma microenvironment interactions”. Neuroncology (2022) IF 13.0.
11. Meister H, Look T, Roth P.... Ravi V.M. et al., “Multifunctional mRNA-based CART cells display promising Antitumor activity against Glioblastoma”. (Clinical Cancer Research) (2022) IF 13.8
12. Guyon J, Fernandez-Moncada, LArrieu, CM…Ravi. V.M et al., “Lactate dehydrogenase promote glioblastoma growth and invasion via a metabolic symbiosis”. (2022) (EMBO Molecular Medicine) IF 14.0
13. Grote A, Heiland DH… Ravi V.M et al., “Hippocampal innate inflamtory gliosis only in pharmacoresistant temporal lobe epilepsy”. (2023) IF 15.26
14. Pichol-Thievand cathy, Anezo Oceane… Ravi. V.M et al “Vessel Co-option and glioblastoma resistance to therapy is induced by a transition to a senescent and slow cycling cell state” (2023) (Under review in Nature Cancers) IF 23.18

Conference Publications (2017-2023)

1. Heiland DH, Ravi. V.M and Schnell O. P11.58 Astrocytic Environment Aid the Evolution of Immunosuppressive Environment in Glioblastoma. Neuro-oncology 21 (Suppl 3), iii57
2. Behringer S, Ravi V.M, Joseph K and Heiland DH. “TAMI-53. The Oncometabolite D-2HG induce inflammatory astrogliosis causing neurotxicity ad seizures in IDH mutated Glioma. Neuro- oncology 22 (Suppl 2)., ii24
3. Ravi, V.M, Neidert N… and Heiland DH. „IMMU-34 Landscape of Glioblastoma Associated Immunity by integration of ScRNA and Spatial Transcriptomics. Neuro-Oncology 22(Suppl 2), ii12
4. Ravi V.M, Joseph K, Beck J, Schnell O, Heiland DH. „ A Novel glioblastoma invasion model using human brain slice cultures”. Brain and Spine 1, 100823
5. Joseph K, Ravi V.M, Beck J, Heiland DH and Schnell O. “Spatiotemporal diversity of cell communication in glioblastoma aids in transcriptional plasticity”. Brain and Spine 1, 100822.
6. Joseph K, Vollmer L, Ravi V.M, Beck J, Schnell O and Heiland DH. „ OS06.6A Inhibition of GBM invasion by the Alpha amino-3-hydroxy-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist Perampanel. Neuro-Oncology
7. Joseph K, Vollmer L, Ravi V.M, Beck J, Schnell O and Heiland DH. „ Diversity of Cellular Communication in Glioblastoma“. Neuro-oncology 23 (suppl 6), vi213
8. Ravi V.M, Neidert N, Joseph K, beck J, Schnell O and Heiland DH. “JAK-STAT publication inhibition reverses myeloid cell induced anti-tumor immunity in T cells. Neuro-oncology 23, 208-208
9. Will P, Kueckelhaus J, Schnell O, Joseph K, Heiland DH and Ravi V.M. „TAMI-64 Imuune Environemnt shapes glioblastoma heterogeneity in Time and Space. Neuro-oncology 23 (Suppl_6), vi211-vi211
10. Benotmane JK, Kueckelhaue J, Joseph K, Beck J, Schnell O, Ravi V.M and Heiland DH. “Deconvolution of spatially resolved T Cell receptor profiling (SPTCR-seq) uncovered regional Anti-Tumor Immunity in Glioblastoma”. Neuro-Oncology 23 (suppl 6), vi98.
11. Kucekelhaus J, Will P, Joseph K, Ricklefs F, Beck J, Schnell O, Ravi V.M and Heiland DH “ TAMI-39 Integration of Spatially resolved transcriptomics and Metabolomics uncovers Hypoxia driven Accumulation of Genomic Instabilities in Human Glioma. Neuro-oncology 23 (Suppl 6) vi206.
12. Zhang J, Joseph K, Schnell O, Beck J, Heiland DH and Ravi V.M „ A personalized BRAF Mutant Glioblastoma with Human2Human Ex-vivo Cortical cultures. Neuro-oncology 24.