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Institute of Neuropathology

Selected Publications

Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Ćiković T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O. “The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.” Cell Rep. 2017 Dec 26;21(13):3846-3859.

Groß CJ*, Mishra R*, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AA, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O: "K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria." Immunity. 2016 Oct 18;45(4):761-773.

Höckendorf U, Yabal M, Herold T, Munkhbaatar E, Rott S, Jilg S, Kauschinger J, Magnani G, Reisinger F, Heuser M, Kreipe H, Sotlar K, Engleitner T, Rad R, Weichert W, Peschel C, Ruland J, Heikenwalder M, Spiekermann K, Slotta-Huspenina J, Groß O, Jost PJ. "RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells." Cancer Cell. 2016 Jul 11;30(1):75-91. doi: 10.1016/j.ccell.2016.06.002.

Neumann K, Castiñeiras-Vilariño M, Höckendorf U, Hannesschläger N, Lemeer S, Kupka D, Meyermann S, Lech M, Anders HJ, Kuster B, Busch DH, Gewies A, Naumann R, Groß O, Ruland J: "Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death." Immunity. 2014 Mar 20;40(3):389-99.  

Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, and Tschopp J: "Inflammasome Activators Induce Interleukin-1a Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1." Immunity. 2012; 36(3): p. 388-400.

Gross O, Thomas CJ, Guarda G, and Tschopp J : "The inflammasome: an integrated view." Immunol Rev. 2011; 243, 136-151.

Poeck H*, Bscheider M*, Gross O*, Finger K, Roth S, Rebsamen M, Hannesschlager N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J: "Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production." Nat Immunol. 2010; 11(1): 63-69.

Gross O*, Poeck H*, Bscheider M, Dostert C, Hannesschlager N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J: "Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence." Nature. 2009; 459(7245): 433-436.

Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J: "Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity." Nature. 2006; 442(7103): 651-656.

Principle Investigator

Prof. Dr. Olaf Groß

University Clinic Freiburg

Institute of Neuropathologie
Breisacher Straße 64
79106 Freiburg

Tel: +49 761 270 63810