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MEC 2016

Wednesday, 21 September 2016

Festive Opening of the Institute for Experimental Cardiovascular Medicine in Freiburg

Chair: Ursula Ravens (Freiburg)

Welcome addresses by:

Prof. Dr. Dr. h.c. Hans-Jochen Schiewer
Rector of the University of Freiburg, Chairman of the University Heart Centre Freiburg - Bad Krozingen

Prof. Dr. Dr. h.c. mult. J. Rüdiger Siewert
Chief Medical Director of the Medical Centre - University of Freiburg,
Medical Director of the University Heart Centre Freiburg - Bad Krozingen

Prof. Dr. Carola Hunte
Prodean of Research, Faculty of Medicine, University of Freiburg

Volker Kieber
Chairman of the Board of the Benedikt Kreutz Charitable Foundation Bad Krozingen


Kit Parker (Wyss Institute at Harvard University, Boston): Cardiovascular Engineering: Macro to Nano

Natalia Trayanova (Johns Hopkins University, Baltimore): Computational Cardiology: Nano to Macro

Peter Kohl (Director of Research of the University Heart Centre Freiburg-Bad Krozingen, Director of the Institute for Experimental Cardiovascular Medicine)


Thursday, 22 September 2016

Peter Kohl (Freiburg): Greeting

Ursula Ravens (Freiburg): A tribute to Professor Max Lab 

Session 1: Stretch & Structure

Chair: Gentaro Iribe (Okayama)

Takashi Mikawa (San Francisco): Mechanical effects on developmental patterning of atrial conduction

Andrew McCulloch (San Diego): Stretch-induced changes in sarcolemmal organisation

Coffee and Posters

Eva Rog-Zielinska (London): Structural changes in cell membrane compartments during contraction and relaxation

Stephan Rohr (Bern): Aggravation of cardiac myofibroblast arrhythmogeneicity by mechanical stress

Lunch and Posters

Session 2: Mechano-Sensing Mechanisms in Striated Muscle 

Chair: Fred Sachs (Buffalo)

Malcolm Irving (KCL): Sarcomeric mechanosensing by myosin filaments: Frank-Starling reloaded?

Christopher Ward (Baltimore): Microtubules modulate mechanotransduction in heart muscle

Gudrun Antoons (Maastricht): Stretch-induced modulation of Ca2+ handling in atrial and ventricular myocytes

Tea and Posters

Pieter de Tombe (Chicago): Measuring organelle-entrapped calcium in ventricular sarcoplasmic reticulum: new methods and insights

Delphine Dean (Clemson): AFM-based mechanical characterisation of cardiac muscle cells 

Poster Session

With Refreshments, and Nibbles, and more…

Friday, 23 September 2016

Session 3: Quantifying & Classifying Mechanical Stimuli 

Chair: Veronique Meijborg (Amsterdam)

Boris Martinac (Sydney): Single molecule FRET to study pore size and opening mechanism of mechano-sensitive ion channels

Brenton Hoffman (Durham): Construction, imaging, and analysis of FRET-based tension sensors in living cells

Tomaso Zambelli (ETH Zurich): Force-controlled patch clamp of beating cardiac cells

Coffee and Posters

Dirk Trauner (Munich): Controlling Biological Pathways with Synthetic Photoswitches​

Stefan Luther (Göttingen): Simultaneous Mapping of Electrical and Mechanical Activity in the Non-Uncoupled Langendorff Heart​​ 

Lunch and Posters

Session 4: Stretch & Ion Handling 

Chair: Olga Solovyova (Ekaterinburg)

Mario Delmar (New York): Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc

Stephane Sebille (Poitiers): Cardiac TRPV2 channels: role in mediating cardiac pathology

Thomas Suchyna (Buffalo): GsMTx-4: Mechanism of MSC inhibition and cardioprotective potential

Tea and Posters

Remi Peyronnet (Freiburg): Stretch-activated channels in human heart valves

Yoram Etzion (Ben-Gurion University): Leadless Pacing by Magnetic Actuation of Injected Iron-Microparticles

Free Evening or Guided walking tour of historic Freiburg (optional)

Saturday, 24 September 2016

Session 5: MEC & Arrhythmias: Animal Models 

Chair: Larissa Fabritz (University of Birmingham) 

Alex Quinn (Halifax): Mechanically-Induced Ventricular Ectopy and Fibrillation in the Isolated Heart

Ruben Coronel (Amsterdam): Synchronization of repolarization by mechano-electrical coupling in the heart

David Filgueiras-Rama (Madrid): Increased intraventricular pressure favouring sustained re-entry in the swine heart 

Coffee and Posters

José A. Barrabés (Barcelona): Stretch-activated channel block: effects on cardiac electrophysiology ex- and in-situ

Fanny Vaillant (Bordeaux): The isolated working porcine heart model for the study of mechanical, electrophysiological and metabolic functions.​

Lunch and Posters

Session 6: MEC & Arrhythmias in Human 

Chair: Michael R. Franz (Washington)

Dennis Lau (Adelaide): Acute atrial stretch and pulmonary vein arrhythmogenesis

Cathrin Theis (Mainz): Percutaneous Mitral Valve Repair and Ventricular Arrhythmias

Teri Whitman (Minneapolis): Influence of intracardiac pressure on spontaneous ventricular arrhythmias: lessons from the REDUCEhf trial

Tea and Posters

Closing Session

Chair: Peter Kohl (Freiburg)

Mark Marshall (Medtronic): What we’ve learned

Natalia Trayanova (Baltimore): Where we go from here

Discussion, Participant feedback

Meeting Dinner and Dance at Peterhofkeller