Eva Rog-Zielinska, PhD
Head of 4D Imaging, Emmy Noether Fellow
Contact
eva.rog-zielinska@uniklinik-freiburg.de
+49 (0)761 270 63954
Research Interests:
- Nano-to-micro scale investigation of the impact of mechanical activity on cardiac T-tubular system
- Mechanisms of mechanosensing
- Properties of myocardial infarction scars
Brief CV:
Eva obtained her Biotechnology Master’s degree from the Nicolaus Copernicus University in Torun, Poland. She was then awarded a 4-year British Heart Foundation PhD studentship at the University of Edinburgh in 2008, during which time she investigated late gestation development of the heart. Since 2013 she has been working with Professor Peter Kohl at Imperial College London and IEKM at Freiburg. In 2015 Eva has been awarded a 3-year BHF Immediate Post-doctoral Basic Research Fellowship. She maintains close collaborations with University of Colorado Boulder, University of Bristol, and EMBL Heidelberg. Since 2017 she heads the 4D Imaging section at the IEKM in Freiburg, since August 2018 as an Emmy Noether Fellow.
Selected Publications:
- Greiner J, Schiatti T, Kaltenbacher W, Dente M, Semenajakin A, Kok T [...] Ravens U, Kohl P, Peyronnet R, Rog-Zielinska EA. Consecutive-Day Ventricular and Atrial Cardiomyocyte Isolations from the Same Heart: Shifting the Cost-Benefit Balance of Cardiac Primary Cell Research. Cells 2022/11(2):233
- Rog-Zielinska EA , Moss R, Kaltenbacher W, Greiner J [...] Seemann G, Kohl P, Cannell MB. Nano-scale morphology of cardiomyocyte t-tubule/sarcoplasmic reticulum junctions revealed by ultra-rapid high-pressure freezing and electron tomography. J Mol Cell Cardiol 2021/153:86-92
- Rog-Zielinska EA [...] Peyronnet R, Zgierski-Johnston, Greiner J, Madl J [...] Kohl P. Beat-by-beat cardiomyocyte T-tubule deformation drives tubular content exchange. Circ Res 2020/128(2):203-215
- MacDonald EA, Madl J, Greiner J […] Rog-Zielinska EA*, Quinn TA*. Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse. Front Physiol 2020/11:908 (*joint authorship)
- Lyon AR [...] Rog-Zielinska EA [...] Harding SE. Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure and a left ventricular assist device – the SERCA-LVAD trial. Gene Therapy 2020/e-pub ahead of print
- Karoutas A [...] Rog-Zielinska EA, Peyronnet R […] Kohl P […] Akhtar A. The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nat Cell Biol 2019/21:1248-1260
- Shahinian JH, Rog-Zielinska EA […] Siepe M. Impact of left ventricular assist device therapy on the cardiac proteome and metabolome composition in ischemic cardiomyopathy. Artif Organs 2020/44:257-267
- Toomer KA […] Kohl P, Rog-Zielinska EA [...] Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med 2019/11:eaax0290
- Brandenburg S […] Kohl P, Rog-Zielinska EA […] Lehnart SE. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight 2019/4:e127116
- Rog-Zielinska EA [...] Zgierski-Johnston CM […] Kohl P. Species differences in the morphology of transverse tubule openings in cardiomyocytes. Europace 2018/20:120-124
- Rog-Zielinska EA, O'Toole ET, Hoenger A, Kohl P. Mitochondrial Deformation During the Cardiac Mechanical Cycle. Anat Rec 2018/302:146-152
- Kong CHT*, Rog-Zielinska EA*, Kohl P, Orchard CH, Cannell MB. Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes. PNAS USA 2018/115:E7073-E7080 (*joint authors)
- Legchenko E [...] Rog-Zielinska EA [...] Hansmann G. PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation. Sci Transl Med 2018/10:eaao0303
- Tsushima K [...] Rog-Zielinska EA, Kohl P [...] Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission. Circ Res 2018/122:58-73
- Burton RAB, Rog-Zielinska EA [...] Peyronnet R [...] Kohl P. Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation. Biophys J 2017/113:1047-1059
- Kong CHT, Rog-Zielinska EA, Orchard CH, Kohl P, Cannell MB. Sub-microscopic analysis of t-tubule geometry in living cardiac ventricular myocytes using a shape-based analysis method. J Mol Cell Cardiol 2017/108:1-7
- Scardigli M [...] Rog-Zielinska EA, Kohl P [...] Sacconi L. Quantitative assessment of passive electrical properties of the cardiac T-tubular system by FRAP microscopy. PNAS USA 2017/114:5737-5742
- Aston D [...] Rog-Zielinska EA, Kohl P [...] Terrar DA. High resolution structural evidence suggests the sarcoplasmic reticulum forms microdomains with acidic stores (lysosomes) in the heart. Sci Rep 2017/7:40620
- Quinn TA, Camelliti P, Rog-Zielinska EA [....] Kohl P. Electrotonic coupling of excitable and non-excitable cells in the heart revealed by optogenetics. PNAS USA 2016/113:14852-14857
- Brandenburg S [...] Rog-Zielinska EA [...] Kohl P [...] Lehnart SE. Axial tubule junctions control rapid calcium signalling in atria. J Clin Invest 2016/126:3999-4015
- Rog-Zielinska EA, Johnston CM [...] Kohl P. Electron tomography of rabbit cardiomyocyte three-dimensional ultrastructure. Prog Biophys Mol Biol 2016/121:77-84
- Rog-Zielinska EA, Norris RA, Kohl P, Markwald R. The Living Scar - Cardiac Fibroblasts and the Injured Heart. Trends Mol Med 2016/22:99-114