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AG Macrophage Physiology

Dr. K. Kierdorf

Intrinsic and extrinsic factors regulating macrophage development and homeostasis

Resident tissue macrophages are found in nearly all metazoan organisms and are distributed throughout most tissues in the body. In vertebrates, it was recently shown that most resident macrophage populations are long-lived cell populations of embryonic origin with a slow endogenous turn over. Similarly in adult Drosophila, tissue macrophages are long-lived cells with embryonic or larval origin, however these cells do not show any turn-over or proliferation. In many tissues, macrophages offer a first line of defense upon injury or infection by secretion of a wide range of inflammatory molecules as well as the efficient phagocytosis of cell debris or pathogens. Beside their role in infection and inflammation, tissue macrophages also serve a plethora of physiological effects on the function of the organ and result in severe pathologies. In our group, we are interested to understand the intrinsic and extrinsic factors which control the establishment of a healthy and homeostatic macrophage network within adult tissues. Besides studying macrophages in the mouse model, we take advantage of the fruit fly Drosophila melanogaster, as a model to screen for potential candidate genes involved in physiological macrophage function.

Lab Members AG Kierdorf

Maria Oberle BTA +49 761 270 63131
Fabian Hersperger Postdoc +49 761 270 63108
Philippe Petry PhD Student +49 761 270 63118
Alexander Oschwald PhD Student +49 761 270 63118
Lance Bosch PhD Student +49 761 270 63119
Philipp Aktories PhD Student +49 761 270 63119
Tim Meyring MD Student +49 761 270 63117
Pia Weber MD Student +49 761 270 63117
Sidney Doerr MD Student +49 761 270 63118
Katja Freytag M.Sc. Student +49 761 270 63108
Lara Bohnen M.Sc. Student +49 761 270 63117
Alex Lane M.Sc. Student +49 761 270 63119
Daniel Brock M.Sc. Student +49 761 270 63131
Helene Hackenbroch B.Sc. Student +49 761 270 63119


Principal Investigator

Dr. Katrin Kierdorf

University Clinic Freiburg

Institute of Neuropathology
Breisacher Straße 64
79106 Freiburg

Tel.: +49 761 270 63109
Fax: +49 761 270 50500