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Klinik für Plastische und Handchirurgie

Complement system and CRP

Hr. Oscar Winninger

Modulation of the innate immune system by understanding CRP-complement interaction

Confocal fluorescence microscopy of human neutrophils. Upon stimulation with monomeric CRP neutrophils show enhanced expression of complement 5a receptor 1 (C5aR1). Nucleus - DAPI (blue), anti-C5aR1-FITC (green), 63x oil, scale bar 10 µm

The complement system and C-reactive protein are both part of the innate immune system. While both are indispensable for an effective immune response, both must be kept in narrow tracks and exacerbation is detrimental for the host. In polytrauma these strict regulations fail and patients suffer from an uncontrolled activation of the conplement system. Activation of the complement factor C5 is of particular importance in this disregulated processes: 

Pro-inflammatory effects of monomeric CRP are primarily mediated by the Fc-γ receptor family and induces an activation of the complement system cascade when bound to nectrotic or disturbed cell membranes. Thereby, the bioactive conformation of CRP enhances tissue damage as a function of the complement system and via Fc-γ receptors.

This DFG funded study aims to elucidate molecular mechanism of the complement dependent and independent pro-inflammatory effects of CRP. The clinical relevance and feasable therapeutic implications are etablished in "second hit" in vivo models. This study is conducted in cooperation with the Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, where a clinical study arm is implemented parallelly.

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Klinik für Plastische und Handchirurgie

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