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Klinik für Plastische und Handchirurgie

Tissue engineering of skin and oral mucosa

Dr. Sandra Straßburg

PD Dr. Filip Simunovic

To date, clinical applicability of current wound dressings is limited, particularly regarding large soft tissue defects, and there is evidence that impact of a vascular component is beneficial in the re-epithelization context. This combinatorial project, located at the material science-life science-interface, initially aims at creating a novel biohybrid gradient layered nonwoven (BGSV) as cell matrix for treatment of soft tissue defects. In the developmental part of this project, the biomechanical BGSV properties will be individually optimized during the manufacturing process, concerning their E-moduli, such that they successfully facilitate establishment of a vascular component, optionally comprising (i) umbilical endothelial cells (HUVECs) or (ii) endothelial progenitor cells (EPCs). Ideally, iterative biomechanics optimization will yield endothelial differentiation of EPCs or formation of capillary endothelial structures inside the BGSV, which with matched avascular controls will be preclinically evaluated under in vitro conditions. This validation is conducted qualitatively, by comparative experimental analysis of putative improvement and/or acceleration of oral mucosa or skin epithelial morphogenesis. In analogy to the previously described modus operandi for the preclinical validation, in vivo validation of re-epithelization is carried out in a nude mouse wound healing model, to address the translational level that means a prospective clinical utilization of vascularized BGSVs. This project is funded by the German Research Community (DFG) and carried out in cooperation with the Department of Oral Biotechnology (University Medical Center, Freiburg).

Aktuelle Informationen


Unsere Abteilung hat den elektiven Ambulanzbetrieb wieder aufgenommen

  • Wir bitten Sie Termine zuvor telefonisch oder online zu vereinbaren.
  • Das Tragen eines Mundschutzes in der Klinik ist verpflichtend.
  • Wir bitten Sie um das Einhalten der allgemeinen Hygieneregeln (Abstand von mind. 1,5 m, Hände waschen/desinfizieren).
  • Keine Termine bei akuten Erkältungssymptomen oder Kontakt zu Covid-Erkrankten in den letzten zwei Wochen.

Klinik für Plastische und Handchirurgie

Hugstetter Straße 55
79106 Freiburg

Telefon: 0761 270-27790

Montag-Freitag 10:00-13:00

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